Molecular approach in human tumor investigation: oncogenes, tumor suppressor genes and DNA tumor polyomaviruses (review).

abstract：:The present study aimed to develop a tumor necrosis factor‑α (TNF‑α) B‑cell epitope/IL‑1β helper T lymphocyte epitope complex MAP vaccine for the alleviation of ulcerative colitis (UC) in mice. The B cell epitopes of murine TNF‑α (mTNF‑α) were predicted in silico and coupled with the universal interleukin 1β (IL‑1β) h...

journal_title：International journal of molecular medicine

authors： Sun Y,Pan W,Zhang J,Cui Y,Wang H,Ru G,Chen L

更新日期：2019-09-01 00:00:00

abstract：:Soy sauce (Shoyu) is a traditional fermented seasoning of Japan and available throughout the world. Polysaccharides were obtained from dialysate of Shoyu, and these Shoyu polysaccharides (SPS) were examined for anti-allergic activity in vitro and in vivo. The SPS originated from partially-degraded polysaccharides of s...

journal_title：International journal of molecular medicine

authors： Kobayashi M,Matsushita H,Yoshida K,Tsukiyama R,Sugimura T,Yamamoto K

更新日期：2004-11-01 00:00:00

abstract：:Retinoic acid (RA) analogs have been used in the treatment of a variety of cancers; however, their application is limited due to serious therapy-related sequelae. In the present study, the effects of a novel RA analog, 4-amino-2-trifluoromethyl-phenyl retinate (ATPR), on the growth of gastric cancer cells were evaluat...

journal_title：International journal of molecular medicine

authors： Hu KW,Pan XH,Chen FH,Qin R,Wu LM,Zhu HG,Wu FR,Ge JF,Han WX,Yin CL,Li HJ

更新日期：2014-02-01 00:00:00

abstract：:The complement system participates in the local immune system of the lung. In this study, we investigated the secretion of complement components of the alternative pathway (C3 and factor B) in the alveolar type II epithelial cell line A549. The levels of C3 and factor B protein in the culture medium were determined by...

journal_title：International journal of molecular medicine

authors： Zhao YX,Andoh A,Shimada M,Takaya H,Hata K,Fujiyama Y,Bamda T

更新日期：2000-04-01 00:00:00

abstract：:Soy sauce (Shoyu) is a traditional Japanese fermented seasoning and is available worldwide. We investigated the effect of Shoyu polysaccharides (SPS) prepared from soy sauce on the intestinal immune system of mice. SPS enhanced the production of immunoglobulin A (IgA) from Peyer's patch cells in vitro, and its oral ad...

journal_title：International journal of molecular medicine

authors： Matsushita H,Kobayashi M,Tsukiyama R,Fujimoto M,Suzuki M,Tsuji K,Yamamoto K

更新日期：2008-08-01 00:00:00

abstract：:We reviewed the effectiveness of commercial serological markers for the early detection of cancer and monitoring cancer patients. Parameters, such as specificity and variability of tumor markers were compared with a new approach for cancer detection which was recently developed in our laboratory. We demonstrate that t...

journal_title：International journal of molecular medicine

authors： Zusman I,Ben-Hur H

更新日期：2001-05-01 00:00:00

abstract：:Hepatocellular carcinoma is a common type of cancer that is usually associated with poor prognosis. In this study, we examined the in vitro and in vivo mechanisms of the traditional Vietnamese herb Zanthoxylum avicennae on the inhibition of HA22T human hepatocellular carcinoma cell ...

journal_title：International journal of molecular medicine

authors： Dung TD,Chang HC,Binh TV,Lee MR,Tsai CH,Tsai FJ,Kuo WW,Chen LM,Huang CY

更新日期：2012-06-01 00:00:00

abstract：:Microglial activation-mediated inflammatory damage to oligodendrocytes is a key step in the etiology of ischemic white matter lesions. The adenosine A1 receptor (A1R) and adenosine A2a receptor (A2aR) have been reported to regulate the activation of microglia, however, the underlying mechanisms remain elusive. Thus, t...

journal_title：International journal of molecular medicine

authors： Huang W,Bai S,Zuo X,Tang W,Chen P,Chen X,Wang G,Wang H,Xie P

更新日期：2018-06-01 00:00:00

abstract：:The tumor microenvironment is thought to affect malignant transformation and tumor progression. The histone methyltransferase, enhancer of zeste homologue 2 (EZH2), has recently been suggested to play a critical role in the tumorigenesis of several types of human cancer. The aim of this study was to investigate the ef...

journal_title：International journal of molecular medicine

authors： Xu L,Deng Q,Pan Y,Peng M,Wang X,Song L,Xiao M,Wang Z

更新日期：2014-01-01 00:00:00

abstract：:Mutations in the known predisposing breast cancer genes BRCA1 and BRCA2 account for only a small proportion (<10%) of breast cancer families in the Stockholm region of Sweden. This study aims to identify novel predisposing genes in non-BRCA1/BRCA2 breast cancer families. We have employed comparative genomic hybridizat...

journal_title：International journal of molecular medicine

authors： Maguire P,Holmberg K,Kost-Alimova M,Imreh S,Skoog L,Lindblom A

更新日期：2005-07-01 00:00:00

abstract：:In some patients with common variable immunodeficiency (CVID) and immunoglobulin (Ig) A deficiency (IgAD), tumor necrosis factor (TNF) family receptor transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI) gene mutations have been reported. B cells from individuals with TACI mutations d...

journal_title：International journal of molecular medicine

authors： Jin R,Kaneko H,Suzuki H,Arai T,Teramoto T,Fukao T,Kondo N

更新日期：2008-02-01 00:00:00

abstract：:Non‑alcoholic fatty liver disease (NAFLD) is the consequence of insulin resistance, fatty acid accumulation, oxidative stress and lipotoxicity. The present study aimed to elucidate the effect of Quaking 5 (QKI 5) as mediated by Sirtuin 1 (SIRT1) on triglyceride (TG) synthesis in the liver of an NAFLD mouse model. A hi...

journal_title：International journal of molecular medicine

authors： Zhang W,Sun Y,Liu W,Dong J,Chen J

更新日期：2019-03-01 00:00:00

abstract：:The antioxidant 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox) is implicated in migration and invasion of metastatic tumors. However, the molecular mechanism underlying the effect of Trolox on metastatic cancer cells is not known. We found that a non-cytotoxic dose ...

journal_title：International journal of molecular medicine

authors： Sung HJ,Kim Y,Kang H,Sull JW,Kim YS,Jang SW,Ko J

更新日期：2012-02-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is one of the most aggressive brain tumors. GBM represents >50% of primary tumors of the nervous system and ~20% of intracranial neoplasms. Standard treatment involves surgery, radiation and chemotherapy. However, the prognosis of GBM is usually poor, with a median survival of 15 months. ...

journal_title：International journal of molecular medicine

authors： Bryukhovetskiy I,Ponomarenko A,Lyakhova I,Zaitsev S,Zayats Y,Korneyko M,Eliseikina M,Mischenko P,Shevchenko V,Shanker Sharma H,Sharma A,Khotimchenko Y

更新日期：2018-08-01 00:00:00

abstract：:Chondrocyte senescence is associated with the aging and degeneration of cartilage, and eventually leads to joint destruction. The aim of this study was to elucidate the mechanisms responsible for the cytoprotective effects of heme oxygenase‑1 (HO‑1) on chondrocytes in cartilage. Chondrocyte senescence was induced usin...

journal_title：International journal of molecular medicine

authors： Kim KM,Park SE,Lee MS,Kim K,Park YC

更新日期：2014-11-01 00:00:00

abstract：:Mutations in mitochondrial DNA (mtDNA) are a major cause of hearing loss. In this study, we performed a systematic mutational screening of the 12S rRNA, tRNA Ser(UCN), tRNA Lys and tRNA Leu(UUR) genes in 227 unrelated patients with nonsyndromic hearing impairment for the first time in a Korean population. We found two...

journal_title：International journal of molecular medicine

authors： Bae JW,Lee KY,Choi SY,Lee SH,Park HJ,Kim UK

更新日期：2008-08-01 00:00:00

abstract：:Biologically well-tolerated materials are at the core of intense research. In this study, we report both the intrinsic features of formic acid (FA)-crosslinked three-dimensional (3D) nonwoven scaffolds consisting of sericin-deprived, Bombyx mori silk fibroin (SF) in beta-sheet form and the long-term co-culture of adul...

journal_title：International journal of molecular medicine

authors： Dal Pra I,Chiarini A,Boschi A,Freddi G,Armato U

更新日期：2006-08-01 00:00:00

abstract：:Influenza is the most common infectious disease and is caused by influenza A virus (IAV) infection. Hemagglutinin (HA) is an important viral protein of influenza A and is a major component of current IAV vaccines. The side effects associated with IAV vaccination are well studied; however, the HA‑induced immunopatholog...

journal_title：International journal of molecular medicine

authors： Li Y,Hu H,Qi Z,Sun J,Li Y,Feng Q,Guo C,Wang H,Zhao P,Liu Y,Zhao X,Wang G,Zhang H,Liu L,Hu J

更新日期：2018-03-01 00:00:00

abstract：:In the absence of antibodies specific for lymphatic vessels, analysis of lymphatic vessels within different tissues has been widely performed with light microscopic and, most importantly, electron microscopic techniques. In regard to lymphatic vessels in the ocular globe and the periocular structures, controversy rema...

journal_title：International journal of molecular medicine

authors： Fogt F,Zimmerman RL,Daly T,Gausas RE

更新日期：2004-05-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) is the major pathological mechanism in anterior subcapsular cataract (ASC) and posterior capsule opacification (PCO), which are important causes of visual impairment. Extracellular signal-regulated kinase (ERK)1/2 pathway has been reported to play...

journal_title：International journal of molecular medicine

authors： Chen X,Ye S,Xiao W,Wang W,Luo L,Liu Y

更新日期：2014-06-01 00:00:00

abstract：:Rac3 is a small GTPase of the Rho family, members of which have been implicated in tumorigenesis, cell growth/death and organization of the actin cytoskeleton. Many Rac-interacting proteins or effectors identified to date have a role in cytoskeletal organization. Using the yeast two-hybrid system, we have isolated a n...

journal_title：International journal of molecular medicine

authors： Haataja L,Groffen J,Heisterkamp N

更新日期：1998-04-01 00:00:00

abstract：:Breast cancer accounts for 30-40% of all deaths from cancers in females. In an effort to identify tumor associated antigens that may be useful for immunotherapy, we utilized serological analysis of recombinant cDNA expression libraries (SEREX) technique to identify breast cancer-associated antigens. SEREX screening of...

journal_title：International journal of molecular medicine

authors： Qian F,Odunsi K,Blatt LM,Scanlan MJ,Mannan M,Shah N,Montgomery J,Haddad F,Taylor M

更新日期：2005-01-01 00:00:00

abstract：:Chronic asthma is characterized by inflammatory cell infiltration and tissue remodeling, leading to subepithelial inflammation. In order to evaluate the anti-asthmatic activity of LX519290, a derivative of L-allo threonine, we performed several in vitro and in vivo anti-asthmatic assays. Using ovalbumin (OVA)-sensitiz...

journal_title：International journal of molecular medicine

authors： Heo JC,Lee SH

更新日期：2013-04-01 00:00:00

abstract：:Cerebellin (CER) is a regulatory peptide, originally isolated from rat cerebellum, which derives from the cleavage of precerebellin (Cbln), three types of which (Cbln1-3) have been identified in humans and rats. CER is also expressed in several extra-cerebellar tissues, including adrenal gland, and evidence has been p...

journal_title：International journal of molecular medicine

authors： Rucinski M,Albertin G,Spinazzi R,Ziolkowska A,Nussdorfer GG,Malendowicz LK

更新日期：2005-03-01 00:00:00

abstract：:Gap junctions are intercellular channels made of connexin proteins, mediating both electrical and biochemical signals between cells. The ability of gap junction proteins to regulate immune responses, cell proliferation, migration, apoptosis and carcinogenesis makes them attractive therapeutic targets for treating infl...

journal_title：International journal of molecular medicine

authors： Wong P,Laxton V,Srivastava S,Chan YW,Tse G

更新日期：2017-03-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is one of the most frequent causes of abnormal liver dysfunction, and its prevalence has markedly increased. We previously evaluated the expression of fatty acid metabolism-related genes in NAFLD and reported changes in expression that could contribute to increased fatty acid s...

journal_title：International journal of molecular medicine

authors： Kohjima M,Enjoji M,Higuchi N,Kato M,Kotoh K,Yoshimoto T,Fujino T,Yada M,Yada R,Harada N,Takayanagi R,Nakamuta M

更新日期：2007-09-01 00:00:00

abstract：:The increased proliferation and decreased apoptosis of pulmonary artery smooth muscle cells (PASMCs) are the main causes of hypoxic pulmonary hypertension. In this study, we investigated the role of troglitazone [peroxisome proliferator-activated receptor γ (PPARγ) agonist] in the regulation of phosphatase and tensin ...

journal_title：International journal of molecular medicine

authors： Pi WF,Guo XJ,Su LP,Xu WG

更新日期：2013-11-01 00:00:00

abstract：:Manumycin was reported to have inhibitory effect on farnesyltransferase by competing with the farnesyl pyrophosphate substrate. It exhibited different antiproliferative activity in human hepatocellular carcinoma HepG2 cells, primary cultured human cardiac muscle cells and human liver cells (CLC). HepG2 cells overexpre...

journal_title：International journal of molecular medicine

authors： Zhou JM,Zhu XF,Pan QC,Liao DF,Li ZM,Liu ZC

更新日期：2003-06-01 00:00:00

abstract：:Baicalin, extracted and purified from the Chinese medicinal plant, Scutellaria baicalensis Georgi (Huang qin in Chinese), exhibits potent anti-inflammatory activity against asthma. However, it remains unknown whether baicalin inhibits the activity of CC chemokine receptor 7 (CCR7) and its ligands, which are crucial fo...

journal_title：International journal of molecular medicine

authors： Liu J,Wei Y,Luo Q,Xu F,Zhao Z,Zhang H,Lu L,Sun J,Liu F,Du X,Li M,Wei K,Dong J

更新日期：2016-11-01 00:00:00

abstract：:Nail-Patella syndrome, or osteo-onychodysplasia, is an autosomal dominant disorder characterized by nail dysplasia, absent or hypoplastic patellae, iliac horns and nephropathy. Previous studies have demonstrated linkage of the Nail-Patella locus with polymorphic markers on human chromosome 9q34. Recently, point mutati...

journal_title：International journal of molecular medicine

authors： Seri M,Melchionda S,Dreyer S,Marini M,Carella M,Cusano R,Piemontese MR,Caroli F,Silengo M,Zelante L,Romeo G,Ravazzolo R,Gasparini P,Lee B

更新日期：1999-09-01 00:00:00