Abstract：
BACKGROUND:Electrophysiological recordings contain mixtures of signals from distinct neural sources, impeding a straightforward interpretation of the sensor-level data. This mixing is particularly detrimental when distinct sources resonate in overlapping frequencies. Fortunately, the mixing is linear and instantaneous. Multivariate source separation methods may therefore successfully separate statistical sources, even with overlapping spatial distributions. NEW METHOD:We demonstrate a feature-guided multivariate source separation method that is tuned to narrowband frequency content as well as binary condition differences. This method - comparison scanning generalized eigendecomposition, csGED - harnesses the covariance structure of multichannel data to find directions (i.e., eigenvectors) that maximally separate two subsets of data. To drive condition specificity and frequency specificity, our data subsets were taken from different task conditions and narrowband-filtered prior to applying GED. RESULTS:To validate the method, we simulated MEG data in two conditions with shared noise characteristics and unique signal. csGED outperformed the best sensor at reconstructing the ground truth signals, even in the presence of large amounts of noise. We next applied csGED to a published empirical MEG dataset on visual perception vs. imagery. csGED identified sources in alpha, beta, and gamma bands, and successfully separated distinct networks in the same frequency band. COMPARISON WITH EXISTING METHOD(S):GED is a flexible feature-guided decomposition method that has previously successfully been applied. Our combined frequency- and condition-tuning is a novel adaptation that extends the power of GED in cognitive electrophysiology. CONCLUSIONS:We demonstrate successful condition-specific source separation by applying csGED to simulated and empirical data.
journal_name
J Neurosci Methodsjournal_title
Journal of neuroscience methodsauthors
Zuure MB,Cohen MXdoi
10.1016/j.jneumeth.2020.109063subject
Has Abstractpub_date
2020-12-25 00:00:00pages
109063eissn
0165-0270issn
1872-678Xpii
S0165-0270(20)30486-6journal_volume
350pub_type
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