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Leiomyoma phosphoproteins involved in inhibition of oxidative stress and synthesis of reactive oxygen species.

Abstract：

:Uterine leiomyomas are benign smooth muscle cell tumors originating from the myometrium. The present study focused on leiomyoma and myometrium phosphoproteome enrichment by using immobilized metal affinity chromatography (IMAC). The phosphoproteome was analyzed by two‑dimensional gel electrophoresis coupled with mass spectrometry. Western blotting was used for data validation. The results from IMAC identified 26 proteins significantly differentially phosphorylated in leiomyomas compared with normal myometrium. Three upregulated proteins (peroxiredoxin 2, protein disulfide isomerase family A member 3 and peroxiredoxin 4) were further validated by western blotting. Ingenuity pathway analysis revealed that four phosphoproteins were involved in the inhibition of oxidative stress and synthesis of reactive oxygen species. The present results demonstated for the first time an association between oxidative stress and phosphorylation in leiomyoma development.

journal_name

Int J Mol Med

journal_title

International journal of molecular medicine

authors

Ura B,Monasta L,Arrigoni G,Licastro D,Di Lorenzo G,Romano F,Gaita B,Scrimin F,Ricci G

doi

10.3892/ijmm.2019.4377

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

2329-2335

issue

6

eissn

1107-3756

issn

1791-244X

journal_volume

44

pub_type

杂志文章

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