Differential expression of peroxisomal proliferator activated receptors alpha and delta in skeletal muscle in response to changes in diet and exercise.


:Peroxisome proliferator-activated receptors (PPARs) alpha, delta and gamma are nuclear transcription factors that control key genes involved in fatty acid metabolism and energy homeostasis. Little is known about PPAR activation in vivo and the existence of overlapping functions between PPARalpha, -delta and -gamma. As skeletal muscle is an important site for insulin action and acts as a significant sensor for life-style-induced influences in whole-body energy metabolism, we investigated the expression of PPARalpha, -delta and -gamma in rat skeletal muscle in response to exercise after four- and twelve-weeks of high-fat feeding, respectively. PPARalpha mRNA expression in skeletal muscle increased in parallel with other signs of developing metabolic syndrome such as increased visceral fat pad volymes, plasma free fatty acids and muscle triglyceride concentrations. PPARalpha mRNA expression was up-regulated 3-fold after four weeks of high-fat feeding (p<0.01). Exercise reversed the high-fat induced increase in PPARalpha expression in young lean rats (p<0.05), but did not change the PPARalpha, -delta and -gamma expression in the skeletal muscle in the normal nutritional state. The increase in PPARalpha expression declined during a longer term of high-fat feeding. In contrast, exercise increased PPARdelta mRNA and protein expression 3- to 6-fold in skeletal muscle after longer-term high-fat feeding (p<0.05). This effect was accompanied by a reduction in skeletal muscle fat content. These findings suggest that parallel activation of PPARalpha and -delta expression in skeletal muscle may be an important adaptive mechanism in response to increased fatty acid loads in young, lean animals, protecting them from insulin resistance, whereas exercise might be needed to mediate the same positive effects in older animals.


Int J Mol Med


Kannisto K,Chibalin A,Glinghammar B,Zierath JR,Hamsten A,Ehrenborg E


Has Abstract


2006-01-01 00:00:00












  • Downregulation of type I collagen expression in silibinin-treated human skin fibroblasts by blocking the activation of Smad2/3-dependent signaling pathways: potential therapeutic use in the chemoprevention of keloids.

    abstract::The inhibition of the Smad2/3 pathway is a key step involved in the downregulation of type I collagen synthesis, thus preventing keloid formation in tissue. In this study, we investigated the effect of silibinin on the proliferation of human skin fibroblasts (HSFs), as well as its effect on the expression of type I co...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Cho JW,Il KJ,Lee KS

    更新日期:2013-05-01 00:00:00

  • Simvastatin induces apoptosis in PTEN‑haploinsufficient lipoma cells.

    abstract::Adipose tissue tumors (lipomas) frequently develop in patients with heterozygous germ line phosphatase and tensin homolog (PTEN) mutations. simvastatin has been demonstrated to exhibit antitumor effects, and so the aim of the present study was to assess the effects of simvastatin on the growth of human PTEN haploinsuf...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Kässner F,Sauer T,Penke M,Richter S,Landgraf K,Körner A,Kiess W,Händel N,Garten A

    更新日期:2018-06-01 00:00:00

  • Molecular mechanisms of astragaloside‑IV in cancer therapy (Review).

    abstract::Radix Astragali (RA) is widely used in traditional Chinese medicine (TCM), and astragaloside IV (AS‑IV) is the most critical component of RA. Previous studies have demonstrated that AS‑IV exerts effects on the myocardium, nervous system and endocrine system, among others. In the present review article, data from studi...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Chen T,Yang P,Jia Y

    更新日期:2021-03-01 00:00:00

  • Allosteric regulation of the calcium-sensing receptor in obese individuals.

    abstract::We have previously reported that the calcium-sensing receptor (CaSR) plays an important role in modulating lipid metabolism under low calcium conditions. The aim of this study was to identify possible regulators of CaSR and the mechanisms of action of CaSR in obese individuals. Subcutaneous fat samples were obtained f...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: He Y,Perry B,Bi M,Sun H,Zhao T,Li Y,Sun C

    更新日期:2013-08-01 00:00:00

  • The sap of Acer okamotoanum decreases serum alcohol levels after acute ethanol ingestion in rats.

    abstract::In the present study, we examined whether Acer okamotoanum (A. okamotoanum) sap decreased the serum alcohol and acetaldehyde levels after acute ethanol treatment in a rat model. Male rats were orally administered 25, 50 or 100% A. okamotoanum sap 30 min prior to oral challenge with 3 ml of ethanol (15 ml/kg of a 20% e...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Yoo YM,Jung EM,Kang HY,Choi IG,Choi KC,Jeung EB

    更新日期:2011-10-01 00:00:00

  • FERM family proteins and their importance in cellular movements and wound healing (review).

    abstract::Motility is a requirement for a number of biological processes, including embryonic development, neuronal development, immune responses, cancer progression and wound healing. Specific to wound healing is the migration of endothelial cells, fibroblasts and other key cellular players into the wound space. Aberrations in...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章,评审


    authors: Bosanquet DC,Ye L,Harding KG,Jiang WG

    更新日期:2014-07-01 00:00:00

  • Effects of genetic and nutritional factors on bone mineral density in young adults.

    abstract::To estimate the genetic and dietary factors influencing bone mineral density (BMD) in young adults, a total of 53 healthy volunteers (HV) (age 20.89+/-1.34), from whom informed consent was obtained, answered a questionnaire on dietary factors and had DNA from peripheral blood mononuclear cells analyzed for single nucl...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Otsuki T,Sakaguchi H,Hatta E,Hatayama T,Hatada S,Miura Y,Takata-Tomokuni A,Hyodoh F,Tomomitsu T,Fukunaga M,Katsuyama H

    更新日期:2004-10-01 00:00:00

  • Adenosine and the adenosine A2A receptor agonist, CGS21680, upregulate CD39 and CD73 expression through E2F-1 and CREB in regulatory T cells isolated from septic mice.

    abstract::The number of regulatory T cells (Treg cells) and the expression of ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1; also known as CD39) and 5'-ectonucleotidase (NT5E; also known as CD73) on the Treg cell surface are increased during sepsis. In this study, to determine the factors leading to the high expressi...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Bao R,Shui X,Hou J,Li J,Deng X,Zhu X,Yang T

    更新日期:2016-09-01 00:00:00

  • Effects of vitamin D receptor gene polymorphisms on low-resistance training using exercise machines: the 'Power Rehabilitation' program.

    abstract::The enhancement and promotion of health is necessary to maintain the quality of life (QOL) of the aged population in developed nations such as Japan where the number of elderly has been increasing rapidly. For this purpose, low-resistance training using exercise machines ('Power Rehabilitation') has been established a...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Murakami S,Otsuki T,Maeda M,Miura Y,Morii S,Kiyokane K,Hayakawa S,Maeda A,Imakawa T,Harada S,Handa T,Nishimura Y,Murakami S,Kumagai N,Hayashi H,Chen Y,Suemori S,Fukushima Y,Nishida S,Fukushima K

    更新日期:2009-01-01 00:00:00

  • Human chondrocytes differentially express matrix modulators during in vitro expansion for tissue engineering.

    abstract::Cartilage tissue engineering plays an important role in the generation of grafts for reconstructive surgery. In cultured chondrocytes, the dedifferentiation of cells seems unavoidable for multiplication. Dedifferentiated cells produce matrix of less quality, and the molecular basis is still not well understood. Theref...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Goessler UR,Bieback K,Bugert P,Naim R,Schafer C,Sadick H,Hormann K,Riedel F

    更新日期:2005-10-01 00:00:00

  • Monoclonal antibody against Toll-like receptor 4 attenuates ventilator-induced lung injury in rats by inhibiting MyD88- and NF-κB-dependent signaling.

    abstract::The mechanisms through which mechanical ventilation causes non-infectious inflammatory diseases and lung injury are poorly understood. Animals models of this type of injury suggest that it involves signaling mediated by Toll‑like receptor (TLR)4 and 9. In this study, in order to gain further insight into the involveme...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Huang C,Pan L,Lin F,Dai H,Fu R

    更新日期:2017-03-01 00:00:00

  • In vivo gene electroporation confers nutritionally-regulated foreign gene expression in the liver.

    abstract::Whether or not nutritionally-regulated foreign gene expression in vivo is achievable was examined in mouse liver after in vivo gene transfer by electroporation (EP). Electric pulses were applied to a left liver lobe immediately after injection of a luciferase reporter gene driven by the liver-type phosphoenolpyruvate ...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Muramatsu T,Ito N,Tamaoki N,Oda H,Park HM

    更新日期:2001-01-01 00:00:00

  • Expression of p57/Kip2 protein in normal and neoplastic thyroid tissues.

    abstract::p57 (Kip2) belongs to the Cip/Kip family and is one of the universal negative regulators of the cell cycle. In this study, we investigated the p57 expression of various types of thyroid neoplasm. p57 overexpression was observed in only 4.2% of normal thyroid tissues. In follicular adenoma and minimally invasive follic...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Ito Y,Yoshida H,Nakano K,Kobayashi K,Yokozawa T,Hirai K,Matsuzuka F,Matsuura N,Kuma K,Miyauchi A

    更新日期:2002-04-01 00:00:00

  • Serological markers for detection of cancer (Review).

    abstract::We reviewed the effectiveness of commercial serological markers for the early detection of cancer and monitoring cancer patients. Parameters, such as specificity and variability of tumor markers were compared with a new approach for cancer detection which was recently developed in our laboratory. We demonstrate that t...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章,评审


    authors: Zusman I,Ben-Hur H

    更新日期:2001-05-01 00:00:00

  • Comparative epidemiology of cancers of the testis, lung, bladder and stomach with special reference to the possible implication of environmental hormones in the recent risk changes of the 4 neoplasia types.

    abstract::The purpose of this study is to extract common features of an environmental hormone-oriented neoplasia by comparatively investigating the epidemiological characteristics of testicular cancer in Denmark with those of other cancers, of which the age-adjusted incidence rates (AAIRs) underwent remarkable increase or decre...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Kodama M,Kodama T

    更新日期:1998-12-01 00:00:00

  • Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review).

    abstract::β‑catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules (E‑cadherin/CDH1, N‑cadherin/CDH2, VE‑cadherin/CDH5 and α‑catenins), transmembrane‑type mucins (MUC1/CD227 and MUC16/CA125), signaling regulators (APC, AXIN1, AXIN2 and NHERF1/EBP50) and epigenetic or transcriptional regulator...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章,评审


    authors: Katoh M

    更新日期:2018-08-01 00:00:00

  • The elevation of natural killer cell activity induced by laughter in a crossover designed study.

    abstract::The elevation of natural killer cell activity (NKCA) by laughter was not confirmed due to incomplete methodology of previous studies although positive emotion is believed to be favorable for health. To verify NKCA elevation by laughter in a crossover design, we measured NKCA before and after watching films, presenting...

    journal_title:International journal of molecular medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Takahashi K,Iwase M,Yamashita K,Tatsumoto Y,Ue H,Kuratsune H,Shimizu A,Takeda M

    更新日期:2001-12-01 00:00:00

  • Dysregulation of microRNA‑23b‑3p contributes to the development of intracranial aneurysms by targeting phosphatase and tensin homolog.

    abstract::MicroRNA‑23b‑3p (miR‑23b‑3p) has been reported to be involved in the pathogenesis of a number of diseases, including non‑small cell lung cancer and gastric cancer, by acting on different signaling pathways. The present study aimed to understand the association between the miR‑23b‑3p level of intracranial aneurysms (IA...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Guo D,Wang YW,Yan L,Ma J,Han XW,Shui SF

    更新日期:2018-09-01 00:00:00

  • Thymoquinone regulates gene expression levels in the estrogen metabolic and interferon pathways in MCF7 breast cancer cells.

    abstract::New drugs are continuously being developed for the treatment of patients with estrogen receptor-positive breast cancer. Thymoquinone is one of the drugs that exhibits anticancer characteristics based on in vivo and in vitro models. This study further investigates the effects of thymoquinone on human gene expression us...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Motaghed M,Al-Hassan FM,Hamid SS

    更新日期:2014-01-01 00:00:00

  • Melatonin improves experimental colitis with sleep deprivation.

    abstract::Sleep deprivation (SD) is an epidemic phenomenon in modern countries, and its harmful effects are well known. SD acts as an aggravating factor in inflammatory bowel disease. Melatonin is a sleep-related neurohormone, also known to have antioxidant and anti-inflammatory effects in the gastrointestinal tract; however, t...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Park YS,Chung SH,Lee SK,Kim JH,Kim JB,Kim TK,Kim DS,Baik HW

    更新日期:2015-04-01 00:00:00

  • Protective effect of Xuebijing injection on D-galactosamine- and lipopolysaccharide-induced acute liver injury in rats through the regulation of p38 MAPK, MMP-9 and HO-1 expression by increasing TIPE2 expression.

    abstract::Xuebijing injection (XBJ) has long been used to treat infectious diseases in China. The therapeutic effect of XBJ is probably associated with anti-inflammatory effects. However, the precise mechanisms responsible for the effects of XBJ remain unknown. The present study was conducted in order to evaluate the protective...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Liu MW,Liu R,Wu HY,Zhang W,Xia J,Dong MN,Yu W,Wang Q,Xie FM,Wang R,Huang YQ,Qian CY

    更新日期:2016-11-01 00:00:00

  • Investigating the regulatory role of ORMDL3 in airway barrier dysfunction using in vivo and in vitro models.

    abstract::The airway epithelium (AE) is the main protective barrier between the host and external environmental factors causing asthma. Allergens or pathogens induce AE dysfunction, including epithelial permeability alteration, trans‑epithelial electrical resistance (TEER) reduction, upregulation of inflammatory mediators and d...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Yang R,Tan M,Xu J,Zhao X

    更新日期:2019-08-01 00:00:00

  • 15-Deoxy-Δ(12,14)-prostaglandin J(2) induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer cell lines.

    abstract::15-Deoxy-∆(12,14)-prostaglandin J(2) (15d-PGJ(2)), a peroxisome proliferator-activated receptor γ ligand, has been reported to have antiproliferative activity in certain types of cancer. The purpose of this study was to elucidate the effect of 15d-PGJ(2) on endometrial cancer cells, as well as the mechanism of action....

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Li H,Narahara H

    更新日期:2013-04-01 00:00:00

  • Functional differences between neonatal and adult fibroblasts and keratinocytes: Donor age affects epithelial-mesenchymal crosstalk in vitro.

    abstract::Clinical evidence suggests that healing is faster and almost scarless at an early neonatal age in comparison with that in adults. In this study, the phenotypes of neonatal and adult dermal fibroblasts and keratinocytes (nestin, smooth muscle actin, keratin types 8, 14 and 19, and fibronectin) were compared. Furthermor...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Mateu R,Živicová V,Krejčí ED,Grim M,Strnad H,Vlček Č,Kolář M,Lacina L,Gál P,Borský J,Smetana K Jr,Dvořánková B

    更新日期:2016-10-01 00:00:00

  • miR-19a/b and MeCP2 repress reciprocally to regulate multidrug resistance in gastric cancer cells.

    abstract::Despite the improvement in gastric cancer (GC) treatment, multidrug resistance (MDR) is still a significant reason for chemotherapy failure. Our previous studies have demonstrated that miR-19a/b upregulation directly promoted MDR in GC cells. However, the exact regulation and the potential molecule mechanisms have not...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Zhu F,Wu Q,Ni Z,Lei C,Li T,Shi Y

    更新日期:2018-07-01 00:00:00

  • Angiogenic changes in co-cultures of mast cells and myocardial microvascular endothelial cells under hyperglycemic conditions.

    abstract::The aim of the present study was to determine the correlation between angiogenesis and the differential expression of growth factors and their receptors when myocardial microvascular endothelial cells (MMVECs) were co-cultured with mast cell granules (MCGs) under hyperglycemic conditions. MMVECs and mast cells (MCs) w...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Wang Z,Zhang Q,Zhu W,Tao J,Wei M

    更新日期:2013-05-01 00:00:00

  • Proinflammatory circulating molecules in peripheral arterial disease.

    abstract::Peripheral arterial disease (PAD) affects about 5% of the elderly population in the western world. It has been reported that PAD is associated with elevated plasma levels of the inflammatory markers. The goal of this review is to describe which proinflammatory molecules may play a role in PAD development, C-reactive p...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章,评审


    authors: Signorelli SS,Mazzarino MC,Spandidos DA,Malaponte G

    更新日期:2007-09-01 00:00:00

  • Aryl hydrocarbon receptor inhibits inflammation in DSS‑induced colitis via the MK2/p‑MK2/TTP pathway.

    abstract::The pathogenesis of inflammatory bowel disease (IBD) is believed to be associated with the abnormal expression of inflammatory factors. The aryl hydrocarbon receptor (AhR) is a ligand‑dependent transcription factor, which can suppress the inflammatory response and attenuate experimental colitis. However, the detailed ...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Wang Q,Yang K,Han B,Sheng B,Yin J,Pu A,Li L,Sun L,Yu M,Qiu Y,Xiao W,Yang H

    更新日期:2018-02-01 00:00:00

  • Bone morphogenetic protein 2 alleviated intervertebral disc degeneration through mediating the degradation of ECM and apoptosis of nucleus pulposus cells via the PI3K/Akt pathway.

    abstract::The present study aimed to explore the underlying mechanisms of bone morphogenetic protein 2 (BMP2) in alleviating intervertebral disc degeneration (IDD). A rat puncture IDD model was constructed, and the rats were randomly divided into six groups: Control; IDD (model); IDD+PBS [containing 1010 adeno‑associated virus ...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Tan Y,Yao X,Dai Z,Wang Y,Lv G

    更新日期:2019-01-01 00:00:00

  • miR‑335 promotes stress granule formation to inhibit apoptosis by targeting ROCK2 in acute ischemic stroke.

    abstract::Under harmful environmental conditions, stress granules (SGs), macromolecular aggregates that are associated with cell survival and death, are produced in the eukaryotic cytoplasm. However, whether and how microRNAs (miRNAs/miRs) modulate SG formation induced by acute ischemic stroke has not been investigated. In the ...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Si W,Ye S,Ren Z,Liu X,Wu Z,Li Y,Zhou J,Zhang S,Li Y,Deng R,Chen D

    更新日期:2019-03-01 00:00:00