Abstract：
:An ongoing question in neuroscience is how the peripheral nervous system can repair itself following an injury or insult whereas the central nervous system has a profoundly limited ability for repair. The recent and rapid advancement of our understanding of the gene expression and corresponding biochemical profiles of Schwann cells, within the distal segments of injured peripheral nerves, has helped elucidate the potential mechanisms underlying the unique ability for these cells to enable regeneration of peripheral nerve tissue. Meanwhile, with a new understanding and appreciation for the capabilities of the peripheral nervous system, we are beginning to unlock the potential for neural regeneration and repair within the central nervous system. The aim of this review is to briefly outline the historical advancements that lead to the recent concept of utilizing peripheral nerve tissue grafts or Schwann cell culture implants to serve as repair mechanisms for the central nervous system in the clinical setting of spinal cord injury, multiple sclerosis, and neurodegenerative disorders such as Parkinson's disease.
journal_name
J Neurosci Methodsjournal_title
Journal of neuroscience methodsauthors
El Seblani N,Welleford AS,Quintero JE,van Horne CG,Gerhardt GAdoi
10.1016/j.jneumeth.2020.108623subject
Has Abstractpub_date
2020-04-01 00:00:00pages
108623eissn
0165-0270issn
1872-678Xpii
S0165-0270(20)30045-5journal_volume
335pub_type
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