Dynamic hyperinflation and intrinsic positive end-expiratory pressure in ARDS patients.

abstract：BACKGROUND:The acute respiratory distress syndrome (ARDS) is characterized by disruption of the alveolar-capillary barrier resulting in accumulation of proteinaceous edema and increased inflammatory cells in the alveolar space. We previously found that endothelial progenitor cell (EPC) exosomes prevent endothelial dysf...

journal_title：Critical care (London, England)

authors： Zhou Y,Li P,Goodwin AJ,Cook JA,Halushka PV,Chang E,Zingarelli B,Fan H

更新日期：2019-02-13 00:00:00

abstract：:Acute kidney injury (AKI) is now well recognized as an independent risk factor for increased morbidity and mortality, particularly when dialysis is needed. The wide variation in dialysis utilization contributes to a lack of consensus on what parameters should guide the decision to start dialysis. While the association...

journal_title：Critical care (London, England)

authors： Macedo E,Mehta RL

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:This small observational study was motivated by our belief that scaling the tidal volume in mechanically ventilated patients to the size of the injured lung is safer and more 'physiologic' than scaling it to predicted body weight, i.e. its size before it was injured. We defined Total Lung Capacity (TLC) as...

journal_title：Critical care (London, England)

authors： Mattingley JS,Holets SR,Oeckler RA,Stroetz RW,Buck CF,Hubmayr RD

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The plasma colloid osmotic pressure (COP) plays a major role in transcapillary fluid balance. There is no information on plasma COP of healthy infants beyond the first post-natal week. The normal COP in healthy adult subjects (25 mmHg) is currently also applied as a reference value for healthy infants. This ...

journal_title：Critical care (London, England)

authors： Sussmane JB,de Soto M,Torbati D

更新日期：2001-10-01 00:00:00

abstract：:Novel insights into the metabolic alterations of critical illness were published in Critical Care in 2009. The association between early hypoglycaemia/high glycemic variability and poor outcome was confirmed. Improvements in the understanding of the pathophysiological mechanisms of stress hyperglycemia and potential p...

journal_title：Critical care (London, England)

authors： Huberlant V,Preiser JC

更新日期：2010-01-01 00:00:00

abstract：:This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2019 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available...

journal_title：Critical care (London, England)

authors： Milford EM,Reade MC

更新日期：2019-03-09 00:00:00

abstract：:In the publication of this article [1], there are 4 collaborating authors missing from the 'MARS consortium'. This has now been included in this correction article. ...

journal_title：Critical care (London, England)

authors： Klein Klouwenberg PMC,Spitoni C,van der Poll T,Bonten MJ,Cremer OL,MARS consortium.

更新日期：2020-02-06 00:00:00

abstract：INTRODUCTION:Serum B-type natriuretic peptide (BNP) is frequently elevated after subarachnoid hemorrhage (SAH), but whether this high BNP level is related to transient elevation of left ventricular filling pressure (LVFP) is unknown. However, in patients with preexistent cardiac pathologies, it is impossible to differe...

journal_title：Critical care (London, England)

authors： Meaudre E,Jego C,Kenane N,Montcriol A,Boret H,Goutorbe P,Habib G,Palmier B

更新日期：2009-01-01 00:00:00

abstract：:The composition and function of intestinal microflora are emerging as integral to both health and disease. During critical illness the normal microbiota are rapidly replaced by pathogenic species as a result of both the physiologic stress itself and the use of antibiotics. In this report, the authors use fecal pH as a...

journal_title：Critical care (London, England)

authors： Alverdy JC

更新日期：2012-09-12 00:00:00

abstract：BACKGROUND:Frailty is a state of vulnerability to poor resolution of homeostasis after a stressor event and is strongly associated with adverse outcomes. Therefore, the assessment of frailty may be an essential part of evaluation in any healthcare encounter that might result in an escalation of care. The purpose of the...

journal_title：Critical care (London, England)

authors： So RKL,Bannard-Smith J,Subbe CP,Jones DA,van Rosmalen J,Lighthall GK,METHOD study investigators.

更新日期：2018-09-22 00:00:00

abstract：:Many aspects of left ventricular function are explained by considering ventricular pressure-volume characteristics. Contractility is best measured by the slope, Emax, of the end-systolic pressure-volume relationship. Ventricular systole is usefully characterized by a time-varying elastance (ΔP/ΔV). An extended area, t...

journal_title：Critical care (London, England)

authors： Walley KR

更新日期：2016-09-10 00:00:00

abstract：:Experiencing treatment on a modern intensive care unit (ICU) is a potentially traumatic event. People who experience traumatic events have an increased risk of depression, anxiety disorders and post-traumatic stress disorder (PTSD). Extended follow-up has confirmed that many patients suffer physical and psychological ...

journal_title：Critical care (London, England)

authors： Hatch R,McKechnie S,Griffiths J

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Sepsis remains a complex medical problem and a major challenge in healthcare. Diagnostics and outcome predictions are focused on physiological parameters with less consideration given to patients' medical background. Given the aging population, not only are diseases becoming increasingly prevalent but occur ...

journal_title：Critical care (London, England)

authors： Zador Z,Landry A,Cusimano MD,Geifman N

更新日期：2019-07-08 00:00:00

abstract：:The diagnosis of patients presenting to the emergency department with acute heart failure (AHF) is challenging due to the similarity of AHF symptoms to other conditions such as chronic obstructive pulmonary disease and pneumonia. Additionally, because AHF is most common in an older population, the presentation of coex...

journal_title：Critical care (London, England)

authors： Peacock WF,Cannon CM,Singer AJ,Hiestand BC

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:Bloodstream infections are associated with high morbidity and mortality, both of which contribute substantially to healthcare costs. The effects of early administration of appropriate antimicrobials on the prognosis and timing of defervescence of bacteremic patients remain under debate. METHODS:In a 6-year ...

journal_title：Critical care (London, England)

authors： Lee CC,Lee CH,Yang CY,Hsieh CC,Tang HJ,Ko WC

更新日期：2019-11-20 00:00:00

abstract：INTRODUCTION:Protocols for the delivery of analgesia, sedation and delirium care of the critically ill, mechanically ventilated patient have been shown to improve outcomes but are not uniformly used. The extent to which elements of analgesia, sedation and delirium guidelines are incorporated into order sets at hospital...

journal_title：Critical care (London, England)

authors： Dale CR,Hayden SJ,Treggiari MM,Curtis JR,Seymour CW,Yanez ND 3rd,Fan VS

更新日期：2012-06-18 00:00:00

abstract：:Cardiogenic shock is a lethal condition. Physicians are searching for hemodynamic markers which could help risk-stratification of patients in this picture. Torgersen and coworkers present an hourly time integral of the cardiac power index and cardiac index drops to predict outcomes in the setting of cardiogenic shock....

journal_title：Critical care (London, England)

authors： Yilmaz MB,Mebazaa A

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Subarachnoid haemorrhage (SAH) may damage the hypothalamo-pituitary-adrenal gland (HPA) axis and disturb cortisol metabolism. There are no available data that relates to the response of the HPA axis in the acute phase of SAH. We aimed to characterise the behavior of serum adrenocorticotropic hormone (ACTH)...

journal_title：Critical care (London, England)

authors： Bendel S,Koivisto T,Ruokonen E,Rinne J,Romppanen J,Vauhkonen I,Kiviniemi V,Uusaro A

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:It is recognized that administration of insulin with glucose decreases catabolic response in sepsis. The aim of the present study was to compare the effects of two levels of insulinaemia on glucose metabolism and energy expenditure in septic patients and volunteers. METHODS:Glucose uptake, oxidation and s...

journal_title：Critical care (London, England)

authors： Rusavy Z,Sramek V,Lacigova S,Novak I,Tesinsky P,Macdonald IA

更新日期：2004-08-01 00:00:00

abstract：:In an effort to reduce the complications related to invasive ventilation, the use of noninvasive ventilation (NIV) has increased over the last years in patients with acute respiratory failure. However, failure rates for NIV remain high in specific patient categories. Several studies have identified factors that contri...

journal_title：Critical care (London, England)

authors： Oppersma E,Doorduin J,van der Heijden EH,van der Hoeven JG,Heunks LM

更新日期：2013-12-05 00:00:00

abstract：INTRODUCTION:Functional assessment of arterial load by dynamic arterial elastance (Eadyn), defined as the ratio between pulse pressure variation (PPV) and stroke volume variation (SVV), has recently been shown to predict the arterial pressure response to volume expansion (VE) in hypotensive, preload-dependent patients....

journal_title：Critical care (London, England)

authors： García MI,Romero MG,Cano AG,Aya HD,Rhodes A,Grounds RM,Cecconi M

更新日期：2014-11-19 00:00:00

abstract：INTRODUCTION:The ventilator and the endotracheal tube impose additional workload in mechanically ventilated patients breathing spontaneously. The total work of breathing (WOB) includes elastic and resistive work. In a bench test we assessed the imposed WOB using 3100 A/3100 B SensorMedics high-frequency oscillatory ven...

journal_title：Critical care (London, England)

authors： van Heerde M,van Genderingen HR,Leenhoven T,Roubik K,Plötz FB,Markhorst DG

更新日期：2006-02-01 00:00:00

abstract：INTRODUCTION:Despite recent modifications, the clinical definition of the acute respiratory distress syndrome (ARDS) remains non-specific, leading to under-diagnosis and under-treatment. This study was designed to test the hypothesis that a biomarker panel would be useful for biologic confirmation of the clinical diagn...

journal_title：Critical care (London, England)

authors： Ware LB,Koyama T,Zhao Z,Janz DR,Wickersham N,Bernard GR,May AK,Calfee CS,Matthay MA

更新日期：2013-10-24 00:00:00

abstract：BACKGROUND:As more patients are surviving intensive care, mental health concerns in survivors have become a research priority. Among these, post-traumatic stress disorder (PTSD) can have an important impact on the quality of life of critical care survivors. However, data on its burden are conflicting. Therefore, this s...

journal_title：Critical care (London, England)

authors： Righy C,Rosa RG,da Silva RTA,Kochhann R,Migliavaca CB,Robinson CC,Teche SP,Teixeira C,Bozza FA,Falavigna M

更新日期：2019-06-11 00:00:00

abstract：:Metrics typically used to report the performance of an early warning score (EWS), such as the area under the receiver operator characteristic curve or C-statistic, are not useful for pre-implementation analyses. Because physiological deterioration has an extremely low prevalence of 0.02 per patient-day, these metrics ...

journal_title：Critical care (London, England)

authors： Romero-Brufau S,Huddleston JM,Escobar GJ,Liebow M

更新日期：2015-08-13 00:00:00

abstract：INTRODUCTION:Tight glucose control therapy (TGC) has been implemented to control hyperglycemia in ICU patients. TGC may also influence serum potassium concentrations. We therefore investigated the influence of TGC on both serum glucose and serum potassium concentrations and associated mortality. METHOD:We performed a ...

journal_title：Critical care (London, England)

authors： Uijtendaal EV,Zwart-van Rijkom JE,de Lange DW,Lalmohamed A,van Solinge WW,Egberts TC

更新日期：2015-06-22 00:00:00

abstract：BACKGROUND:Survivors of an acute critical illness with continuing organ dysfunction and uncontrolled inflammatory responses are prone to become chronically critically ill. As mental sequelae, a post-traumatic stress disorder and an associated decrease in the health-related quality of life (QoL) may occur, not only in t...

journal_title：Critical care (London, England)

authors： Wintermann GB,Petrowski K,Weidner K,Strauß B,Rosendahl J

更新日期：2019-02-08 00:00:00

abstract：INTRODUCTION:The aim of this study was to determine whether the degree of fluid responsiveness in critically ill septic patients is related to baseline mixed venous oxygen saturation (SvO2) levels. We also sought to define whether fluid responsiveness would be less likely in the presence of a high SvO2 (>70%). METHODS...

journal_title：Critical care (London, England)

authors： Velissaris D,Pierrakos C,Scolletta S,De Backer D,Vincent JL

更新日期：2011-07-26 00:00:00

abstract：INTRODUCTION:Critical illness is commonly complicated by hyperglycaemia caused by mediators of stress and inflammation. Severity of disease is the main risk factor for development of hyperglycaemia, but not all severely ill develop hyperglycemia and some do even in mild disease. We hypothesised that acute disease only ...

journal_title：Critical care (London, England)

authors： Gornik I,Vujaklija-Brajkovic A,Renar IP,Gasparovic V

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Augmented renal clearance (ARC) is recognized as a leading cause of β-lactam subexposure when conventional dosing regimens are used. The main objective was to compare the clinical outcome of ARC patients treated by conventional or increased β-lactam dosing regimens for a first episode of hospital or ventilat...

journal_title：Critical care (London, England)

authors： Carrié C,Chadefaux G,Sauvage N,de Courson H,Petit L,Nouette-Gaulain K,Pereira B,Biais M

更新日期：2019-11-27 00:00:00