Protein chemical identification and characterization of the human variants of far upstream element binding protein in medulloblastoma DAOY cell line.

abstract：:The transcription factor E2F4 plays a critical role in cell cycle progression of normal and cancerous intestinal epithelial cells. Contrary to other E2Fs, the coding region of the E2F4 gene contains a longer spacer segment of a CAG trinucleotide repeat sequence encoding 13 consecutive serine residues, which is highly ...

journal_title：International journal of oncology

authors： Paquin MC,Leblanc C,Lemieux E,Bian B,Rivard N

更新日期：2013-12-01 00:00:00

abstract：:Phosphatase of regenerating liver-3 (PRL-3) has been found to be overexpressed in liver metastases of colorectal cancer and rarely expressed in primary tumors, which plays an important role in the metastasis of colorectal cancer cells. Metabolism reprogramming has been found to be a hallmark of cancer cells, and aerob...

journal_title：International journal of oncology

authors： Xu H,Zeng Y,Liu L,Gao Q,Jin S,Lan Q,Lai W,Luo X,Wu H,Huang Y,Chu Z

更新日期：2017-10-01 00:00:00

abstract：:Licochalcone A (LCA) is a natural product derived from the roots of Glycyrrhiza inflata exhibiting a wide range of bioactivities such as antitumor, anti-oxidant and anti-bacterial effects. Malignant pleural mesothelioma (MPM) is an extremely aggressive type of cancer with a poor prognosis because of its rapid progress...

journal_title：International journal of oncology

authors： Kim KH,Yoon G,Cho JJ,Cho JH,Cho YS,Chae JI,Shim JH

更新日期：2015-03-01 00:00:00

abstract：:Eukaryotic initiation factor 3c (eIF3C) is involved in the initiation of protein translation. Aberrant eIF3C expression has been reported in different types of human cancer. The present study aimed to assess the role of eIF3C in the malignant behavior of renal cell carcinoma in vitro and in vivo. eIF3C expression was ...

journal_title：International journal of oncology

authors： Fan M,Wang K,Wei X,Yao H,Chen Z,He X

更新日期：2019-12-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is cytotoxic to the majority of cancer cells while sparing most normal cells. However, different prostate carcinoma cell lines respond with different sensitivities to TRAIL, urging us to disclose the mechanisms that determine TRAIL sensitivity in prostate...

journal_title：International journal of oncology

authors： Sonnemann J,Gekeler V,Sagrauske A,Müller C,Hofmann HP,Beck JF

更新日期：2004-10-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) poses a significant challenge clinically where one of the mechanisms responsible for the invasion into facial bones occurs via the activation of osteoclasts. Copper has been demonstrated to play a key role in skeletal remodeling. However, the role of copper in cancer-assoc...

journal_title：International journal of oncology

authors： Morisawa A,Okui T,Shimo T,Ibaragi S,Okusha Y,Ono M,Nguyen TTH,Hassan NMM,Sasaki A

更新日期：2018-03-01 00:00:00

abstract：:Surfactant proteins play important roles in lung surfactant function and innate immunity. The DNA methylation state of 11 CpG sites of surfactant protein (SP)-A1, -B, -C, and -D was determined using universal bead arrays. A total of 90 cancerous and non-cancerous tissues from 23 patients with adenocarcinoma and 22 wit...

journal_title：International journal of oncology

authors： Lin Z,Thomas NJ,Bibikova M,Seifart C,Wang Y,Guo X,Wang G,Vollmer E,Goldmann T,Garcia EW,Zhou L,Fan JB,Floros J

更新日期：2007-07-01 00:00:00

abstract：:Epidemiologic studies on the protective role of omega-3 fatty acids (n:3) on breast cancer prevention remain inconclusive but studies in preclinical models provide more positive outcome. However, the mechanisms accounting for the protective effect of n:3 are not defined. In the present study, conducted in the N-methyl...

journal_title：International journal of oncology

authors： Manni A,Richie JP Jr,Xu H,Washington S,Aliaga C,Cooper TK,Bruggeman R,Das A,Prokopczyk B,Calcagnotto A,Trushin N,Dickinson R,Liao J,Verderame MF,El-Bayoumy K

更新日期：2011-11-01 00:00:00

abstract：:Gene expression of dihydropyrimidine dehydrogenase (DPD) and newly multidrug resistance-associated protein (MRP) was found to correlate well with primary 5-FU resistance in 7 human gastrointestinal cancer cell lines. Although mRNA and protein levels of thymidylate synthase (TS) did not relate to the resistance, 5-FU t...

journal_title：International journal of oncology

authors： Kirihara Y,Yamamoto W,Toge T,Nishiyama M

更新日期：1999-03-01 00:00:00

abstract：:Cancer stem cells (CSC) exhibit therapy resistance and drive self-renewal of the tumour, making cancer stem cells an important target for therapy. The PI3K signalling pathway has been the focus of considerable research effort, including in glioblastoma (GBM), a cancer that is notoriously resistant to conventional ther...

journal_title：International journal of oncology

authors： Jones NM,Rowe MR,Shepherd PR,McConnell MJ

更新日期：2016-07-01 00:00:00

abstract：:Myofibroblasts in the stroma of pancreatic cancers promote tumor proliferation, invasion and metastasis by increasing extracellular matrix and secretion of several growth factors. In contrast, the role of myofibroblasts at peritoneally disseminated sites of pancreatic cancer has not yet been determined. This study was...

journal_title：International journal of oncology

authors： Akagawa S,Ohuchida K,Torata N,Hattori M,Eguchi D,Fujiwara K,Kozono S,Cui L,Ikenaga N,Ohtsuka T,Aishima S,Mizumoto K,Oda Y,Tanaka M

更新日期：2014-07-01 00:00:00

abstract：:Genotoxic stress such as ionizing radiation can induce DNA damage and promote cell-cycle arrest or apoptosis through either a p53-dependent or -independent pathway. Recently, members of the FOXO Forkhead transcription factor family have been implicated in playing a role in both DNA repair and apoptosis in mammalian ce...

journal_title：International journal of oncology

authors： Yang JY,Xia W,Hu MC

更新日期：2006-09-01 00:00:00

abstract：:Previous studies from this laboratory have shown that bioflavonoids including luteolin and quercetin possess antiestrogenic activity in the female reproductive tract and appear to elicit this activity by interaction with type II [H-3]estradiol binding sites in the cell nucleus. Studies by a number of laboratories incl...

journal_title：International journal of oncology

authors： Markaverich B,Alejandro M

更新日期：1997-12-01 00:00:00

abstract：:A disintegrin and metalloproteinase-17 (ADAM17) can cut and release a wide variety of epidermal growth factor receptor (EGFR) ligands to promote survival, invasion and proliferation of cancer cell, and therefore, is considered to be a potential therapeutic target for cancer. The main goal of the present study was to o...

journal_title：International journal of oncology

authors： Meng X,Hu B,Hossain MM,Chen G,Sun Y,Zhang X

更新日期：2016-08-01 00:00:00

abstract：:Human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase, is very closely associated with telomerase activity. Telomerase has been implicated in cellular immortalization and carcinogenesis. In situ detection of hTERT will aid in determining the localization of telomerase-positive cells. The ...

journal_title：International journal of oncology

authors： Kammori M,Izumiyama N,Hashimoto M,Nakamura K,Okano T,Kurabayashi R,Naoki H,Honma N,Ogawa T,Kaminishi M,Takubo K

更新日期：2005-11-01 00:00:00

abstract：:The expression of myeloid cell leukemia-1 (Mcl‑1), a member of the anti-apoptotic Bcl-2 protein family, has been associated with tumor progression and adverse patient outcome. The aims of current study were to evaluate whether Mcl-1 affects the survival or death of gastric cancer cells, and to investigate the prognost...

journal_title：International journal of oncology

authors： Lee WS,Park YL,Kim N,Oh HH,Son DJ,Kim MY,Oak CY,Chung CY,Park HC,Kim JS,Myung DS,Cho SB,Joo YE

更新日期：2015-05-01 00:00:00

abstract：:There is increasing evidence that different types of breast cancers are related to distinct risk factors. We analyzed the risk of breast cancer with respect to circulating insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-3, 17beta-estradiol, estrone, testosterone, androstenedione and sex hormone-binding...

journal_title：International journal of oncology

authors： Kahán Z,Gardi J,Nyári T,Földesi I,Hajnal-Papp R,Ormándi K,Lázár G,Thurzó L,Schally AV

更新日期：2006-07-01 00:00:00

abstract：:Pristimerin (PM), a quinonemethide triterpenoid, is a promising anticancer agent with potent antiproliferative and apoptosis-inducing activities against cancer cell lines. However, the anticancer activity and mechanisms of PM in prostate cancer cells have not been adequately investigated. Here we report that the degra...

journal_title：International journal of oncology

authors： Liu YB,Gao X,Deeb D,Brigolin C,Zhang Y,Shaw J,Pindolia K,Gautam SC

更新日期：2014-10-01 00:00:00

abstract：:The efficacy of radioimmunotherapy with radiolabelled monoclonal antibody (Mab) depends on the amount of antibody taken up by the tumour and on its intratumoral distribution. Multicellular spheroids (MTS) of lung cell carcinoma was investigated to study cellular and subcellular distribution of a Mab Po66 labelled with...

journal_title：International journal of oncology

authors： Dazord L,Thomas D,Brichory F,Cavalier A,Meritte H,Desrues B,Cauletmaugendre S,Bourguet P

更新日期：1997-03-01 00:00:00

abstract：:The expression of microRNA-375 (miR-375) is significantly reduced in cancer tissues of maxillary sinus squamous cell carcinoma (MSSCC). The aim of this study was to investigate the functional significance of miR-375 and a possible regulatory role in the MSSCC networks. Restoration o...

journal_title：International journal of oncology

authors： Kinoshita T,Nohata N,Yoshino H,Hanazawa T,Kikkawa N,Fujimura L,Chiyomaru T,Kawakami K,Enokida H,Nakagawa M,Okamoto Y,Seki N

更新日期：2012-01-01 00:00:00

abstract：:MicroRNAs (miRs) are short non-coding single stranded RNAs regulating the translation of target mRNAs in normal and cancer cells in which they are frequently dysregulated promoting tumor progression. Cancer stem cells (CSCs) of head and neck squamous cell carcinoma (HNSCC), identified by aldehyde-dehydrogenase express...

journal_title：International journal of oncology

authors： Sun Z,Hu W,Xu J,Kaufmann AM,Albers AE

更新日期：2015-10-01 00:00:00

abstract：:Cancer cells genetically modified to secrete immunoregulatory cytokines offer great promise for human cancer treatment as tumor vaccines. However, in preclinical animal studies, large established cancer burdens have appeared difficult to eradicate with such vaccines. For example, lethally-irradiated GM-CSF-secreting C...

journal_title：International journal of oncology

authors： Nigam A,Yacavone RF,Zahurak ML,Johns CM,Pardoll DM,Piantadosi S,Levitsky HI,Nelson WG

更新日期：1998-01-01 00:00:00

abstract：:Photodynamic therapy (PDT) is a tool against neoplastic and non-neoplastic diseases. PDT is capable to induce different cell death mechanisms in vitro, triggered in a dose-dependent manner. Relationships between PDT and apoptosis or necrosis induction are well-known, but other cell death mechanisms triggered after PDT...

journal_title：International journal of oncology

authors： Rello-Varona S,Stockert JC,Cañete M,Acedo P,Villanueva A

更新日期：2008-06-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) and acute myeloid leukemia are the major causes of mortality and morbidity in Fanconi anemia (FA) patients. The objective of this study was to investigate the antineoplastic activity of PB, an antineoplastic nutrient mixture (containing quercetin, curcumin, green tea, cruc...

journal_title：International journal of oncology

authors： Roomi MW,Kalinovsky T,Roomi NW,Niedzwiecki A,Rath M

更新日期：2015-05-01 00:00:00

abstract：:Selenium is considered to be one of the most promising micronutrients for cancer prevention and therapy, based on evidence from epidemiological studies, laboratory-based research and clinical trial intervention. There are ample reports of selenium methionine and sodium selenite's ability to induce apoptosis in various...

journal_title：International journal of oncology

authors： Rooprai HK,Kyriazis I,Nuttall RK,Edwards DR,Zicha D,Aubyn D,Davies D,Gullan R,Pilkington GJ

更新日期：2007-05-01 00:00:00

abstract：:Mesothelioma is an aggressive tumor which is mainly derived from the pleura of lung. In the present study, we evaluated the anticancer effect of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase (HDAC) inhibitor on human mesothelioma cells in relation to the levels of HDAC1, reactive oxygen species (ROS) a...

journal_title：International journal of oncology

authors： You BR,Park WH

更新日期：2016-05-01 00:00:00

abstract：:The presence of tumor cells in the bone marrow (BM) could be relevant to identifying high risk of disease progression and death in gastrointestinal cancer. However, the molecular profile associated with disseminated tumor cells (DTCs) homing to the BM has yet to be defined. MicroRNAs (miRNA) play key roles in cellular...

journal_title：International journal of oncology

authors： Valladares-Ayerbes M,Blanco M,Haz M,Medina V,Iglesias-Díaz P,Lorenzo-Patiño MJ,Reboredo M,Santamarina I,Figueroa A,Antón-Aparicio LM,Calvo L

更新日期：2011-11-01 00:00:00

abstract：:Fanconi anemia complementation group D2 (FANCD2) is involved in the key steps of the Fanconi anemia (FA) pathway, which plays a role in the repair of DNA crosslink damage. However, the role of FANCD2 during radiotherapy for head and neck squamous cell carcinoma (HNSCC) is unclear. In this study, the HNSCC cell line HS...

journal_title：International journal of oncology

authors： Feng HJ,Bao YL,Liang ZP,Zhao FP,Xu SE,Xu W,Zhao C,Qin G

更新日期：2017-03-07 00:00:00

abstract：:Cancer stem cells (CSCs), which have the potential for self-renewal, differentiation and de-differentiation, undergo epigenetic, epithelial-mesenchymal, immunological and metabolic reprogramming to adapt to the tumor microenvironment and survive host defense or therapeutic insults. Intra-tumor heterogeneity and cancer...

journal_title：International journal of oncology

authors： Katoh M

更新日期：2017-11-01 00:00:00

abstract：:Tumor necrosis factor α induced protein 3 (TNFAIP3) is a protein that is induced by TNF-mediated NF-κB activation and has a dual function in regulating NF-κB. TNFAIP3 is associated with inflammatory carcinogenesis in many cancer types. However, the clinical significance of TNFAIP3 expression and function in esophageal...

journal_title：International journal of oncology

authors： Hadisaputri YE,Miyazaki T,Yokobori T,Sohda M,Sakai M,Ozawa D,Hara K,Honjo H,Kumakura Y,Kuwano H

更新日期：2017-03-01 00:00:00