Essential nutrients suppress inflammation by modulating key inflammatory gene expression.

abstract：:betaA25-35, a neurotoxic fragment of the Alzheimer beta-amyloid peptide (betaA), acts as a strong inducer of pro-inflammatory cytokines, such as interleukin (IL)-1 and IL-6, in glial cells. Since IL-1 is known to induce expression of both IL-1 and IL-6, we have investigated to what extent the induction of IL-1alpha an...

journal_title：International journal of molecular medicine

authors： Eriksson G,Zetterström M,Cortes Toro V,Bartfai T,Iverfeldt K

更新日期：1998-01-01 00:00:00

abstract：:The aim of this study was to identify key genes associated with coronary artery disease (CAD) and to explore the related signaling pathways. Gene expression profiles of 110 CAD and 112 non-CAD, healthy patients [CAD index (CADi) >23 and =0, respectively] were downloaded from the Gene Expression Omnibus (GEO) database ...

journal_title：International journal of molecular medicine

authors： Zhang X,Cheng X,Liu H,Zheng C,Rao K,Fang Y,Zhou H,Xiong S

更新日期：2014-09-01 00:00:00

abstract：:Following the publication of the above paper, the authors noted that the first author affiliation was presented incorrectly. Essentially, 'School of Medicine' had been omitted from the address. Therefore, the author and affiliation details for this paper should have been presented as follows (the changes are highlight...

journal_title：International journal of molecular medicine

authors： Jayakumar T,Lin KC,Lu WJ,Lin CY,Pitchairaj G,Li JY,Sheu JR

更新日期：2020-02-01 00:00:00

abstract：:We have recently established a clonal mesenchymal stem cell line (rBM25/S3) from adult rat bone marrow. The cells have practically unlimited proliferation capacity (over 300 PDL), maintaining multipotency for differentiation. In the present study, we examined the potential for rBM25/S3 cells to differentiate into insu...

journal_title：International journal of molecular medicine

authors： Masaka T,Miyazaki M,Du G,Hardjo M,Sakaguchi M,Takaishi M,Kataoka K,Yamamoto K,Huh NH

更新日期：2008-10-01 00:00:00

abstract：:Apelin, the endogenous ligand of APJ which is a member of G protein-coupled receptors, has been shown to be expressed in a variety of tissues in vivo and to exert significant biological effects. Studies have indicated that the apelin/APJ system is involved in the regulation of a variety of physiological functions and ...

journal_title：International journal of molecular medicine

authors： Zhou Q,Cao J,Chen L

更新日期：2016-05-01 00:00:00

abstract：:Intermittent low‑dose injections of parathyroid hormone (PTH) have been reported to exert bone anabolic effects and to promote fracture healing. As an important proangiogenic cytokine, vascular endothelial growth factor (VEGF) is secreted by bone marrow mesenchymal stem cells (BMSCs) and osteoblasts, and serves a cruc...

journal_title：International journal of molecular medicine

authors： Ding Q,Sun P,Zhou H,Wan B,Yin J,Huang Y,Li Q,Yin G,Fan J

更新日期：2018-07-01 00:00:00

abstract：:We evaluated the postoperative adjuvant chemotherapy by UFT using the primary tumor amputation-pulmonary metastasis model. When Lewis lung carcinoma (LLC) primary tumors on the hind foot pad grew palpable, they were amputated on two different days. In experiment (A) (earlier amputation model), micrometastases were det...

journal_title：International journal of molecular medicine

authors： Uchida J,Sato K,Okabe H,Saito H,Nakano K,Fujioka A,Takechi T,Takeda S,Unemi N,Fukushima M

更新日期：2000-04-01 00:00:00

abstract：:MicroRNAs (miRNAs or miRs) play an important regulatory role during adipogenesis, and have been studied extensively in this regard. Specifically, the switch between the differentiation of mesenchymal stem cells (MSCs) towards adipogenic vs. osteogenic lineages is regulated by miR-204 which controls the expression of R...

journal_title：International journal of molecular medicine

authors： He H,Chen K,Wang F,Zhao L,Wan X,Wang L,Mo Z

更新日期：2015-06-01 00:00:00

abstract：:Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus. It can cause adult T cell leukemia (ATL) and other diseases. The HTLV-1 basic leucine zipper (bZIP) factor (HBZ), which is encoded by the minus-strand of the provirus, is expressed in all cases of ATL and involved in T cell proliferation. However,...

journal_title：International journal of molecular medicine

authors： Ma Y,Zhang B,Wang D,Qian L,Song X,Wang X,Yang C,Zhao G

更新日期：2017-03-01 00:00:00

abstract：:Aberrant glycosylation of cell surface glycoprotein due to specific alterations of glycosyltransferase activity is usually associated with invasion and metastasis of cancer, particularly of gastric carcinomas. Polypeptide N-acetylgalactosaminyltransferase 2 (ppGalNAc-T2), which cata...

journal_title：International journal of molecular medicine

authors： Hua D,Shen L,Xu L,Jiang Z,Zhou Y,Yue A,Zou S,Cheng Z,Wu S

更新日期：2012-12-01 00:00:00

abstract：:Chondrocyte senescence is associated with the aging and degeneration of cartilage, and eventually leads to joint destruction. The aim of this study was to elucidate the mechanisms responsible for the cytoprotective effects of heme oxygenase‑1 (HO‑1) on chondrocytes in cartilage. Chondrocyte senescence was induced usin...

journal_title：International journal of molecular medicine

authors： Kim KM,Park SE,Lee MS,Kim K,Park YC

更新日期：2014-11-01 00:00:00

abstract：:The use of finasteride for alleviating hair loss has been investigated, and it has been applied as an oral dose medication. However, due to the inconvenience of daily drug administration over long period of time, novel controllable finasteride delivery has been actively investigated. As a novel method of finasteride d...

journal_title：International journal of molecular medicine

authors： Kim JH,Na J,Bak DH,Lee BC,Lee E,Choi MJ,Ryu CH,Lee S,Mun SK,Park BC,Kim BJ,Lee HS

更新日期：2019-06-01 00:00:00

abstract：:The introduction of bortezomib has resulted in a paradigm shift in the treatment of multiple myeloma (MM) and has contributed to the improved survival of patients with MM. Inevitably, resistance to therapy develops, and thus the clinical efficacy of bortezomib is hampered by drug resistance. The oncogene B-cell‑specif...

journal_title：International journal of molecular medicine

authors： Wu SQ,Xu ZZ,Niu WY,Huang HB,Zhan R

更新日期：2014-08-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is a lethal disease due to its high aggressiveness. The aim of the present study was to investigate the role of xeroderma pigmentosum complementation group D (XPD) in the growth and invasion of ESCC and to elucidate the potential underlying molecular mechanisms. Western blot a...

journal_title：International journal of molecular medicine

authors： Jian J,Li S,Liu LZ,Zhen L,Yao L,Gan LH,Huang YQ,Fang N

更新日期：2020-07-01 00:00:00

abstract：:Hypercholesterolemia is one of primary risk factors of cardiovascular disease, together with metabolic syndrome, hypertension and diabetes. Although progress has been made, the search for novel methods of preventing and treating dyslipidemia is ongoing and current therapies for cardiovascular disease induce various si...

journal_title：International journal of molecular medicine

authors： Sima P,Vannucci L,Vetvicka V

更新日期：2018-04-01 00:00:00

abstract：:Non‑alcoholic fatty liver disease (NAFLD) is the consequence of insulin resistance, fatty acid accumulation, oxidative stress and lipotoxicity. The present study aimed to elucidate the effect of Quaking 5 (QKI 5) as mediated by Sirtuin 1 (SIRT1) on triglyceride (TG) synthesis in the liver of an NAFLD mouse model. A hi...

journal_title：International journal of molecular medicine

authors： Zhang W,Sun Y,Liu W,Dong J,Chen J

更新日期：2019-03-01 00:00:00

abstract：:Human CD46 was identified as a complement regulator and was later shown to be a measles virus receptor. The ubiquitous distribution profile of CD46 accounted for systemic measles infection and general protection of host tissue/organs from autologous complement. A similar ubiquitous distribution was observed for swine ...

journal_title：International journal of molecular medicine

authors： Seya T,Nomura M,Murakami Y,Begum NA,Matsumoto M,Nagasawa S

更新日期：1998-05-01 00:00:00

abstract：:The human prostate-specific antigen (PSA) and glandular kallikrein-1 (hGK-1, also known as hK2) genes are tandemly located on chromosome 19, separated by a 12-kb intergenic region. The coordinate regulation of these two genes suggests the presence of common regulatory elements responsible for tissue specificity and/or...

journal_title：International journal of molecular medicine

authors： Wei C,Callahan BP,Turner MJ,Willis RA,Lord EM,Barth RK,Frelinger JG

更新日期：1998-10-01 00:00:00

abstract：:Van der Woude syndrome (VWS) is the most common autosomal dominant disorder with characteristic lip pits and clefts of the lip and/or palate (CL/P). The interferon regulatory factor 6 gene (IRF6) has been recently identified as the gene mutated in patients with VWS. Here, we report two novel mutations of IRF6 in two u...

journal_title：International journal of molecular medicine

authors： Kim Y,Park JY,Lee TJ,Yoo HW

更新日期：2003-10-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a key coordinator of gene programs in metabolism and energy homeostasis in mammals. The aim of this study was to determine whether PGC-1α is involved in the transcriptional regulation of retinal neovascularization in oxygen-induced retinopathy (OI...

journal_title：International journal of molecular medicine

authors： Zhang L,Jiang J,Xia X

更新日期：2014-06-01 00:00:00

abstract：:Atherosclerotic plaque growth requires angiogenesis, and acute coronary syndrome (ACS) is usually triggered by the rupture of unstable atherosclerotic plaques. Previous studies have identified typically circulating microRNA (miRNA/miR) profiles in patients with ACS. miRNAs serve important roles in the pathophysiology ...

journal_title：International journal of molecular medicine

authors： Li S,Geng Q,Chen H,Zhang J,Cao C,Zhang F,Song J,Liu C,Liang W

更新日期：2018-02-01 00:00:00

abstract：:In some patients with common variable immunodeficiency (CVID) and immunoglobulin (Ig) A deficiency (IgAD), tumor necrosis factor (TNF) family receptor transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI) gene mutations have been reported. B cells from individuals with TACI mutations d...

journal_title：International journal of molecular medicine

authors： Jin R,Kaneko H,Suzuki H,Arai T,Teramoto T,Fukao T,Kondo N

更新日期：2008-02-01 00:00:00

abstract：:Recently we have shown the antiproliferative activity of Gleditsia sinensis fruit extract (GSE) on various solid tumour and leukaemia cell lines as well as primary cultured bone marrow cells isolated from patients with acute and chronic myelogenous leukaemia. We further studied whether the growth inhibitory effect of ...

journal_title：International journal of molecular medicine

authors： Chui CH,Tang JC,Lau FY,Teo IT,Yau MY,Wong RS,Cheng GY,Ho SK,Leung TW,Hui KS,Wong MM,Fatima S,Cheng CH,Cheung F,Tan WQ,Chow LM,Guo D,Chan AS

更新日期：2004-01-01 00:00:00

abstract：:Periodontitis is the main cause of tooth or tissue loss. Human periodontal ligament stem cells (hPDLSCs), which have high proliferative, self‑renewal and multi‑differentiation abilities, are vital for the restoration of periodontitis‑induced injuries. The anti‑inflammatory and anti‑apoptotic agent, tetramethylpyrazine...

journal_title：International journal of molecular medicine

authors： Duan Y,An W,Wu Y,Wang J

更新日期：2020-06-01 00:00:00

abstract：:We analyzed a series of ovarian carcinomas from patients treated with cisplatin-based chemotherapy for loss of heterozygosity (LOH) to determine the relationship between microsatellite alteration and prognosis. Patients with tumors that had lost alleles at loci 3p14-21, 12qter, or 17p13.3 showed significantly reduced ...

journal_title：International journal of molecular medicine

authors： Nakayama S,Nakayama K,Takebayashi Y,Hata K,Fujiwaki R,Fukumoto M,Miyazaki K

更新日期：2003-05-01 00:00:00

abstract：:Reperfusion injury (RI) remains an important limitation of myocardial revascularization. The aim of the present study was to evaluate the influence of the intracoronary injection of adiponectin on RI and cardiomyocyte death in a porcine myocardial infarction model. Acute infarction in 14 Polish domestic pigs was induc...

journal_title：International journal of molecular medicine

authors： Dębiński M,Buszman PP,Milewski K,Wojakowski W,Jackiewicz W,Pająk J,Szurlej D,Fryc-Stanek J,Wiernek S,Jelonek M,Spurlock ME,Martin J,Bochenek A,Buszman PE

更新日期：2011-06-01 00:00:00

abstract：:Many lines of evidence have shown that preproglucagon-derived peptides affect steroid secretion from dispersed adrenocortical cells, and that streptozotocin (STZ)-induced experimental diabetes alters adrenocortical-cell function. Hence, we compared the effects of glucagon, glucagon-like peptide (GLP)-1 and GLP-2 on ba...

journal_title：International journal of molecular medicine

authors： Malendowicz LK,Spinazzi R,Nussdorfer GG,Trejter M

更新日期：2003-07-01 00:00:00

abstract：:The colonic crypt contains highly proliferative cells in its base and differentiated cells on its luminal surface. Carcinogenesis significantly affects this orderly cellular distribution. The aims of this study were: i) to examine the expression of apoptosis-related proteins along the crypt-lumen axis during 1, 2-dime...

journal_title：International journal of molecular medicine

authors： Avivi-Green C,Madar Z,Schwartz B

更新日期：2000-12-01 00:00:00

abstract：:Androgen-independent growth of prostate cancer is correlated with expression of bcl-2. The impact of bcl-2 expression on the growth of prostate cancer cells following androgen ablation, was examined in the androgen-sensitive prostatic carcinoma cell line, LNCaP. Vector control and bcl-2 expressing LNCaP cells were gro...

journal_title：International journal of molecular medicine

authors： Beham AW,Sarkiss M,Brisbay S,Tu SM,von Eschenbach AC,McDonnell TJ

更新日期：1998-06-01 00:00:00

abstract：:Connective tissue growth factor (CTGF) plays an important role in the pathogenesis of atherosclerosis by promoting vascular smooth muscle cell (VSMC) growth, migration, apoptosis, adhesion and the secretion of matrix components. The osteogenic differentiation of VSMCs is essential in the development of vascular calcif...

journal_title：International journal of molecular medicine

authors： Huang J,Huang H,Wu M,Li J,Xie H,Zhou H,Liao E,Peng Y

更新日期：2013-08-01 00:00:00