Microcirculatory perfusion disturbances following cardiac surgery with cardiopulmonary bypass are associated with in vitro endothelial hyperpermeability and increased angiopoietin-2 levels.

abstract：:Severe sepsis is more and more frequent, especially because of an increased rate of immunocompromised patients. Despite the improvement in the overall prognosis of HIV/AIDS patients and the improvement of global ICU care, the prognosis of HIV/ADS patients hospitalized in ICU with severe sepsis remained poor. This situ...

journal_title：Critical care (London, England)

authors： Timsit JF

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Electrical impedance tomography (EIT) is a non-invasive bedside tool which allows an individualized ventilator strategy by monitoring tidal ventilation and lung aeration. EIT can be performed at different cranio-caudal thoracic levels, but data are missing about the optimal belt position. The main goal of th...

journal_title：Critical care (London, England)

authors： Karsten J,Stueber T,Voigt N,Teschner E,Heinze H

更新日期：2016-01-08 00:00:00

abstract：INTRODUCTION:Despite recommendations from professional societies and patient safety organizations, the majority of ICU patients worldwide are not routinely monitored for delirium, thus preventing timely prevention and management. The purpose of this systematic review is to summarize what types of implementation strateg...

journal_title：Critical care (London, England)

authors： Trogrlić Z,van der Jagt M,Bakker J,Balas MC,Ely EW,van der Voort PH,Ista E

更新日期：2015-04-09 00:00:00

abstract：INTRODUCTION:Severe hypoglycemia (blood glucose concentration (BG) < 40 mg/dL) is independently associated with an increased risk of mortality in critically ill patients. The association of milder hypoglycemia (BG < 70 mg/dL) with mortality is less clear. METHODS:Prospectively collected data from two observational coh...

journal_title：Critical care (London, England)

authors： Krinsley JS,Schultz MJ,Spronk PE,Harmsen RE,van Braam Houckgeest F,van der Sluijs JP,Mélot C,Preiser JC

更新日期：2011-07-25 00:00:00

abstract：INTRODUCTION:The appropriate strategy for trauma-induced coagulopathy management is under debate. We report the treatment of major trauma using mainly coagulation factor concentrates. METHODS:This retrospective analysis included trauma patients who received >or= 5 units of red blood cell concentrate within 24 hours. C...

journal_title：Critical care (London, England)

authors： Schöchl H,Nienaber U,Hofer G,Voelckel W,Jambor C,Scharbert G,Kozek-Langenecker S,Solomon C

更新日期：2010-01-01 00:00:00

abstract：:Great white sharks are responsible for about 10 cases of death annually worldwide, as compared with millions of deaths caused by sepsis. However, the basic principles of avoiding shark attacks and fighting sepsis seem to be similar: avoidance, attention, and speed, if necessary. The present review discusses the curren...

journal_title：Critical care (London, England)

authors： Westphal M,Kampmeier T

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:The goal of the current study was to investigate the effect of aging on the development of endothelial dysfunction in a murine model of sepsis, and to compare it with the effect of genetic deficiency of the endothelial isoform of nitric oxide synthase (eNOS). METHODS:Cecal ligation and puncture (CLP) was ...

journal_title：Critical care (London, England)

authors： Coletta C,Módis K,Oláh G,Brunyánszki A,Herzig DS,Sherwood ER,Ungvári Z,Szabo C

更新日期：2014-09-16 00:00:00

abstract：INTRODUCTION:Mechanically ventilated critically ill patients frequently develop ventilator-associated pneumonia (VAP), a life-threatening complication. Proposed preventive measures against VAP include, but are not restricted to, selective decontamination of the digestive tract (SDD), selective oropharyngeal decontamina...

journal_title：Critical care (London, England)

authors： Schultz MJ,Haas LE

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:It has been hypothesized that hyperoncotic colloids might contribute to acute kidney injury (AKI). However, the validity of this hypothesis remains unclear. METHODS:A meta-analysis was conducted of randomized controlled trials evaluating AKI after infusion of hyperoncotic albumin and hydroxyethyl starch (...

journal_title：Critical care (London, England)

authors： Wiedermann CJ,Dunzendorfer S,Gaioni LU,Zaraca F,Joannidis M

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Curricular content is often based on the personal opinions of a small number of individuals. Although convenient, such curricula may not meet the needs of the target learner, the program or the institution. Using an objective method to ensure content validity of a curriculum can alleviate this issue. METH...

journal_title：Critical care (London, England)

authors： Peets AD,McLaughlin K,Lockyer J,Donnon T

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Activation of the sympathetic nervous system has beneficial cardiovascular effects in sepsis, but there is also evidence that sympatholytics have beneficial actions in sepsis. We therefore determined the effect of selective β1-adrenoceptor blockade on cardiac and renal function and cytokine release in ovin...

journal_title：Critical care (London, England)

authors： Calzavacca P,Lankadeva YR,Bailey SR,Bailey M,Bellomo R,May CN

更新日期：2014-11-21 00:00:00

abstract：INTRODUCTION:Patients with acute-on-chronic liver failure show an aggravated hyperdynamic circulation. We evaluated, in a controlled manner, potential changes in systemic haemodynamics induced by the molecular adsorbent recirculating system (MARS) and the Prometheus system liver detoxification devices in a group of pat...

journal_title：Critical care (London, England)

authors： Laleman W,Wilmer A,Evenepoel P,Elst IV,Zeegers M,Zaman Z,Verslype C,Fevery J,Nevens F

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Coronavirus disease 2019 (COVID-19) is a newly emerging infectious disease and rapidly escalating epidemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The pathogenesis of COVID-19 remains to be elucidated. We aimed to clarify correlation of systemic inflammation with disease s...

journal_title：Critical care (London, England)

authors： Zeng Z,Yu H,Chen H,Qi W,Chen L,Chen G,Yan W,Chen T,Ning Q,Han M,Wu D

更新日期：2020-08-27 00:00:00

abstract：BACKGROUND:The present study was designed to (1) establish current sedation practice in UK critical care to inform evidence synthesis and potential future primary research and (2) to compare practice reported via a survey with actual practice assessed in a point prevalence study (PPS). METHODS:UK adult general critica...

journal_title：Critical care (London, England)

authors： Richards-Belle A,Canter RR,Power GS,Robinson EJ,Reschreiter H,Wunsch H,Harvey SE

更新日期：2016-10-27 00:00:00

abstract：:Sepsis is one of the most common conditions encountered in the intensive care unit and is the 10th leading cause of death overall in the United States. Both long-term survival and health-related quality of life are reduced in survivors of sepsis, yet there is little knowledge of the effect of sepsis-specific intervent...

journal_title：Critical care (London, England)

authors： Erickson SE,Martin GS

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:There is a complex interplay between changes in acid-base components and inflammation. This manuscript aims to explore associations between plasma cytokines and chemokines and acid-base status on admission to intensive care. METHODS:We conducted a prospective cohort study in a 13-bed ICU in a tertiary-car...

journal_title：Critical care (London, England)

authors： Zampieri FG,Kellum JA,Park M,Ranzani OT,Barbeiro HV,de Souza HP,da Cruz Neto LM,da Silva FP

更新日期：2014-07-17 00:00:00

abstract：BACKGROUND:Inhaled nitric oxide (iNO) is a rescue therapy for severe hypoxemia in patients with acute respiratory distress syndrome (ARDS). Pooled data from clinical trials have signaled a renal safety warning for iNO therapy, but the significance of these findings in daily clinical practice is unclear. We used primary...

journal_title：Critical care (London, England)

authors： Ruan SY,Wu HY,Lin HH,Wu HD,Yu CJ,Lai MS

更新日期：2016-11-30 00:00:00

abstract：INTRODUCTION:Prevalence of iron deficiency (ID) at intensive care (ICU) admission is around 25 to 40%. Blood losses are important during ICU stay, leading to iron losses, but prevalence of ID at ICU discharge is unknown. ID has been associated with fatigue and muscular weakness, and may thus impair post-ICU rehabilitat...

journal_title：Critical care (London, England)

authors： Lasocki S,Chudeau N,Papet T,Tartiere D,Roquilly A,Carlier L,Mimoz O,Seguin P,Malledant Y,Asehnoune K,Hamel JF,AtlanREA group.

更新日期：2014-09-30 00:00:00

abstract：INTRODUCTION:To systematically review studies evaluating the performance of Sequential Organ Failure Assessment (SOFA)-based models for predicting mortality in patients in the intensive care unit (ICU). METHODS:Medline, EMBASE and other databases were searched for English-language articles with the major objective of ...

journal_title：Critical care (London, England)

authors： Minne L,Abu-Hanna A,de Jonge E

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Pre-existing atrial fibrillation (AF) may worsen prognosis in patients admitted to the intensive care unit (ICU). METHODS:In a cohort study (2005-2011) including all patients with first-time ICU admissions in Denmark (n=57,110), we compared patients with and without pre-existing AF and estimated absolute ...

journal_title：Critical care (London, England)

authors： Gamst J,Christiansen CF,Rasmussen BS,Rasmussen LH,Thomsen RW

更新日期：2015-08-19 00:00:00

abstract：INTRODUCTION:Fluid responsiveness prediction is difficult in spontaneously breathing patients. Because the swings in intrathoracic pressure are minor during spontaneous breathing, dynamic parameters like pulse pressure variation (PPV) and systolic pressure variation (SPV) are usually small. We hypothesized that during ...

journal_title：Critical care (London, England)

authors： Dahl MK,Vistisen ST,Koefoed-Nielsen J,Larsson A

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:New technology using partial carbon dioxide rebreathing has been developed to measure cardiac output. Because rebreathing increases respiratory effort, we investigated whether a newly developed system with 35 s rebreathing causes a lesser increase in respiratory effort under partial ventilatory support tha...

journal_title：Critical care (London, England)

authors： Tachibana K,Imanaka H,Takeuchi M,Nishida T,Takauchi Y,Nishimura M

更新日期：2005-10-05 00:00:00

abstract：:Diagnosis of sepsis is complicated by non-specific clinical definitions and delays in laboratory analysis using tests which may have very poor predictive values. The use of host biomarker signature sets, which when measured in combination have high predictive values, offers a paradigm shift forwards for rapid, near-pa...

journal_title：Critical care (London, England)

authors： Silman NJ

更新日期：2013-12-04 00:00:00

abstract：INTRODUCTION:Recent evidence suggests a link between excess lipid peroxidation and specific organ failures in sepsis. No study has been performed in sepsis by multidrug-resistant (MDR) Gram-negative bacteria. METHODS:Lethal sepsis was induced in rats by the intraperitoneal injection of one MDR isolate of Pseudomonas a...

journal_title：Critical care (London, England)

authors： Toufekoula C,Papadakis V,Tsaganos T,Routsi C,Orfanos SE,Kotanidou A,Carrer DP,Raftogiannis M,Baziaka F,Giamarellos-Bourboulis EJ

更新日期：2013-01-16 00:00:00

abstract：INTRODUCTION:Prophylactic steroid therapy to reduce the occurrence of postextubation laryngeal edema is controversial. Only a limited number of prospective trials involve adults in an intensive care unit. The purpose of this study was to ascertain whether administration of multiple doses of dexamethasone to critically ...

journal_title：Critical care (London, England)

authors： Lee CH,Peng MJ,Wu CL

更新日期：2007-01-01 00:00:00

abstract：:Extracorporeal membrane oxygenation (ECMO) is a technique for providing life support, in case the natural lungs are failing and are not able to maintain a sufficient oxygenation of the body's organ systems. ECMO technique was an adaptation of conventional cardiopulmonary bypass techniques and introduced into treatment...

journal_title：Critical care (London, England)

authors： Lewandowski K

更新日期：2000-01-01 00:00:00

abstract：INTRODUCTION:Currently, little is known about the immunological characteristics of patients with avian influenza A (H7N9) virus infection. METHODS:The numbers and percentages of peripheral blood immune cells were measured in 27 patients with laboratory-confirmed H7N9 virus infection and 30 healthy controls (HCs). The ...

journal_title：Critical care (London, England)

authors： Wu W,Shi Y,Gao H,Liang W,Sheng J,Li L

更新日期：2014-03-24 00:00:00

abstract：OBJECTIVES:To evaluate the incidence and mortality of acute respiratory distress syndrome (ARDS) in medical/respiratory intensive care units (MICUs/RICUs) to assess ventilation management and the use of adjunct therapy in routine clinical practice for patients fulfilling the Berlin definition of ARDS in mainland China....

journal_title：Critical care (London, England)

authors： Huang X,Zhang R,Fan G,Wu D,Lu H,Wang D,Deng W,Sun T,Xing L,Liu S,Wang S,Cai Y,Tian Y,Zhang Y,Xia J,Zhan Q,CHARDSnet group.

更新日期：2020-08-20 00:00:00

abstract：:A progressive rise of oxidative stress due to altered reduction-oxidation (redox) homeostasis appears to be one of the hallmarks of the processes that regulate gene transcription in physiology and pathophysiology. Reactive oxygen species and reactive nitrogen species serve as signaling messengers for the evolution and...

journal_title：Critical care (London, England)

authors： Haddad JJ

更新日期：2003-02-01 00:00:00

abstract：INTRODUCTION:Mechanical ventilation with even moderate-sized tidal volumes synergistically increases lung injury in sepsis and has been associated with proinflammatory low-molecular-weight hyaluronan production. High-molecular-weight hyaluronan (HMW HA), in contrast, has been found to be anti-inflammatory. We hypothesi...

journal_title：Critical care (London, England)

authors： Liu YY,Lee CH,Dedaj R,Zhao H,Mrabat H,Sheidlin A,Syrkina O,Huang PM,Garg HG,Hales CA,Quinn DA

更新日期：2008-01-01 00:00:00