Abstract：
BACKGROUND:Neural coding of sound information is often studied through frequency tuning curve (FTC), spectro-temporal receptive field (STRF), post-stimulus time histogram (PSTH), and other methods such as rate functions. These methods, despite providing a robust characterization of auditory responses in their specific domains, lack a complete description in terms of three sound fundamentals: frequency, amplitude, and time. NEW METHOD:Using the techniques of electrophysiology, neural signal processing and medical image processing, a standalone method is created to illustrate the neural processing of three sound fundamentals in one representation. RESULTS:The new method comprehensively showed frequency tuning, intensity tuning, time tuning as well as a novel representation of frequency and time dependent intensity coding. It provides most of the necessary parameters that are used to quantify neural response properties, such as minimum threshold (MT), frequency tuning, latency, best frequency (BF), characteristic frequency (CF), bandwidth (BW), etc. COMPARISON WITH EXISTING METHODS: Our method shows neural responses as a function of all three sound fundamentals in a single representation that was not possible in previous methods. It covers many functions of conventional methods and allow extracting novel information such as the intensity coding as the function of the spectrotemporal response area of auditory neurons. CONCLUSION:This method can be used as a standalone package to study auditory neural responses and evaluate the performance of different hearing related devices such as cochlear implants and hearing aids in animal models as well as study and compare auditory processing in aged and hearing impaired animal models.
journal_name
J Neurosci Methodsjournal_title
Journal of neuroscience methodsauthors
Qureshi F,Yan Jdoi
10.1016/j.jneumeth.2020.108682subject
Has Abstractpub_date
2020-05-15 00:00:00pages
108682eissn
0165-0270issn
1872-678Xpii
S0165-0270(20)30104-7journal_volume
338pub_type
杂志文章abstract：:Although the classical Golgi method is a powerful means for structural analysis of the brain, it is generally considered to be an unpredictable technique making anatomists wary of using it. Often, even when successful staining has occurred, deposits of silver chromate crystals on the surface of the tissue obscure exam...
journal_title：Journal of neuroscience methods
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journal_title：Journal of neuroscience methods
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journal_title：Journal of neuroscience methods
pub_type： 杂志文章,评审
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journal_title：Journal of neuroscience methods
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journal_title：Journal of neuroscience methods
pub_type： 杂志文章
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journal_title：Journal of neuroscience methods
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journal_title：Journal of neuroscience methods
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journal_title：Journal of neuroscience methods
pub_type： 杂志文章
doi：10.1016/j.jneumeth.2011.10.004
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journal_title：Journal of neuroscience methods
pub_type： 杂志文章
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journal_title：Journal of neuroscience methods
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journal_title：Journal of neuroscience methods
pub_type： 杂志文章
doi：10.1016/j.jneumeth.2011.10.017
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journal_title：Journal of neuroscience methods
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journal_title：Journal of neuroscience methods
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journal_title：Journal of neuroscience methods
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journal_title：Journal of neuroscience methods
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journal_title：Journal of neuroscience methods
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journal_title：Journal of neuroscience methods
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