Regulation of mRNA transport, localization and translation in the nervous system of mammals (Review).

abstract：:In some patients with common variable immunodeficiency (CVID) and immunoglobulin (Ig) A deficiency (IgAD), tumor necrosis factor (TNF) family receptor transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI) gene mutations have been reported. B cells from individuals with TACI mutations d...

journal_title：International journal of molecular medicine

authors： Jin R,Kaneko H,Suzuki H,Arai T,Teramoto T,Fukao T,Kondo N

更新日期：2008-02-01 00:00:00

abstract：:Death-associated protein kinase (DAPK) is a Ca2+/calmodulin-dependent serine/threonine kinase that is thought to mediate apoptosis. We have shown that the kinase domain of DAPK is crucial for the induction of renal tubular cell apoptosis in chronic obstructive uropathy (COU) created by unilateral ureteral ligation. DA...

journal_title：International journal of molecular medicine

authors： Yukawa K,Kishino M,Hoshino K,Shirasawa N,Kimura A,Tsubota Y,Owada-Makabe K,Bai T,Tanaka T,Ueyama T,Ichinose M,Takeda K,Akira S,Maeda M

更新日期：2005-01-01 00:00:00

abstract：:The aim of the current study was to explore the potential of TREK‑TRAAK two‑pore domain potassium (K2P) channels in protecting human retinal pigment epithelium (hRPE) cells against oxidative stress. hRPE cells were obtained from donors, and then cell identification and detection of the expression levels of TREK‑TRAAK ...

journal_title：International journal of molecular medicine

authors： Huang H,Li H,Shi K,Wang L,Zhang X,Zhu X

更新日期：2018-11-01 00:00:00

abstract：:Serum concentration levels of des-gamma-carboxy prothrombin (DCP), alpha-fetoprotein (AFP) and Lens culinaris agglutinin-reactive fraction (AFP-L3) are useful tumor markers for the diagnosis of hepatocellular carcinoma (HCC). Recently, a novel immunoassay using the electrochemiluminescence (ECLIA) was developed to ena...

journal_title：International journal of molecular medicine

authors： Shimizu A,Shiraki K,Ito T,Sugimoto K,Sakai T,Ohmori S,Murata K,Takase K,Tameda Y,Nakano T

更新日期：2002-03-01 00:00:00

abstract：:About 80% of short children are not deficient in endogenous growth hormone (GH) and termed idiopathic short stature (ISS). The causes of impaired growth in children with ISS are various. Short stature and low insulin-like growth factor-I (IGF-I) concentration despite normal to high GH concentration suggest impaired GH...

journal_title：International journal of molecular medicine

authors： Takahashi Y,Chihara K

更新日期：1998-09-01 00:00:00

abstract：:Focal cortical dysplasia (FCD) is one of the most important causes of drug-resistant epilepsy in paediatric patients, particularly in those below the age of 3. Even though over 40 years have passed since the first description of the entity by Taylor, the exact mechanisms causing these cortical abnormalities remain une...

journal_title：International journal of molecular medicine

authors： Siedlecka M,Grajkowska W,Galus R,Dembowska-Bagińska B,Jóźwiak J

更新日期：2016-11-01 00:00:00

abstract：:We examined the P16 expression by immunohistochemical stain and detected the methylation by methylation specific polymerase chain reaction (MSP) in 48 primary oral squamous cell carcinoma (SCC) tissues. The results showed that 20/48 (41.7%) of cancerous tissues had CpG methylation around the promoter region, but 8/48 ...

journal_title：International journal of molecular medicine

authors： Huang MJ,Yeh KT,Shih HC,Wang YF,Lin TH,Chang JY,Shih MC,Chang JG

更新日期：2002-11-01 00:00:00

abstract：:The low survival rate of patients with colorectal cancer (CRC) is mainly due to the drug resistance of tumor cells to chemotherapeutic agents. It has been reported that basic fibroblast growth factor (bFGF) is an essential factor involved in the epigenetic mechanisms of drug resistance, which provides a novel potentia...

journal_title：International journal of molecular medicine

authors： Luo W,Yu Y,Wang R,He D,Wang C,Zeng X,Chen X,Tan X,Huang T,Wu X

更新日期：2014-01-01 00:00:00

abstract：:Although the upregulation of enhancer of zeste homolog 2 (EZH2) expression and downregulation of long non-coding RNA (lncRNA) LET expression are known to be associated with cell apoptosis and proliferation, little is known about the interaction of EZH2 with lncRNA LET. The present study aimed to investigate the intera...

journal_title：International journal of molecular medicine

authors： Zheng W,Yu A

更新日期：2018-04-01 00:00:00

abstract：:Uterine leiomyomas are benign smooth muscle cell tumors originating from the myometrium. The present study focused on leiomyoma and myometrium phosphoproteome enrichment by using immobilized metal affinity chromatography (IMAC). The phosphoproteome was analyzed by two‑dimensional gel electrophoresis coupled with mass ...

journal_title：International journal of molecular medicine

authors： Ura B,Monasta L,Arrigoni G,Licastro D,Di Lorenzo G,Romano F,Gaita B,Scrimin F,Ricci G

更新日期：2019-12-01 00:00:00

abstract：:Bone morphogenetic protein-2 (BMP-2), a multifunctional member of the transforming growth factor (TGF)-beta, superfamily, has powerful osteoinductive effects and causes cell cycle arrest in a variety of transformed cell lines. We have observed BMP-2-induced inhibition of cell proliferation in an androgen-dependent hum...

journal_title：International journal of molecular medicine

authors： Tomari K,Kumagai T,Shimizu T,Takeda K

更新日期：2005-02-01 00:00:00

abstract：:Ezrin is a key protein in membrane-cytoskeleton interaction. Expression of ezrin in actin-rich cell surfaces may play a role in the modulation of cell shape and adhesion. The aim of this study was to detect ezrin, actin and cytoskeleton and to explore their relationship in the apoptosis of esophageal epithelial cells ...

journal_title：International journal of molecular medicine

authors： Shen ZY,Xu LY,Li EM,Li JT,Chen MH,Shen J,Zeng Y

更新日期：2003-09-01 00:00:00

abstract：:The human adrenocortical carcinoma-derived SW-13 cell line is currently used to study the interrelationships occurring between cytokines and growth factors and endothelins (ET) and adrenomedullin (AM). SW-13 cells express either ET-1 and AM or growth factors, and several cytokines stimulate ET-1 and AM release from SW...

journal_title：International journal of molecular medicine

authors： Albertin G,Carraro G,Petrelli L,Guidolin D,Neri G,Nussdorfer GG

更新日期：2005-03-01 00:00:00

abstract：:To analyse the mechanisms of PAR-1 internalisation, we constructed several PAR-1 mutants and stably expressed them in CHO cells. Our study shows that the Ser(306)-->Ala mutation (S306A), which eliminates a potential site of phosphorylation by PKC in the third intracellular loop of PAR-1, did not change the rate of pho...

journal_title：International journal of molecular medicine

authors： Chen X,Berrou J,Vigneau C,Delarue F,Rondeau E

更新日期：2001-06-01 00:00:00

abstract：:Epidemiological and experimental carcinogenesis studies provide evidence that certain components of garlic have anti-cancer activity. Although the biotransformed garlic derivative S-allylmercapto-L-cysteine (SAMC) has been reported to show an inhibitory effect on tumorigenesis, the mechanisms are poorly understood. Th...

journal_title：International journal of molecular medicine

authors： Lee Y

更新日期：2008-06-01 00:00:00

abstract：:Peroxisome proliferator activated receptors (PPARs) are nuclear receptors regulating the expression of genes involved in lipid and glucose metabolism. Three different PPARs; alpha (PPARA), gamma (PPARG) and delta (PPARD) have been characterized and they are distinguished from each other by tissue distribution and cell...

journal_title：International journal of molecular medicine

authors： Skogsberg J,Kannisto K,Roshani L,Gagne E,Hamsten A,Larsson C,Ehrenborg E

更新日期：2000-07-01 00:00:00

abstract：:Myocyte injury due to myocardial reperfusion injury plays a crucial role in the pathogenesis of acute myocardial infarction even after successful coronary revascularization. Identification of compounds that reduce reperfusion-associated myocyte death is important. Therefore, we developed an in vitro model of myocardia...

journal_title：International journal of molecular medicine

authors： Gerö D,Módis K,Nagy N,Szoleczky P,Tóth ZD,Dormán G,Szabó C

更新日期：2007-11-01 00:00:00

abstract：:Glypican-3 (GPC3), a membrane-bound heparan sulfate proteoglycan, is found to be overexpressed in hepatocellular carcinoma (HCC). The purpose of the present study was to investigate the possible role of GPC3 in the development of HCC. In this study, RNA interference (RNAi) with a GPC3 small hairpin RNA (GPC3 shRNA) wa...

journal_title：International journal of molecular medicine

authors： Ruan J,Liu F,Chen X,Zhao P,Su N,Xie G,Chen J,Zheng D,Luo R

更新日期：2011-10-01 00:00:00

abstract：:Clinical trials have started to implement tumor-associated antigens in the form of antigenic peptides in order to augment CD8(+) T-cell responses directed against autologous cancer cells. One of the surrogate markers for successful immunization is the characterization of T-lymphocytes reacting to the immunizing peptid...

journal_title：International journal of molecular medicine

authors： Höhn H,Reichert T,Neukirch C,Pilch H,Maeurer MJ

更新日期：1999-02-01 00:00:00

abstract：:The aim of this study was to identify key genes associated with coronary artery disease (CAD) and to explore the related signaling pathways. Gene expression profiles of 110 CAD and 112 non-CAD, healthy patients [CAD index (CADi) >23 and =0, respectively] were downloaded from the Gene Expression Omnibus (GEO) database ...

journal_title：International journal of molecular medicine

authors： Zhang X,Cheng X,Liu H,Zheng C,Rao K,Fang Y,Zhou H,Xiong S

更新日期：2014-09-01 00:00:00

abstract：:Fas antigen, also termed APO-1 or CD95, is a transmembrane protein and a member of the tumor necrosis factor receptor/nerve growth factor receptor superfamily which mediates apoptosis upon oligomerization. The Fas/Fas ligand system is considered to be a key regulator of apoptosis. Recently, we have demonstrated that F...

journal_title：International journal of molecular medicine

authors： Ogawa Y,Nishioka A,Kubonishi I,Inomata T,Yoshida S,Kataoka S

更新日期：1998-10-01 00:00:00

abstract：:Melatonin is known to reduce the growth of endocrine-responsive breast cancers by interacting with estrogen signaling pathways. Estrogens play an important role in breast cancer, but also in various types of tissues, including vascular tissue. Estrogen sulfatase (STS) converts inactive estrogen sulfates into active es...

journal_title：International journal of molecular medicine

authors： González A,Martínez-Campa C,Alonso-González C,Cos S

更新日期：2015-12-01 00:00:00

abstract：:Maspin, identified as a 42 kDa unique tumor suppressive serine protease inhibitor (serpin), has multifaceted biological functions by interacting with various target molecules under physiological and pathological conditions including oxidative stress. However, the type of post-translational modification that confers th...

journal_title：International journal of molecular medicine

authors： Nawata S,Shi HY,Sugino N,Zhang M

更新日期：2011-02-01 00:00:00

abstract：:Fatty liver is one of the local morphological manifestations of metabolic syndrome and is frequently associated with insulin resistance. Insulin resistance is also common in patients with chronic hepatitis C. Hyperinsulinemia is an independent risk factor for hypertension and cardiovascular mortality. The aim of this ...

journal_title：International journal of molecular medicine

authors： Enjoji M,Kotoh K,Kato M,Higuchi N,Kohjima M,Nakashima M,Nakamuta M

更新日期：2008-10-01 00:00:00

abstract：:Cerebral aneurysms and arteriovenous malformations (AVM) are a common cause of stroke and cerebral hemorrage. Both are often discovered when they rupture, causing subarachnoid hemorrhage (SAH). SAH-induced vasospasm is mediated by enhanced vasoconstriction due to endothelin-1 (ET-1). We investigated whether endothelia...

journal_title：International journal of molecular medicine

authors： Boscolo E,Pavesi G,Zampieri P,Conconi MT,Calore C,Scienza R,Parnigotto PP,Folin M

更新日期：2006-11-01 00:00:00

abstract：:Emerging studies have indicated that the dysregulation of microRNAs (miRNAs or miRs) plays a vital role in the development and metastasis of tumors. However, the role of miR‑93‑5p in esophageal carcinoma (EC) has not been extensively reported. The present study thus focused on the role of miR‑93‑5p and its downstream ...

journal_title：International journal of molecular medicine

authors： Cai Y,Ruan W,Ding J,Wei N,Wang J,Zhang H,Ma N,Weng G,Su WK,Lin Y,Zhu K

更新日期：2021-03-01 00:00:00

abstract：:In hypercholesterolemia increased lipid and lipoprotein peroxidation occurs. The renin-angiotensin system plays an important role in atherogenesis. Angiotensin II induces smooth muscle cells proliferation and stimulates oxidation of LDL particles and foam cell accumulation. Inhibition of ang II production leads to dec...

journal_title：International journal of molecular medicine

authors： Wojakowski W,Gminski J,Siemianowicz K,Goss M,Machalski M

更新日期：2000-11-01 00:00:00

abstract：:Clinical situations with release of proteinases from blood cells or tissues into the circulation may result in a marked decrease of blood proteinase inhibitor content which in turn may result in a capillary leak syndrome, shock and even in exitus letalis. Replenishment of blood proteinase inhibitors is of benefit in s...

journal_title：International journal of molecular medicine

authors： Langner J,Thiem M,Bohning V

更新日期：1999-12-01 00:00:00

abstract：:Resistin is thought to cause insulin resistance and link obesity to type 2 diabetes mellitus. However, little is known about the effects of neuropeptide Y (NPY) on resistin gene expression in white adipose tissue (WAT). Resistin gene expression was determined by northern blot analysis in food-deprived mice after NPY a...

journal_title：International journal of molecular medicine

authors： Yuzuriha H,Inui A,Goto K,Asakawa A,Fujimiya M,Kasuga M

更新日期：2003-05-01 00:00:00

abstract：:Orexins are hypothalamic peptides that regulate food intake, wakefulness, the reward system and energy metabolism. Recent studies have demonstrated the ability of orexins to promote a robust apoptosis and subsequent inhibition of cell growth in various types of cancer cells. The present study was conducted to investig...

journal_title：International journal of molecular medicine

authors： Liu Y,Zhao Y,Ju S,Guo L

更新日期：2015-02-01 00:00:00