Rutin promotes the formation and osteogenic differentiation of human periodontal ligament stem cell sheets in vitro.

abstract：:Glioblastoma is one of the most radioresistant tumors. Exposure of cells to ionizing radiation leads to formation of reactive oxygen species (ROS) that are associated with radiation-induced cytotoxicity. ROS scavengers, therefore, are one of the important factors in protecting cells against ROS injury during ionizing ...

journal_title：International journal of molecular medicine

authors： Lee HC,Kim DW,Jung KY,Park IC,Park MJ,Kim MS,Woo SH,Rhee CH,Yoo H,Lee SH,Hong SI

更新日期：2004-06-01 00:00:00

abstract：:Although various environmental factors, such as a high-salt diet, a smoking habit, excessive alcohol intake, and physical inactivity, influence the development of hypertension, genetic variation also contributes to an individual's susceptibility to this condition. The purpose of the present study was to identify gene ...

journal_title：International journal of molecular medicine

authors： Yamada Y,Kato K,Yoshida T,Yokoi K,Matsuo H,Watanabe S,Ichihara S,Metoki N,Yoshida H,Satoh K,Aoyagi Y,Yasunaga A,Park H,Tanaka M,Nozawa Y

更新日期：2008-01-01 00:00:00

abstract：:Aberrant glycosylation is a universal feature of cancer cells. There are quantitative and qualitative changes in expression of gangliosides observed in tumors of a neuroectodermal origin such as neuroblastoma, melanoma and astrocytoma. The presence of large amounts of GD2 ganglioside on neuroblastoma cells, as compare...

journal_title：International journal of molecular medicine

authors： Horwacik I,Czaplicki D,Talarek K,Kowalczyk A,Bolesta E,Kozbor D,Rokita H

更新日期：2007-05-01 00:00:00

abstract：:Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by aberrant tau protein hyperphosphorylation, which eventually leads to the formation of neurofibrillary tangles. Hyperphosphorylated tau protein is considered as a vital factor in the development of AD and is highly associated with cognitiv...

journal_title：International journal of molecular medicine

authors： Shen XY,Luo T,Li S,Ting OY,He F,Xu J,Wang HQ

更新日期：2018-02-01 00:00:00

abstract：:Clinical situations with release of proteinases from blood cells or tissues into the circulation may result in a marked decrease of blood proteinase inhibitor content which in turn may result in a capillary leak syndrome, shock and even in exitus letalis. Replenishment of blood proteinase inhibitors is of benefit in s...

journal_title：International journal of molecular medicine

authors： Langner J,Thiem M,Bohning V

更新日期：1999-12-01 00:00:00

abstract：:We report on the in silico-initiated cloning and molecular characterization of CTXN3 (cortexin 3), a new human gene that was specifically expressed in the kidney and brain due to tissue-specific alternative exon 1 usage, on chromosome 5q23.2 using digital gene expression displayer (DGED) and a novel in silico cloning ...

journal_title：International journal of molecular medicine

authors： Wang HT,Chang JW,Guo Z,Li BG

更新日期：2007-10-01 00:00:00

abstract：:Reactive oxygen species (ROS), generated either extracellularly or intracellularly through ligand-receptor interactions, can function as signal transduction molecules to activate the chemotactic cytokine interleukin-8 (IL-8) and the cell surface adhesion protein, intercellular adhesion molecule-1 (ICAM-1; CD54). Toget...

journal_title：International journal of molecular medicine

authors： Roebuck KA

更新日期：1999-09-01 00:00:00

abstract：:Toll-like receptor 3 (TLR3) and TLR4 utilize adaptor proteins to activate mitogen‑activated protein kinase (MAPK), resulting in the acute but transient inflammatory response aimed at the clearance of pathogens. In the present study, it was demonstrated that macrophage activation by lipopolysaccharide (LPS) or poly(I:C...

journal_title：International journal of molecular medicine

authors： Bian H,Li F,Wang W,Zhao Q,Gao S,Ma J,Li X,Ren W,Qin C,Qi J

更新日期：2017-11-01 00:00:00

abstract：:Ouabain, an inhibitor of the Na+/K+-ATPase, has been reported to affect the secretory activity of the adrenal cortex, and especially of zona glomerulosa (ZG). However, conflicting results were obtained, depending on the experimental condition used since ouabain appears to interact with angiotensin-II (Ang-II) and its ...

journal_title：International journal of molecular medicine

authors： Neri G,De Toni R,Tortorella C,Rebuffat P,Bova S,Cargnelli G,Petrelli L,Spinazzi R,Nussdorfer GG

更新日期：2006-08-01 00:00:00

abstract：:Death-associated protein kinase (DAPK) is a Ca2+/calmodulin-dependent serine/threonine kinase that has been implicated as a positive mediator of apoptosis. However, little is known about the involvement of DAPK in the apoptosis associated with several pathological states, except for cancer. Here, DAPK-mutant mice were...

journal_title：International journal of molecular medicine

authors： Yukawa K,Hoshino K,Kishino M,Mune M,Shirasawa N,Kimura A,Tsubota Y,Owada-Makabe K,Tanaka T,Ichinose M,Maeda M,Takeda K,Akira S

更新日期：2004-04-01 00:00:00

abstract：:The treatment of locoregional recurrence (LRR) of head and neck squamous cell carcinoma (HNSCC) often requires a combination of surgery, radiation therapy and/or chemotherapy. Survival outcomes are poor and the treatment outcomes are morbid. Cold atmospheric plasma (CAP) is an ionized gas produced at room temperature ...

journal_title：International journal of molecular medicine

authors： Guerrero-Preston R,Ogawa T,Uemura M,Shumulinsky G,Valle BL,Pirini F,Ravi R,Sidransky D,Keidar M,Trink B

更新日期：2014-10-01 00:00:00

abstract：:Mammalian cardiomyocytes may permanently lose their ability to proliferate after birth. Therefore, studying the proliferation and growth arrest of cardiomyocytes during the postnatal period may enhance the current understanding regarding this molecular mechanism. The present study identified the differentially express...

journal_title：International journal of molecular medicine

authors： Wang R,Su C,Wang X,Fu Q,Gao X,Zhang C,Yang J,Yang X,Wei M

更新日期：2018-01-01 00:00:00

abstract：:The molecular cloning and sequencing of the cDNA coding for a novel regucalcin gene promoter region-related protein (RGPR) was investigated using rat, mouse and human liver cDNA library with a yeast one-hybrid system and a rapid amplification of cDNA ends (RACE) method. The clone coding an unknown protein was isolated...

journal_title：International journal of molecular medicine

authors： Misawa H,Yamaguchi M

更新日期：2001-11-01 00:00:00

abstract：:The membrane cytoskeletal component dystrophin and its associated glycoproteins play a central role in the molecular pathogenesis of several muscular dystrophies, i.e. Duchenne/Becker muscular dystrophy, congenital muscular dystrophy and various forms of limb-girdle muscular dystrophy. Although the most frequent of th...

journal_title：International journal of molecular medicine

authors： Culligan KG,Mackey AJ,Finn DM,Maguire PB,Ohlendieck K

更新日期：1998-12-01 00:00:00

abstract：:A microarray analysis of an animal model with experimental sepsis induced by caecal ligation and puncture revealed that the level of microRNA‑195 (miR‑195) was upregulated. However, to the best of our knowledge, the role of miR‑195 in sepsis remains unknown. The present study investigated the effect of miR‑195 on apop...

journal_title：International journal of molecular medicine

authors： Yuan T,Zhang L,Yao S,Deng SY,Liu JQ

更新日期：2020-02-01 00:00:00

abstract：:The thermo-enhancement effects of the sesquiterpene lactone parthenolide (PTL), which targets the transcription factor nuclear factor-kappaB (NF-kappaB), and hyperthermia at 40, 42 and 44 degrees C on the human lung adenocarcinoma A549 cell line were investigated in vitro. Thermotherapy using a combined treatment with...

journal_title：International journal of molecular medicine

authors： Hayashi S,Hatashita M,Hayashi A,Matsumoto H,Shioura H,Kitai R

更新日期：2008-05-01 00:00:00

abstract：:Autologous chondrocyte implantation (ACI) relies on the use of cultured cells. However, the biosynthetic profile of cultured chondrocytes is shown to be altered during in vitro expansion. The purpose of this study therefore, was to examine the cellular phenotype of chondrocytes cultured for ACI and to determine the ap...

journal_title：International journal of molecular medicine

authors： Zheng MH,King E,Kirilak Y,Huang L,Papadimitriou JM,Wood DJ,Xu J

更新日期：2004-05-01 00:00:00

abstract：:The overexpression of interleukin-8 (IL-8) is closely associated with poor tumor differentiation, metastasis and tumor progression. This study aimed to examine the effects and mechanisms of action of SN38 (a metabolite of the camptothecin derivative, CPT-11) on IL-8 expression in HCT8 cells, using ELISA, CCK-8 and wes...

journal_title：International journal of molecular medicine

authors： Zhang L,Lou WH,Xu XF,Wu W,Rong YF,Jin DY

更新日期：2017-01-01 00:00:00

abstract：:The SAM and SH3 domain‑containing 1 (SASH1) genes have been identified as the causal genes of dyschromatosis universalis hereditaria (DUH); these genes cause the pathological phenotypes of DUH, and SASH1 variants have been shown to regulate the abnormal pigmentation phenotype in human skin in various genodermatoses. H...

journal_title：International journal of molecular medicine

authors： Xu Z,Li Y,Wang D,Wu D,Wang J,Chen L,Deng Y,Zhang J,Wu Z,Wan X,Liu Q,Huang H,Hu P,Zeng J,Zhou D

更新日期：2020-09-01 00:00:00

abstract：:Effective drugs and strategies for treating type 2 diabetes mellitus (2‑DM) are urgently required. The aim of the present study was to elucidate the mechanism underlying microRNA (miR)‑6835‑3p regulation of adiponectin receptor 1 (AdipoR1) expression and the miR‑6835‑3p/AdipoR1 signaling pathway in pancreatic islet ce...

journal_title：International journal of molecular medicine

authors： Wang H,Jiang L,Li Z,Wang W,Hao C

更新日期：2018-09-01 00:00:00

abstract：:The aim of the present study was to determine whether osteoprotegerin (OPG) influences the bone resorption activity of osteoclasts. RAW264.7 cells were induced by macrophage colony-stimulating factor (M-CSF) + receptor activator of nuclear factor-κB ligand (RANKL) and 0, 10, 20, 50 and 100 ng/ml OPG were added into va...

journal_title：International journal of molecular medicine

authors： Fu YX,Gu JH,Zhang YR,Tong XS,Zhao HY,Yuan Y,Liu XZ,Bian JC,Liu ZP

更新日期：2013-06-01 00:00:00

abstract：:Pulmonary hypertension (PH) is a life‑threatening lung disease, characterized by an increase in pulmonary arterial pressure caused by vasoconstriction and vascular remodeling. The pathogenesis of PH is not fully understood, and there is a lack of potential biomarkers for the diagnosis and treatment of patients with PH...

journal_title：International journal of molecular medicine

authors： Wang J,Zhu MC,Kalionis B,Wu JZ,Wang LL,Ge HY,Chen CC,Tang XD,Song YL,He H,Xia SJ

更新日期：2018-09-01 00:00:00

abstract：:The ectromelia virus (ECTV) is a mouse specific Orthopoxvirus that causes lethal infection in some mouse strains. ECTV infection of these mouse strains has been used as a valuable model for understanding the interplay between Orthopoxvirus species and their hosts, including variola virus in humans. Although poxviruses...

journal_title：International journal of molecular medicine

authors： Cheng W,Jia H,Wang X,He X,Jin Q,Cao J,Jing Z

更新日期：2018-08-01 00:00:00

abstract：:Hepatocellular carcinoma is a common type of cancer that is usually associated with poor prognosis. In this study, we examined the in vitro and in vivo mechanisms of the traditional Vietnamese herb Zanthoxylum avicennae on the inhibition of HA22T human hepatocellular carcinoma cell ...

journal_title：International journal of molecular medicine

authors： Dung TD,Chang HC,Binh TV,Lee MR,Tsai CH,Tsai FJ,Kuo WW,Chen LM,Huang CY

更新日期：2012-06-01 00:00:00

abstract：:Alopecia is known as a symptom of acute radiation, yet little is known concerning the mechanism of this phenomenon and the alteration of hair protein profiles. To examine this, 6-week-old male C57/BL6 mice were exposed to 6 Gy of X-ray irradiation, which caused acute alopecia. Their hair and skin were collected, and h...

journal_title：International journal of molecular medicine

authors： Nanashima N,Ito K,Ishikawa T,Nakano M,Nakamura T

更新日期：2012-09-01 00:00:00

abstract：:Mechanosensitive (MS) neurons in the periodontal ligament (PDL) pass information to the trigeminal ganglion when excited by mechanical stimulation of the tooth. During occlusal tooth trauma of PDL tissues, MS neurons are injured, resulting in atrophic neurites and eventual degeneration of MS neurons. Nerve growth fact...

journal_title：International journal of molecular medicine

authors： Ohta M,Chosa N,Kyakumoto S,Yokota S,Okubo N,Nemoto A,Kamo M,Joh S,Satoh K,Ishisaki A

更新日期：2018-09-01 00:00:00

abstract：:Non‑small cell lung carcinoma (NSCLC) is a life‑threatening malignancy. The level of the cell growth regulator mitogen‑activated protein kinase kinase kinase kinase 3 (MAP4K3) has been shown to be correlated with a high risk of NSCLC recurrence and poor recurrence‑free survival rate. The present study examined the eff...

journal_title：International journal of molecular medicine

authors： Zhou Y,Hong T,Tong L,Liu W,Yang X,Luo J,Wang F,Li J,Yan L

更新日期：2018-12-01 00:00:00

abstract：:We described that two different murine mammary adenocarcinoma cell lines, LM3 and LM2 constitutively expressed muscarinic acetylcholine receptors (mAchR). We here demonstrate, by competitive binding experiments with the tritiated muscarinic antagonist quinuclidinyl benzilate that M2 subtype predominates in both tumor ...

journal_title：International journal of molecular medicine

authors： Español AJ,Sales ME

更新日期：2004-02-01 00:00:00

abstract：:The development of diabetes mellitus (DM) is accompanied by hyperglycemia-induced oxidative stress. Hyperoside is a major bioactive component in Zanthoxylum bungeanum leaves (HZL) and is a natural antioxidant. However, the effects of HZL on DM and its mechanisms of action remain undefined. The present study evaluated ...

journal_title：International journal of molecular medicine

authors： Zhang Y,Wang M,Dong H,Yu X,Zhang J

更新日期：2018-01-01 00:00:00

abstract：:Dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp., is known to exhibit significant selective cytotoxicity against several human tumor cell lines. In the present study, we investigated the possible mechanisms by which dideoxypetrosynol A exerts its anti-proliferative action in cultured human SK-MEL-2 sk...

journal_title：International journal of molecular medicine

authors： Choi HJ,Bae SJ,Kim ND,Jung JH,Choi YH

更新日期：2004-12-01 00:00:00