解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Candidemia is an opportunistic infection associated with high morbidity and mortality in patients hospitalized both inside and outside intensive care units (ICUs). Identification of patients at risk is crucial to ensure prompt antifungal therapy. We sought to assess risk factors for candidemia and death, bot...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-2766-1
更新日期:2020-03-18 00:00:00
abstract:BACKGROUND:Intensive care unit (ICU) delirium is a frequent secondary neurological complication in critically ill patients undergoing prolonged mechanical ventilation. Quantitative pupillometry is an emerging modality for the neuromonitoring of primary acute brain injury, but its potential utility in patients at risk o...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-2796-8
更新日期:2020-02-24 00:00:00
abstract:OBJECTIVE:In septic patients, multiple retrospective studies show an association between large volumes of fluids administered in the first 24 h and mortality, suggesting a benefit to fluid restrictive strategies. However, these studies do not directly estimate the causal effects of fluid-restrictive strategies, nor do ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-2767-0
更新日期:2020-02-22 00:00:00
abstract::In the publication of this article [1], there are 4 collaborating authors missing from the 'MARS consortium'. This has now been included in this correction article. ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,已发布勘误
doi:10.1186/s13054-020-2758-1
更新日期:2020-02-06 00:00:00
abstract::Vasoplegic syndrome is a common occurrence following cardiothoracic surgery and is characterized as a high-output shock state with poor systemic vascular resistance. The pathophysiology is complex and includes dysregulation of vasodilatory and vasoconstrictive properties of smooth vascular muscle cells. Specific bypas...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-020-2743-8
更新日期:2020-02-04 00:00:00
abstract:BACKGROUND:Septic shock (SS) and cardiogenic shock (CS) are two types of circulatory shock with a different etiology. Several studies have described the molecular alterations in SS patients, whereas the molecular factors involved in CS have been poorly investigated. We aimed to assess in the whole blood of CS and SS pa...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/s13054-019-2670-8
更新日期:2019-12-19 00:00:00
abstract:BACKGROUND:Critically ill patients in the intensive care unit (ICU) are at high risk for developing Clostridioides difficile infections (CDI). Risk factors predicting their mortality or standardized treatment recommendations have not been defined for this cohort. Our goal is to determine outcome and mortality associate...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2648-6
更新日期:2019-12-09 00:00:00
abstract:BACKGROUND:In ARDS patients, changes in respiratory mechanical properties and ventilatory settings can cause incomplete lung deflation at end-expiration. Both can promote dynamic hyperinflation and intrinsic positive end-expiratory pressure (PEEP). The aim of this study was to investigate, in a large population of ARDS...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2611-6
更新日期:2019-11-27 00:00:00
abstract:BACKGROUND:Augmented renal clearance (ARC) is recognized as a leading cause of β-lactam subexposure when conventional dosing regimens are used. The main objective was to compare the clinical outcome of ARC patients treated by conventional or increased β-lactam dosing regimens for a first episode of hospital or ventilat...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2621-4
更新日期:2019-11-27 00:00:00
abstract:BACKGROUND:Higher inspiratory airway pressures are associated with worse outcomes in mechanically ventilated patients with the acute respiratory distress syndrome (ARDS). This relationship, however, has not been well investigated in patients without ARDS. We hypothesized that higher driving pressures (ΔP) and plateau p...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2635-y
更新日期:2019-11-21 00:00:00
abstract:BACKGROUND:Bloodstream infections are associated with high morbidity and mortality, both of which contribute substantially to healthcare costs. The effects of early administration of appropriate antimicrobials on the prognosis and timing of defervescence of bacteremic patients remain under debate. METHODS:In a 6-year ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2632-1
更新日期:2019-11-20 00:00:00
abstract:BACKGROUND:For patients who survive a critical illness and have their oral endotracheal tube removed, dysphagia is highly prevalent, and without intervention, it may persist far beyond hospital discharge. This pre- and post-intervention study with historical controls tested the effects of a swallowing and oral care (SO...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2623-2
更新日期:2019-11-09 00:00:00
abstract:BACKGROUND:Intensive care units (ICUs) face financial, bed management, and staffing constraints. Detailed data covering all aspects of patients' journeys into and through intensive care are now collected and stored in electronic health records: machine learning has been used to analyse such data in order to provide dec...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2564-9
更新日期:2019-08-22 00:00:00
abstract::Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is an increasingly adopted life-saving mechanical circulatory support for a number of potentially reversible or treatable cardiac diseases. It is also started as a bridge-to-transplantation/ventricular assist device in the case of unrecoverable cardiac or ca...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-019-2541-3
更新日期:2019-07-30 00:00:00
abstract:BACKGROUND:Sepsis remains a complex medical problem and a major challenge in healthcare. Diagnostics and outcome predictions are focused on physiological parameters with less consideration given to patients' medical background. Given the aging population, not only are diseases becoming increasingly prevalent but occur ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2486-6
更新日期:2019-07-08 00:00:00
abstract:BACKGROUND:ICU-acquired weakness is a debilitating consequence of prolonged critical illness that is associated with poor outcome. Recently, premorbid obesity has been shown to protect against such illness-induced muscle wasting and weakness. Here, we hypothesized that this protection was due to increased lipid and ket...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2506-6
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:The first FDA-approved test to assess risk for acute kidney injury (AKI), [TIMP-2]•[IGFBP7], is clinically available in many parts of the world, including the USA and Europe. We sought to understand how the test is currently being used clinically. METHODS:We invited a group of experts knowledgeable on the u...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2504-8
更新日期:2019-06-20 00:00:00
abstract::Until relatively recently, critical illness was considered as a separate entity and the intensive care unit (ICU), often a little cut-off from other areas of the hospital, was in many cases used as a last resort for patients so severely ill that it was no longer possible to care for them on the general ward. However, ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-019-2393-x
更新日期:2019-06-14 00:00:00
abstract:BACKGROUND:The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. METHODS:A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/s13054-019-2497-3
更新日期:2019-06-14 00:00:00
abstract:BACKGROUND:As more patients are surviving intensive care, mental health concerns in survivors have become a research priority. Among these, post-traumatic stress disorder (PTSD) can have an important impact on the quality of life of critical care survivors. However, data on its burden are conflicting. Therefore, this s...
journal_title:Critical care (London, England)
pub_type: 杂志文章,meta分析
doi:10.1186/s13054-019-2489-3
更新日期:2019-06-11 00:00:00
abstract::Malignant stroke occurs in a subgroup of patients suffering from ischemic cerebral infarction and is characterized by neurological deterioration due to progressive edema, raised intracranial pressure, and cerebral herniation. Decompressive craniectomy (DC) is a surgical technique aiming to open the "closed box" repres...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-019-2490-x
更新日期:2019-06-07 00:00:00
abstract:IMPORTANCE:The optimal approach to airway management during in-hospital cardiac arrest is unknown. OBJECTIVE:To describe hospital-level variation in endotracheal intubation during cardiopulmonary resuscitation (CPR) for in-hospital cardiac arrest and the association between hospital use of endotracheal intubation and ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2426-5
更新日期:2019-05-06 00:00:00
abstract:OBJECTIVES:We sought to study the association between sedation status, medications (benzodiazepines, opioids, and antipsychotics), and clinical outcomes in a resource-limited setting. DESIGN:A longitudinal study of critically ill participants on mechanical ventilation. SETTING:Five intensive care units (ICUs) in four...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/s13054-019-2394-9
更新日期:2019-04-17 00:00:00
abstract:BACKGROUND:Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery. We investigated the postoperative course of renal and pulmonary endothelial barrier function and the association with microcircula...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2418-5
更新日期:2019-04-11 00:00:00
abstract:OBJECTIVES:To evaluate the resuscitative effects of mechanical and manual chest compression in patients with out-of-hospital cardiac arrest (OHCA). METHODS:All randomized controlled and cohort studies comparing the effects of mechanical compression and manual compression on cardiopulmonary resuscitation in OHCA patien...
journal_title:Critical care (London, England)
pub_type: 杂志文章,meta分析
doi:10.1186/s13054-019-2389-6
更新日期:2019-03-27 00:00:00
abstract::This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2019 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-019-2371-3
更新日期:2019-03-09 00:00:00
abstract::This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2019 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-019-2369-x
更新日期:2019-03-09 00:00:00
abstract:BACKGROUND:The acute respiratory distress syndrome (ARDS) is characterized by disruption of the alveolar-capillary barrier resulting in accumulation of proteinaceous edema and increased inflammatory cells in the alveolar space. We previously found that endothelial progenitor cell (EPC) exosomes prevent endothelial dysf...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2339-3
更新日期:2019-02-13 00:00:00
abstract:: ...
journal_title:Critical care (London, England)
pub_type: 评论,社论
doi:10.1186/s13054-019-2325-9
更新日期:2019-02-13 00:00:00
abstract:BACKGROUND:Survivors of an acute critical illness with continuing organ dysfunction and uncontrolled inflammatory responses are prone to become chronically critically ill. As mental sequelae, a post-traumatic stress disorder and an associated decrease in the health-related quality of life (QoL) may occur, not only in t...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2321-0
更新日期:2019-02-08 00:00:00
abstract:OBJECTIVE:Exposure to hyperoxemia and hypoxemia is common in out-of-hospital cardiac arrest (OHCA) patients following return of spontaneous circulation (ROSC), but its effects on neurological outcome are uncertain, and study results are inconsistent. METHODS:Exploratory post hoc substudy of the Target Temperature Mana...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13054-019-2322-z
更新日期:2019-01-28 00:00:00
abstract:: ...
journal_title:Critical care (London, England)
pub_type: 评论,信件
doi:10.1186/s13054-019-2310-3
更新日期:2019-01-17 00:00:00
abstract:: ...
journal_title:Critical care (London, England)
pub_type: 评论,信件
doi:10.1186/s13054-018-2297-1
更新日期:2019-01-09 00:00:00
abstract:PURPOSE:The histopathology of sepsis-associated acute kidney injury (AKI) in critically ill patients remains an understudied area. Previous studies have identified that acute tubular necrosis (ATN) is not the only driver of sepsis-AKI. The focus of this study was to identify additional candidate processes that may driv...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-018-2287-3
更新日期:2018-12-27 00:00:00
abstract:BACKGROUND:The association between isolated admission heart rate (HR) and prognosis has been discussed, but not that between gross HR change and neurological outcome in patients with severe traumatic brain injury (TBI). In the acute phase of severe TBI, HR is influenced by several factors (e.g., pain, sympathetic activ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s13054-018-2276-6
更新日期:2018-12-19 00:00:00
abstract:BACKGROUND:Prior retrospective cross-sectional work has associated antimicrobials with a non-specific phrase: encephalopathy without seizures. The purpose of this study is to determine whether different classes of antimicrobials have differential associations with the daily risk of delirium after critical illness is ad...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-018-2262-z
更新日期:2018-12-12 00:00:00
abstract:BACKGROUND:Sepsis is an important cause of neonatal morbidity and mortality; therefore, the early diagnosis of neonatal sepsis is essential. METHOD:Our aim was to compare the diagnostic accuracy of procalcitonin (PCT), C-reactive protein (CRP), procalcitonin combined with C-reactive protein (PCT + CRP) and presepsin i...
journal_title:Critical care (London, England)
pub_type: 杂志文章,meta分析
doi:10.1186/s13054-018-2236-1
更新日期:2018-11-21 00:00:00
abstract:BACKGROUND:We sought to determine the effects of alternative resuscitation strategies on microcirculatory perfusion and examine any association between microcirculatory perfusion and mortality in sepsis. METHODS:This was a prospective, formally designed substudy of participants in the Protocolized Care in Early Septic...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s13054-018-2240-5
更新日期:2018-11-20 00:00:00
abstract:: ...
journal_title:Critical care (London, England)
pub_type: 社论
doi:10.1186/s13054-018-2249-9
更新日期:2018-11-16 00:00:00
abstract:: ...
journal_title:Critical care (London, England)
pub_type: 信件
doi:10.1186/s13054-018-2244-1
更新日期:2018-11-14 00:00:00