Abstract：
:Parkinson's disease (PD) exhibits symptoms of motor dysfunction such as tremor, akinesia and rigidity. Agents that selectively disrupt or destroy catecholaminergic systems, such as reserpine, methamphetamine, 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, have been used to develop PD models and to study the animal behavior like catalepsy, akinesia, swim-test, etc. The major apprehension while working with these chemicals is their irreversible neuro-toxic effect. Haloperidol is a classical antipsychotic drug, which produces extra-pyrimidal Parkinson's symptoms (EPS). Measuring catalepsy and akinesia in the treated mice monitored the haloperidol-induced EPS. Alternatively, swimming disability was tested as a new parameter to monitor haloperidol-induced EPS. The results showed that the restoration of swimming disability in haloperidol-induced L-dopa and caffeine pre-treated mice could be used as pre-clinical model to study PD.
journal_name
J Neurosci Methodsjournal_title
Journal of neuroscience methodsauthors
Luthra PM,Barodia SK,Raghubir Rdoi
10.1016/j.jneumeth.2008.12.019subject
Has Abstractpub_date
2009-04-15 00:00:00pages
284-90issue
2eissn
0165-0270issn
1872-678Xpii
S0165-0270(08)00714-0journal_volume
178pub_type
杂志文章abstract：:Research into therapeutics for neuropsychiatric disorders is increasingly focusing on drugs with new mechanisms of action, and such agents are often assessed in preclinical studies using nonhuman primates. However, researchers lack a standardised method to compare different drugs for common adverse effects on the nerv...
journal_title：Journal of neuroscience methods
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更新日期：2013-04-30 00:00:00
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journal_title：Journal of neuroscience methods
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journal_title：Journal of neuroscience methods
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journal_title：Journal of neuroscience methods
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journal_title：Journal of neuroscience methods
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journal_title：Journal of neuroscience methods
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journal_title：Journal of neuroscience methods
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更新日期：2012-03-15 00:00:00
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journal_title：Journal of neuroscience methods
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doi：10.1016/j.jneumeth.2009.02.017
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journal_title：Journal of neuroscience methods
pub_type： 杂志文章
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journal_title：Journal of neuroscience methods
pub_type： 杂志文章
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更新日期：2015-02-15 00:00:00
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更新日期：2000-11-15 00:00:00
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journal_title：Journal of neuroscience methods
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更新日期：2013-05-30 00:00:00
