abstract：BACKGROUND:Sensory suppression is an important brain function for appropriate processing of information and is known to be impaired in patients with various types of mental illness. Long latency suppression which is a paradigm using change-related cortical response with repeated paired pulses embedded in a train of con...

journal_title：Journal of neuroscience methods

authors： Takeuchi N,Fujita K,Kinukawa T,Sugiyama S,Kanemoto K,Nishihara M,Inui K

更新日期：2021-01-25 00:00:00

abstract：BACKGROUND:The construction of multichannel micro-electrode arrays (MEA) generally requires complex and expensive procedures. Here we describe a simple, cheap, flexible method of linear MEA construction. NEW METHOD:Our method allows manufacture of linear MEA (cross section ∼ 375 × 250 μm with 12 electrodes) of any des...

journal_title：Journal of neuroscience methods

authors： Banstola A,Silva C,Ulrich K,Ruan M,Robertson L,McNaughton N

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND:Whole-cell patch-clamp recording in vivo is the gold-standard method for measuring subthreshold electrophysiology from single cells during behavioural tasks, sensory stimulations, and optogenetic manipulation. However, these recordings require a tight, gigaohm resistance, seal between a glass pipette electro...

journal_title：Journal of neuroscience methods

authors： Stoy WM,Yang B,Kight A,Wright NC,Borden PY,Stanley GB,Forest CR

更新日期：2021-01-15 00:00:00

abstract：:Diffusion Magnetic Resonance Imaging (dMRI) is one of the most important contemporary non-invasive modalities for probing tissue structure at the microscopic scale. The majority of dMRI techniques employ standard single diffusion encoding (SDE) measurements, covering different sequence parameter ranges depending on th...

journal_title：Journal of neuroscience methods

authors： Henriques RN,Palombo M,Jespersen SN,Shemesh N,Lundell H,Ianuş A

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND:The ongoing crisis related to non-medical use of opioids makes it of continued importance to understand the risk factors for opioid addiction, the behavioral and neurobiological consequences of opioid exposure and to seek potential avenues for therapy. Pre-clinical rodent models have been critical to advanci...

journal_title：Journal of neuroscience methods

authors： Gutierrez A,Creehan KM,Taffe MA

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND:Mild traumatic brain injury (mTBI) strongly associates with chronic neurodegenerative impairments such as post-traumatic stress disorder (PTSD) and mild cognitive impairment. Early detection of concussive events would significantly enhance the understanding of head injuries and provide better guidance for ur...

journal_title：Journal of neuroscience methods

authors： Zhuang Y,Yang Q,Han T,O'Malley R,Kumar A,Gerald RE 2nd,Huang J

更新日期：2021-01-10 00:00:00

abstract：BACKGROUND:Detecting human drowsiness during some critical works like vehicle driving, crane operating, mining blasting, etc. is one of the safeguards to prevent accidents. Among several drowsiness detection (DD) methods, a combination of neuroscience and computer science knowledge has a better ability to differentiate...

journal_title：Journal of neuroscience methods

authors： B VP,Chinara S

更新日期：2021-01-01 00:00:00

abstract：:Diffusion-weighted MRI is the forerunner of the rapidly developed microstructure MRI (μMRI) aimed at in vivo evaluation of the cellular tissue architecture. This brief review focuses on the spatiotemporal scales of the microstructure that are accessible using different diffusion MRI techniques and the need to weight t...

journal_title：Journal of neuroscience methods

authors： Kiselev VG

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The application of single-cell RNA sequencing (scRNASeq) represents a unique approach to identify hundreds to millions of cells in mammalian cortical multilayers at different stages of embryogenesis. ScRNASeq technology applied to neurological studies requires the use of fresh starting materials because stan...

journal_title：Journal of neuroscience methods

authors： Verrillo L,Mangano E,Drongitis D,Merelli I,Pischedda F,Piccoli G,Consolandi C,Bordoni R,Miano MG

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Electrophysiological recordings contain mixtures of signals from distinct neural sources, impeding a straightforward interpretation of the sensor-level data. This mixing is particularly detrimental when distinct sources resonate in overlapping frequencies. Fortunately, the mixing is linear and instantaneous....

journal_title：Journal of neuroscience methods

authors： Zuure MB,Cohen MX

更新日期：2020-12-25 00:00:00

abstract：BACKGROUND:In clinical practice, small myelinated sensory fibers, Aδ-fibers, conveying mainly pain and temperature sensations, cannot be examined with available nerve conduction study techniques. Currently, these fibers can only be examined with experimental or very specialized and not commonly available nerve conducti...

journal_title：Journal of neuroscience methods

authors： Raabe W,Walk D

更新日期：2020-12-24 00:00:00

abstract：BACKGROUND:Independent component analysis (ICA) has been widely used for blind source separation in the field of medical imaging. However, despite of previous substantial efforts, the stability of ICA components remains a critical issue which has not been adequately addressed, despite numerous previous efforts. Most cr...

journal_title：Journal of neuroscience methods

authors： Zhao W,Li H,Hu G,Hao Y,Zhang Q,Wu J,Frederick BB,Cong F

更新日期：2020-12-11 00:00:00

abstract：BACKGROUND:The myelin sheath produced by glial cells insulates the axons, and supports the function of the nervous system. Myelin sheath degeneration causes neurodegenerative disorders, such as multiple sclerosis (MS). There are no therapies for MS that promote remyelination. Drug discovery frequently involves screenin...

journal_title：Journal of neuroscience methods

authors： Çimen Yetiş S,Çapar A,Ekinci DA,Ayten UE,Kerman BE,Töreyin BU

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:To map and quantify the proton exchange rate (kex) of brain tissues using improved omega plots in ischemic stroke patients and to investigate whether kex can serve as a potential endogenous surrogate imaging biomarker for detecting the metabolic state and the pathologic changes due to ischemic stroke. NEW M...

journal_title：Journal of neuroscience methods

authors： Wang Z,Shaghaghi M,Zhang S,Zhang G,Zhou Y,Wu D,Zhang Z,Zhu W,Cai K

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:There is a growing need for analyzing medical data such as brain connectomes. However, the unavailability of large-scale training samples increases risks of model over-fitting. Recently, deep learning (DL) architectures quickly gained momentum in synthesizing medical data. However, such frameworks are primar...

journal_title：Journal of neuroscience methods

authors： Sserwadda A,Rekik I

更新日期：2020-11-04 00:00:00

abstract：BACKGROUND:MRI-histology correlation studies of the ex vivo brain mostly employ fresh, extracted (ex situ) specimens, aldehyde fixed by immersion, which has several disadvantages for MRI scanning (e.g. deformation of the organ). A minority of studies are done ex vivo-in situ (unfixed brain), requiring an MRI scanner re...

journal_title：Journal of neuroscience methods

authors： Maranzano J,Dadar M,Bertrand-Grenier A,Frigon EM,Pellerin J,Plante S,Duchesne S,Tardif CL,Boire D,Bronchti G

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Manual annotation of seizures and interictal-ictal-injury continuum (IIIC) patterns in continuous EEG (cEEG) recorded from critically ill patients is a time-intensive process for clinicians and researchers. In this study, we evaluated the accuracy and efficiency of an automated clustering method to accelerat...

journal_title：Journal of neuroscience methods

authors： Jing J,d'Angremont E,Ebrahim S,Tabaeizadeh M,Ng M,Herlopian A,Dauwels J,Westover MB

更新日期：2020-10-22 00:00:00

abstract：BACKGROUND:The local field potential (LFP) is usually calculated from current sources arising from transmembrane currents, in particular in asymmetric cellular morphologies such as pyramidal neurons. NEW METHOD:Here, we adopt a different point of view and relate the spiking of neurons to the LFP through efferent synap...

journal_title：Journal of neuroscience methods

authors： Telenczuk B,Telenczuk M,Destexhe A

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Anatomically and physiologically, there is strong relationship between the brain and body. A new MRI platform covering both the brain and the limb would be beneficial for a more thorough understanding of the brain-body interactions. NEW METHOD:A new arm-over-head (AOH) position was developed to collect MRI ...

journal_title：Journal of neuroscience methods

authors： Tang IN,Jao T,Huang YA,Li CW,Yu YC,Chen JH

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:The introduction of viral transneuronal tracers in the toolbox of neural tract-tracing methods has been an important addition in the field of connectomics for deciphering circuit-level architecture of the nervous system. One of the added values of viral compared to conventional retrograde tracers, in particu...

journal_title：Journal of neuroscience methods

authors： Salin P,Blondel D,Kerkerian-Le Goff L,Coulon P

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Processing and quantitative analysis of magnetic resonance spectroscopy (MRS) data are far from standardized and require interfacing with third-party software. Here, we present Osprey, a fully integrated open-source data analysis pipeline for MRS data, with seamless integration of pre-processing, linear-comb...

journal_title：Journal of neuroscience methods

authors： Oeltzschner G,Zöllner HJ,Hui SCN,Mikkelsen M,Saleh MG,Tapper S,Edden RAE

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Despite extensive environmental standardization and the use of genetically and microbiologically defined mice of similar age and sex, individuals of the same mouse inbred strain commonly differ in quantitative traits. This is a major issue as it affects the quality of experimental results. Standard analysis ...

journal_title：Journal of neuroscience methods

authors： van der Goot MH,Boleij H,van den Broek J,Salomons AR,Arndt SS,van Lith HA

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:This article addresses the automatic classification of reconstructed neurons through their morphological features. The purpose was to extend the capabilities of the L-Measure software. METHODS:New morphological features were developed, based on modifications of the conventional Sholl analysis. The lengths o...

journal_title：Journal of neuroscience methods

authors： López-Cabrera JD,Hernández-Pérez LA,Orozco-Morales R,Lorenzo-Ginori JV

更新日期：2020-09-01 00:00:00

abstract：:Parkinson's disease (PD) has a long prodromal period that precedes the appearance of typical motor symptoms. This phase is extremely heterogeneous and is characterized by a wide range of non-motor alterations including REM sleep behavior disorders, constipation, olfactory and urinary dysfunctions. The increasing clini...

journal_title：Journal of neuroscience methods

authors： Cerri S,Blandini F

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Advances in the control of transcranial magnetic stimulation (TMS) have enabled greater randomisation of stimulus intensity. It is unclear if such randomisation improves assessments of corticospinal excitability. NEW METHOD:We recorded the amplitude of TMS-induced motor evoked potentials (MEPs) from the fir...

journal_title：Journal of neuroscience methods

authors： Suckley JJ,Waters TJ,Tran M,Stapley PJ,Shemmell J,Walsh JA,McAndrew DJ

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Rodents have been used for decades to probe neural circuits involved in behavior. Increasingly, attempts have been developed to standardize training paradigms across labs; and to use visual/auditory paradigms that can be also tested in humans. Commercially available systems are expensive and thus do not scal...

journal_title：Journal of neuroscience methods

authors： Buscher N,Ojeda A,Francoeur M,Hulyalkar S,Claros C,Tang T,Terry A,Gupta A,Fakhraei L,Ramanathan DS

更新日期：2020-08-01 00:00:00

abstract：:Aggregates of alpha-synuclein (αSyn) have been described in Parkinson's disease (PD) patients, and recent evidence has suggested that the most toxic αSyn species in PD are small soluble aggregates including oligomers, prefibrils, protofibrils. The physiological function of αSyn is still highly debated, with a possible...

journal_title：Journal of neuroscience methods

authors： Carta AR,Boi L,Pisanu A,Palmas MF,Carboni E,De Simone A

更新日期：2020-05-15 00:00:00

abstract：BACKGROUND:Peripheral autonomic nerves control visceral organs and convey information regarding their functional states and are, therefore, potential targets for new therapeutic and diagnostic approaches. Conventionally recorded multi-unit nerve activity in vivo undergoes slow differential drift of signal and noise amp...

journal_title：Journal of neuroscience methods

authors： Davey CE,Soto-Breceda A,Shafton A,McAllen RM,Furness JB,Grayden DB,Stebbing MJ

更新日期：2020-05-15 00:00:00

abstract：BACKGROUND:Due to the lack of understanding of the fascicular organisation, vagus nerve stimulation (VNS) leads to unwanted off-target effects. Micro-computed tomography (microCT) can be used to trace fascicles from periphery and image fascicular anatomy. NEW METHOD:In this study, we present a simple and reproducible ...

journal_title：Journal of neuroscience methods

authors： Thompson N,Ravagli E,Mastitskaya S,Iacoviello F,Aristovich K,Perkins J,Shearing PR,Holder D

更新日期：2020-05-15 00:00:00

abstract：BACKGROUND:Neural coding of sound information is often studied through frequency tuning curve (FTC), spectro-temporal receptive field (STRF), post-stimulus time histogram (PSTH), and other methods such as rate functions. These methods, despite providing a robust characterization of auditory responses in their specific ...

journal_title：Journal of neuroscience methods

authors： Qureshi F,Yan J

更新日期：2020-05-15 00:00:00

abstract：BACKGROUND:Experimental investigation of sleep-wake dynamics in animals is an important part of pharmaceutical development. Typically, it involves recording of electroencephalogram, electromyogram, locomotor activity, and electrooculogram. Visual identification, or scoring, of the sleep-wake states from these recording...

journal_title：Journal of neuroscience methods

authors： Svetnik V,Wang TC,Xu Y,Hansen BJ,V Fox S

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Extraneural cuffs are among the least invasive peripheral nerve interfaces as they remain outside the nerve. However, compared with more invasive interfaces, these electrodes may suffer from lower selectivity and sensitivity since the targeted nerve fibers are more distanced from the electrodes. NEW METHOD:...

journal_title：Journal of neuroscience methods

authors： Elyahoodayan S,Larson C,Cobo AM,Meng E,Song D

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Functional magnetic resonance imaging (fMRI) enables non-invasive examination of both the structure and the function of the human brain. The prevalence of high spatial-resolution (sub-millimeter) fMRI has triggered new research on the intra-cortex, such as cortical columns and cortical layers. At present, ec...

journal_title：Journal of neuroscience methods

authors： Duong STM,Phung SL,Bouzerdoum A,Boyd Taylor HG,Puckett AM,Schira MM

更新日期：2020-04-15 00:00:00

abstract：:An ongoing question in neuroscience is how the peripheral nervous system can repair itself following an injury or insult whereas the central nervous system has a profoundly limited ability for repair. The recent and rapid advancement of our understanding of the gene expression and corresponding biochemical profiles of...

journal_title：Journal of neuroscience methods

authors： El Seblani N,Welleford AS,Quintero JE,van Horne CG,Gerhardt GA

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Brain parcellation is important for exploiting neuroimaging data. Variability in physiology between individuals has led to the need for data-driven approaches to parcellation, with recent research focusing on simultaneously estimating and partitioning the network structure of the brain. NEW METHOD:We view d...

journal_title：Journal of neuroscience methods

authors： Dillon K,Wang YP

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Neuronal cell cultures are widely used in the field of neuroscience. Cell dissociation allows for the isolation of a desired cell type, yet the neuronal complexity that distinguishes the nervous system is often lost as a result. Thus, culturing neural tissues in ex vivo format provides a physiological contex...

journal_title：Journal of neuroscience methods

authors： Kuan SP,Atanasova KR,Guevara MV,Collins EN,Reznikov LR

更新日期：2020-02-15 00:00:00

abstract：BACKGROUND:A breakthrough in the microglia and macrophages field was the identification of the macrophage colony stimulating factor-1 (CSF-1) as a pro-survival factor. Its pharmacological inhibition in animals depletes rapidly all microglia and macrophages. Microglial depletion in mixed glial cultures has always repres...

journal_title：Journal of neuroscience methods

authors： Hupp S,Iliev AI

更新日期：2020-02-15 00:00:00

abstract：BACKGROUND:Sholl analysis has been used to analyze neuronal morphometry and dendritic branching and complexity for many years. While the process has become semi-automated in recent years, existing software packages are still dependent on user tracing and hence are subject to observer bias, variability, and increased us...

journal_title：Journal of neuroscience methods

authors： Srinivasan A,Srinivasan A,Ferland RJ

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Previous studies have measured whisker movements and locomotion to characterise mouse models of neurodegenerative disease. However, these studies have always been completed in isolation, and do not involve standardized procedures for comparisons across multiple mouse models and background strains. NEW METHO...

journal_title：Journal of neuroscience methods

authors： Simanaviciute U,Ahmed J,Brown RE,Connor-Robson N,Farr TD,Fertan E,Gambles N,Garland H,Morton AJ,Staiger JF,Skillings EA,Trueman RC,Wade-Martins R,Wood NI,Wong AA,Grant RA

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Cytokines are key signaling molecules within the immune system that regulate a host's response to pathogens and neuronal damage. Aberrant cytokine signaling has been implicated in many neurological diseases. Therefore, accurately measuring cytokine concentrations within the brain is crucial. NEW METHOD:This...

journal_title：Journal of neuroscience methods

authors： Walker WH 2nd,Bumgarner JR,Nelson RJ,Courtney DeVries A

更新日期：2020-01-22 00:00:00