Genetic polymorphisms associated with the development and clinical course of multiple sclerosis (review).

abstract：:DJ-1 plays roles in transcriptional regulation and anti-oxidative stress, and loss of its function is thought to result in the onset of Parkinson's disease. DJ-1 has a protease-like structure and transthyretin (TTR), a protein causing familial amyloidotic polyneuropathy (FAP), was identified as a substrate for DJ-1 pr...

journal_title：International journal of molecular medicine

authors： Koide-Yoshida S,Niki T,Ueda M,Himeno S,Taira T,Iguchi-Ariga SM,Ando Y,Ariga H

更新日期：2007-06-01 00:00:00

abstract：:Psoriasis is an inflammatory skin disease with or without joint involvement. In this disease, the thickened epidermis and impaired barrier are associated with altered calcium gradients. Calcium and vitamin D are known to play important roles in keratinocyte differentiation and bone metabolism. Intracellular calcium is...

journal_title：International journal of molecular medicine

authors： Cubillos S,Norgauer J

更新日期：2016-10-01 00:00:00

abstract：:Protein phosphorylation/dephosphorylation on tyrosine residues are regulated by tyrosine kinases/phosphatases. The tyrosine phosphatase SH-PTP2 (PTP1D, PTP2C) interacts physically through its SH2 domain with phosphorylated epidermal growth factor receptor (EGFR). In KB cells, an oral epidermoid carcinoma, high epiderm...

journal_title：International journal of molecular medicine

authors： Kamer AR,Hoghooghi SA,Liebow C

更新日期：1998-04-01 00:00:00

abstract：:Apoptosis may limit the utility of cell-based therapies for articular cartilage disorders. We tested the hypothesis that chondrocyte apoptosis can be reduced by optimizing the conditions employed to expand chondrocyte numbers in culture. Chondrocyte apoptosis was examined in monolayer and suspension culture, in the pr...

journal_title：International journal of molecular medicine

authors： Takahashi T,Yamamoto H,Ogawa Y,Yoshida S,Kataoka S,Majumdar M,Morris E,Tripple SB

更新日期：2003-03-01 00:00:00

abstract：:The present study aimed to explore the underlying mechanisms of bone morphogenetic protein 2 (BMP2) in alleviating intervertebral disc degeneration (IDD). A rat puncture IDD model was constructed, and the rats were randomly divided into six groups: Control; IDD (model); IDD+PBS [containing 1010 adeno‑associated virus ...

journal_title：International journal of molecular medicine

authors： Tan Y,Yao X,Dai Z,Wang Y,Lv G

更新日期：2019-01-01 00:00:00

abstract：:Myocardial ischemic injury results from severe impairment of the coronary blood supply and may lead to metabolic and ultrastructural changes, thereby causing irreversible damage. MicroRNA (miR)‑20b‑5p has been demonstrated to be involved in malignancies of the breast, colorectum, stomach, blood and oropharynx. The pre...

journal_title：International journal of molecular medicine

authors： Liang ZG,Yao H,Xie RS,Gong CL,Tian Y

更新日期：2018-08-01 00:00:00

abstract：:Type I interferon (IFN) receptor consists of two chains (Hu-IFN-alphaR1 and Hu-IFN-alphaR2), and Hu-IFN-alphaR2 takes a soluble, short, or long form (Hu-IFN-alphaR2a, Hu-IFN-alphaR2b, or Hu-IFN-alphaR2c, respectively). We examined Hu-IFN-alphaR2 expression in hepatocellular carcinoma (HCC) tissues and their correspond...

journal_title：International journal of molecular medicine

authors： Takayama A,Yano H,Ogasawara S,Higaki K,Kojiro M

更新日期：2000-12-01 00:00:00

abstract：:White blood cell (WBC) count is considered a prognostic risk factor in acute myeloid leukemia. As density of leukemic cells increases, the cytotoxic activity of certain anticancer drugs, such as vincristine and doxorubicin, progressively decreases. In this study, we investigated the cell density-dependent induction of...

journal_title：International journal of molecular medicine

authors： Navrátilová J,Jungová P,Vanhara P,Preisler J,Kanicky V,Smarda J

更新日期：2009-11-01 00:00:00

abstract：:Temozolomide (TMZ) is an alkylating agent commonly used as a first‑line treatment for high‑grade glioblastoma. However, TMZ has short half‑life and frequently induces tumor resistance, which can limit its therapeutic efficiency. In the present study, it was hypothesized that combined treatment with TMZ and acteoside h...

journal_title：International journal of molecular medicine

authors： Hwang TW,Kim DH,Kim DB,Jang TW,Kim GH,Moon M,Yoon KA,Choi DE,Park JH,Kim JJ

更新日期：2019-03-01 00:00:00

abstract：:Hirschsprung disease (HSCR), or congenital intestinal aganglionosis, is a common hereditary disorder causing intestinal obstruction, thereby showing considerable phenotypic variation in conjunction with complex inheritance. Moreover, phenotypic assessment of the disease has been complicated since a subset of the obser...

journal_title：International journal of molecular medicine

authors： Pusch CM,Sasiadek MM,Blin N

更新日期：2002-10-01 00:00:00

abstract：:Proteasome inhibitors, like MG132, can exert cell growth inhibitory and apoptotic effects in different tumor types. The apoptotic mechanism of these compounds involves the activation of the effector caspases. beta-catenin, also an oncogene, represents one of the substrates of these proteases, but the consequences of i...

journal_title：International journal of molecular medicine

authors： Cervello M,Giannitrapani L,La Rosa M,Notarbartolo M,Labbozzetta M,Poma P,Montalto G,D'Alessandro N

更新日期：2004-05-01 00:00:00

abstract：:A tight relationship has been revealed between cellular microRNAs (miRNAs) and the course of hepatitis C virus (HCV) replication in human hepatoma cells. Although the detection of the antigenomic HCV RNA strand in peripheral blood mononuclear cells (PBMCs) has provided evidence for viral replication in PBMCs, no repor...

journal_title：International journal of molecular medicine

authors： Grek M,Piekarska A,Bartkowiak J,Fendler W,Kuydowicz J,Wroblewski P,Paradowski M,Sidorkiewicz M

更新日期：2011-11-01 00:00:00

abstract：:The uptake of D-[3H]mannoheptulose by isolated pancreatic islets was recently proposed as a tool to assess the relative contribution of insulin-producing cells to the total mass of the islets. In the present study, the uptake of the tritiated heptose over 60 min incubation at 37 degrees C was about 21% lower in islets...

journal_title：International journal of molecular medicine

authors： Sener A,Ladriere L,Malaisse WJ

更新日期：2001-08-01 00:00:00

abstract：:MicroRNAs (miRNAs or miRs) play an important role in the tumorigenesis and progression of breast cancer. However, the function of miR‑28‑5p in breast cancer migration has yet to be determined. In the present study, Human MicroRNA Expression Database (HMED) analysis revealed that the expression level of miR‑28‑5p was s...

journal_title：International journal of molecular medicine

authors： Ma L,Zhang Y,Hu F

更新日期：2020-10-01 00:00:00

abstract：:Ghrelin is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R), which was originally isolated from rat stomach. Ghrelin and GHS-R are also expressed in several peripheral tissues, including adrenal glands, and this prompted us to study ghrelin expression and ghrelin-binding site localization in th...

journal_title：International journal of molecular medicine

authors： Tortorella C,Macchi C,Spinazzi R,Malendowicz LK,Trejter M,Nussdorfer GG

更新日期：2003-08-01 00:00:00

abstract：:Apelin, the endogenous ligand of APJ which is a member of G protein-coupled receptors, has been shown to be expressed in a variety of tissues in vivo and to exert significant biological effects. Studies have indicated that the apelin/APJ system is involved in the regulation of a variety of physiological functions and ...

journal_title：International journal of molecular medicine

authors： Zhou Q,Cao J,Chen L

更新日期：2016-05-01 00:00:00

abstract：:The number of patients suffering from diabetes mellitus is constantly rising worldwide, and diabetic retinopathy (DR) has become the most frequent cause of postnatal blindness. Vascular endothelial growth factor (VEGF) is known to play a central role during DR development. Thus, inhibiting the effects of VEGF may hamp...

journal_title：International journal of molecular medicine

authors： Ideno J,Mizukami H,Kakehashi A,Saito Y,Okada T,Urabe M,Kume A,Kuroki M,Kawakami M,Ishibashi S,Ozawa K

更新日期：2007-01-01 00:00:00

abstract：:Molecular analysis are useful for diagnosis, prognosis and follow-up of the patients, as well as for addressing therapeutic choices. Most of the molecular methods are based on the analysis of nucleic acids. The DNA and RNA methodologies of routine applicability include Southern and Northern hybridizations and polymera...

journal_title：International journal of molecular medicine

authors： Scarpa A,Tognon M

更新日期：1998-06-01 00:00:00

abstract：:In some patients with common variable immunodeficiency (CVID) and immunoglobulin (Ig) A deficiency (IgAD), tumor necrosis factor (TNF) family receptor transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI) gene mutations have been reported. B cells from individuals with TACI mutations d...

journal_title：International journal of molecular medicine

authors： Jin R,Kaneko H,Suzuki H,Arai T,Teramoto T,Fukao T,Kondo N

更新日期：2008-02-01 00:00:00

abstract：:Poligoni Multiflori Radix (PMR) is a traditional Korean medicinal herb that is known to have various pharmacological effects, including antihyperlipidemic, anticancer, and anti‑inflammatory effects. However, the effects of PMR on bone metabolism have not been elucidated to date. The present study aimed to investigate ...

journal_title：International journal of molecular medicine

authors： Han SY,Lee KH,Kim YK

更新日期：2018-07-01 00:00:00

abstract：:In contrast to healthy intervertebral discs (IVDs), degenerate IVDs become vascularized. Here, we determined the role of an angiogenesis promoter, angiopoietin (Ang)-2, in the pathology of IVD degeneration (IDD). We evaluated degree of IDD using the Pfirrmann grading system. We used quantitative real-time polymerase c...

journal_title：International journal of molecular medicine

authors： Wang K,Kang L,Liu W,Song Y,Wu X,Zhang Y,Hua W,Zhao K,Li S,Tu J,Luo R,Yang C

更新日期：2018-06-01 00:00:00

abstract：:Musk has been traditionally used in East Asia to alleviate the symptoms of angina pectoris. However, it remains unclear as to whether muscone, the main active ingredient of musk, has any beneficial effects on persistent myocardial ischemia in vivo. The aim of the present study was to investigate whether muscone can im...

journal_title：International journal of molecular medicine

authors： Wang X,Meng H,Chen P,Yang N,Lu X,Wang ZM,Gao W,Zhou N,Zhang M,Xu Z,Chen B,Tao Z,Wang L,Yang Z,Zhu T

更新日期：2014-07-01 00:00:00

abstract：:Midkine (MK), a retinoic acid responsible protein, is regulated during development and may play an important role in tumorigenesis. A search for genetic variations of the MK gene, located on chromosome 11q11.2 in humans, has not yet been conducted in cancers. To examine the entire coding region, as well as 4 regions o...

journal_title：International journal of molecular medicine

authors： Ahmed KM,Shitara Y,Kuwano H,Takenoshita S,Uchimuro K,Shinozawa T

更新日期：2000-09-01 00:00:00

abstract：:The transcription factor nuclear factor-κB (NF-κB) has been shown to function as a key regulator of cell death or survival in neuronal cells. Previous studies indicate that the biphasic activation of NF-κB occurs following experimental neonatal hypoxia-ischemia and subarachnoid hemorrhage. However, the comprehensive u...

journal_title：International journal of molecular medicine

authors： Zhang H,Zhang D,Li H,Yan H,Zhang Z,Zhou C,Chen Q,Ye Z,Hang C

更新日期：2018-06-01 00:00:00

abstract：:Hyperosmotic stress may be initiated during a diverse range pathological circumstances, which in turn results in tissue damage. In this process, the activation of survival signaling, which has the capacity to restore cell homeostasis, determines cell fate. Autophagy is responsible for cell survival and is activated by...

journal_title：International journal of molecular medicine

authors： Zhu H,Cao W,Zhao P,Wang J,Qian Y,Li Y

更新日期：2018-12-01 00:00:00

abstract：:Von Hippel-Lindau (VHL) disease is a hereditary tumor syndrome caused by mutations or deletions within the VHL tumor-suppressor gene, but VHL germline mutations in the Chinese have rarely been studied. To investigate the genetic profile of VHL mutations in the Chinese population, we evaluated the clinical characterist...

journal_title：International journal of molecular medicine

authors： Huang Y,Zhou D,Liu J,Zhou P,Li X,Wang Z

更新日期：2012-01-01 00:00:00

abstract：:CREB binding protein (CBP) plays a central role in cell differentiation and proliferation, interacting with a large number of nuclear factors. To find novel nuclear factors associating with CBP, we have carried out yeast two-hybrid screening of human chondrocyte cDNA library using the C/H3 region of CBP as a bait and ...

journal_title：International journal of molecular medicine

authors： Hirose T,Fujii R,Nakamura H,Aratani S,Fujita H,Nakazawa M,Nakamura K,Nishioka K,Nakajima T

更新日期：2003-06-01 00:00:00

abstract：:Zinc has been shown to have an inhibitory effect on osteoclastic bone resorption in vitro. This study was undertaken to determine whether the inhibitory action of zinc on osteoclastogenesis is related to receptor activator of NF-kappaB ligand (RANKL), which plays a pivotal role in differentiation from pre-osteoclasts ...

journal_title：International journal of molecular medicine

authors： Yamaguchi M,Uchiyama S

更新日期：2004-07-01 00:00:00

abstract：:The present study investigated the mechanism underlying the effects of glucosamine (GlcN) on the proliferation of chondrocytes isolated from the knee cartilage of Sprague‑Dawley rats. Chondrocytes were treated with various concentrations of GlcN or without GlcN. The effects of GlcN on chondrocyte proliferation were de...

journal_title：International journal of molecular medicine

authors： Ma Y,Zheng W,Chen H,Shao X,Lin P,Liu X,Li X,Ye H

更新日期：2018-07-01 00:00:00

abstract：:Synovial membrane consists of fibroblasts and macrophages forming the synovial lining supported by vascularized subsynovium. Each of these components may specifically react to a particular stimulus. Thus, reactions of isolated synovial cells may not correspond to that of intact tissue. We characterized the production ...

journal_title：International journal of molecular medicine

authors： Hyc A,Osiecka-Iwan A,Niderla-Bielinska J,Jankowska-Steifer E,Moskalewski S

更新日期：2009-10-01 00:00:00