Identification of the full-length β-actin sequence and expression profiles in the tree shrew (Tupaia belangeri).

abstract：:Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by aberrant tau protein hyperphosphorylation, which eventually leads to the formation of neurofibrillary tangles. Hyperphosphorylated tau protein is considered as a vital factor in the development of AD and is highly associated with cognitiv...

journal_title：International journal of molecular medicine

authors： Shen XY,Luo T,Li S,Ting OY,He F,Xu J,Wang HQ

更新日期：2018-02-01 00:00:00

abstract：:The cellular events leading to cerebral vasospasm after subarachnoid hemorrhage (SAH) are poorly understood, although the family of protein kinase C (PKC) is already known to play crucial roles in this pathology. Hemoglobin (Hb) is one of the major causes of the cerebral vasospasm that follows SAH. In the present stud...

journal_title：International journal of molecular medicine

authors： Lefranc F,Lubicz B,Dewitte O

更新日期：2007-10-01 00:00:00

abstract：:The transcription factor nuclear factor-κB (NF-κB) has been shown to function as a key regulator of cell death or survival in neuronal cells. Previous studies indicate that the biphasic activation of NF-κB occurs following experimental neonatal hypoxia-ischemia and subarachnoid hemorrhage. However, the comprehensive u...

journal_title：International journal of molecular medicine

authors： Zhang H,Zhang D,Li H,Yan H,Zhang Z,Zhou C,Chen Q,Ye Z,Hang C

更新日期：2018-06-01 00:00:00

abstract：:Breast cancer (BC) is a leading cause of cancer-related mortality in females and is recognized as a molecularly heterogeneous disease. Previous studies have suggested that alternative messenger RNA (mRNA) processing, particularly alternative polyadenylation [poly(A)] (APA), can be a powerful molecular biomarker with p...

journal_title：International journal of molecular medicine

authors： Wang X,Li M,Yin Y,Li L,Tao Y,Chen D,Li J,Han H,Hou Z,Zhang B,Wang X,Ding Y,Cui H,Zhang H

更新日期：2015-01-01 00:00:00

abstract：:Metastasis is a hallmark of malignant neuroblastoma and is the main reason for therapeutic failure and recurrence of the tumor. The CXC chemokine receptor-4 (CXCR4), a Gi protein-coupled receptor for the ligand CXCL12/stromal cell-derived factor-1α (SDF-1α), is expressed in various types of tumor. This receptor mediat...

journal_title：International journal of molecular medicine

authors： Zhi Y,Lu H,Duan Y,Sun W,Guan G,Dong Q,Yang C

更新日期：2015-02-01 00:00:00

abstract：:Temozolomide (TMZ) is an alkylating agent commonly used as a first‑line treatment for high‑grade glioblastoma. However, TMZ has short half‑life and frequently induces tumor resistance, which can limit its therapeutic efficiency. In the present study, it was hypothesized that combined treatment with TMZ and acteoside h...

journal_title：International journal of molecular medicine

authors： Hwang TW,Kim DH,Kim DB,Jang TW,Kim GH,Moon M,Yoon KA,Choi DE,Park JH,Kim JJ

更新日期：2019-03-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) epidemic in Brazil is spreading to small municipalities as well as the innermost parts of the country and scarce information has been reported on the frequency of HIV-1 resistance-associated mutations in these areas. To determine the frequency and diversity of the HIV-1 ...

journal_title：International journal of molecular medicine

authors： Figueiredo Saad F,Kaminami Morimoto H,Wiechmann SL,Bonametti AM,Ueda LT,Matsuo T,Reiche EM

更新日期：2010-10-01 00:00:00

abstract：:The number of patients suffering from diabetes mellitus is constantly rising worldwide, and diabetic retinopathy (DR) has become the most frequent cause of postnatal blindness. Vascular endothelial growth factor (VEGF) is known to play a central role during DR development. Thus, inhibiting the effects of VEGF may hamp...

journal_title：International journal of molecular medicine

authors： Ideno J,Mizukami H,Kakehashi A,Saito Y,Okada T,Urabe M,Kume A,Kuroki M,Kawakami M,Ishibashi S,Ozawa K

更新日期：2007-01-01 00:00:00

abstract：:Human histocompatibility leukocyte antigen (HLA)-G is a nonclassical major histocompatibility complex class I molecule. HLA-G is known to provide tolerance from recognition by natural killer cells. We studied HLA-G expression in 39 human colorectal cancers and 23 extra-neoplastic colon tissue samples by RT-PCR. The ex...

journal_title：International journal of molecular medicine

authors： Fukushima Y,Oshika Y,Nakamura M,Tokunaga T,Hatanaka H,Abe Y,Yamazaki H,Kijima H,Ueyama Y,Tamaoki N

更新日期：1998-09-01 00:00:00

abstract：:Triticum aestivum sprout-derived polysaccharide (TASP) has anti-diabetic properties, but no information is available in regards to its protective effect against ethanol-induced hepatic injury. This study aimed to investigate the mechanism behind the protective role of TASP against ethanol-induced liver injury in vivo....

journal_title：International journal of molecular medicine

authors： Nepali S,Ki HH,Lee JH,Cha JY,Lee YM,Kim DK

更新日期：2017-10-01 00:00:00

abstract：:The positive correlation between the number of M2 phenotype TAMs (M2‑TAMs) and tumour development suggests a supportive role of M2‑TAMs in glioma progression. In the present study, the molecular link between glioma cells and M2‑TAMs was investigated and it was demonstrated that transforming growth factor‑β1 (TGF‑β1) s...

journal_title：International journal of molecular medicine

authors： Liu Z,Kuang W,Zhou Q,Zhang Y

更新日期：2018-12-01 00:00:00

abstract：:The complement system participates in the local immune system of the lung. In this study, we investigated the secretion of complement components of the alternative pathway (C3 and factor B) in the alveolar type II epithelial cell line A549. The levels of C3 and factor B protein in the culture medium were determined by...

journal_title：International journal of molecular medicine

authors： Zhao YX,Andoh A,Shimada M,Takaya H,Hata K,Fujiyama Y,Bamda T

更新日期：2000-04-01 00:00:00

abstract：:Free radicals derived from the reaction of iron and oxygen are thought to be one of the causes of tissue injury. In order to identify whether oxygen concentrations are an important factor in iron-mediated damage to cells, cytotoxic effects of Fe(3+)-NTA on human fibroblasts (KMST-6 line) were studied under the conditi...

journal_title：International journal of molecular medicine

authors： Pu H,Sakaguchi M,Kondo T,Kondo A,Kawabata T,Namba M

更新日期：2001-03-01 00:00:00

abstract：:The anti-cancer and cancer-preventive effects of green tea and its main constituent (-)-epigallocatechin gallate [(-)-EGCG] are well documented by a variety of studies, including epidemiological, cell culture, animal, and clinical studies. While (-)-EGCG remains the most potent polyphenol in green tea, it is very unst...

journal_title：International journal of molecular medicine

authors： Landis-Piwowar KR,Kuhn DJ,Wan SB,Chen D,Chan TH,Dou QP

更新日期：2005-04-01 00:00:00

abstract：:Intermedin (IMD) is a recently discovered peptide closely related to adrenomedullin. Its principal physiological activity is its role in the regulation of the cardiovascular system, where it exerts a potent hypotensive effect. In addition, data were recently provided showing that this peptide is able to exert a clearc...

journal_title：International journal of molecular medicine

authors： Albertin G,Sorato E,Oselladore B,Mascarin A,Tortorella C,Guidolin D

更新日期：2010-08-01 00:00:00

abstract：:Although various environmental factors, such as a high-salt diet, a smoking habit, excessive alcohol intake, and physical inactivity, influence the development of hypertension, genetic variation also contributes to an individual's susceptibility to this condition. The purpose of the present study was to identify gene ...

journal_title：International journal of molecular medicine

authors： Yamada Y,Kato K,Yoshida T,Yokoi K,Matsuo H,Watanabe S,Ichihara S,Metoki N,Yoshida H,Satoh K,Aoyagi Y,Yasunaga A,Park H,Tanaka M,Nozawa Y

更新日期：2008-01-01 00:00:00

abstract：:The existence of at least two distinct alpha 1,2fucosyltransferases has been postulated for many years, and recently confirmed in humans with the cloning of the human and rabbit secretor type alpha 1,2fucosyltransferase. We now describe the cloning and analysis of PFUT2, the pig secretor type alpha 1,2fucosyltransfera...

journal_title：International journal of molecular medicine

authors： Cohney S,Mouhtouris E,McKenzie IF,Sandrin MS

更新日期：1999-02-01 00:00:00

abstract：:Inflammatory response has been shown to play a critical role in brain damage after cerebral ischemia-reperfusion (I/R) injury, which is tightly regulated by the Toll-like receptor (TLR)4/nuclear factor (NF)-κB pathway; therefore, suppression of TLR4/NF-κB signaling has become a prom...

journal_title：International journal of molecular medicine

authors： Lan L,Tao J,Chen A,Xie G,Huang J,Lin J,Peng J,Chen L

更新日期：2013-01-01 00:00:00

abstract：:DNA vaccines raise immune responses by expressing proteins in vaccinated hosts. Responses are raised by nanogram levels of protein expression. Popular methods of DNA delivery include intramuscular (i. m.) injections of DNA in saline and gene gun delivery of DNA-coated gold beads to the epidermis. Professional antigen-...

journal_title：International journal of molecular medicine

authors： Robinson HL

更新日期：1999-11-01 00:00:00

abstract：:In hepatolithiasis, chronic proliferative cholangitis (CPC), an active and longstanding inflammation of stone‑containing bile ducts with enhanced mucin‑producing activity, not only affects the progression of the disease, it can also induce biliary carcinogenesis. The present study aimed to examine the effect of the ep...

journal_title：International journal of molecular medicine

authors： Liu SH,Chen XF,Xie ZB,Zhou J

更新日期：2019-07-01 00:00:00

abstract：:Zinc has been shown to have an inhibitory effect on osteoclastic bone resorption in vitro. This study was undertaken to determine whether the inhibitory action of zinc on osteoclastogenesis is related to receptor activator of NF-kappaB ligand (RANKL), which plays a pivotal role in differentiation from pre-osteoclasts ...

journal_title：International journal of molecular medicine

authors： Yamaguchi M,Uchiyama S

更新日期：2004-07-01 00:00:00

abstract：:Hypercholesterolemia is one of primary risk factors of cardiovascular disease, together with metabolic syndrome, hypertension and diabetes. Although progress has been made, the search for novel methods of preventing and treating dyslipidemia is ongoing and current therapies for cardiovascular disease induce various si...

journal_title：International journal of molecular medicine

authors： Sima P,Vannucci L,Vetvicka V

更新日期：2018-04-01 00:00:00

abstract：:The purpose of the present study was to investigate whether bone marrow mesenchymal stem cells (BMMSCs) modified by CXC‑chemokine receptor type 3 (CXCR3) and heme oxygenase‑1 (HO‑1) genes can repair damaged intestinal epithelial cells in vitro, and the role of the p38 mitogen‑activated protein kinase (p38‑MAPK) pathwa...

journal_title：International journal of molecular medicine

authors： Yin M,Shen Z,Yang L,Zheng W,Song H

更新日期：2019-05-01 00:00:00

abstract：:Mostotrin (MT), a novel compound, at least five orders of magnitude more soluble in water than its mother substance, was designed and synthesised from tryptanthrin (TR). Its structure was established by nuclear magnetic resonance and mass spectrometry data and confirmed by X‑ray analysis, revealing that MT is a pentac...

journal_title：International journal of molecular medicine

authors： Popov A,Klimovich A,Styshova O,Moskovkina T,Shchekotikhin A,Grammatikova N,Dezhenkova L,Kaluzhny D,Deriabin P,Gerasimenko A,Udovenko A,Stonik V

更新日期：2020-10-01 00:00:00

abstract：:During the development of autoimmune and inflammatory diseases, infiltration by multiple leukocyte types is commonly observed at the site of inflammation. These cells are chemotactically recruited via activated integrins expressed on their cell surfaces. However, the detailed mechanism of integrin activation has not b...

journal_title：International journal of molecular medicine

authors： Ohkuro M,Hishinuma I

更新日期：2010-03-01 00:00:00

abstract：:Acute renal failure (ARF) is a common disease with high morbidity and mortality. Recovery from ARF is dependent on the replacement of necrotic tubular cells with functional tubular epithelium. Recent advancement in developmental biology led to the discovery of immature mesenchymal stem cells (MSCs) in bone marrow and ...

journal_title：International journal of molecular medicine

authors： Herrera MB,Bussolati B,Bruno S,Fonsato V,Romanazzi GM,Camussi G

更新日期：2004-12-01 00:00:00

abstract：:The presence of cells positive for cytokeratins or prostate-specific antigen (PSA) in bone marrow aspirates (BMAs) has been used to indicate the presence of micrometastasis. The aim of this prospective study of prostate cancer patients was to determine the presence of prostate cells in blood and BMAs and to compare th...

journal_title：International journal of molecular medicine

authors： Murray NP,Reyes E,Tapia P,Badinez L,Orellana N,Fuentealba C,Olivares R,Porcell J,Dueñas R

更新日期：2012-10-01 00:00:00

abstract：:Several recent studies have reported an association between neurodegeneration and histone modifications, such as acetylation, deacetylation and methylation. In addition, questions have been raised regarding a potential functional role for the histone acetylation enzymes in β-amyloid (Aβ)-mediated neurotoxicity, partic...

journal_title：International journal of molecular medicine

authors： Park SY,Kim MJ,Kim YJ,Lee YH,Bae D,Kim S,Na Y,Yoon HG

更新日期：2015-04-01 00:00:00

abstract：:The aim of the current study was to explore the potential of TREK‑TRAAK two‑pore domain potassium (K2P) channels in protecting human retinal pigment epithelium (hRPE) cells against oxidative stress. hRPE cells were obtained from donors, and then cell identification and detection of the expression levels of TREK‑TRAAK ...

journal_title：International journal of molecular medicine

authors： Huang H,Li H,Shi K,Wang L,Zhang X,Zhu X

更新日期：2018-11-01 00:00:00

abstract：:The present study investigated the mechanism underlying the effects of glucosamine (GlcN) on the proliferation of chondrocytes isolated from the knee cartilage of Sprague‑Dawley rats. Chondrocytes were treated with various concentrations of GlcN or without GlcN. The effects of GlcN on chondrocyte proliferation were de...

journal_title：International journal of molecular medicine

authors： Ma Y,Zheng W,Chen H,Shao X,Lin P,Liu X,Li X,Ye H

更新日期：2018-07-01 00:00:00