Abstract:
:Chemotherapy is the preferred and most common treatment for cancer in clinical practice. An increasing number of researchers all over the world are focusing on natural medicines to find new antitumor drugs, and several reports have shown that Camellia nitidissima (C. nitidissima) Chi could reduce blood-lipid, decrease blood pressure, resist oxidation, prevent carcinogenesis and inhibit tumors. Therefore, the pharmacodynamics of the chemical constituents in C. nitidissima need to be investigated further. In the present study, 16 chemical constituents were isolated from the leaves of C. nitidissima, of which 6 compounds are reported to be found in this plant for the first time. Furthermore, all these phytochemicals were screened for antitumor activity on 4 common cancer cell lines, while compound 3, one oleanane-type triterpene, exhibited the most potential antitumor effects. Interestingly, to our knowledge, this was the first report that compound 3 inhibits cancer cells. Compound 3 inhibited EGFR-mutant lung cancer cell line, NCI-H1975 via apoptosis effect, with an IC50 of 13.37±2.05 µM at 48 h. Based on the data, compound 3 showed potential for antitumor drug development, suggesting the scientific basis for the antitumor activity of C. nitidissima.
journal_name
Int J Mol Medjournal_title
International journal of molecular medicineauthors
Hou X,Du H,Yang R,Qi J,Huang Y,Feng S,Wu Y,Lin S,Liu Z,Jia AQ,Yuan S,Sun Ldoi
10.3892/ijmm.2018.3502subject
Has Abstractpub_date
2018-05-01 00:00:00pages
2793-2801issue
5eissn
1107-3756issn
1791-244Xjournal_volume
41pub_type
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