abstract：:Emerging studies have indicated that the dysregulation of microRNAs (miRNAs or miRs) plays a vital role in the development and metastasis of tumors. However, the role of miR‑93‑5p in esophageal carcinoma (EC) has not been extensively reported. The present study thus focused on the role of miR‑93‑5p and its downstream ...

journal_title：International journal of molecular medicine

authors： Cai Y,Ruan W,Ding J,Wei N,Wang J,Zhang H,Ma N,Weng G,Su WK,Lin Y,Zhu K

更新日期：2021-03-01 00:00:00

abstract：:Radix Astragali (RA) is widely used in traditional Chinese medicine (TCM), and astragaloside IV (AS‑IV) is the most critical component of RA. Previous studies have demonstrated that AS‑IV exerts effects on the myocardium, nervous system and endocrine system, among others. In the present review article, data from studi...

journal_title：International journal of molecular medicine

authors： Chen T,Yang P,Jia Y

更新日期：2021-03-01 00:00:00

abstract：:Acute myocardial infarction is the leading cause of cardiovascular‑related mortality and chronic heart failure worldwide. As regards treatment, the reperfusion of ischemic tissue generates irreversible damage to the myocardium, which is termed 'cardiac ischemia‑reperfusion (IR) injury'. Due to the large number of mito...

journal_title：International journal of molecular medicine

authors： Marin W,Marin D,Ao X,Liu Y

更新日期：2021-02-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) have been discovered to participate in the progression of various types of disease and may be a promising biomarker for atherosclerosis (AS). The present study aimed to investigate the regulatory mechanisms of the lncRNA, small nucleolar RNA host gene 7‑003 (SNHG7‑003), on the proliferat...

journal_title：International journal of molecular medicine

authors： Zheng J,Tan Q,Chen H,Chen K,Wang H,Chen Z,Xi Y,Yin H,Lai K,Liu Y

更新日期：2021-02-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of microRNA (miR)‑142‑3p on neuropathic pain caused by sciatic nerve injury in chronic compression injury (CCI) rats, and further investigate its mechanism. Rat experiments were divided into four parts in the study. In the first part, the rats were divided in...

journal_title：International journal of molecular medicine

authors： Li X,Wang S,Yang X,Chu H

更新日期：2021-02-01 00:00:00

abstract：:Resveratrol is a representative polyphenol of diet‑derived putative cancer chemopreventive agents, which have attracted increasing interest in the cancer chemoprevention community. The inhibition of the action of human papillomavirus (HPV) E6 and E7 has been considered a key approach for cervical cancer therapy. Resve...

journal_title：International journal of molecular medicine

authors： Sun X,Fu P,Xie L,Chai S,Xu Q,Zeng L,Wang X,Jiang N,Sang M

更新日期：2021-01-01 00:00:00

abstract：:Intralesional injection of bleomycin‑A5 (BLE‑A5) is a novel treatment for nasal polyps. Our previous study clarified that BLE‑A5 could induce nasal polyp‑derived fibroblast (NPDF) apoptosis in nasal polyps. However, the detailed mechanisms are still unclear. The present study aimed to determine the effects of BLE‑A5 o...

journal_title：International journal of molecular medicine

authors： Wu F,Ma Y,Wang J,Ou H,Dang H,Zheng Y,Tian P,Zou H

更新日期：2021-01-01 00:00:00

abstract：:Osteoarthritis (OA) is a chronic disease that results in chronic arthralgia and functional disability of the affected joint. To date, there is no effective treatment available for this disease. Circular RNAs (circRNAs) are a type of intracellular stable RNA that can regulate the development and progression of OA. Howe...

journal_title：International journal of molecular medicine

authors： Xiao J,Wang R,Zhou W,Cai X,Ye Z

更新日期：2021-01-01 00:00:00

abstract：:As hyperprolactinemia is observed in patients with bromocriptine‑resistant prolactinoma, prolactin (PRL) has been implicated in the development of bromocriptine resistance. Since PRL primarily mediates cell survival and drug resistance via the Janus kinase‑2 (JAK2)/signal transducer and activator of transcription 5A (...

journal_title：International journal of molecular medicine

authors： Xiao Z,Liang J,Deng Q,Song C,Yang X,Liu Z,Shao Z,Zhang K,Wang X,Li Z

更新日期：2021-01-01 00:00:00

abstract：:The enhanced migratory ability of endometrial stromal cells (ESCs) is a key factor in the formation of functional endometrium‑like tissues outside the uterine cavity during endometriosis (EMS). Although accumulating evidence has suggested the importance of microRNAs (miRNAs) in the pathogenesis of EMS, the role of par...

journal_title：International journal of molecular medicine

authors： Zhang D,Wang L,Guo HL,Zhang ZW,Wang C,Chian RC,Zhang ZF

更新日期：2020-12-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) have been increasingly recognized as important immune checkpoints involved in the pathogenesis of autoimmune diseases. However, the exact role of lncRNAs in Hashimoto's thyroiditis (HT) has been rarely studied. The aim of the present study was to investigate the role of lncRNAs and the p...

journal_title：International journal of molecular medicine

authors： Peng H,Xiong S,Ding X,Tang X,Wang X,Wang L,Liu Y

更新日期：2020-12-01 00:00:00

abstract：:Mostotrin (MT), a novel compound, at least five orders of magnitude more soluble in water than its mother substance, was designed and synthesised from tryptanthrin (TR). Its structure was established by nuclear magnetic resonance and mass spectrometry data and confirmed by X‑ray analysis, revealing that MT is a pentac...

journal_title：International journal of molecular medicine

authors： Popov A,Klimovich A,Styshova O,Moskovkina T,Shchekotikhin A,Grammatikova N,Dezhenkova L,Kaluzhny D,Deriabin P,Gerasimenko A,Udovenko A,Stonik V

更新日期：2020-10-01 00:00:00

abstract：:MicroRNAs (miRNAs or miRs) play an important role in the tumorigenesis and progression of breast cancer. However, the function of miR‑28‑5p in breast cancer migration has yet to be determined. In the present study, Human MicroRNA Expression Database (HMED) analysis revealed that the expression level of miR‑28‑5p was s...

journal_title：International journal of molecular medicine

authors： Ma L,Zhang Y,Hu F

更新日期：2020-10-01 00:00:00

abstract：:The SAM and SH3 domain‑containing 1 (SASH1) genes have been identified as the causal genes of dyschromatosis universalis hereditaria (DUH); these genes cause the pathological phenotypes of DUH, and SASH1 variants have been shown to regulate the abnormal pigmentation phenotype in human skin in various genodermatoses. H...

journal_title：International journal of molecular medicine

authors： Xu Z,Li Y,Wang D,Wu D,Wang J,Chen L,Deng Y,Zhang J,Wu Z,Wan X,Liu Q,Huang H,Hu P,Zeng J,Zhou D

更新日期：2020-09-01 00:00:00

abstract：:FAT atypical cadherin 1 (FAT1) regulates complex mechanisms for the promotion of oncogenesis or the suppression of malignancies. Sulforaphane (SFN) has antioxidant and anti‑tumor activities. The present study investigated the roles of SFN and FAT1 in bladder cancer (BC). The expression of FAT1 in BC cell lines and tis...

journal_title：International journal of molecular medicine

authors： Wang F,Liu P,An H,Zhang Y

更新日期：2020-09-01 00:00:00

abstract：:Propofol is a commonly used drug for the induction and maintenance of anesthesia. Previous studies have reported that propofol is involved in the progression of numerous human cancer types, including hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms in HCC are yet to be elucidated. The prese...

journal_title：International journal of molecular medicine

authors： Song F,Liu J,Feng Y,Jin Y

更新日期：2020-09-01 00:00:00

abstract：:Cardiovascular diseases (CVDs), such as atherosclerosis, hypertension, myocardial infarction and diabetic heart disease, are associated with high morbidity and mortality rates worldwide, and may also induce multiple organ failure in their later stages, greatly reducing the long‑term survival of the patients. There are...

journal_title：International journal of molecular medicine

authors： Zhu Y,Shui X,Liang Z,Huang Z,Qi Y,He Y,Chen C,Luo H,Lei W

更新日期：2020-09-01 00:00:00

abstract：:Accumulating evidence has demonstrated that endometrial stromal cells (ESCs) are responsible for the pathogenesis of endometriosis (Ems), which is characterized by the presence of functional endometrial‑like tissues outside the uterine cavity. Abnormal expression of microRNAs (miRNAs) in ESCs may be implicated in the ...

journal_title：International journal of molecular medicine

authors： Wang X,Ren R,Shao M,Lan J

更新日期：2020-08-01 00:00:00

abstract：:Type 2 cytokine‑associated immunity may be involved in the pathogenesis of allergic asthma. Although interleukin 27 (IL‑27) has been reported as an initiator and suppressor of T‑helper 1 (Th1) and T‑helper 2 (Th2) responses, respectively, its effects on the development of asthma remain unclear. In the present study, m...

journal_title：International journal of molecular medicine

authors： Lu D,Lu J,Ji X,Ji Y,Zhang Z,Peng H,Sun F,Zhang C

更新日期：2020-08-01 00:00:00

abstract：:Interleukin (IL)‑18, a pro‑inflammatory cytokine, plays an important role in a number of skin diseases. The aim of the present study was to investigate the role of IL‑18 in the development of atopic dermatitis (AD). For this purpose, mice were divided into 4 groups (n=5/group) as follows: i) The wild‑type (WT) control...

journal_title：International journal of molecular medicine

authors： Chen JL,Niu XL,Gao YL,Ma L,Gao XH,Chen HD,Qi RQ

更新日期：2020-08-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is a lethal disease due to its high aggressiveness. The aim of the present study was to investigate the role of xeroderma pigmentosum complementation group D (XPD) in the growth and invasion of ESCC and to elucidate the potential underlying molecular mechanisms. Western blot a...

journal_title：International journal of molecular medicine

authors： Jian J,Li S,Liu LZ,Zhen L,Yao L,Gan LH,Huang YQ,Fang N

更新日期：2020-07-01 00:00:00

abstract：:The pathologic mechanisms of pulmonary fibrosis (PF), one of the most common chronic pulmonary diseases, remain unclear. Napsin A is an aspartic proteinase that has been regarded as a hallmark of pulmonary adenocarcinoma. The present study aimed to investigate the specific function and molecular mechanisms of Napsin A ...

journal_title：International journal of molecular medicine

authors： Guan S,Wu Y,Zhang Q,Zhou J

更新日期：2020-07-01 00:00:00

abstract：:Sevoflurane (Sevo) is one of the most frequently used volatile anesthetic agents in surgical oncology and has various effects on tumors, including inhibiting tumor growth, recurrence, and metastases; however, the molecular mechanisms are unknown. This study tried to investigate the influence of Sevo on hepatocellular ...

journal_title：International journal of molecular medicine

authors： Cao Y,Lv W,Ding W,Li J

更新日期：2020-07-01 00:00:00

abstract：:A long non‑coding RNA (lncRNA) called prostate cancer‑associated non‑coding RNA 1 (PRNCR1) serves crucial roles in the aggressive phenotypes of colorectal cancer and non‑small cell lung cancer. However, there is little research on the expression profile, clinical value and detailed functions of PRNCR1 in tongue squamo...

journal_title：International journal of molecular medicine

authors： Lin C,Zou Y,Li R,Liu D

更新日期：2020-07-01 00:00:00

abstract：:Promoter methylation‑associated silencing of cancer‑associated microRNAs (miRNAs) is a common epigenetic mechanism during tumorigenesis in various types of human cancer. However, this has not been comprehensively examined in endometrial carcinoma (EC). In the present study, an miRNA microarray consisting of 1,347 comm...

journal_title：International journal of molecular medicine

authors： Ni J,Liang S,Shan B,Tian W,Wang H,Ren Y

更新日期：2020-06-01 00:00:00

abstract：:Krüppel‑like family (KLF) members are important regulators of proinflammatory activation in the vasculature. A transcriptome study involving RNA sequencing (RNA‑seq) and quantitative PCR (qPCR) was performed to investigate Klf15 and Klf15‑regulated gene levels in C57BL/6 mice with inferior vena cava thrombi and in con...

journal_title：International journal of molecular medicine

authors： Zhou J,Zhao X,Xie S,Zhou R

更新日期：2020-06-01 00:00:00

abstract：:The present study aimed to investigate the roles of miR‑132 in myocardial ischaemia/reperfusion (I/R) injury and the underlying mechanisms. The myocardial I/R model was established using C57BL/J6 mice. Haematoxylin and eosin staining was performed to observe the injury of myocardial tissues. Commercial kits were used ...

journal_title：International journal of molecular medicine

authors： Zhou Y,Li KS,Liu L,Li SL

更新日期：2020-06-01 00:00:00

abstract：:Periodontitis is the main cause of tooth or tissue loss. Human periodontal ligament stem cells (hPDLSCs), which have high proliferative, self‑renewal and multi‑differentiation abilities, are vital for the restoration of periodontitis‑induced injuries. The anti‑inflammatory and anti‑apoptotic agent, tetramethylpyrazine...

journal_title：International journal of molecular medicine

authors： Duan Y,An W,Wu Y,Wang J

更新日期：2020-06-01 00:00:00

abstract：:The aim of the present study was to investigate the expression of bone morphogenetic protein 7 (BMP7) in cervical cancer tissues, the effect of BMP7 on the proliferation, migration and epithelial‑mesenchymal transition (EMT) of cervical cancer HeLa cells and the possible mechanism involved. Immunohistochemistry was us...

journal_title：International journal of molecular medicine

authors： Sun R,Guan H,Liu W,Liang J,Wang F,Li C

更新日期：2020-05-01 00:00:00

abstract：:Physical exercise has a neuroprotective effect and is an important treatment after ischemic stroke. Promoting neurogenesis and myelin repair in the penumbra is an important method for the treatment of ischemic stroke. However, the role and potential mechanism of exercise in neurogenesis and myelin repair still needs t...

journal_title：International journal of molecular medicine

authors： Cheng J,Shen W,Jin L,Pan J,Zhou Y,Pan G,Xie Q,Hu Q,Wu S,Zhang H,Chen X

更新日期：2020-05-01 00:00:00

abstract：:Sepsis‑induced cardiomyopathy (SIC) is a complication of severe sepsis and septic shock characterized by an invertible myocardial depression. This study sought to explore the potential effects and mechanism of luteolin, a flavonoid polyphenolic compound, in lipopolysaccharide (LPS)‑induced myocardial injury. Experimen...

journal_title：International journal of molecular medicine

authors： Wu B,Song H,Fan M,You F,Zhang L,Luo J,Li J,Wang L,Li C,Yuan M

更新日期：2020-05-01 00:00:00

abstract：:Our previous study demonstrated that intranasal administration of histone deacetylase inhibitor sodium butyrate (NaB) exhibits therapeutic effects on a mouse model of allergic rhinitis (AR). However, whether NaB is effective on AR when administered orally and prophylactically, as well as its potential effects on gene ...

journal_title：International journal of molecular medicine

authors： Wang J,Cui M,Sun F,Zhou K,Fan B,Qiu JH,Chen FQ

更新日期：2020-04-01 00:00:00

abstract：:The present study sought to investigate the correlation between adipose cytokines (visfatin, leptin and adiponectin) and markers of multiple myeloma bone disease, and to determine the effects and mechanism of action of adiponectin on the differentiation and maturation of osteoclasts in multiple myeloma (MM). The level...

journal_title：International journal of molecular medicine

authors： Liu Z,Liu H,Li Y,Wang Y,Xing R,Mi F,Xiang C,Fu R

更新日期：2020-04-01 00:00:00

abstract：:Pyrroloquinoline quinone (PQQ) is a naturally occurring redox co‑factor that functions as an essential nutrient and antioxidant, and has been reported to exert potent anti‑inflammatory effects. However, the therapeutic potential of PQQ for isoproterenol hydrochloride (Iso)‑induced cardiac hypertrophy has not yet been ...

journal_title：International journal of molecular medicine

authors： Wen J,Shen J,Zhou Y,Zhao X,Dai Z,Jin Y

更新日期：2020-03-01 00:00:00

abstract：:A microarray analysis of an animal model with experimental sepsis induced by caecal ligation and puncture revealed that the level of microRNA‑195 (miR‑195) was upregulated. However, to the best of our knowledge, the role of miR‑195 in sepsis remains unknown. The present study investigated the effect of miR‑195 on apop...

journal_title：International journal of molecular medicine

authors： Yuan T,Zhang L,Yao S,Deng SY,Liu JQ

更新日期：2020-02-01 00:00:00

abstract：:Following the publication of the above paper, the authors noted that the first author affiliation was presented incorrectly. Essentially, 'School of Medicine' had been omitted from the address. Therefore, the author and affiliation details for this paper should have been presented as follows (the changes are highlight...

journal_title：International journal of molecular medicine

authors： Jayakumar T,Lin KC,Lu WJ,Lin CY,Pitchairaj G,Li JY,Sheu JR

更新日期：2020-02-01 00:00:00

abstract：:Microsporum canis (M. canis) is a common pathogen that causes tinea capitis and is present worldwide. The incidence of M. canis infection, particularly tinea capitis, has been increasing in China. In our previous studies, family of serine hydrolases 1 (FSH1) was identified as a potential virulence factor in tinea capi...

journal_title：International journal of molecular medicine

authors： Zhang F,Tan C,Xu Y,Yang G

更新日期：2019-12-01 00:00:00

abstract：:Cell sheet technology is a novel tissue engineering technology that has been rapidly developed in recent years. As a novel technology, cell sheet technology is expected to become one of the preferred methods for cell transplantation. The present study investigated the biological effects of rutin on the formation of pe...

journal_title：International journal of molecular medicine

authors： Zhao B,Zhang Y,Xiong Y,Xu X

更新日期：2019-12-01 00:00:00

abstract：:Uterine leiomyomas are benign smooth muscle cell tumors originating from the myometrium. The present study focused on leiomyoma and myometrium phosphoproteome enrichment by using immobilized metal affinity chromatography (IMAC). The phosphoproteome was analyzed by two‑dimensional gel electrophoresis coupled with mass ...

journal_title：International journal of molecular medicine

authors： Ura B,Monasta L,Arrigoni G,Licastro D,Di Lorenzo G,Romano F,Gaita B,Scrimin F,Ricci G

更新日期：2019-12-01 00:00:00

abstract：:Recent studies have suggested that calcium‑activated potassium channel (KCa) agonists increase the proportion of mouse embryonic stem cell‑derived cardiomyocytes and promote the differentiation of pacemaker cells. In the present study, it was hypothesized that adipose‑derived stem cells (ADSCs) can differentiate into ...

journal_title：International journal of molecular medicine

authors： Yang M,Zhao Q,Zhao H,Yang A,Wang F,Wang X,Tang Y,Huang C

更新日期：2019-12-01 00:00:00