Enhanced tumorigenic and metastatic potential of an androgen-sensitive human prostate cancer cell line, LNCaP, by intratesticular inoculation in SCID mice.

abstract：:Telomerase activation in differentiated cells is associated with cell immortalization. Detection of telomerase expression in cancer provides a potential biomarker to be evaluated in the diagnosis and prognosis of cancer patients. Analysis of telomerase activity in biopsy specimens may serve as a useful marker for the ...

journal_title：International journal of oncology

authors： Pearson AS,Chiao P,Zhang L,Zhang W,Larry L,Katz RL,Evans DB,Abbruzzese JL

更新日期：2000-08-01 00:00:00

abstract：:Telomerase has been recognized as a common factor in most tumor cells, and in turn a distinctive feature with respect to non-malignant cells. This feature has made telomerase a promising target for cancer therapy. Telomerase studies revealed that it is a multi-subunit complex possessing different levels of regulation,...

journal_title：International journal of oncology

authors： Gómez DL,Farina HG,Gómez DE

更新日期：2013-11-01 00:00:00

abstract：:Recombinant adenovirus-associated vector serotype 2 (rAAV2) is one of the most promising gene transfer vectors due to its advantage of causing non-pathogenic infection, low immunogenicity, and long-term gene expression in human clinical trials. Human interleukin 15 (hIL15) has been implicated in modulation of antitumo...

journal_title：International journal of oncology

authors： Yu YL,Wei CW,Chen YL,Chen MH,Yiang GT

更新日期：2010-02-01 00:00:00

abstract：:Using two malignant rat glioma cell lines, we tested to what extent peripheral immunization could affect tumor growth in the brain of syngeneic rats. Peripheral subcutaneous (s.c.) immunization was performed with autologous Newcastle-disease-virus (NDV)-infected or non-infected live tumor cells. Thus immunized rats or...

journal_title：International journal of oncology

authors： Naujocks G,Schmitz A,Schramm J,Wiestler O,Schirrmacher V

更新日期：1995-04-01 00:00:00

abstract：:Chronic administration of 17 beta-estradiol to male Syrian hamsters for at least six months induces estrogen-dependent kidney tumors, which express high levels of c-fos mRNA compared to surrounding renal or control tissues. We have investigated the cellular localization of c-Fos oncoprotein in these tissues and studie...

journal_title：International journal of oncology

authors： Bhat H,Hacker H,Thompson E,Liehr J

更新日期：1995-09-01 00:00:00

abstract：:Elderly patients with advanced non-small cell lung cancer (NSCLC) require chemotherapy that is effective and minimally toxic. We evaluated the activity of a combination of vinorelbine and 5-fluorouracil (5-FU)/UFT (a fixed combination of tegafur and uracil) in vitro and in vivo to establish a rationale for clinical us...

journal_title：International journal of oncology

authors： Matsumoto S,Igishi T,Hashimoto K,Kodani M,Shigeoka Y,Nakanishi H,Touge H,Kurai J,Makino H,Takeda K,Yasuda K,Hitsuda Y,Shimizu E

更新日期：2004-11-01 00:00:00

abstract：:Tumor necrosis factor α induced protein 3 (TNFAIP3) is a protein that is induced by TNF-mediated NF-κB activation and has a dual function in regulating NF-κB. TNFAIP3 is associated with inflammatory carcinogenesis in many cancer types. However, the clinical significance of TNFAIP3 expression and function in esophageal...

journal_title：International journal of oncology

authors： Hadisaputri YE,Miyazaki T,Yokobori T,Sohda M,Sakai M,Ozawa D,Hara K,Honjo H,Kumakura Y,Kuwano H

更新日期：2017-03-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is typified by translocation t(11;14)(q13;q32) causing upregulation of cyclin D1 and deregulation of cell cycle. The cyclin D1 activation plays a critical role in MCL pathogenesis but additional oncogenic events, such as aberrations of the ARF/MDM2/p53 pathway are also necessary for progress...

journal_title：International journal of oncology

authors： Stefancikova L,Moulis M,Fabian P,Ravcukova B,Vasova I,Muzik J,Malcikova J,Falkova I,Slovackova J,Smardova J

更新日期：2010-03-01 00:00:00

abstract：:Retroviral infection of hTERT, the catalytic component of telomerase, into BJ fibroblasts (population doubling 28) resulted in reconstitution of telomerase activity, telomere maintenance, and extension of in vitro lifespan. The hTERT-infected cells also exhibited increased growth rate and colony forming efficiency rel...

journal_title：International journal of oncology

authors： Forsythe HL,Elmore LW,Jensen KO,Landon MR,Holt SE

更新日期：2002-06-01 00:00:00

abstract：:To examine the possibility that chemical inducers of cytochrome P450 may have effects on the expression of oncogenes and a tumor suppressor gene, human colon LS174T cells were treated with different cytochrome P450 inducers such as benzanthracene (Ba), pyrazole (Pyr) and phenobarbital-hydrocortisone (Pb-Hc). Three for...

journal_title：International journal of oncology

authors： Vasquez H,Strobel H

更新日期：1996-09-01 00:00:00

abstract：:A disintegrin and metalloproteinase-17 (ADAM17) can cut and release a wide variety of epidermal growth factor receptor (EGFR) ligands to promote survival, invasion and proliferation of cancer cell, and therefore, is considered to be a potential therapeutic target for cancer. The main goal of the present study was to o...

journal_title：International journal of oncology

authors： Meng X,Hu B,Hossain MM,Chen G,Sun Y,Zhang X

更新日期：2016-08-01 00:00:00

abstract：:Changes in the expression of the putative p53-inducible inhibitor p21 of cyclin-dependent kinase (CDK) and p21-associated CDK activity were examined in relation to the DNA synthesis-associated nuclear exclusion of p53 after stimulating growth arrested human breast cancer MCF7 cells with serum. Following stimulation, p...

journal_title：International journal of oncology

authors： Takahashi K,Suzuki K

更新日期：1994-11-01 00:00:00

abstract：:Gene amplification occurs frequently in human glioblastomas. We report the amplification and expression analysis of glioma amplified sequence 64 (GAS64) which was recently identified by microdissection mediated cDNA capture from the amplicon at 12q13-15. Herein we analyzed primary tumor tissues for amplification frequ...

journal_title：International journal of oncology

authors： Fischer U,Schütz N,Hemmer D,Meese E

更新日期：2002-01-01 00:00:00

abstract：:To compare the oncosuppressive activity of integrated and episomal adeno-associated virus (AAV), two Epstein-Barr virus (EBV) derived episomal form vectors, p205 and p220, were used to generate plasmids containing episomal AAV. HeLa cells transfected with p205, p220, and the plasmids with forward (pA205-1, pA220-1) an...

journal_title：International journal of oncology

authors： Wu FY,Wu CY,Lin CH,Wu CH

更新日期：1999-07-01 00:00:00

abstract：:TP53 gene, encoding tumor protein P53, is frequently inactivated in various types of human cancer, including colorectal, lung, and gastric cancer. Cancer cells with TP53 mutation acquire malignant potentials, such as selective growth advantage, genomic instability, resistance to apoptosis, and promotion of angiogenesi...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2004-07-01 00:00:00

abstract：:Photodynamic therapy (PDT) following lung-sparing extended pleurectomy for malignant pleural mesothelioma (MPM) has been investigated as a potential means to kill residual microscopic cells. High expression levels of folate receptor 1 (FOLR1) have been reported in MPM; therefore, targeting FOLR1 has been considered a ...

journal_title：International journal of oncology

authors： Kato T,Jin CS,Lee D,Ujiie H,Fujino K,Hu HP,Wada H,Wu L,Chen J,Weersink RA,Kanno H,Hatanaka Y,Hatanaka KC,Kaga K,Matsui Y,Matsuno Y,De Perrot M,Wilson BC,Zheng G,Yasufuku K

更新日期：2018-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is known to be resistant to chemotherapy. Survivin, a member of the inhibitor of apoptosis proteins, is overexpressed in most cancers but is absent in most normal adult tissue. The aim of this study was to investigate whether expression of survivin contributes to resistance to cisplatin-...

journal_title：International journal of oncology

authors： Asechi H,Hatano E,Nitta T,Tada M,Iwaisako K,Tamaki N,Nagata H,Narita M,Yanagida A,Ikai I,Uemoto S

更新日期：2010-07-01 00:00:00

abstract：:Functional defects in DNA mismatch repair genes have been shown to be associated mainly with hereditary human malignancies. We examined genomic DNA from 88 sporadic transitional cell carcinomas (TCCs) of the urinary tract for mutations in hMSH6 gene by polymerase chain reaction and direct sequencing analysis. Mutation...

journal_title：International journal of oncology

authors： Furihata M,Shuin T,Takeuchi T,Sonobe H,Ohtsuki Y,Akiyama Y,Yuasa Y

更新日期：2000-03-01 00:00:00

abstract：:Recent studies demonstrated an epigenetic inactivation of the runt-related transcription factor 3 (RUNX3) gene in human colon cancer. However, it remains unclear whether RUNX3 is tumor suppressive in colon cancer and, if so, the underlying molecular mechanisms of this activity are still unknown. In the present study, ...

journal_title：International journal of oncology

authors： Peng Z,Tang H,Wang X,Zhou C,Fan J,Wang L,Jia Z,Li Q,Le X,Wei D,Xie K

更新日期：2008-11-01 00:00:00

abstract：:Prostate cancer, the third most common cancer in men worldwide, varies substantially according to geographic region and race/ethnicity. Obesity and associated endocrine variation are foremost among the risk factors that may underlie these regional and ethnic differences. The association between obesity and prostate ca...

journal_title：International journal of oncology

authors： Baillargeon J,Rose DP

更新日期：2006-03-01 00:00:00

abstract：:Obesity is considered a risk factor for many cancers, including breast cancer. Our laboratory has previously shown that leptin is mitogenic in many cancer cell lines, including breast. Information regarding the effects of high leptin levels on leptin receptor expression and signaling is lacking. The purpose of this st...

journal_title：International journal of oncology

authors： Frankenberry KA,Skinner H,Somasundar P,McFadden DW,Vona-Davis LC

更新日期：2006-04-01 00:00:00

abstract：:Pristimerin (PM), a quinonemethide triterpenoid, is a promising anticancer agent with potent antiproliferative and apoptosis-inducing activities against cancer cell lines. However, the anticancer activity and mechanisms of PM in prostate cancer cells have not been adequately investigated. Here we report that the degra...

journal_title：International journal of oncology

authors： Liu YB,Gao X,Deeb D,Brigolin C,Zhang Y,Shaw J,Pindolia K,Gautam SC

更新日期：2014-10-01 00:00:00

abstract：:The relationship between p53 point mutation and patient survival was examined in 328 colorectal cancer patients. Point mutation was detected in 51% (166/328) of cases and was associated with a poorer prognosis in univariate and multivariate analysis. However, subcohort analysis showed that this relationship was restri...

journal_title：International journal of oncology

authors： Goh HS,Elnatan J,Low CH,Smith DR

更新日期：1999-09-01 00:00:00

abstract：:MicroRNAs can govern up to hundred different mRNAs and are important regulators of gene expression programs in development and disease. We analyzed the expression of microRNA-21, one of the most common oncomirs, in non-small cell lung cancer (NSCLC). Using northern blots the microRNA-21 expression levels of NSCLC-deri...

journal_title：International journal of oncology

authors： Haigl B,Vanas V,Setinek U,Hegedus B,Gsur A,Sutterlüty-Fall H

更新日期：2014-04-01 00:00:00

abstract：:VSELs are a population of rare Oct-4+CXCR4+ CD133+lin-CD45- cells that are deposited during early embryogenesis in developing organs/tissues as a reserve population of pluripotent stem cells for regeneration. We reported recently that they are mobilized into peripheral blood during acute myocardial infarction (AMI) in...

journal_title：International journal of oncology

authors： Wojakowski W,Tendera M,Kucia M,Zuba-Surma E,Milewski K,Wallace-Bradley D,Kazmierski M,Buszman P,Hrycek E,Cybulski W,Kaluza G,Wieczorek P,Ratajczak J,Ratajczak MZ

更新日期：2010-08-01 00:00:00

abstract：:The purpose of this study was to determine whether DU145, a human prostate cancer cell line: (a) transcribes mRNAs coding for beta A- and beta B-subunits of activin, a member of transforming growth factor beta (TGF beta) superfamily, and activin receptors I, II, and IIB; and (b) produces activin proteins. The expressi...

journal_title：International journal of oncology

authors： Furst B,Zhang Z,Ying S

更新日期：1995-08-01 00:00:00

abstract：:We studied the mechanism by which the para and meta positional isomers of nitric oxide-donating aspirin (NO-ASA) inhibit human colon cancer cell growth. These compounds are promising chemopreventive agents and represent a broader class of novel drugs. The two isomers differ drastically in their 24-h IC50s for cell gro...

journal_title：International journal of oncology

authors： Hua A,Mackenzie GG,Rigas B

更新日期：2009-10-01 00:00:00

abstract：:In contrast to normal cells, cancer cells typically undergo metabolic reprogramming. Studies have shown that oncogenes play an important role in this metabolic reprogramming. CD38 is a multifunctional transmembrane protein that is expressed abnormally in a variety of tumor types. To investigate the effect and possible...

journal_title：International journal of oncology

authors： Liao S,Liang L,Yue C,He J,He Z,Jin X,Luo G,Zhou Y

更新日期：2020-07-01 00:00:00

abstract：:Dendritic cells play a major role in cellular immunity. The crucial steps of antigen presentation and processing by DCs may be limiting factors for adoptive cellular immunotherapy. Here, we investigated whether hyperthermia of human hepatocellular carcinoma (HCC) cells induces enhanced cytotoxic cellular immune respon...

journal_title：International journal of oncology

authors： Schueller G,Stift A,Friedl J,Dubsky P,Bachleitner-Hofmann T,Benkoe T,Jakesz R,Gnant M

更新日期：2003-06-01 00:00:00

abstract：:Irvalec® (elisidepsin trifluoroacetate, PM02734) is a novel marine-derived cyclic peptide belonging to the Kahaladide family of compounds, currently in clinical trials with preliminary evidence of antitumor activity. Previous studies have shown a correlation between elisidepsin sens...

journal_title：International journal of oncology

authors： Teixidó C,Arguelaguet E,Pons B,Aracil M,Jimeno J,Somoza R,Marés R,Ramón Y Cajal S,Hernández-Losa J

更新日期：2012-07-01 00:00:00