Identification of a novel Rac3-interacting protein C1D.

abstract：:Death-associated protein kinase (DAPK) is a Ca2+/calmodulin-dependent serine/threonine kinase that has been implicated as a positive mediator of apoptosis. However, little is known about the involvement of DAPK in the apoptosis associated with several pathological states, except for cancer. Here, DAPK-mutant mice were...

journal_title：International journal of molecular medicine

authors： Yukawa K,Hoshino K,Kishino M,Mune M,Shirasawa N,Kimura A,Tsubota Y,Owada-Makabe K,Tanaka T,Ichinose M,Maeda M,Takeda K,Akira S

更新日期：2004-04-01 00:00:00

abstract：:A number of cell-penetrating peptides (CPPs) have been reported, but their transduction efficiencies are too low to be used as intracellular carriers for therapeutic purposes. We conducted a comprehensive search to find novel CPPs using an in vitro virus (IVV) library, which presented random peptides consisting of 15 ...

journal_title：International journal of molecular medicine

authors： Kamide K,Nakakubo H,Uno S,Fukamizu A

更新日期：2010-01-01 00:00:00

abstract：:Van der Woude syndrome (VWS) is the most common autosomal dominant disorder with characteristic lip pits and clefts of the lip and/or palate (CL/P). The interferon regulatory factor 6 gene (IRF6) has been recently identified as the gene mutated in patients with VWS. Here, we report two novel mutations of IRF6 in two u...

journal_title：International journal of molecular medicine

authors： Kim Y,Park JY,Lee TJ,Yoo HW

更新日期：2003-10-01 00:00:00

abstract：:Despite recent advances in the management of thyroid cancer, the survival rate of this tumor may still be improved. Therefore, the identification of biological and molecular features of indolent and aggressive disease would be critical to define clinically useful predictors of high-...

journal_title：International journal of molecular medicine

authors： Leonardi GC,Candido S,Carbone M,Colaianni V,Garozzo SF,Cinà D,Libra M

更新日期：2012-11-01 00:00:00

abstract：:Neuromedin-U (NMU) is a brain-gut peptide, which has been previously found to stimulate hypothalamic-pituitary-adrenal axis in the rat. Enucleation-induced adrenal regeneration in rats with contralateral adrenalectomy is a well-established model of adrenal growth, that not only depends on the compensatory ACTH hyperse...

journal_title：International journal of molecular medicine

authors： Trejter M,Neri G,Rucinski M,Majchrzak M,Nussdorfer GG,Malendowicz LK

更新日期：2008-06-01 00:00:00

abstract：:Acute necrotizing pancreatitis (ANP) is a common severe critical illness with a high mortality rate. Resveratrol, a polyphenol compound derived from various plants such as grape skin, peanut, berry and veratrum, exhibits multiple biological activities, especially potent anti‑inflammatory activity, but its effect on AN...

journal_title：International journal of molecular medicine

authors： Wang N,Zhang F,Yang L,Zou J,Wang H,Liu K,Liu M,Zhang H,Xiao X,Wang K

更新日期：2017-08-01 00:00:00

abstract：:The development of angiogenesis within a tumor brings on a sequence of extremely complex molecular events. We have developed a methodology which enables a wide set of biological parameters to be quantitatively determined in the field of anti-angiogenesis pharmacology. This methodology which includes a video cell track...

journal_title：International journal of molecular medicine

authors： Farinelle S,Dehauwer C,Darro F,Decaestecker C,Fontaine J,Pasteels JL,Van Ham P,Atassi G,Kiss R

更新日期：1998-11-01 00:00:00

abstract：:Tree shrews, one of the closest relatives of primates, have attracted increasing attention as a model of human diseases, particularly for viral infections. As the first line of defense against microbial pathogens, the innate immune system is crucial in tree shrews. Interleukin-6 (IL-6) is important in the pathophysiol...

journal_title：International journal of molecular medicine

authors： Han Y,Sun X,Kuang D,Tong P,Lu C,Wang W,Li N,Chen Y,Wang X,Dai J,Zhang H

更新日期：2017-12-01 00:00:00

abstract：:The tree shrew (Tupaia belangeri) diverges from the primate order (Primates) and is classified as a separate taxonomic group of mammals - Scandentia. It has been suggested that the tree shrew can be used as an animal model for studying human diseases; however, the genomic sequence of the tree shrew is largely unidenti...

journal_title：International journal of molecular medicine

authors： Zheng Y,Yun C,Wang Q,Smith WW,Leng J

更新日期：2015-02-01 00:00:00

abstract：:D-mannoheptulose was recently proposed as a tool to label preferentially insulin-producing cells in the pancreatic gland in the perspective of the non-invasive imaging of the endocrine pancreas. In such a perspective, we have now synthesized 1-deoxy-1-[125I]iodo-D-mannoheptulose ([125I]MH) and examined its uptake by d...

journal_title：International journal of molecular medicine

authors： Sener A,Bessieres B,Courtois P,Ladriere L,Louchami K,Jijakli H,Malaisse WJ

更新日期：2001-05-01 00:00:00

abstract：:Neural stem cell transplantation is a promising new treatment of ischemic or traumatic brain injury. We have now investigated the involvement of the peroxynitrite - poly(ADP-ribose) polymerase (ONOO- - PARP) activation cascade in brain trauma and neural stem cell transplantation. The forelimb motor cortex of adult mal...

journal_title：International journal of molecular medicine

authors： Lacza Z,Horváth EM,Komjáti K,Hortobágyi T,Szabó C,Busija DW

更新日期：2003-08-01 00:00:00

abstract：:Racemic fluoxetine is a widely used SSRI antidepressant compound having also anticonvulsant effect. In addition, it was shown that it blocked several types of voltage gated ion channels including neural and cardiac calcium channels. In the present study the effects of enantiomers of fluoxetine (R(-)-fluoxetine and S(+...

journal_title：International journal of molecular medicine

authors： Magyar J,Rusznák Z,Harasztosi C,Körtvély A,Pacher P,Bányász T,Pankucsi C,Kovács L,Szûcs G,Nánási PP,Kecskeméti V

更新日期：2003-04-01 00:00:00

abstract：:The aim of the present study was to evaluate the effects of blocking the Rho kinase pathway on non-perfused regions and angiogenesis in the retina of rats using a rat model of oxygen-induced retinopathy (OIR) by observing the sequential expression of intercellular adhesion molecule-1 (ICAM-1), hypoxia-inducible factor...

journal_title：International journal of molecular medicine

authors： Wang H,Chen X

更新日期：2013-08-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation plays a critical role in the development of vascular diseases. In the present study, we tested the efficacy and the mechanisms of action of gastrodin, a bioactive component of the Chinese herb Gastrodia elata Bl, in relation to platelet-derived growth factor-BB (PDGF-BB...

journal_title：International journal of molecular medicine

authors： Zhu L,Guan H,Cui C,Tian S,Yang D,Wang X,Zhang S,Wang L,Jiang H

更新日期：2012-11-01 00:00:00

abstract：:Mycobacterium tuberculosis (MTB), one of the major bacterial pathogens for lethal infectious diseases, is capable of surviving within the phagosomes of host alveolar macrophages; therefore, host genetic variations may alter the susceptibility to MTB. In this study, to identify host genes exploited by MTB during infect...

journal_title：International journal of molecular medicine

authors： Bao Z,Chen R,Zhang P,Lu S,Chen X,Yao Y,Jin X,Sun Y,Zhou J

更新日期：2016-09-01 00:00:00

abstract：:The presence of cells positive for cytokeratins or prostate-specific antigen (PSA) in bone marrow aspirates (BMAs) has been used to indicate the presence of micrometastasis. The aim of this prospective study of prostate cancer patients was to determine the presence of prostate cells in blood and BMAs and to compare th...

journal_title：International journal of molecular medicine

authors： Murray NP,Reyes E,Tapia P,Badinez L,Orellana N,Fuentealba C,Olivares R,Porcell J,Dueñas R

更新日期：2012-10-01 00:00:00

abstract：:Neovascularization occurring in atherosclerotic plaque leads to acceleration of plaque growth through increased leukocyte infiltration and reactive oxygen species (ROS) production. Sema4D (CD100), a class IV semaphorin, not only plays a crucial role in axon guidance but also functions in the neovascularization process...

journal_title：International journal of molecular medicine

authors： Yukawa K,Tanaka T,Kishino M,Yoshida K,Takeuchi N,Ito T,Takamatsu H,Kikutani H,Kumanogoh A

更新日期：2010-07-01 00:00:00

abstract：:The prognosis of patients suffering from glioblastoma [also referred to as glioblastoma multiforme (GBM)] is dismal despite multimodal therapy. Chemotherapy with temozolomide may suppress tumor growth for a certain period of time (a few months); however, invariable tumor recurrence suggests that glioblastoma initiatin...

journal_title：International journal of molecular medicine

authors： Cheng ZX,Yin WB,Wang ZY

更新日期：2017-11-01 00:00:00

abstract：:Clinical evidence suggests that healing is faster and almost scarless at an early neonatal age in comparison with that in adults. In this study, the phenotypes of neonatal and adult dermal fibroblasts and keratinocytes (nestin, smooth muscle actin, keratin types 8, 14 and 19, and fibronectin) were compared. Furthermor...

journal_title：International journal of molecular medicine

authors： Mateu R,Živicová V,Krejčí ED,Grim M,Strnad H,Vlček Č,Kolář M,Lacina L,Gál P,Borský J,Smetana K Jr,Dvořánková B

更新日期：2016-10-01 00:00:00

abstract：:Catamenial epilepsy is a common phenomenon in female epileptic patients that is, in part, influenced by the 17-β-estradiol level during the menstrual cycle, which modulates the strength of the epileptic seizures. However, the underlying mechanism(s) for catamenial epilepsy remains unknown. In the present study, the ef...

journal_title：International journal of molecular medicine

authors： Zhang Y,Huang Y,Liu X,Wang G,Wang X,Wang Y

更新日期：2015-09-01 00:00:00

abstract：:The purpose of this study was to investigate the expression of different CD44 and hyaluronan synthase isoforms in cartilage, their alterations during the chondrocyte dedifferentiation process in monolayer culture and during the redifferentiation process on 3D scaffolds. Chondrocytes isolated from human articular carti...

journal_title：International journal of molecular medicine

authors： Albrecht C,Schlegel W,Eckl P,Jagersberger T,Sadeghi K,Berger A,Vécsei V,Marlovits S

更新日期：2009-02-01 00:00:00

abstract：:We investigated the expression and function of laminin and type IV collagen (COL-4) in the human endometrial epithelium throughout the menstrual cycle. Their expression was demonstrated by immunohistochemistry, while cytological analysis of the human endometrial epithelial cell line HHUA cultured on laminin- or COL-4-...

journal_title：International journal of molecular medicine

authors： Tanaka T,Wang C,Umesaki N

更新日期：2009-02-01 00:00:00

abstract：:Idiopathic cardiomyopathy is reviewed from molecular standpoint. About a half of all patients with hypertrophic cardiomyopathy show intra-familial occurrence. In familial hypertrophic cardiomyopathy, nine gene abnormalities have been discovered in the sarcomere, i.e. the genes of beta cardiac myosin heavy chain, cardi...

journal_title：International journal of molecular medicine

authors： Takeda N

更新日期：2003-01-01 00:00:00

abstract：:The dysregulation of microRNA‑939‑5p (miR‑939) is involved in the development of multiple types of human cancer. However, the expression and roles of miR‑939 in osteosarcoma (OS) have yet to be clarified. The expression level of miR‑939 in OS was measured using reverse transcription quantitative polymerase chain react...

journal_title：International journal of molecular medicine

authors： Zhao X,Li J,Yu D

更新日期：2019-11-01 00:00:00

abstract：:Curcumin, a component of turmeric (Curcuma longa), is known to exert a variety of biological functions including anti-inflammatory activity. We examined the inhibitory effects of chemically synthesized derivatives of curcumin against inflammatory responses and compared them with those of curcumin, in order to find der...

journal_title：International journal of molecular medicine

authors： Nishida M,Nishiumi S,Mizushina Y,Fujishima Y,Yamamoto K,Masuda A,Mizuno S,Fujita T,Morita Y,Kutsumi H,Yoshida H,Azuma T,Yoshida M

更新日期：2010-05-01 00:00:00

abstract：:Small cell lung cancer (SCLC) is a highly aggressive lung neoplasm. To study the pathogenesis of SCLC, we investigated roles of ABCE1, a member of the ATP-binding cassette (ABC) superfamily, in the development of small cell lung cancer. RNA interference was used to knock down ABCE1 expression in human small cell lung ...

journal_title：International journal of molecular medicine

authors： Huang B,Gao Y,Tian D,Zheng M

更新日期：2010-05-01 00:00:00

abstract：:Geranylgeranylacetone (GGA) has recently been reported to have a protective effect against ischemic, injurious and apoptotic stress in several tissues. The aim of this study was to determine the effect of GGA on colitis induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) in mice. Colitis was induced by intrarectal i...

journal_title：International journal of molecular medicine

authors： Ohkawara T,Nishihira J,Takeda H,Katsurada T,Kato K,Yoshiki T,Sugiyama T,Asaka M

更新日期：2006-02-01 00:00:00

abstract：:We report on the in silico-initiated cloning and molecular characterization of CTXN3 (cortexin 3), a new human gene that was specifically expressed in the kidney and brain due to tissue-specific alternative exon 1 usage, on chromosome 5q23.2 using digital gene expression displayer (DGED) and a novel in silico cloning ...

journal_title：International journal of molecular medicine

authors： Wang HT,Chang JW,Guo Z,Li BG

更新日期：2007-10-01 00:00:00

abstract：:Emerging studies have indicated that the dysregulation of microRNAs (miRNAs or miRs) plays a vital role in the development and metastasis of tumors. However, the role of miR‑93‑5p in esophageal carcinoma (EC) has not been extensively reported. The present study thus focused on the role of miR‑93‑5p and its downstream ...

journal_title：International journal of molecular medicine

authors： Cai Y,Ruan W,Ding J,Wei N,Wang J,Zhang H,Ma N,Weng G,Su WK,Lin Y,Zhu K

更新日期：2021-03-01 00:00:00

abstract：:The anti-allergic activity of the 50% methanol extract of Citrus unshiu powder (MEC) was examined. Fifty percent methanol extract of MEC powder showed potent inhibitory activity against histamine release from basophils of patients suffering from seasonal allergic rhinitis to ceder pollen. To examine this anti-allergic...

journal_title：International journal of molecular medicine

authors： Kobayashi S,Tanabe S

更新日期：2006-03-01 00:00:00