Correlation of the response of recurrent malignant gliomas treated with interferon alpha with tumor interferon alpha gene content.

abstract：:Conjugated linoleic acid (CLA) refers to a group of naturally occurring positional and geometrical conjugated dienoic isomers of linoleic acid (C18:2), of which the cis-9,trans-11 (c9,t11) and trans-10,cis-12 (t10,c12) isomers predominate. Accumulating evidence has demonstrated that CLA isomers are capable of inhibiti...

journal_title：International journal of oncology

authors： Lui OL,Mak NK,Leung KN

更新日期：2005-12-01 00:00:00

abstract：:Increased expression levels of the long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (Malat1) have been associated with enhanced proliferation and metastasis of several cancer cell types. Hypoxia, a hallmark characteristic of solid tumors, has been linked to an increase in the activity of the ...

journal_title：International journal of oncology

authors： Sallé-Lefort S,Miard S,Nolin MA,Boivin L,Paré MÈ,Debigaré R,Picard F

更新日期：2016-10-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is one of the most promising anti-cancer agents, but some tumor types develop resistance to TRAIL. Here, we report that chetomin, an inhibitor of hypoxia-inducible factors, is a potent enhancer of TRAIL-induced apoptosis. TRAIL or chetomin alone weakly in...

journal_title：International journal of oncology

authors： Yano K,Horinaka M,Yoshida T,Yasuda T,Taniguchi H,Goda AE,Wakada M,Yoshikawa S,Nakamura T,Kawauchi A,Miki T,Sakai T

更新日期：2011-02-01 00:00:00

abstract：:Frizzled (FZD) genes encode receptors for WNTs, which play key roles in carcinogenesis and embryogenesis. We have previously cloned the FZD10 gene, and demonstrated up-regulation of FZD10 mRNA in the cervical cancer cell line HeLa S3, gastric cancer cell lines TMK1 and MKN74, and 4 cases out of 10 cases of primary gas...

journal_title：International journal of oncology

authors： Saitoh T,Mine T,Katoh M

更新日期：2002-01-01 00:00:00

abstract：:The ability of lonidamine (LND), an energolytic derivative of indazol-carboxylic acid, to modulate the cytotoxic activity of idarubicin (IDA) and doxorubicin (DX) was investigated in two human lymphoma cell lines (H9 and U937). A different pattern of interaction between the drugs was observed as a function of treatmen...

journal_title：International journal of oncology

authors： Zaffaroni N,Villa R,Gornati D,Folini M,Silvestrini R

更新日期：1997-10-01 00:00:00

abstract：:We have isolated a new -ene, named BAC, which is the human equivalent of the murine H19 gene and is highly expressed in most fetal tissues and in a variety of fresh tumors. BAC was analyzed in 130 untreated invasive carcinomas of different types. The frequency of BAC-expressing cancers as well as the level of expressi...

journal_title：International journal of oncology

authors： Doucrasy S,Coll J,Barrois M,Joubel A,Prost S,Dozier C,Stehelin D,Riou G

更新日期：1993-05-01 00:00:00

abstract：:Peripheral blood was examined for the presence of tumor cells at multiple time points over a one-year period in 45 patients with a history of surgical resection of breast carcinoma. The number of circulating epithelial cells in 8 of 8 patients with clinically active disease concurred or preceded changes in the disease...

journal_title：International journal of oncology

authors： Terstappen LW,Rao C,Gross S,Weiss AJ

更新日期：2000-09-01 00:00:00

abstract：:Squamous cell carcinoma antigen (SCCA) is overexpressed in many squamous cell cancers and SCCA‑derived peptide-specific CD8(+) cytotoxic T lymphocytes can display cytotoxicity against tumor cells. In the present study, we screened the SCCA amino acid sequence for potential HLA-A*0201-binding CD8(+) T‑cell epitopes usi...

journal_title：International journal of oncology

authors： Duan ZL,Wang ZB,Guo JL,Liu WQ,Hu J,Li J,Wang SN,Li Q,Wen JS

更新日期：2013-04-01 00:00:00

abstract：:Mos is a germ cell-specific serine/threonine protein kinase that plays an important role during meiotic divisions of oocytes. Upon expression in somatic cells, Mos causes cell cycle perturbations leading to neoplastic transformation. Mos activates the MAP kinase pathway in both oocytes and transformed somatic cells. T...

journal_title：International journal of oncology

authors： Yang Y,Pham CD,Arlinghaus RB,Khillan JS,Singh B

更新日期：1998-05-01 00:00:00

abstract：:Large granular lymphocyte (LGL) leukemia is a lymphoproliferative disease often associated with autoimmune disorders such as rheumatoid arthritis. High levels of soluble Fas ligand have been implicated in development of chronic neutropenia. However, a comprehensive analysis of constitutive chemokine and lymphokine pro...

journal_title：International journal of oncology

authors： Kothapalli R,Nyland SB,Kusmartseva I,Bailey RD,McKeown TM,Loughran TP Jr

更新日期：2005-02-01 00:00:00

abstract：:Family with sequence similarity 83 member A (FAM83A) has been recently observed to be upregulated in various types of cancer and hypothesized to be serve as an oncogene. The present study aimed to determine the functional roles and the underlying molecular mechanism of FAM83A in cervical cancer. The results demonstrat...

journal_title：International journal of oncology

authors： Xu J,Lu W

更新日期：2020-08-01 00:00:00

abstract：:The proper structure of the extracellular matrix, in particular of the basement membrane and the adjacent interstitial matrix, are essential prerequisites for a proper function of tissues. Invasive growth in malignant tumors is associated with a destruction of various matrix structures. Due to extensive recent analyse...

journal_title：International journal of oncology

authors： Hagedorn HG,Bachmeier BE,Nerlich AG

更新日期：2001-04-01 00:00:00

abstract：:Protein disulfide‑isomerase A3 (PDIA3) is a chaperone protein that modulates folding of newly synthesized glycoproteins and responds to endoplasmic reticulum (ER) stress. Previous studies reported that increased expression of PDIA3 in hepatocellular carcinoma (HCC) is a marker for poor prognosis. However, the mechanis...

journal_title：International journal of oncology

authors： Kondo R,Ishino K,Wada R,Takata H,Peng WX,Kudo M,Kure S,Kaneya Y,Taniai N,Yoshida H,Naito Z

更新日期：2019-04-01 00:00:00

abstract：:Metastatic colorectal cancer is the second most common cause of cancer mortality. The liver is a common site of metastasis and only a minority of patients with liver metastases are candidates for potentially curative surgical resection. The treatment of patients with unresectable liver tumors is a major clinical probl...

journal_title：International journal of oncology

authors： Cai SR,Garbow JR,Culverhouse R,Church RD,Zhang W,Shannon WD,McLeod HL

更新日期：2005-07-01 00:00:00

abstract：:Cholangiocarcinoma is the most common biliary duct malignancy and the second most common primary liver cancer, accounting for 10‑20% of hepatic malignancies. With high mortality and poor prognosis, the 5‑year survival rate of cholangiocarcinoma is only 10%. A previous study demonstrated a significant association betwe...

journal_title：International journal of oncology

authors： Shi T,Gong J,Fujita K,Nishiyama N,Iwama H,Liu S,Nakahara M,Yoneyama H,Morishita A,Nonura T,Kobara H,Okano K,Suzuki Y,Masaki T

更新日期：2020-12-30 00:00:00

abstract：:Cytokine expression in a tumor microenvironment can impact both host defense against the tumor and tumor cell survival. In this study, we sought to clarify whether the cytokine gene expression profile could have clinical associations with ovarian cancer. We analyzed the expression of 16 cytokine genes (IL-1α, IL-1β, I...

journal_title：International journal of oncology

authors： Yanaihara N,Anglesio MS,Ochiai K,Hirata Y,Saito M,Nagata C,Iida Y,Takakura S,Yamada K,Tanaka T,Okamoto A

更新日期：2012-09-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) are key determinants in the malignant progression of cancer, supporting tumorigenesis and metastasis. CAFs also mediate epithelial to mesenchymal transition (EMT) in tumor cells and their achievement of stem cell traits. Curcumin has recently been found to possess anticancer activi...

journal_title：International journal of oncology

authors： Du Y,Long Q,Zhang L,Shi Y,Liu X,Li X,Guan B,Tian Y,Wang X,Li L,He D

更新日期：2015-12-01 00:00:00

abstract：:The p53 homologue p73 is overexpressed in many tumors, including lung cancer. We have evaluated the differential expression and subcellular localization of the functionally distinct apoptotic (TA) and anti-apoptotic (DeltaN) isoforms of p73 in non-small cell lung cancer (NSCLC), their possible association with p53 exp...

journal_title：International journal of oncology

authors： Di Vinci A,Sessa F,Casciano I,Banelli B,Franzi F,Brigati C,Allemanni G,Russo P,Dominioni L,Romani M

更新日期：2009-02-01 00:00:00

abstract：:Breast cancer (BrC) is a major public health problem worldwide. The intra-tumoral heterogeneity and tumor cell plasticity importantly contribute to disease progression and treatment failure. However, the dynamic interactions between different tumor clones, as well as their contribution to tumor aggressiveness are stil...

journal_title：International journal of oncology

authors： Espinoza-Sánchez NA,Vadillo E,Balandrán JC,Monroy-García A,Pelayo R,Fuentes-Pananá EM

更新日期：2017-11-01 00:00:00

abstract：:Claudin 6 (CLDN6), a member of tight junction protein claudin (CLDN) family, inhibits proliferation and induces apoptosis of MCF-7 breast cancer cells. However, these molecular mechanisms of CLDN6-induced apoptosis remain largely elusive. We previously found that restoration of human CLDN6 gene expression was correlat...

journal_title：International journal of oncology

authors： Guo Y,Lin D,Zhang M,Zhang X,Li Y,Yang R,Lu Y,Jin X,Yang M,Wang M,Zhao S,Quan C

更新日期：2016-06-01 00:00:00

abstract：:Chromosomal aneuploidy is associated with invasive bladder cancer and one of the genes implicated in these changes is Aurora-A/STK15/BTAK, that is localized on chromosome 20q13 and encodes a centrosome-associated serine/threonine kinase. To better understand the association between Aurora-A/STK15 expression, tumor ane...

journal_title：International journal of oncology

authors： Fraizer GC,Diaz MF,Lee IL,Grossman HB,Sen S

更新日期：2004-12-01 00:00:00

abstract：:Chemotherapy is an important treatment option for gastric cancer (GC); however, chemotherapy usually fails due to drug resistance, particularly multidrug resistance (MDR). In our previous studies, microRNA (miR)‑874 was demonstrated to serve an important role in tumour growth, apoptosis and angiogenesis. In the presen...

journal_title：International journal of oncology

authors： Huang H,Tang J,Zhang L,Bu Y,Zhang X

更新日期：2018-12-01 00:00:00

abstract：:Angiogenesis is a prerequisite for the growth and metastasis of solid tumors. Studies have confirmed that in the absence of angiogenesis, tumors rarely have the ability to develop beyond a few millimeters in diameter. Tumor-associated endothelium is activated by the production of soluble factors by tumor and stromal c...

journal_title：International journal of oncology

authors： Isayeva T,Kumar S,Ponnazhagan S

更新日期：2004-08-01 00:00:00

abstract：:Regulation of cytoplasmic p21CIP/WAF1 (p21) is of great clinical significance in molecular oncology due to its identification as an antiapoptotic factor, a poor survival predictor as well as a drug-resistance inducer. A retrospective study of the immunohistochemical (IHC) profiles of 128 human primary breast cancers s...

journal_title：International journal of oncology

authors： Ping B,He X,Xia W,Lee DF,Wei Y,Yu D,Mills G,Shi D,Hung MC

更新日期：2006-11-01 00:00:00

abstract：:Knowledge of intrinsic tumor heterogeneity is vital for understanding of tumor progression mechanisms as well as for providing efficient treatments. In situ proteomic profiling of tumors is a powerful technology with potential to enhance our understanding of tumor biology, but sources of variability due to patient and...

journal_title：International journal of oncology

authors： Li JQ,Xu BJ,Shakhtour B,Deane N,Merchant N,Heslin MJ,Washington K,Coffey RJ,Beauchamp RD,Shyr Y,Billheimer D

更新日期：2007-07-01 00:00:00

abstract：:Docetaxel is one of the most commonly used chemotherapeutic agents in breast cancer. To avert from significant toxicities with no clinical benefit, identification of predictive markers for response is one of the most important unsolved clinical needs. Therefore, the potential associ...

journal_title：International journal of oncology

authors： Gil EY,Jo UH,Jeong H,Whang YM,Woo OH,Cho KR,Seo JH,Kim A,Lee ES,Koh I,Kim YH,Park KH

更新日期：2012-08-01 00:00:00

abstract：:Mechanisms leading to inhibitory effects of an anti-GD2 ganglioside (GD2) 14G2a mouse monoclonal antibody (mAb) and PI3K/Akt/mTOR pathway inhibitors on human neuroblastoma cell survival were studied in vitro. We have recently shown on IMR-32, CHP‑134, and LA-N-1 neuroblastoma cells that targeting GD2 with the mAb decr...

journal_title：International journal of oncology

authors： Durbas M,Horwacik I,Boratyn E,Kamycka E,Rokita H

更新日期：2015-09-01 00:00:00

abstract：:The presence of tumor cells in the bone marrow (BM) could be relevant to identifying high risk of disease progression and death in gastrointestinal cancer. However, the molecular profile associated with disseminated tumor cells (DTCs) homing to the BM has yet to be defined. MicroRNAs (miRNA) play key roles in cellular...

journal_title：International journal of oncology

authors： Valladares-Ayerbes M,Blanco M,Haz M,Medina V,Iglesias-Díaz P,Lorenzo-Patiño MJ,Reboredo M,Santamarina I,Figueroa A,Antón-Aparicio LM,Calvo L

更新日期：2011-11-01 00:00:00

abstract：:Hexadecylphosphocholine (HPC, D-18506, INN: Miltefosine) was characterized in a clonogenic micro assay in vitro with respect to its cytotoxicity against a panel of human and murine tumor cell lines and murine bone marrow cultures (GM-CFC). The KB human epithelial carcinoma line was found to be more sensitive by at lea...

journal_title：International journal of oncology

authors： Voegeli R,Echarti C,Maurer H,Stekar J,Hilgard P,Unger C

更新日期：1993-02-01 00:00:00

abstract：:The Her-2 receptor coded for by the proto-oncogenic erbB-2 gene is a clinically validated target for treatment of a significant genetic subclass of breast cancers, and Her-2 is also overexpressed or mutated in a range of other cancers. In an approach to exploit antisense mediated splicing interference as a means of ma...

journal_title：International journal of oncology

authors： Pankratova S,Nielsen BN,Shiraishi T,Nielsen PE

更新日期：2010-01-01 00:00:00