Prevention of diabetic retinopathy by intraocular soluble flt-1 gene transfer in a spontaneously diabetic rat model.

abstract：:Excessive preadipocyte differentiation/adipogenesis is closely linked to the development of obesity. LY3009120 is a pan‑Raf kinase inhibitor and is known for its anticancer activities. In the present study, the effect of LY3009120 on 3T3‑L1 cell adipogenesis was investigated. The differentiation of 3T3‑L1 preadipocyte...

journal_title：International journal of molecular medicine

authors： Yang SM,Park YK,Kim JI,Lee YH,Lee TY,Jang BC

更新日期：2018-12-01 00:00:00

abstract：:The elevation of natural killer cell activity (NKCA) by laughter was not confirmed due to incomplete methodology of previous studies although positive emotion is believed to be favorable for health. To verify NKCA elevation by laughter in a crossover design, we measured NKCA before and after watching films, presenting...

journal_title：International journal of molecular medicine

authors： Takahashi K,Iwase M,Yamashita K,Tatsumoto Y,Ue H,Kuratsune H,Shimizu A,Takeda M

更新日期：2001-12-01 00:00:00

abstract：:Decreased skeletal muscle capillarization is considered to significantly contribute to the development of pulmonary cachexia syndrome (PCS) and progressive muscle wasting in several chronic inflammatory diseases, including chronic obstructive pulmonary disease (COPD). It is unclear to which extent the concurrent prese...

journal_title：International journal of molecular medicine

authors： Basic VT,Jacobsen A,Sirsjö A,Abdel-Halim SM

更新日期：2014-07-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation plays a critical role in the development of vascular diseases. In the present study, we tested the efficacy and the mechanisms of action of gastrodin, a bioactive component of the Chinese herb Gastrodia elata Bl, in relation to platelet-derived growth factor-BB (PDGF-BB...

journal_title：International journal of molecular medicine

authors： Zhu L,Guan H,Cui C,Tian S,Yang D,Wang X,Zhang S,Wang L,Jiang H

更新日期：2012-11-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a key coordinator of gene programs in metabolism and energy homeostasis in mammals. The aim of this study was to determine whether PGC-1α is involved in the transcriptional regulation of retinal neovascularization in oxygen-induced retinopathy (OI...

journal_title：International journal of molecular medicine

authors： Zhang L,Jiang J,Xia X

更新日期：2014-06-01 00:00:00

abstract：:Clinical trials have started to implement tumor-associated antigens in the form of antigenic peptides in order to augment CD8(+) T-cell responses directed against autologous cancer cells. One of the surrogate markers for successful immunization is the characterization of T-lymphocytes reacting to the immunizing peptid...

journal_title：International journal of molecular medicine

authors： Höhn H,Reichert T,Neukirch C,Pilch H,Maeurer MJ

更新日期：1999-02-01 00:00:00

abstract：:Dyslipidemia is an important risk factor for myocardial infarction (MI). We previously showed that gene polymorphisms associated with MI differed among individuals with different lipid profiles. We further examined whether genetic variants that confer susceptibility to MI might differ among individuals with low or hig...

journal_title：International journal of molecular medicine

authors： Yoshida T,Kato K,Yokoi K,Oguri M,Watanabe S,Metoki N,Yoshida H,Satoh K,Aoyagi Y,Nozawa Y,Yamada Y

更新日期：2010-04-01 00:00:00

abstract：:The aim of this study was to identify key genes associated with coronary artery disease (CAD) and to explore the related signaling pathways. Gene expression profiles of 110 CAD and 112 non-CAD, healthy patients [CAD index (CADi) >23 and =0, respectively] were downloaded from the Gene Expression Omnibus (GEO) database ...

journal_title：International journal of molecular medicine

authors： Zhang X,Cheng X,Liu H,Zheng C,Rao K,Fang Y,Zhou H,Xiong S

更新日期：2014-09-01 00:00:00

abstract：:Arachidin-1 [trans-4-(3-methyl-1-butenyl)-3,5,3',4'-tetrahydroxystilbene] is a polyphenol produced by peanut kernels during germination. The aim of the present study was to investigate the mechanism underlying the anti-inflammatory effect of arachidin-1 in endothelial cells (ECs). The results of cell adhesion and west...

journal_title：International journal of molecular medicine

authors： Chen LG,Zhang YQ,Wu ZZ,Hsieh CW,Chu CS,Wung BS

更新日期：2018-01-01 00:00:00

abstract：:Numerous studies have demonstrated the antioxidant effects of grape seed proanthocyanidin extract (GSPE). The generation of free radicals and the ensuing apoptosis may contribute to the pathogenesis of epilepsy; therefore, in the present study, we examined the effects of GSPE on cognitive impairment and neuronal damag...

journal_title：International journal of molecular medicine

authors： Zhen J,Qu Z,Fang H,Fu L,Wu Y,Wang H,Zang H,Wang W

更新日期：2014-08-01 00:00:00

abstract：:The inhibition of the Smad2/3 pathway is a key step involved in the downregulation of type I collagen synthesis, thus preventing keloid formation in tissue. In this study, we investigated the effect of silibinin on the proliferation of human skin fibroblasts (HSFs), as well as its effect on the expression of type I co...

journal_title：International journal of molecular medicine

authors： Cho JW,Il KJ,Lee KS

更新日期：2013-05-01 00:00:00

abstract：:Uterine leiomyomas are benign smooth muscle cell tumors originating from the myometrium. The present study focused on leiomyoma and myometrium phosphoproteome enrichment by using immobilized metal affinity chromatography (IMAC). The phosphoproteome was analyzed by two‑dimensional gel electrophoresis coupled with mass ...

journal_title：International journal of molecular medicine

authors： Ura B,Monasta L,Arrigoni G,Licastro D,Di Lorenzo G,Romano F,Gaita B,Scrimin F,Ricci G

更新日期：2019-12-01 00:00:00

abstract：:Many viruses have been investigated for their oncolytic properties and potential use as therapeutic agents for cancer treatment. Most of these replication-competent viruses are human pathogens. We investigated the oncolytic properties of an animal virus which is non pathogenic for both its natural host and humans. Bov...

journal_title：International journal of molecular medicine

authors： Smyth M,Symonds A,Brazinova S,Martin J

更新日期：2002-07-01 00:00:00

abstract：:High-fidelity maintenance of genomic integrity in eukaryotes is ensured by cell cycle checkpoints and DNA repair. The checkpoint kinase, Chk2, has been implicated in both of these responses. In response to DNA damage, Chk2 is initially phosphorylated at Thr-68, which leads to its full activation. The fully activated C...

journal_title：International journal of molecular medicine

authors： Liang X,Reed E,Yu JJ

更新日期：2006-05-01 00:00:00

abstract：:The present study aimed to investigate the diagnostic and prognostic values of contrast‑enhanced ultrasound (CEUS) combined with diffusion‑weighted magnetic resonance imaging (DW‑MRI) in different subtypes of breast cancer (BC). CEUS and DW‑MRI were conducted in 232 patients with BC prior to surgical treatment. Patien...

journal_title：International journal of molecular medicine

authors： Liu GF,Wang ZQ,Zhang SH,Li XF,Liu L,Miao YY,Yu SN

更新日期：2018-07-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) is the major pathological mechanism in anterior subcapsular cataract (ASC) and posterior capsule opacification (PCO), which are important causes of visual impairment. Extracellular signal-regulated kinase (ERK)1/2 pathway has been reported to play...

journal_title：International journal of molecular medicine

authors： Chen X,Ye S,Xiao W,Wang W,Luo L,Liu Y

更新日期：2014-06-01 00:00:00

abstract：:Hyperosmotic stress may be initiated during a diverse range pathological circumstances, which in turn results in tissue damage. In this process, the activation of survival signaling, which has the capacity to restore cell homeostasis, determines cell fate. Autophagy is responsible for cell survival and is activated by...

journal_title：International journal of molecular medicine

authors： Zhu H,Cao W,Zhao P,Wang J,Qian Y,Li Y

更新日期：2018-12-01 00:00:00

abstract：:Melatonin is known to reduce the growth of endocrine-responsive breast cancers by interacting with estrogen signaling pathways. Estrogens play an important role in breast cancer, but also in various types of tissues, including vascular tissue. Estrogen sulfatase (STS) converts inactive estrogen sulfates into active es...

journal_title：International journal of molecular medicine

authors： González A,Martínez-Campa C,Alonso-González C,Cos S

更新日期：2015-12-01 00:00:00

abstract：:Soy sauce (Shoyu) is a traditional Japanese fermented seasoning and is available worldwide. We investigated the effect of Shoyu polysaccharides (SPS) prepared from soy sauce on the intestinal immune system of mice. SPS enhanced the production of immunoglobulin A (IgA) from Peyer's patch cells in vitro, and its oral ad...

journal_title：International journal of molecular medicine

authors： Matsushita H,Kobayashi M,Tsukiyama R,Fujimoto M,Suzuki M,Tsuji K,Yamamoto K

更新日期：2008-08-01 00:00:00

abstract：:A wide range of therapeutic options exists for the treatment of keloids, all of which have their own strengths; however, a high risk of side‑effects and frequent recurrence remains. Therefore, the present study aimed to identify improved therapeutic approaches or drugs for the treatment of keloids. Ginsenoside Rg3 (Rg...

journal_title：International journal of molecular medicine

authors： Tang M,Bian W,Cheng L,Zhang L,Jin R,Wang W,Zhang Y

更新日期：2018-03-01 00:00:00

abstract：:The relationship between cell proliferation, protein tyrosine phosphorylation, phosphotyrosine kinase activity and bradykinin receptor activation in rat mesangial cells was investigated. We demonstrated that bradykinin (BK), through the B2 receptor, induced a dose-dependent inhibition of mesangial cell proliferation s...

journal_title：International journal of molecular medicine

authors： Alric C,Pecher C,Schanstra JP,Bascands JL,Girolami JP

更新日期：2000-01-01 00:00:00

abstract：:The aim of the present study was to investigate the role of the angiotensin-converting enzyme (ACE)2-angiotensin‑(Ang)-(1-7)-Mas axis in the pathogenesis of pancreatitis and the association between this axis and the p38 mitogen-activated protein kinase (p38 MAPK)/nuclear factor (NF-κB) signaling pathway in pancreatic ...

journal_title：International journal of molecular medicine

authors： Yu X,Cui L,Hou F,Liu X,Wang Y,Wen Y,Chi C,Li C,Liu R,Yin C

更新日期：2018-01-01 00:00:00

abstract：:We reviewed the effectiveness of commercial serological markers for the early detection of cancer and monitoring cancer patients. Parameters, such as specificity and variability of tumor markers were compared with a new approach for cancer detection which was recently developed in our laboratory. We demonstrate that t...

journal_title：International journal of molecular medicine

authors： Zusman I,Ben-Hur H

更新日期：2001-05-01 00:00:00

abstract：:Inducible heat shock protein 70 (HSP70; also known as HSPA1 or HSP72) is implicated in cancer. As a stress‑inducible heat shock protein, HSP70 is highly expressed in a variety of cancers and correlates with metastasis, chemotherapy resistance and tumor prognosis. The present study demonstrated that suppression of HSP7...

journal_title：International journal of molecular medicine

authors： Sheng L,Tang T,Liu Y,Ma Y,Wang Z,Tao H,Zhang Y,Qi Z

更新日期：2018-10-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is recognized as a main regulator of energy homeostasis. Osteocalcin (OC), which is produced specifically by mature osteoblasts, is stored in bone matrix, strongly binds to hydroxyapatite and is released into the circulation, has been recognized as a marker of bone metabolism. It ha...

journal_title：International journal of molecular medicine

authors： Kondo A,Otsuka T,Kato K,Matsushima-Nishiwaki R,Kuroyanagi G,Mizutani J,Tokuda H,Kozawa O

更新日期：2013-06-01 00:00:00

abstract：:Orexins are hypothalamic peptides that regulate food intake, wakefulness, the reward system and energy metabolism. Recent studies have demonstrated the ability of orexins to promote a robust apoptosis and subsequent inhibition of cell growth in various types of cancer cells. The present study was conducted to investig...

journal_title：International journal of molecular medicine

authors： Liu Y,Zhao Y,Ju S,Guo L

更新日期：2015-02-01 00:00:00

abstract：:We had shown previously that the novel, marine, anticancer compound dehydrothyrsiferol (DHT) does not modulate P-glycoprotein (P-gp) dependent drug efflux. Many chemotherapeutics with clinical impact are substrates for the structurally distant related membrane transport protein MRP1 (multidrug resistance-associated pr...

journal_title：International journal of molecular medicine

authors： Pec MK,Aguirre A,Fernández JJ,Souto ML,Dorta JF,Villar J

更新日期：2002-11-01 00:00:00

abstract：:Oxygen-related free radicals have been suggested as a cause of aging and various diseases, for example, various cancers and rheumatoid arthritis. Because of this a radical scavenger as an antioxidant has been sought in many foods. 'Nikogori' gelatin gel from cooked fish is a traditional food in Japan. Recently, 'Nikog...

journal_title：International journal of molecular medicine

authors： Nagatsuka N,Harada K,Ando M,Nagao K

更新日期：2005-09-01 00:00:00

abstract：:Zinc has been shown to have an inhibitory effect on osteoclastic bone resorption in vitro. This study was undertaken to determine whether the inhibitory action of zinc on osteoclastogenesis is related to receptor activator of NF-kappaB ligand (RANKL), which plays a pivotal role in differentiation from pre-osteoclasts ...

journal_title：International journal of molecular medicine

authors： Yamaguchi M,Uchiyama S

更新日期：2004-07-01 00:00:00

abstract：:Genetic alterations occurring in various chromosomes have been described in many human tumors. The DCC gene was originally identified in colorectal cancer and was reported as a tumor suppressor gene that might be related to tumor metastasis. We investigated 10 cell lines and 15 fresh tumors of childhood rhabdomyosarco...

journal_title：International journal of molecular medicine

authors： Choi SH,Kong XT,Taki T,Tsuchida Y,Kawaguchi H,Kato H,Hanada R,Look AT,Hayashi Y

更新日期：2000-10-01 00:00:00