β-glucans and cholesterol (Review).

abstract：:We describe a novel spontaneous autosomal recessive mutation, cervelet-4 (crv4), which arose in a BALB/c strain. Mice homozygous for the mutation exhibit principally a reduced body size, a congenital neurological phenotype characterized by ataxic gait and intention tremor, with no gross anomalies observed in brain or ...

journal_title：International journal of molecular medicine

authors： Conti V,Aghaie A,Cilli M,Martin N,Caridi G,Musante L,Candiano G,Castagna M,Fairen A,Ravazzolo R,Guenet JL,Puliti A

更新日期：2006-10-01 00:00:00

abstract：:Calcium channel blocker is useful for a variety of purposes and is effective for preventing hepatitis elicited by different inducers, suggesting its possible clinical application for treating hepatitis. The alpha1-subunit of the dihydropyridine-sensitive L-type calcium channel is a target of calcium channel blocker. F...

journal_title：International journal of molecular medicine

authors： Okamoto T,Jeong SY,Takahashi Y,Baughman KW,Ogata K,Goto J,Kanazawa I

更新日期：2001-10-01 00:00:00

abstract：:Chemotherapy is the preferred and most common treatment for cancer in clinical practice. An increasing number of researchers all over the world are focusing on natural medicines to find new antitumor drugs, and several reports have shown that Camellia nitidissima (C. nitidissima) Chi could reduce blood-lipid, decrease...

journal_title：International journal of molecular medicine

authors： Hou X,Du H,Yang R,Qi J,Huang Y,Feng S,Wu Y,Lin S,Liu Z,Jia AQ,Yuan S,Sun L

更新日期：2018-05-01 00:00:00

abstract：:D-mannoheptulose was recently proposed as a tool to label preferentially insulin-producing cells in the pancreatic gland in the perspective of the non-invasive imaging of the endocrine pancreas. In such a perspective, we have now synthesized 1-deoxy-1-[125I]iodo-D-mannoheptulose ([125I]MH) and examined its uptake by d...

journal_title：International journal of molecular medicine

authors： Sener A,Bessieres B,Courtois P,Ladriere L,Louchami K,Jijakli H,Malaisse WJ

更新日期：2001-05-01 00:00:00

abstract：:The DAL-1/41B gene (differentially expressed in adenocarcinoma of the lung), located in the chromosome 18p11.3 region, belongs to the protein family 4.1 (membrane-associated proteins), which includes the product of the NF2 gene (merlin), and the proteins, ezrin, radixin, and moesin. DAL-1/4.1B is normally expressed at...

journal_title：International journal of molecular medicine

authors： Martinez-Glez V,Bello MJ,Franco-Hernandez C,De Campos JM,Isla A,Vaquero J,Rey JA

更新日期：2005-10-01 00:00:00

abstract：:Anorectal malformations (ARMs) comprise a broad spectrum of anomalies, including anal atresia, congenital anal fistula and persistence of the cloaca. Research suggests that genetic factors play an important role in ARM development. However, few genetic variants have been identified....

journal_title：International journal of molecular medicine

authors： Draaken M,Prins W,Zeidler C,Hilger A,Mughal SS,Latus J,Boemers TM,Schmidt D,Schmiedeke E,Spychalski N,Bartels E,Nöthen MM,Reutter H,Ludwig M

更新日期：2012-12-01 00:00:00

abstract：:About 80% of short children are not deficient in endogenous growth hormone (GH) and termed idiopathic short stature (ISS). The causes of impaired growth in children with ISS are various. Short stature and low insulin-like growth factor-I (IGF-I) concentration despite normal to high GH concentration suggest impaired GH...

journal_title：International journal of molecular medicine

authors： Takahashi Y,Chihara K

更新日期：1998-09-01 00:00:00

abstract：:Thrombospondin-1 (TSP-1) is a naturally occurring anti-angiogenic compound that induces apoptosis of endothelial and cancer cells via its receptor CD36. The objectives of our study were to investigate the in vitro effects of TSP-1 on the apoptosis of primary human leukemia cells as well as leukemia cell lines and the ...

journal_title：International journal of molecular medicine

authors： Li K,Yang M,Yuen PM,Chik KW,Li CK,Shing MM,Lam HK,Fok TF

更新日期：2003-12-01 00:00:00

abstract：:Magnetic beads coated with an anionic polymer, poly(methyl vinyl ether-maleic anhydrate) [poly(MVE-MA)], were used in a method to capture human immunodeficiency virus type-1 (HIV-1). The beads were incubated with either HIV-1-infected cell culture medium or plasma from HIV-1 infecte...

journal_title：International journal of molecular medicine

authors： Sakudo A,Ikuta K

更新日期：2012-08-01 00:00:00

abstract：:MicroRNAs (miRNAs or miRs) have emerged as key regulators of gene expression in essential cellular processes, such as cell growth, differentiation and development. Recent findings have established that the levels of miRNAs are modulated by cell signaling mechanisms, including the bone morphogenetic protein (BMP) signa...

journal_title：International journal of molecular medicine

authors： Hata A,Kang H

更新日期：2015-03-01 00:00:00

abstract：:It is known that cancers develop by a multi-step process. Normal cells are first immortalized, and then transformed into tumorigenic cells. Normal human cells are very rarely immortalized, but once they are, they are relatively easily transformed into tumorigenic cells. This indicates that the immortalization step pla...

journal_title：International journal of molecular medicine

authors： Katayama B,Sakaguchi M,Li JW,Pu H,Inoue Y,Namba M

更新日期：1998-11-01 00:00:00

abstract：:Differential diagnosis between adrenal cortical and adrenal medullary lesions may be difficult in many cases. Different immunohistochemical, histochemical tools as well as ultrastructural diagnostic techniques have been employed to aid in differentiating between these lesions. Recently, both inhibin-A and BCL-2 have b...

journal_title：International journal of molecular medicine

authors： Fogt F,Zimmerman RL,Mulligan N,Vortmeyer AO,Poremba C,Harris CA,Alsaigh N,Tomaszewski JE,Nikulasson ST

更新日期：1999-03-01 00:00:00

abstract：:Racemic fluoxetine is a widely used SSRI antidepressant compound having also anticonvulsant effect. In addition, it was shown that it blocked several types of voltage gated ion channels including neural and cardiac calcium channels. In the present study the effects of enantiomers of fluoxetine (R(-)-fluoxetine and S(+...

journal_title：International journal of molecular medicine

authors： Magyar J,Rusznák Z,Harasztosi C,Körtvély A,Pacher P,Bányász T,Pankucsi C,Kovács L,Szûcs G,Nánási PP,Kecskeméti V

更新日期：2003-04-01 00:00:00

abstract：:Receptor-mediated gene delivery is an attractive method for gene transfer in vitro and shows promise for in vivo gene therapy applications. In the current study, we have selected the cytokine interleukin-2 (IL-2) gene to explore the feasibility of receptor-mediated gene transfer into human hepatocellular carcinoma Hep...

journal_title：International journal of molecular medicine

authors： Junbo H,Li Q,Zaide W,Yunde H

更新日期：1999-06-01 00:00:00

abstract：:The inhibition of the Smad2/3 pathway is a key step involved in the downregulation of type I collagen synthesis, thus preventing keloid formation in tissue. In this study, we investigated the effect of silibinin on the proliferation of human skin fibroblasts (HSFs), as well as its effect on the expression of type I co...

journal_title：International journal of molecular medicine

authors： Cho JW,Il KJ,Lee KS

更新日期：2013-05-01 00:00:00

abstract：:Focal cortical dysplasia (FCD) is one of the most important causes of drug-resistant epilepsy in paediatric patients, particularly in those below the age of 3. Even though over 40 years have passed since the first description of the entity by Taylor, the exact mechanisms causing these cortical abnormalities remain une...

journal_title：International journal of molecular medicine

authors： Siedlecka M,Grajkowska W,Galus R,Dembowska-Bagińska B,Jóźwiak J

更新日期：2016-11-01 00:00:00

abstract：:To investigate whether in vivo gene transfer causes leptin-antagonistic effects on food intake, animal body weight and fat tissue weight, the R128Q mutated-leptin gene, an R to Q substitution at position 128 of mouse leptin, was transferred into mouse liver and leg muscle by electroporation and hydrodynamics-based gen...

journal_title：International journal of molecular medicine

authors： Xiang L,Murai A,Muramatsu T

更新日期：2005-12-01 00:00:00

abstract：:Oral squamous cell carcinomas (OSCCs), a major public health problem worldwide, are the most common neoplasms of the head and neck. The most important prognostic indicator for patients with OSCC is metastasis to cervical lymph nodes or distant organs. Galectin-9 is correlated with cellular adhesion and aggregation in ...

journal_title：International journal of molecular medicine

authors： Kasamatsu A,Uzawa K,Nakashima D,Koike H,Shiiba M,Bukawa H,Yokoe H,Tanzawa H

更新日期：2005-08-01 00:00:00

abstract：:PU.1 is a key transcription factor for hematopoiesis and the reduction of this protein expression plays important roles in various hematological malignancies. To identify PU.1 downstream target genes, we recently reported dual microarray analyses, using PU.1 knockdown K562 (K562PU.1...

journal_title：International journal of molecular medicine

authors： Iseki Y,Nakahara M,Kubo M,Obata F,Harigae H,Takahashi S

更新日期：2012-02-01 00:00:00

abstract：:WNT5A, WNT5B, WNT11, FZD3, FZD6, VANGL1, VANGL2, DVL1, DVL2, DVL3, PRICKLE1, PRICKLE2, ANKRD6, NKD1, NKD2, DAAM1, DAAM2, CELSR1, CELSR2, CELSR3, ROR1 and ROR2 are planar cell polarity (PCP) signaling molecules implicated in the regulation of cellular polarity, convergent extension, and invasion. FAT1, FAT2, FAT3 and F...

journal_title：International journal of molecular medicine

authors： Katoh Y,Katoh M

更新日期：2006-09-01 00:00:00

abstract：:Dietary fat is an important factor involved in the pathogenesis of inflammatory bowel disease (IBD). It remains unclear how n-3 and n-6 fatty acids modulate intestinal inflammation. In this study, we investigated the effects of n-3 and n-6 fatty acid-rich diets on trinitrobenzene sulfonic acid (TNBS)-induced enteritis...

journal_title：International journal of molecular medicine

authors： Andoh A,Tsujikawa T,Ishizuka I,Araki Y,Sasaki M,Koyama S,Fujiyama Y

更新日期：2003-11-01 00:00:00

abstract：:Atherosclerosis is a major pathogenic factor in patients with cardiovascular diseases, and endothelial dysfunction (ED) plays a primary role in its occurrence and development. Simvastatin is a lipid‑lowering drug, which is commonly used to prevent or treat risk factors of cardiovascular diseases with a significant ant...

journal_title：International journal of molecular medicine

authors： He Z,Du X,Wu Y,Hua L,Wan L,Yan N

更新日期：2019-10-01 00:00:00

abstract：:Evodiamine is a botanical alkaloid compound extracted from Tetradium plants. Previous studies have reported that evodiamine (Evo) treatment can reduce food uptake and improve insulin resistance in animals . The skeletal muscle comprises about 40% of the body mass of adults and has a vital role in regulating whole body...

journal_title：International journal of molecular medicine

authors： Yao X,Yu T,Zhao C,Li Y,Peng Y,Xi F,Yang G

更新日期：2018-03-01 00:00:00

abstract：:The tree shrew (Tupaia belangeri) diverges from the primate order (Primates) and is classified as a separate taxonomic group of mammals - Scandentia. It has been suggested that the tree shrew can be used as an animal model for studying human diseases; however, the genomic sequence of the tree shrew is largely unidenti...

journal_title：International journal of molecular medicine

authors： Zheng Y,Yun C,Wang Q,Smith WW,Leng J

更新日期：2015-02-01 00:00:00

abstract：:The purpose of the present study was to investigate whether bone marrow mesenchymal stem cells (BMMSCs) modified by CXC‑chemokine receptor type 3 (CXCR3) and heme oxygenase‑1 (HO‑1) genes can repair damaged intestinal epithelial cells in vitro, and the role of the p38 mitogen‑activated protein kinase (p38‑MAPK) pathwa...

journal_title：International journal of molecular medicine

authors： Yin M,Shen Z,Yang L,Zheng W,Song H

更新日期：2019-05-01 00:00:00

abstract：:Postmenopausal osteoporosis (PMO) increases bone fragility and the risk of fractures, and impairs the healing procedure of bone defects in aged women. The stromal cell‑derived factor-1α (SDF-1α)/CXC chemokine receptor type 4 (CXCR4) axis helps to maintain the biological and physiological functions of bone marrow mesen...

journal_title：International journal of molecular medicine

authors： Liu Q,Zhang X,Jiao Y,Liu X,Wang Y,Li SL,Zhang W,Chen FM,Ding Y,Jiang C,Jin Z

更新日期：2018-02-01 00:00:00

abstract：:Cysteine (Cys) is known to exert various effects, such as antioxidant, antipancreatitic and antidiabetic effects. However, the effects of Cys on longitudinal bone growth have not been elucidate to date. Thus, the aim of the present study was to evaluate the effects of Cys on bone growth. Growth-plate thickness and bon...

journal_title：International journal of molecular medicine

authors： Moon PD,Kim MH,Oh HA,Nam SY,Han NR,Jeong HJ,Kim HM

更新日期：2015-08-01 00:00:00

abstract：:In the absence of antibodies specific for lymphatic vessels, analysis of lymphatic vessels within different tissues has been widely performed with light microscopic and, most importantly, electron microscopic techniques. In regard to lymphatic vessels in the ocular globe and the periocular structures, controversy rema...

journal_title：International journal of molecular medicine

authors： Fogt F,Zimmerman RL,Daly T,Gausas RE

更新日期：2004-05-01 00:00:00

abstract：:POU domain proteins are a family of critical regulators of development and differentiation due to their transcriptional activity in the nucleus. Skn‑1a, a member of the POU domain protein family, appears to be expressed predominantly in epidermal keratinocytes and is thought to play a critical role in keratinocyte dif...

journal_title：International journal of molecular medicine

authors： Moritsugu R,Tamai K,Nakano H,Aizu T,Nakajima K,Yamazaki T,Sawamura D

更新日期：2014-08-01 00:00:00

abstract：:The present study reports the identification of human sex hormone binding globulin (SHBG)-interacting proteins in the brain using a phage display-based screening technology. Phage display is a system in which a foreign protein is displayed on the surface of a bacteriophage as a fusion protein with one of the coat prot...

journal_title：International journal of molecular medicine

authors： Gnanasekar M,Suleman FG,Ramaswamy K,Caldwell JD

更新日期：2009-10-01 00:00:00