CGH analysis of familial non-BRCA1/BRCA2 breast tumors and mutation screening of a candidate locus on chromosome 17q11.2-12.

abstract：:For tumor progression, a cascade of linked sequential biological events is essential. We tried to test whether biological therapy can modulate specific biological phenotypes and increase the anti-tumor effect when combined with chemotherapy. Five human gastric cancer cell lines (YCC-1, YCC-2, YCC-3, YCC-7, AGS) were u...

journal_title：International journal of molecular medicine

authors： Rha SY,Noh SH,Kim TS,Yoo NC,Roh JK,Min JS,Kim BS

更新日期：1999-08-01 00:00:00

abstract：:The mechanisms through which mechanical ventilation causes non-infectious inflammatory diseases and lung injury are poorly understood. Animals models of this type of injury suggest that it involves signaling mediated by Toll‑like receptor (TLR)4 and 9. In this study, in order to gain further insight into the involveme...

journal_title：International journal of molecular medicine

authors： Huang C,Pan L,Lin F,Dai H,Fu R

更新日期：2017-03-01 00:00:00

abstract：:Uterine leiomyomas are benign smooth muscle cell tumors originating from the myometrium. The present study focused on leiomyoma and myometrium phosphoproteome enrichment by using immobilized metal affinity chromatography (IMAC). The phosphoproteome was analyzed by two‑dimensional gel electrophoresis coupled with mass ...

journal_title：International journal of molecular medicine

authors： Ura B,Monasta L,Arrigoni G,Licastro D,Di Lorenzo G,Romano F,Gaita B,Scrimin F,Ricci G

更新日期：2019-12-01 00:00:00

abstract：:High mobility group box-1 protein (HMGB1), primarily from the nucleus, is released into the extracellular milieu either passively from necrotic cells or actively through secretion by monocytes/macrophages. Extracellular HMGB1 acts as a potent inflammatory agent by promoting the release of cytokines such as tumor necro...

journal_title：International journal of molecular medicine

authors： Kawahara K,Hashiguchi T,Masuda K,Saniabadi AR,Kikuchi K,Tancharoen S,Ito T,Miura N,Morimoto Y,Biswas KK,Nawa Y,Meng X,Oyama Y,Takenouchi K,Shrestha B,Sameshima H,Shimizu T,Adachi T,Adachi M,Maruyama I

更新日期：2009-05-01 00:00:00

abstract：:The present study aimed to investigate the influence of microRNA-4649-3p on nasopharyngeal carcinoma (NPC) cell proliferation and how it regulated SHP-1 expression. The online software TargetScan was used to predict the microRNAs targeting SHP-1 and identified that miR-4649-3p was one of the possible miRNAs targeting ...

journal_title：International journal of molecular medicine

authors： Pan X,Peng G,Liu S,Sun Z,Zou Z,Wu G

更新日期：2015-08-01 00:00:00

abstract：:The kallikrein-kinin system (KKS) is a complex multi-enzyme system which is composed of circulating and tissue kallikrein and kinin. It is well established that tissue kallikrein and kinin play crucial and diverse roles in cardiovascular and renal homeostasis. Recent data indicate t...

journal_title：International journal of molecular medicine

authors： Xu X,Tu L,Jiang W,Feng W,Zhao CX,Wang DW

更新日期：2012-05-01 00:00:00

abstract：:(-)-Epigallocatechin gallate [(-)-EGCG] has been implicated in cancer chemoprevention and has been shown as an inhibitor of tumor proteasomal chymotrypsin-like activity in vitro and in vivo. However, EGCG is subjected to rapid biotransforming modifications such as methylation by catechol-Omicron-methyltransferase (COM...

journal_title：International journal of molecular medicine

authors： Kanwar J,Mohammad I,Yang H,Huo C,Chan TH,Dou QP

更新日期：2010-08-01 00:00:00

abstract：:To date, Korean hinoki cypress (Chamaecyparis obtusa), has been widely used for household and commercial purposes. Although the medicinal efficacy of hinoki cypress essential oil has been observed, that of the essential oil‑derived terpenes, which exhibit a mechanism that acts against lung inflammation, remains to be ...

journal_title：International journal of molecular medicine

authors： Raha S,Kim SM,Lee HJ,Lee SJ,Heo JD,Venkatarame Gowda Saralamma V,Ha SE,Kim EH,Mun SP,Kim GS

更新日期：2019-01-01 00:00:00

abstract：:Geranylgeranylacetone (GGA) has recently been reported to have a protective effect against ischemic, injurious and apoptotic stress in several tissues. The aim of this study was to determine the effect of GGA on colitis induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) in mice. Colitis was induced by intrarectal i...

journal_title：International journal of molecular medicine

authors： Ohkawara T,Nishihira J,Takeda H,Katsurada T,Kato K,Yoshiki T,Sugiyama T,Asaka M

更新日期：2006-02-01 00:00:00

abstract：:Overconsumption of fats and sugars is a major cause of development of non‑alcoholic fatty liver disease (NAFLD). The main objectives of the present study were to explore the pathways sustaining the interfering metabolic effects of excess fructose and fatty acids in hepatocytes, and to clarify the mechanisms through wh...

journal_title：International journal of molecular medicine

authors： Grasselli E,Baldini F,Vecchione G,Oliveira PJ,Sardão VA,Voci A,Portincasa P,Vergani L

更新日期：2019-08-01 00:00:00

abstract：:The dysregulation of microRNA‑939‑5p (miR‑939) is involved in the development of multiple types of human cancer. However, the expression and roles of miR‑939 in osteosarcoma (OS) have yet to be clarified. The expression level of miR‑939 in OS was measured using reverse transcription quantitative polymerase chain react...

journal_title：International journal of molecular medicine

authors： Zhao X,Li J,Yu D

更新日期：2019-11-01 00:00:00

abstract：:Acute lung injury (ALI) is among the most common causes of mortality in intensive care units. Recent in vivo and in vitro studies have suggested that mesenchymal stem cells (MSCs) attenuate pulmonary edema and inflammatory factors, but the mechanisms of the effects of MSCs on pulmonary vascular function remain unknown...

journal_title：International journal of molecular medicine

authors： Gao P,Yang X,Mungur L,Kampo S,Wen Q

更新日期：2013-06-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of impaired vision and blindness in the aging population. The aims of our studies were to identify qualitative and quantitative alterations in mitochondria in human retinal pigment epithelium (RPE) from AMD patients and con...

journal_title：International journal of molecular medicine

authors： Bianchi E,Scarinci F,Ripandelli G,Feher J,Pacella E,Magliulo G,Gabrieli CB,Plateroti R,Plateroti P,Mignini F,Artico M

更新日期：2013-01-01 00:00:00

abstract：:The active fraction of the extract of Asiasari radix, the 60% methanol chromatographic fraction from the ethyl acetate layer (PPAR), was used to investigate the melanogenesis signal pathway in B16F10 melanoma cells. PPAR led to significantly decreased melanin synthesis and tyrosinase activity in a dose-dependent manne...

journal_title：International journal of molecular medicine

authors： Jang JY,Lee JH,Shin HK,Choi YH,Lee JD,Choi BT

更新日期：2010-02-01 00:00:00

abstract：:The activation of the classical angiotensin (Ang)-converting enzyme (ACE)/Ang II/Ang II type 1 receptor (AT1R) axis of the renin-angiotensin system (RAS) has been associated with islet dysfunction and insulin resistance. Hyperglycaemia, hypertension and obesity, major components of metabolic syndrome, are all associat...

journal_title：International journal of molecular medicine

authors： Härdtner C,Mörke C,Walther R,Wolke C,Lendeckel U

更新日期：2013-10-01 00:00:00

abstract：:The existence of at least two distinct alpha 1,2fucosyltransferases has been postulated for many years, and recently confirmed in humans with the cloning of the human and rabbit secretor type alpha 1,2fucosyltransferase. We now describe the cloning and analysis of PFUT2, the pig secretor type alpha 1,2fucosyltransfera...

journal_title：International journal of molecular medicine

authors： Cohney S,Mouhtouris E,McKenzie IF,Sandrin MS

更新日期：1999-02-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation and migration has been proven to be a critical event in the development of varicosity. Variations in estrogen levels, a pathological event related to age and pregnancy, play a role in the pathogenesis of varicosity. Previous studies have reported a different response of...

journal_title：International journal of molecular medicine

authors： Huang X,Jin Y,Zhou D,Xu G,Huang J,Shen L

更新日期：2015-05-01 00:00:00

abstract：:Midkine (MK), a retinoic acid responsible protein, is regulated during development and may play an important role in tumorigenesis. A search for genetic variations of the MK gene, located on chromosome 11q11.2 in humans, has not yet been conducted in cancers. To examine the entire coding region, as well as 4 regions o...

journal_title：International journal of molecular medicine

authors： Ahmed KM,Shitara Y,Kuwano H,Takenoshita S,Uchimuro K,Shinozawa T

更新日期：2000-09-01 00:00:00

abstract：:Post-operative pulmonary complications such as systemic inflammatory response syndrome (SIRS), acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are strongly associated with morbidity and mortality after esophagectomy. Post-operative administration of sivelestat sodium hydrate (sivelestat), a sele...

journal_title：International journal of molecular medicine

authors： Yamaguchi K,Sugasawa Y,Takeuchi K,Kugimiya T,Kumakura S,Iwanuma Y,Kajiyama Y,Tsurumaru M,Nagaoka I,Inada E

更新日期：2011-08-01 00:00:00

abstract：:We have previously reported on a novel autoantibody in a patient with paraneoplastic sensory-dominant neuropathy. This autoantibody immunostains the rat primary sensory system and reacts with a 47 kDa protein on immunoblotting. Here, we report on the isolation from rat spinal cord of a molecule that is recognized by t...

journal_title：International journal of molecular medicine

authors： Arawaka S,Daimon M,Sasaki H,Suzuki JI,Kato T

更新日期：1998-03-01 00:00:00

abstract：:The opioid growth factor (OGF) is a constitutively expressed negative growth regulator whose action is mediated by the OGF receptor (OGFr). The OGF-OGFr axis tonically regulates the growth of human squamous cell carcinoma of the head and neck (SCCHN). To examine the repercussions of amplifying OGFr in SCCHN, construct...

journal_title：International journal of molecular medicine

authors： McLaughlin PJ,Verderame MF,Hankins JL,Zagon IS

更新日期：2007-03-01 00:00:00

abstract：:Skeletal metastasis is the major problem in the management of prostate cancer (PCa). Even though the regulatory role of microRNAs (miRNAs) in the control of tumor metastases has been well described in numerous types of cancer, the importance in bone metastasis of PCa remains largely unknown. In the present study, the ...

journal_title：International journal of molecular medicine

authors： Fu Q,Liu X,Liu Y,Yang J,Lv G,Dong S

更新日期：2015-11-01 00:00:00

abstract：:Gene therapy is becoming an important treatment modality against various diseases including cancer, genetic disorders, infectious diseases and inflammatory diseases. For achieving successful gene therapy, it is extremely important to control the expression of a transduced therapeutic gene. However, there have been few...

journal_title：International journal of molecular medicine

authors： Akahane M,Kuriyama S,Ohgushi H,Akahane T,Kawamura K,Watanabe S,Funakoshi F,Yoshiji H,Ikenaka K,Takakura Y

更新日期：2002-07-01 00:00:00

abstract：:Stannous ion, as a chloride salt, influenced on the survival and adhesive properties of two toxigenic Corynebacterium diphtheriae of the sucrose-fermenting (241 strain) and non-sucrose-fermenting (CDC-E8392 strain) biotypes. Differences in survival fractions suggested differences in susceptibility of strains to bacter...

journal_title：International journal of molecular medicine

authors： Silva De Souza SM,Hirata R Jr,Moreira LO,Gomes ML,Braga De Andrade AF,Bernardo-Filho M,Mattos-Guaraldi AL

更新日期：2003-10-01 00:00:00

abstract：:The immunosuppressive effect of triptolide has been associated with suppression of T-cell activation. However, the immunosuppressive effects of triptolide on innate immunity in the epithelial barrier remain to be elucidated. Human beta-defensin (HBD)-2 is an inducible antimicrobial peptide and plays an important role ...

journal_title：International journal of molecular medicine

authors： Jang BC,Lim KJ,Choi IH,Suh MH,Park JG,Mun KC,Bae JH,Shin DH,Suh SI

更新日期：2007-05-01 00:00:00

abstract：:Human interleukin-15 (hIL15) exerts anticancer effects through the activities of lymphokine-activated killer (LAK) cells. However, its short half-life hinders its clinical application. Recombinant adeno-associated virus serotype 2 (rAAV2) is used for hIL15 gene transfer vectors, bec...

journal_title：International journal of molecular medicine

authors： Yiang GT,Chou PL,Tsai HF,Chen LA,Chang WJ,Yu YL,Wei CW

更新日期：2012-05-01 00:00:00

abstract：:Adrenomedullin (AM) is a hypotensive peptide, which originates from the proteolytic cleavage of pro(p)AM and acts via AM22-52-sensitive receptors. Reverse transcription polymerase chain reaction allowed the detection of the specific mRNAs of pAM in the mononuclear hematopoietic cells of the cord blood and immunocytoch...

journal_title：International journal of molecular medicine

authors： Del Pup L,Belloni AS,Carraro G,De Angeli S,Parnigotto PP,Nussdorfer GG

更新日期：2003-02-01 00:00:00

abstract：:Human skin fibroblasts may be the target cells for estrogens. The aim of present study was to confirm the presence of both isoforms of estrogen receptors (ER) in these cells. Experiments were carried out in primary cultures of human skin fibroblasts. ER-alpha and ER-beta mRNAs were measured by quantitative assays base...

journal_title：International journal of molecular medicine

authors： Haczynski J,Tarkowski R,Jarzabek K,Slomczynska M,Wolczynski S,Magoffin DA,Jakowicki JA,Jakimiuk AJ

更新日期：2002-08-01 00:00:00

abstract：:Effective drugs and strategies for treating type 2 diabetes mellitus (2‑DM) are urgently required. The aim of the present study was to elucidate the mechanism underlying microRNA (miR)‑6835‑3p regulation of adiponectin receptor 1 (AdipoR1) expression and the miR‑6835‑3p/AdipoR1 signaling pathway in pancreatic islet ce...

journal_title：International journal of molecular medicine

authors： Wang H,Jiang L,Li Z,Wang W,Hao C

更新日期：2018-09-01 00:00:00

abstract：:Biochemical modification of extracellular matrix (ECM) proteins can alter the function in overlying cells. We tested the hypothesis that metal-catalyzed oxidation of native ECM and individual matrix proteins modulates the activity of inducible nitric oxide synthase (iNOS) in cultured rat mesangial cells (RMC). Oxidize...

journal_title：International journal of molecular medicine

authors： Trachtman H,Futterweit S,Koss E,Bogart M,Mermelstein A

更新日期：1999-03-01 00:00:00