MicroRNA-200 family members and ZEB2 are associated with brain metastasis in gastric adenocarcinoma.

abstract：:Although HIF-1α is considered an attractive target for the development of cancer therapies, like other transcriptional factors, it has been regarded as 'undruggable'. The decoy approach is a new class of antigene strategy that can be used to modulate the function of endogenous transcriptional factors. Here, we designe...

journal_title：International journal of oncology

authors： Zhu X,Li Q,Li S,Chen B,Zou H

更新日期：2015-01-01 00:00:00

abstract：:Collagen type I is an abundant component of the extracellular matrix and due to its longevity, constitutes a prominent target of non-enzymatic post-translational in vivo modifications such as carbamylation and glycation. These protein modifications involved in aging, renal diseases and diabetes, are linked to elevated...

journal_title：International journal of oncology

authors： Said G,Guilbert M,Millerot-Serrurot E,Van Gulick L,Terryn C,Garnotel R,Jeannesson P

更新日期：2012-06-01 00:00:00

abstract：:Radiotherapy (RT) is one of the major modalities for non‑small cell lung cancer (NSCLC), but its efficacy is often compromised by cellular resistance caused by various mechanisms including the overexpression of epidermal growth factor receptor (EGFR). Although cis‑diamminedichloroplatinum(Ⅱ) (cisplatin, CDDP) has been...

journal_title：International journal of oncology

authors： Jung J,Jeong SY,Park SS,Shin SH,Ju EJ,Choi J,Park J,Lee JH,Kim I,Suh YA,Hwang JJ,Kuroda S,Lee JS,Song SY,Choi EK

更新日期：2015-03-01 00:00:00

abstract：:Cordycepin (3'-deoxyadenosine), a major bioactive compound of Cordyceps militaris, has many pharmacological actions, such as anti-inflammatory and anticancer activities. In this study, the relationship between inhibition of cell motility and anti-invasive activity by cordycepin in L...

journal_title：International journal of oncology

authors： Jeong JW,Jin CY,Park C,Han MH,Kim GY,Moon SK,Kim CG,Jeong YK,Kim WJ,Lee JD,Choi YH

更新日期：2012-05-01 00:00:00

abstract：:Cancer progression has been associated with an increase in genomic instability indicated by inactivation of tumor suppressor genes and activation of oncogenes. Epidemiological and experimental evidence has implicated estrogens in the etiology of breast cancer. To study environmental organophosphorous pesticides is of ...

journal_title：International journal of oncology

authors： Calaf GM,Echiburu-Chau C,Roy D

更新日期：2009-11-01 00:00:00

abstract：:We previously showed that the B cell leukemia cell line NALM-6 had the highest susceptibility among a number of leukemia cell lines to spiruchostatin B (SP-B), a potent histone deacetylase (HDAC) inhibitor. We also showed that SP-B-induced cytotoxicity depended on induction of apopt...

journal_title：International journal of oncology

authors： Kanno S,Maeda N,Tomizawa A,Yomogida S,Katoh T,Ishikawa M

更新日期：2012-09-01 00:00:00

abstract：:Changes in the expression of the putative p53-inducible inhibitor p21 of cyclin-dependent kinase (CDK) and p21-associated CDK activity were examined in relation to the DNA synthesis-associated nuclear exclusion of p53 after stimulating growth arrested human breast cancer MCF7 cells with serum. Following stimulation, p...

journal_title：International journal of oncology

authors： Takahashi K,Suzuki K

更新日期：1994-11-01 00:00:00

abstract：:TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) preferentially induces apoptosis of cancer cells without toxicity in normal cells. TRAIL plays an important role in host immune surveillance against tumor metastasis. Cathepsin B (CB) is a mediator of apoptosis whose activity is regulated by its inhibitor...

journal_title：International journal of oncology

authors： Vigneswaran N,Wu J,Nagaraj N,Adler-Storthz K,Zacharias W

更新日期：2005-01-01 00:00:00

abstract：:A rat mammary tumor cell line maintained in low serum (1%) medium exhibited a slower growth rate, altered cell cycle distribution, decreased DNA synthesis, and increased immunoprecipitable p53, when compared with culture in 10% serum. Addition of linoleic acid (LA; 18:2, n-6) to low serum medium partially restored nor...

journal_title：International journal of oncology

authors： Tillotson J,Darzynkiewicz Z,Cohen L,Ronai Z

更新日期：1993-07-01 00:00:00

abstract：:In this study we examined the levels of IL-1 alpha, IL-1 beta, IL-2, IL-6, TNF-alpha and sIL-2R in the sera and culture supernatants of PHA-stimulated lymphocytes from a series of 90 cancer patients. The expression of the IL-2R p55 chain (alpha subunit) on PHA-stimulated lymphocytes was also evaluated together with th...

journal_title：International journal of oncology

authors： Mantovani G,Maccio A,Esu S,Lai P,Ghiani M,Turnu E,Contu G,Volpe A,Delgiacco G

更新日期：1994-12-01 00:00:00

abstract：:One of the major obstacles in curing prostate cancer is the development of drug resistance. It is not only imperative to discover the molecular basis of resistance but also to find therapeutic agents that can disrupt the resistant pathways. Tumor necrosis factor TNF-related apoptosis-inducing ligand TRAIL-like ligands...

journal_title：International journal of oncology

authors： Festuccia C,Gravina GL,D'Alessandro AM,Millimaggi D,Di Rocco C,Dolo V,Ricevuto E,Vicentini C,Bologna M

更新日期：2008-08-01 00:00:00

abstract：:Despite recent advances in targeted therapies and immunotherapies metastatic melanoma remains only rarely curable. The objective of the present study was to identify novel therapeutic targets for metastatic melanoma. A library of 160 well-characterised and potent protein kinase inhibitors was screened in the BRAF muta...

journal_title：International journal of oncology

authors： Mahgoub T,Eustace AJ,Collins DM,Walsh N,O'Donovan N,Crown J

更新日期：2015-09-01 00:00:00

abstract：:Neuroblastoma is a paediatric solid tumor characterized by recurrent genomic abnormalities of prognostic importance. One of the most commonly observed abnormalities is deletion of the short arm of chromosome 1 and reduced expression of cancer related genes in this chromosomal arm. The long isoform of the retinoblastom...

journal_title：International journal of oncology

authors： Geli J,Kiss N,Kogner P,Larsson C

更新日期：2010-11-01 00:00:00

abstract：:Although CD138 expression is a hallmark of plasma cells and myeloma cells, reduced CD138 expression is occasionally found. However, the mechanisms underlying CD138 downregulation in myeloma cells remain unclear. Previous reports suggest that the bone marrow microenvironment may contribute to CD138 downregulation. Amon...

journal_title：International journal of oncology

authors： Kawano Y,Kikukawa Y,Fujiwara S,Wada N,Okuno Y,Mitsuya H,Hata H

更新日期：2013-12-01 00:00:00

abstract：:Multidrug-resistance (MDR) is largely caused by the efflux of therapeutics from the tumor cell by means of P-glycoprotein (P-gp), resulting in reduced efficacy of the chemotherapy. In order to overcome MDR, substances, such as verapamil and cyclosporin A (CsA), were employed. As these P-gp modulating agents did not se...

journal_title：International journal of oncology

authors： Meschini S,Marra M,Calcabrini A,Federici E,Galeffi C,Arancia G

更新日期：2003-12-01 00:00:00

abstract：:We have previously demonstrated the multipotent nature of human umbilical cord blood stem cells (hUCB). In this study, we have attempted to show the use of hUCB in glioma therapy. We used hUCB enriched in CD44 and CD133 cells for our studies and observed that glioma cells co-cultured with hUCB undergo apoptosis. To pr...

journal_title：International journal of oncology

authors： Gondi CS,Gogineni VR,Chetty C,Dasari VR,Gorantla B,Gujrati M,Dinh DH,Rao JS

更新日期：2010-05-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common solid neoplasm of adult kidney, and the major treatment for metastatic RCC (mRCC) is molecular targeted therapy. Sorafenib, as a multi-targeted tyrosine kinase inhibitor (TKI), has significantly improved clinical outcomes of mRCC patients. However, complete or long-term re...

journal_title：International journal of oncology

authors： Zhang P,Xing Z,Li X,Song Y,Zhao J,Xiao Y,Xing Y

更新日期：2016-04-01 00:00:00

abstract：:Loss of chromosome sequences at 13q14 (Rbl) and 17p13 (p53) associated with squamous cell carcinoma of head and neck (SCCHN) was evaluated in 12 recurrent tumors and 51 primary tumors from 63 patients. The incidence of LOH at 17p13 was 19 of 50 (38%) tumors, and at 13q14 was 21 of 57 (37%). LOH affecting Rbl and/or p5...

journal_title：International journal of oncology

authors： Li Y,Pavelic Z,Wang L,Wang X,Gleich L,Biddinger P,Gartside P,Wilson K,Gluckman J,Stambrook P

更新日期：1997-06-01 00:00:00

abstract：:5-Fluorouracil (5-FU), a fluoropyrimidine analogue, is one of the most commonly used anticancer drugs for the treatment of gastrointestinal malignancies. Some studies reported that the cytotoxicity of fluoropyrimidines is mediated, in large part, by inhibition of the thymidylate synthase (TS), an essential DNA synthet...

journal_title：International journal of oncology

authors： Matsuoka K,Tsukuda K,Suda M,Kobayashi K,Ota T,Okita A,Watanabe K,Suzuki E,Murakami M,Doihara H,Shimizu N

更新日期：2004-01-01 00:00:00

abstract：:Regulatory T cells (CD4+CD25+FoxP3+, Treg) have been shown to play a major role in suppression of the immune response to malignant gliomas. In this study, we investigated the kinetics of Treg infiltration in metastatic brain tumor models, including melanoma, breast and colon cancers. Our data indicate that both CD4+ a...

journal_title：International journal of oncology

authors： Sugihara AQ,Rolle CE,Lesniak MS

更新日期：2009-06-01 00:00:00

abstract：:Ovarian cancer is a lethal malignancy, rarely diagnosed early, and there is currently little, if any, preventive strategies which can be followed. This study attempts to identify lifestyle profiles which might be associated with ovarian cancer, and could then be subject to subsequent modification in an effort to preve...

journal_title：International journal of oncology

authors： Loesch M,Fischer M,Shurpin K,Mann W

更新日期：1994-03-01 00:00:00

abstract：:Adenosine monophosphate-activated protein kinase (AMPK) is a principal intracellular energy sensor which regulates energy producing pathways and energy requiring pathways when the cellular AMP/ATP ratio is altered. BML-275 (compound C), a well-known inhibitor of AMPK, has been found...

journal_title：International journal of oncology

authors： Duong HQ,Hwang JS,Kim HJ,Seong YS,Bae I

更新日期：2012-12-01 00:00:00

abstract：:Prostate cancer is characterized by structural rearrangements, most frequently including translocations between androgen-dependent genes and members of the ETS family of transcription factor like TMPRSS2:ERG. In a recent whole genome sequencing study we identified 140 gene fusions that were unrelated to ETS genes in 1...

journal_title：International journal of oncology

authors： Kluth M,Galal R,Krohn A,Weischenfeldt J,Tsourlakis C,Paustian L,Ahrary R,Ahmed M,Scherzai S,Meyer A,Sirma H,Korbel J,Sauter G,Schlomm T,Simon R,Minner S

更新日期：2015-04-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC), the most common esophageal cancer in East Asia, is among the six cancers with the highest fatality rates worldwide. Unfortunately, multidisciplinary treatment strategies have not achieved satisfactory outcomes. Therefore, novel insights into the molecular biology of ESCC are ...

journal_title：International journal of oncology

authors： Tanaka H,Kanda M,Koike M,Iwata N,Shimizu D,Ezaka K,Sueoka S,Tanaka Y,Takami H,Hashimoto R,Tanaka C,Yamada S,Fujii T,Nakayama G,Sugimoto H,Fujiwara M,Kodera Y

更新日期：2015-11-01 00:00:00

abstract：:The present in vitro study on three human renal cell carcinoma (RCC) cell lines (A-498, ACHN, SN12C) evaluated the efficacy of 2',2'-difluorodeoxycytidine (dFdC, gemcitabine), vinblastine (VBL), rhu-interferon-alpha (IFN-alpha) and rhu-interferon-gamma (IFN-gamma) alone or in combinations. The cytotoxicity was measure...

journal_title：International journal of oncology

authors： Rohde D,Hayn HK,Blatter J,Jakse G

更新日期：1998-06-01 00:00:00

abstract：:PTEN, a gene encoding a dual specificity phosphatase, is frequently altered in endometrial carcinoma. Moreover, these alterations are observed even in atypical hyperplasia of the endometrium. This evidence suggests that mutation of PTEN is an early genetic alteration involved in endometrial carcinogenesis. Adenovirus-...

journal_title：International journal of oncology

authors： Sakurada A,Hamada H,Fukushige S,Yokoyama T,Yoshinaga K,Furukawa T,Sato S,Yajima A,Sato M,Fujimura S,Horii A

更新日期：1999-12-01 00:00:00

abstract：:VSELs are a population of rare Oct-4+CXCR4+ CD133+lin-CD45- cells that are deposited during early embryogenesis in developing organs/tissues as a reserve population of pluripotent stem cells for regeneration. We reported recently that they are mobilized into peripheral blood during acute myocardial infarction (AMI) in...

journal_title：International journal of oncology

authors： Wojakowski W,Tendera M,Kucia M,Zuba-Surma E,Milewski K,Wallace-Bradley D,Kazmierski M,Buszman P,Hrycek E,Cybulski W,Kaluza G,Wieczorek P,Ratajczak J,Ratajczak MZ

更新日期：2010-08-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer commonly associated with asbestos exposure that stems from the thoracic mesothelium with high mortality rate. Currently, treatment options for MPM are limited, and new molecular targets for treatments are urgently needed. Using quantitative r...

journal_title：International journal of oncology

authors： Kato T,Lee D,Wu L,Patel P,Young AJ,Wada H,Hu HP,Ujiie H,Kaji M,Kano S,Matsuge S,Domen H,Kaga K,Matsui Y,Kanno H,Hatanaka Y,Hatanaka KC,Matsuno Y,de Perrot M,Yasufuku K

更新日期：2016-08-01 00:00:00

abstract：:The anti-inflammatory effects of oridonin (Ordn) have been well established in previous studies. However, the apoptotic effects of Ordn on oral cancer cells have not yet been evaluated, at least to the best of our knowledge. The aim of this study was to examine the apoptotic activity of Ordn in oral squamous cell carc...

journal_title：International journal of oncology

authors： Oh HN,Seo JH,Lee MH,Yoon G,Cho SS,Liu K,Choi H,Oh KB,Cho YS,Kim H,Han AL,Chae JI,Shim JH

更新日期：2018-05-01 00:00:00

abstract：:The presence of S-100 protein positive dendritic cells (S-100(+)DC) in primary hepatocellular carcinoma (HCC) were immunohistochemically investigated in relation to clinicopathological factors. The patients who showed a marked infiltration of S-100(+)DC survived longer especially in the group of non-curative resection...

journal_title：International journal of oncology

authors： Ido E,Furihata M,Ohtsuki Y,Iwata J,Sonobe H

更新日期：1994-08-01 00:00:00