Growth suppression mediated by transfection of wild-type hMLH1 in human cancer cells expressing endogenous truncated hMLH1 protein.

abstract：:Cognate interactions between naïve tumor antigen (TA)-specific T cells and TA-presenting dendritic cells (DCs) are facilitated by secondary lymphoid organs such as lymph nodes or the spleen. These can result either in TA-specific tolerance or, depending on environmental costimulatory signals, in TA-specific immune res...

journal_title：International journal of oncology

authors： Schirrmacher V

更新日期：2015-12-01 00:00:00

abstract：:All p53 family members are expressed in several isoforms through alternative promoters and alternative splicing. However, the significance of these isoforms is not yet well understood in cholangiocarcinoma (CCA). In this study, we investigated the expression of p53, p63, p73 and their isoforms at the mRNA and protein ...

journal_title：International journal of oncology

authors： Nutthasirikul N,Limpaiboon T,Leelayuwat C,Patrakitkomjorn S,Jearanaikoon P

更新日期：2013-04-01 00:00:00

abstract：:Chemotherapeutic resistance remains a critical clinical issue is responsible for treatment failure in patients with ovarian cancer. Evidence of the involvement of miRNAs in chemoresistance in ovarian cancer has been recently emerging. However, the underlying molecular links between chemoresistance and miRNAs remain la...

journal_title：International journal of oncology

authors： Xu M,Xiao J,Chen M,Yuan L,Li J,Shen H,Yao S

更新日期：2018-03-01 00:00:00

abstract：:Matrix metalloproteinases (MMP) play an important role in tumor cell invasion and metastasis. We examined the expression of MMPs in hepatocellular carcinoma (HCC) to determine whether they may help indicate the progression of HCC and patient outcome. The expression of MMP-1, -2, -7, -9, and MT1-MMP were determined in ...

journal_title：International journal of oncology

authors： Sakamoto Y,Mafune K,Mori M,Shiraishi T,Imamura H,Mori M,Takayama T,Makuuchi M

更新日期：2000-08-01 00:00:00

abstract：:Magnolol, a neolignan from the traditional medicinal plant Magnolia obovata, has been shown to possess neuroprotective, anti-inflammatory, anticancer and anti-angiogenic activities. However, the precise mechanism of the anti-angiogenic activity of magnolol remains to be elucidated. In the present study, the anti-angio...

journal_title：International journal of oncology

authors： Kim GD,Oh J,Park HJ,Bae K,Lee SK

更新日期：2013-08-01 00:00:00

abstract：:A normal human lymphocyte-derived 54 kDa polypeptide, capable of regulating cell growth has been identified as an isoform variant (abbreviated as NP54) of protein neuroleukin-phosphoglucose isomerase (PGI). Since distinct PGI variants undetectable in normal tissues had been identified in breast cancer tissues, the eff...

journal_title：International journal of oncology

authors： Chiao JW,Xu W,Yang YM,Kancherla R,Seiter K,Ahmed T,Mittelman A

更新日期：1999-10-01 00:00:00

abstract：:MicroRNA (miRNA or miR)-506 is a novel miRNA related to the survival of breast cancer patients. However, the mechanism underlying miRNA-506 involvement in breast carcinogenesis remains unclear. In the present study, we found that miR-506 was downregulated in human breast malignant tissues and breast cancer cell lines ...

journal_title：International journal of oncology

authors： Sun G,Liu Y,Wang K,Xu Z

更新日期：2015-11-01 00:00:00

abstract：:Hedgehog (HH) pathway Smoothened (Smo) inhibitors are active against Gorlin syndrome-associated basal cell carcinoma (BCC) and medulloblastoma where Patched (Ptch) mutations occur. We interrogated 705 epithelial cancer cell lines for growth response to the Smo inhibitor cyclopamine ...

journal_title：International journal of oncology

authors： Galimberti F,Busch AM,Chinyengetere F,Ma T,Sekula D,Memoli VA,Dragnev KH,Liu F,Johnson KC,Guo Y,Freemantle SJ,Andrew AS,Greninger P,Robbins DJ,Settleman J,Benes C,Dmitrovsky E

更新日期：2012-11-01 00:00:00

abstract：:One of the genes that the authors have isolated by a differential display of hepatocellular carcinoma compared to adjacent liver is the alpha6 integrin. alpha6 integrin is the major adhesion receptor for laminin and is suggested to be involved in tumor cell invasion and metastasis. To our knowledge, however, there are...

journal_title：International journal of oncology

authors： Tanaka Y,Mimori K,Shiraishi T,Ohkura Y,Takubo K,Mafune K,Barnard GF,Mori M

更新日期：2000-04-01 00:00:00

abstract：:Cell division cycle 20 (CDC20) encodes a regulatory protein interacting with the anaphase-promoting complex/cyclosome (APC/C) in the cell cycle and plays important roles in tumorigenesis and progression of multiple tumors. The present study aimed to investigate the clinical significance of CDC20 in hepatocellular carc...

journal_title：International journal of oncology

authors： Li J,Gao JZ,Du JL,Huang ZX,Wei LX

更新日期：2014-10-01 00:00:00

abstract：:Thirty-four children with newly diagnosed acute nonlymphoblastic leukemia were analysed for the expression of P-glycoprotein (P-170), glutathione S-transferase-pi, (GST-pi) topoisomerase II (Topo II) and the proliferation antigen Ki-67 by the streptavidin-biotin-peroxidase method. Overexpression of P-170 was present i...

journal_title：International journal of oncology

authors： Sauerbrey A,Zintl F,Volm M

更新日期：1994-10-01 00:00:00

abstract：:Knowledge of intrinsic tumor heterogeneity is vital for understanding of tumor progression mechanisms as well as for providing efficient treatments. In situ proteomic profiling of tumors is a powerful technology with potential to enhance our understanding of tumor biology, but sources of variability due to patient and...

journal_title：International journal of oncology

authors： Li JQ,Xu BJ,Shakhtour B,Deane N,Merchant N,Heslin MJ,Washington K,Coffey RJ,Beauchamp RD,Shyr Y,Billheimer D

更新日期：2007-07-01 00:00:00

abstract：:The α6 integrin subunit (α6) has been implicated in cancer cell migration and in the progression of several malignancies, but its role in tumor angiogenesis is unclear. In mice, anti-α6 blocking antibodies reduce tumor angiogenesis, whereas Tie1-dependent α6 gene deletion enhances neovessel formation in melanoma and l...

journal_title：International journal of oncology

authors： Bouvard C,Segaoula Z,De Arcangelis A,Galy-Fauroux I,Mauge L,Fischer AM,Georges-Labouesse E,Helley D

更新日期：2014-11-01 00:00:00

abstract：:Lin28 is a family of RNA binding proteins and microRNA regulators. Two members of this family have been identified: Lin28A and Lin28B, which are encoded by genes localized in different chromosomes but share a high degree of sequence identity. The role of Lin28B in androgen-independent prostate cancer (AIPC) is not wel...

journal_title：International journal of oncology

authors： Borrego-Diaz E,Powers BC,Azizov V,Lovell S,Reyes R,Chapman B,Tawfik O,McGregor D,Diaz FJ,Wang X,Veldhuizen PV

更新日期：2014-12-01 00:00:00

abstract：:Sentinel node (SN) mapping and biopsy is a procedure that accurately stages the regional lymph node (LN) basin. Defined patterns of lymphatic drainage allow intraoperative determination of the first (sentinel) lymph node in the regional basin, and the absence of metastatic disease in the SN accurately reflects the abs...

journal_title：International journal of oncology

authors： Gennari R,Stoldt HS,Bartolomei M,Zurrida S,Testori A,Mazzarol G,Paganelli G,Veronesi U

更新日期：1999-07-01 00:00:00

abstract：:Human chorionic gonadotropin (hCG) inhibits the growth of human breast epithelial cells MCF-7. Differential display was utilized for analyzing RNA of hCG-treated MCF-7 cells in order to determine whether this effect was mediated by specific gene activation or repression. Three cDNA clones, 19, 29 and 44, were differen...

journal_title：International journal of oncology

authors： Srivastava P,Silva ID,Russo J,Mgbonyebi OP,Russo IH

更新日期：1998-09-01 00:00:00

abstract：:This study aimed to analyze expression of Müllerian inhibiting substance type II receptor (MISRII) protein and mRNA in cervical neoplasia, to demonstrate the growth inhibition of cervical cancer cells by administration of highly purified recombinant human Müllerian inhibiting substa...

journal_title：International journal of oncology

authors： Song JY,Jo HH,Kim MR,Lew YO,Ryu KS,Cha JH,Kang CS,Donahoe PK,MacLaughlin DT,Kim JH

更新日期：2012-06-01 00:00:00

abstract：:The regions upstream from the human N-myc gene were examined for both transcription and replication. The plasmids containing several N-myc regions linked to the bacterial chloramphenicol acetyltransferase (CAT) gene were transfected to human neuroblastoma IMR32 cells. The results indicated that the region spanning fro...

journal_title：International journal of oncology

authors： Nakagawa T,Imamura Y,Iguchiariga S,Ariga H

更新日期：1994-09-01 00:00:00

abstract：:KRAS‑mutant colorectal cancer (CRC) is a highly malignant cancer with a poor prognosis, however specific therapies targeting KRAS mutations do not yet exist. Anti‑epidermal growth factor receptor (EGFR) agents, including cetuximab and panitumumab, are effective for the treatment of certain patients with CRC. However, ...

journal_title：International journal of oncology

authors： Koyama M,Kitazawa M,Nakamura S,Matsumura T,Miyazaki S,Miyagawa Y,Muranaka F,Tokumaru S,Okumura M,Yamamoto Y,Ehara T,Hondo N,Takahata S,Takeoka M,Miyagawa SI,Soejima Y

更新日期：2020-11-01 00:00:00

abstract：:ETS variant 1 (ETV1) is an oncogenic transcription factor. However, its role in colorectal cancer has remained understudied. The present study demonstrated that ETV1 downregulation led to reduced HCT116 colorectal cancer cell growth and clonogenic activity. Furthermore, the ETV1 mRNA levels were enhanced in colorectal...

journal_title：International journal of oncology

authors： Oh S,Song H,Freeman WM,Shin S,Janknecht R

更新日期：2020-12-01 00:00:00

abstract：:Patients with long-standing ulcerative colitis (UC) have higher risk of developing colorectal cancer. Albeit the causes remain to be understood, epigenetic alterations have been suggested to play a role in the long-term cancer risk of these patients. In this work, we developed a novel microarray platform based on meth...

journal_title：International journal of oncology

authors： Koizumi K,Alonso S,Miyaki Y,Okada S,Ogura H,Shiiya N,Konishi F,Taya T,Perucho M,Suzuki K

更新日期：2012-04-01 00:00:00

abstract：:Bovine lactoferricin (LfcinB) is a cationic antimicrobial peptide that selectively induces apoptosis in several different types of human cancer cells. However, the potential use of LfcinB as an anticancer agent is presently limited by the need for relatively high concentrations of the peptide to trigger apoptosis. Cer...

journal_title：International journal of oncology

authors： Furlong SJ,Ridgway ND,Hoskin DW

更新日期：2008-03-01 00:00:00

abstract：:In the study of 69 matched pairs of lung tumors and normal lung parenchyma, the median activities of cathepsin B (CB) and cystein proteinase inhibitors (CPI's) in tumors were found to be increased 4.4-fold and twofold, respectively. The levels of CB and CPI activities did not correlate with TNM stages nor with cell di...

journal_title：International journal of oncology

authors： Knoch H,Werle B,Ebert W,Spiess E

更新日期：1994-07-01 00:00:00

abstract：:To determine the relation between apoptosis and cytotoxicity the number of apoptotic (AP) cells was measured in MOLT-4 and HL-60 cultures treated with adriamycin, etoposide, cisplatin and 1-B-D-arabinofuranosylcytosine (ara-C) in the dose range inducing 20-95% growth inhibition. DNA degradation in individual AP cells ...

journal_title：International journal of oncology

authors： Frankfurt O,Seckinger D,Sugarbaker E

更新日期：1994-02-01 00:00:00

abstract：:Prostate cancer (CaP), the most common malignancy in American men, presents its greatest challenge to clinicians when the cancer progresses to the hormone-refractory state. In the present investigation, we studied the combined effects of interferon (IFN) and onconase, each of which has reported antitumor activity, on ...

journal_title：International journal of oncology

authors： Tsai SY,Hsieh TC,Ardelt B,Darzynkiewicz Z,Wu JM

更新日期：2002-05-01 00:00:00

abstract：:We found that a mouse p53 cDNA clone (pP53-5; Jenkins et al, Nature 312: 651-654, 1984), which previously was characterized as encoding mutant p53 protein, in fact represents wild-type mouse p53 cDNA, as we were able to demonstrate that the mutations described represented sequencing artefacts (compressions). Such sequ...

journal_title：International journal of oncology

authors： Kolzau T,Deppert W

更新日期：1993-07-01 00:00:00

abstract：:To evaluate the distribution of cyclin protein expression, in relation to cell proliferation rate and clinical behavior, an immunohistochemical study was performed on 92 tumor samples of patients with high grade osteosarcoma (OS). A large cyclin A- and cyclin E-positive fraction was found respectively in 59% and 47% o...

journal_title：International journal of oncology

authors： Molendini L,Benassi MS,Magagnoli G,Merli M,Sollazzo MR,Ragazzini P,Gamberi G,Ferrari C,Balladelli A,Bacchini P,Picci P

更新日期：1998-05-01 00:00:00

abstract：:Secreted frizzled related proteins (SFRPs) are a family of Wnt regulators which are frequently downregulated in cancers. In malignant mesothelioma (MM), downregulation of SFRP4 has been reported as a mechanism which contributes to aberrant activation of oncogenic Wnt signaling. Here we investigated the biological cons...

journal_title：International journal of oncology

authors： Perumal V,Dharmarajan AM,Fox SA

更新日期：2017-07-01 00:00:00

abstract：:Nanoparticles are promising novel drug delivery carriers that allow tumor targeting and controlled drug release. In the present study, we prepared poly butyl-cyanoacrylate nanoparticles (PBCA-NP) entrapped with hypocrellin B (HB) to improve the effect of photodynamic therapy (PDT) in ovarian cancer. An ovarian cancer ...

journal_title：International journal of oncology

authors： Li Z,Sun L,Lu Z,Su X,Yang Q,Qu X,Li L,Song K,Kong B

更新日期：2015-09-01 00:00:00

abstract：:The interaction between the colon tumor cell surface and the endothelial cell layer is an important component of tumor intravasation, extravasation, and metastasis. Multiple studies suggest that tumor cells may bind to E-selectin expressed on endothelial cells during these processes. To identify possible E-selectin li...

journal_title：International journal of oncology

authors： Tomlinson J,Wang JL,Barsky SH,Lee MC,Bischoff J,Nguyen M

更新日期：2000-02-01 00:00:00