当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE期刊下所有文献 > Deletion of the kinase domain in death-associated protein kinase attenuates renal tubular cell apoptosis in chronic obstructive uropathy.

Deletion of the kinase domain in death-associated protein kinase attenuates renal tubular cell apoptosis in chronic obstructive uropathy.

Abstract：

:Death-associated protein kinase (DAPK) is a Ca2+/calmodulin-dependent serine/threonine kinase that has been implicated as a positive mediator of apoptosis. However, little is known about the involvement of DAPK in the apoptosis associated with several pathological states, except for cancer. Here, DAPK-mutant mice were used in order to examine the role of DAPK in renal cell apoptosis in chronic obstructive uropathy (COU) created by unilateral ureteral ligation. These mice express mutant DAPK with a deletion of 74 amino acids from the catalytic kinase domain. Obstructed kidneys in wild-type and mutant mice were examined for both DAPK protein levels and renal cell apoptosis during the course of COU. Obstructed kidneys in wild-type and mutant mice showed a marked increase in the DAPK and mutant DAPK protein levels, respectively, at day 14 after ureteric ligation. The obstructed kidneys in DAPK-mutant mice displayed a significant attenuation of tubular cell apoptosis, compared with wild-type mice. In contrast, no significant difference in interstitial cell apoptosis was observed between the obstructed kidneys from wild-type and mutant mice. Thus, these results indicate that the part of the kinase domain deleted by the gene targeting is crucial for the execution of tubular cell apoptosis, but is not essential for interstitial cell apoptosis in a COU model in mice.

journal_name

Int J Mol Med

journal_title

International journal of molecular medicine

authors

Yukawa K,Hoshino K,Kishino M,Mune M,Shirasawa N,Kimura A,Tsubota Y,Owada-Makabe K,Tanaka T,Ichinose M,Maeda M,Takeda K,Akira S

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

515-20

issue

4

eissn

1107-3756

issn

1791-244X

journal_volume

13

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE文献大全
  • Centipedegrass extract induces apoptosis through the activation of caspases and the downregulation of PI3K/Akt and MAPK phosphorylation in leukemia cells.

    abstract：:Acute lymphoblastic leukemia (ALL), which involves the blood and bone marrow, is the most common type of cancer in children younger than 5 years of age. Previous studies have investigated the effects of centipedegrass extract (CGE), which is mainly composed of maysin and its derivatives, and have demonstrated that it ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2014.2012

    authors： Bai HW,Badaboina S,Park CH,Choi BY,Na YH,Chung BY

    更新日期：2015-02-01 00:00:00

  • AMP-activated protein kinase regulates thyroid hormone-stimulated osteocalcin synthesis in osteoblasts.

    abstract：:AMP-activated protein kinase (AMPK) is recognized as a main regulator of energy homeostasis. Osteocalcin (OC), which is produced specifically by mature osteoblasts, is stored in bone matrix, strongly binds to hydroxyapatite and is released into the circulation, has been recognized as a marker of bone metabolism. It ha...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2013.1349

    authors： Kondo A,Otsuka T,Kato K,Matsushima-Nishiwaki R,Kuroyanagi G,Mizutani J,Tokuda H,Kozawa O

    更新日期：2013-06-01 00:00:00

  • Comparative determination of the antiproteolytic potential of therapeutically used blood protein preparations.

    abstract：:Clinical situations with release of proteinases from blood cells or tissues into the circulation may result in a marked decrease of blood proteinase inhibitor content which in turn may result in a capillary leak syndrome, shock and even in exitus letalis. Replenishment of blood proteinase inhibitors is of benefit in s...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.4.6.605

    authors： Langner J,Thiem M,Bohning V

    更新日期：1999-12-01 00:00:00

  • Glucosamine promotes chondrocyte proliferation via the Wnt/β‑catenin signaling pathway.

    abstract：:The present study investigated the mechanism underlying the effects of glucosamine (GlcN) on the proliferation of chondrocytes isolated from the knee cartilage of Sprague‑Dawley rats. Chondrocytes were treated with various concentrations of GlcN or without GlcN. The effects of GlcN on chondrocyte proliferation were de...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2018.3587

    authors： Ma Y,Zheng W,Chen H,Shao X,Lin P,Liu X,Li X,Ye H

    更新日期：2018-07-01 00:00:00

  • Recombination of replicon and helper RNAs and the emergence of propagation-competent vectors upon Sindbis virus vector production.

    abstract：:Sindbis vectors have shown remarkable antitumor efficacy and tumor-targeting capacity in animal models and hold promise for cancer therapy. Different packaging systems are used to produce propagation-incompetent Sindbis vectors. However, the vectors produced using either DH-BB single helper RNA or split helper RNA can...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2013.1395

    authors： Hyvärinen A,Yongabi F,Mäkinen K,Wahlfors J,Pellinen R

    更新日期：2013-08-01 00:00:00

  • Evodiamine promotes differentiation and inhibits proliferation of C2C12 muscle cells.

    abstract：:Evodiamine is a botanical alkaloid compound extracted from Tetradium plants. Previous studies have reported that evodiamine (Evo) treatment can reduce food uptake and improve insulin resistance in animals . The skeletal muscle comprises about 40% of the body mass of adults and has a vital role in regulating whole body...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2017.3321

    authors： Yao X,Yu T,Zhao C,Li Y,Peng Y,Xi F,Yang G

    更新日期：2018-03-01 00:00:00

  • Characteristics of circular RNA expression in lung tissues from mice with hypoxia‑induced pulmonary hypertension.

    abstract：:Pulmonary hypertension (PH) is a life‑threatening lung disease, characterized by an increase in pulmonary arterial pressure caused by vasoconstriction and vascular remodeling. The pathogenesis of PH is not fully understood, and there is a lack of potential biomarkers for the diagnosis and treatment of patients with PH...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2018.3740

    authors： Wang J,Zhu MC,Kalionis B,Wu JZ,Wang LL,Ge HY,Chen CC,Tang XD,Song YL,He H,Xia SJ

    更新日期：2018-09-01 00:00:00

  • Differential effects of fluoxetine enantiomers in mammalian neural and cardiac tissues.

    abstract：:Racemic fluoxetine is a widely used SSRI antidepressant compound having also anticonvulsant effect. In addition, it was shown that it blocked several types of voltage gated ion channels including neural and cardiac calcium channels. In the present study the effects of enantiomers of fluoxetine (R(-)-fluoxetine and S(+...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Magyar J,Rusznák Z,Harasztosi C,Körtvély A,Pacher P,Bányász T,Pankucsi C,Kovács L,Szûcs G,Nánási PP,Kecskeméti V

    更新日期：2003-04-01 00:00:00

  • Role of bone morphogenetic protein 2 in the crosstalk between endothelial progenitor cells and mesenchymal stem cells.

    abstract：:In recent studies, we and others have demonstrated that bone morphogenetic protein-2 (BMP-2) promotes vascularization, inhibits hypoxic cell death of cancer cells and may be involved in tumor angiogenesis. The activation of circulating endothelial progenitor cells (EPCs) and mesenchymal stem cells (MSCs) represents a ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.18.4.735

    authors： Raida M,Heymann AC,Günther C,Niederwieser D

    更新日期：2006-10-01 00:00:00

  • Troglitazone upregulates PTEN expression and induces the apoptosis of pulmonary artery smooth muscle cells under hypoxic conditions.

    abstract：:The increased proliferation and decreased apoptosis of pulmonary artery smooth muscle cells (PASMCs) are the main causes of hypoxic pulmonary hypertension. In this study, we investigated the role of troglitazone [peroxisome proliferator-activated receptor γ (PPARγ) agonist] in the regulation of phosphatase and tensin ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2013.1487

    authors： Pi WF,Guo XJ,Su LP,Xu WG

    更新日期：2013-11-01 00:00:00

  • In vitro and in vivo anti-allergic activity of soy sauce.

    abstract：:Soy sauce (Shoyu) is a traditional fermented seasoning of Japan and available throughout the world. Polysaccharides were obtained from dialysate of Shoyu, and these Shoyu polysaccharides (SPS) were examined for anti-allergic activity in vitro and in vivo. The SPS originated from partially-degraded polysaccharides of s...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Kobayashi M,Matsushita H,Yoshida K,Tsukiyama R,Sugimura T,Yamamoto K

    更新日期：2004-11-01 00:00:00

  • Triticum aestivum sprout-derived polysaccharide exerts hepatoprotective effects against ethanol-induced liver damage by enhancing the antioxidant system in mice.

    abstract：:Triticum aestivum sprout-derived polysaccharide (TASP) has anti-diabetic properties, but no information is available in regards to its protective effect against ethanol-induced hepatic injury. This study aimed to investigate the mechanism behind the protective role of TASP against ethanol-induced liver injury in vivo....

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2017.3095

    authors： Nepali S,Ki HH,Lee JH,Cha JY,Lee YM,Kim DK

    更新日期：2017-10-01 00:00:00

  • Uncoupling protein 3 expression and intramyocellular lipid accumulation by NMR following local burn trauma.

    abstract：:Burn trauma is a clinical condition accompanied by muscle wasting that severely impedes rehabilitation in burn survivors. Mitochondrial uncoupling protein 3 (UCP3) is uniformly expressed in myoskeletal mitochondria and its expression has been found to increase in other clinical syndromes that, like burn trauma, are as...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Zhang Q,Cao H,Astrakas LG,Mintzopoulos D,Mindrinos MN,Schulz J 3rd,Tompkins RG,Rahme LG,Tzika AA

    更新日期：2006-12-01 00:00:00

  • A long-lasting dipeptidyl peptidase-4 inhibitor, teneligliptin, as a preventive drug for the development of hepatic steatosis in high-fructose diet-fed ob/ob mice.

    abstract：:Non-alcoholic fatty liver disease (NAFLD) occurs in patients with components of metabolic syndrome such as type 2 diabetes mellitus (T2DM). At present, the central pathophysiological problem in patients afflicted with NAFLD is insulin resistance. In this study, we aimed to determine the effects of a dipeptidyl peptida...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2017.2899

    authors： Nakamura K,Fukunishi S,Yokohama K,Ohama H,Tsuchimoto Y,Asai A,Tsuda Y,Higuchi K

    更新日期：2017-04-01 00:00:00

  • Hirschsprung, RET-SOX and beyond: the challenge of examining non-mendelian traits (Review).

    abstract：:Hirschsprung disease (HSCR), or congenital intestinal aganglionosis, is a common hereditary disorder causing intestinal obstruction, thereby showing considerable phenotypic variation in conjunction with complex inheritance. Moreover, phenotypic assessment of the disease has been complicated since a subset of the obser...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章,评审

    doi：

    authors： Pusch CM,Sasiadek MM,Blin N

    更新日期：2002-10-01 00:00:00

  • The metabolic syndrome of omega3-depleted rats. IV. Intestinal phospholipid omega3 fatty acids.

    abstract：:A dietary deprivation in long-chain polyunsaturated omega3 fatty acids initiated in 7-week old normal rats provokes within 3 to 7 months the appearance of several features of the metabolic syndrome. Likewise, within 2 to 4-5 weeks exposure to a flaxseed oil-enriched diet, these anomalies are rapidly corrected. The pre...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm_00000304

    authors： Hacquebard M,Portois L,Malaisse WJ,Carpentier YA

    更新日期：2009-12-01 00:00:00

  • High-dose hydrocortisone reduces expression of the pro-inflammatory chemokines CXCL8 and CXCL10 in SARS coronavirus-infected intestinal cells.

    abstract：:Clinical observations and our high-density oligonucleotide microarray results demonstrated increased expression of proinflammatory chemokines after SARS-CoV infection. Here, we investigated the influence of SARS-CoV infection on CXCL8 (interleukin 8) and CXCL10 (interferon-gamma-inducible protein 10) in human intestin...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Cinatl J Jr,Michaelis M,Morgenstern B,Doerr HW

    更新日期：2005-02-01 00:00:00

  • Identification of LMX1B gene point mutations in italian patients affected with Nail-Patella syndrome.

    abstract：:Nail-Patella syndrome, or osteo-onychodysplasia, is an autosomal dominant disorder characterized by nail dysplasia, absent or hypoplastic patellae, iliac horns and nephropathy. Previous studies have demonstrated linkage of the Nail-Patella locus with polymorphic markers on human chromosome 9q34. Recently, point mutati...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.4.3.285

    authors： Seri M,Melchionda S,Dreyer S,Marini M,Carella M,Cusano R,Piemontese MR,Caroli F,Silengo M,Zelante L,Romeo G,Ravazzolo R,Gasparini P,Lee B

    更新日期：1999-09-01 00:00:00

  • Characterization of the nuclear localization signal in the DNA helicase responsible for Bloom syndrome.

    abstract：:Bloom syndrome (BS) is a rare genetic disorder characterized by small body size, photosensitivity, immunodeficiency and a high predisposition to various types of cancer. BLM was identified as the causative gene for BS. The BLM protein is homologous to DNA helicase and has two basic amino acid clusters in its C-termina...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.5.5.477

    authors： Hayakawa S,Kaneko H,Fukao T,Kasahara K,Matsumoto T,Furuichi Y,Kondo N

    更新日期：2000-05-01 00:00:00

  • Dysfunction of Ca2+/CaM kinase IIalpha cascades in the amygdala in post-traumatic stress disorder.

    abstract：:Single-prolonged stress (SPS) is an established animal model for post-traumatic stress disorder (PTSD). The calcium (Ca2+)-calmodulin (CaM)-CaM kinase (K)IIalpha signal passage plays an important role in the plasticity of central nervous, learning and memory, mind and behavior and other types of cognitive activities. ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm_00000294

    authors： Xiao B,Han F,Shi YX

    更新日期：2009-12-01 00:00:00

  • Differential expression of peroxisomal proliferator activated receptors alpha and delta in skeletal muscle in response to changes in diet and exercise.

    abstract：:Peroxisome proliferator-activated receptors (PPARs) alpha, delta and gamma are nuclear transcription factors that control key genes involved in fatty acid metabolism and energy homeostasis. Little is known about PPAR activation in vivo and the existence of overlapping functions between PPARalpha, -delta and -gamma. As...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Kannisto K,Chibalin A,Glinghammar B,Zierath JR,Hamsten A,Ehrenborg E

    更新日期：2006-01-01 00:00:00

  • Inhibitory effect of Trolox on the migration and invasion of human lung and cervical cancer cells.

    abstract：:The antioxidant 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox) is implicated in migration and invasion of metastatic tumors. However, the molecular mechanism underlying the effect of Trolox on metastatic cancer cells is not known. We found that a non-cytotoxic dose ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2011.832

    authors： Sung HJ,Kim Y,Kang H,Sull JW,Kim YS,Jang SW,Ko J

    更新日期：2012-02-01 00:00:00

  • Isolation of novel cell-penetrating peptides from a random peptide library using in vitro virus and their modifications.

    abstract：:A number of cell-penetrating peptides (CPPs) have been reported, but their transduction efficiencies are too low to be used as intracellular carriers for therapeutic purposes. We conducted a comprehensive search to find novel CPPs using an in vitro virus (IVV) library, which presented random peptides consisting of 15 ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Kamide K,Nakakubo H,Uno S,Fukamizu A

    更新日期：2010-01-01 00:00:00

  • Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells.

    abstract：:The cooperation of liver X receptors (LXRs) alpha and beta, and retinoic X receptor (RXR) modulate the expression of several genes involved in lipid metabolism in hepatocyte and macrophages. Using cDNA microarray technology, we have shown previously that several of these genes are also expressed in endothelial cells. ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Norata GD,Ongari M,Uboldi P,Pellegatta F,Catapano AL

    更新日期：2005-10-01 00:00:00

  • Essential oil from Korean Chamaecyparis obtusa leaf ameliorates respiratory activity in Sprague‑Dawley rats and exhibits protection from NF-κB-induced inflammation in WI38 fibroblast cells.

    abstract：:To date, Korean hinoki cypress (Chamaecyparis obtusa), has been widely used for household and commercial purposes. Although the medicinal efficacy of hinoki cypress essential oil has been observed, that of the essential oil‑derived terpenes, which exhibit a mechanism that acts against lung inflammation, remains to be ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2018.3966

    authors： Raha S,Kim SM,Lee HJ,Lee SJ,Heo JD,Venkatarame Gowda Saralamma V,Ha SE,Kim EH,Mun SP,Kim GS

    更新日期：2019-01-01 00:00:00

  • RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoid arthritis.

    abstract：:Rheumatoid arthritis (RA) significantly affects quality of life. We recently cloned synoviolin, a RING-type E3 ubiquitin ligase implicated in the endoplasmic reticulum-associated degradation (ERAD) pathway. Synoviolin is highly expressed in rheumatoid synovial cells and may be invol...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2012.1129

    authors： Yagishita N,Aratani S,Leach C,Amano T,Yamano Y,Nakatani K,Nishioka K,Nakajima T

    更新日期：2012-12-01 00:00:00

  • Mutated-leptin gene transfer induces increases in body weight by electroporation and hydrodynamics-based gene delivery in mice.

    abstract：:To investigate whether in vivo gene transfer causes leptin-antagonistic effects on food intake, animal body weight and fat tissue weight, the R128Q mutated-leptin gene, an R to Q substitution at position 128 of mouse leptin, was transferred into mouse liver and leg muscle by electroporation and hydrodynamics-based gen...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Xiang L,Murai A,Muramatsu T

    更新日期：2005-12-01 00:00:00

  • Influence of interleukin-13 on beta-catenin levels in eosinophilic chronic rhinosinusitis cell culture.

    abstract：:Chronic rhinosinusitis (CRS) is one of the most common chronic diseases. The etiology and classification of CRS, with and without nasal polyps, remain unclear. Eosinophils and their products are important in the pathophysiology of allergic diseases and in host immunity to certain organisms. Interleukin 13 (IL-13) play...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Sauter A,Stern-Straeter J,Chang RC,Hörmann K,Naim R

    更新日期：2008-04-01 00:00:00

  • The elevation of natural killer cell activity induced by laughter in a crossover designed study.

    abstract：:The elevation of natural killer cell activity (NKCA) by laughter was not confirmed due to incomplete methodology of previous studies although positive emotion is believed to be favorable for health. To verify NKCA elevation by laughter in a crossover design, we measured NKCA before and after watching films, presenting...

    journal_title：International journal of molecular medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.3892/ijmm.8.6.645

    authors： Takahashi K,Iwase M,Yamashita K,Tatsumoto Y,Ue H,Kuratsune H,Shimizu A,Takeda M

    更新日期：2001-12-01 00:00:00

  • Tumor associated antigen recognition by autologous serum in patients with breast cancer.

    abstract：:Breast cancer accounts for 30-40% of all deaths from cancers in females. In an effort to identify tumor associated antigens that may be useful for immunotherapy, we utilized serological analysis of recombinant cDNA expression libraries (SEREX) technique to identify breast cancer-associated antigens. SEREX screening of...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Qian F,Odunsi K,Blatt LM,Scanlan MJ,Mannan M,Shah N,Montgomery J,Haddad F,Taylor M

    更新日期：2005-01-01 00:00:00