Stimulatory effect of Shoyu polysaccharides from soy sauce on the intestinal immune system.

abstract：:As hyperprolactinemia is observed in patients with bromocriptine‑resistant prolactinoma, prolactin (PRL) has been implicated in the development of bromocriptine resistance. Since PRL primarily mediates cell survival and drug resistance via the Janus kinase‑2 (JAK2)/signal transducer and activator of transcription 5A (...

journal_title：International journal of molecular medicine

authors： Xiao Z,Liang J,Deng Q,Song C,Yang X,Liu Z,Shao Z,Zhang K,Wang X,Li Z

更新日期：2021-01-01 00:00:00

abstract：:Airway remodeling is characterized by airway wall thickening, subepithelial fibrosis, increased smooth muscle mass, angiogenesis and increased mucus secretion, which can lead to chronic and obstinate asthma and can obstruct pulmonary function. In this study, the effects of Bangpungtongseong-san water extract (BPTS) on ...

journal_title：International journal of molecular medicine

authors： Lee MY,Shin IS,Jeon WY,Shin N,Shin HK

更新日期：2014-04-01 00:00:00

abstract：:Histone deacetylase inhibitor (HDAI) induces accumulation of highly acetylated histones by inhibiting the activity of histone deacetylase and inhibits cell proliferation, induces differentiation, and promotes apoptosis. TNF-related apoptosis inducing ligand (TRAIL) induces apoptosis in various human cancer cells, a pr...

journal_title：International journal of molecular medicine

authors： Inoue H,Shiraki K,Ohmori S,Sakai T,Deguchi M,Yamanaka T,Okano H,Nakano T

更新日期：2002-05-01 00:00:00

abstract：:Clinical observations and our high-density oligonucleotide microarray results demonstrated increased expression of proinflammatory chemokines after SARS-CoV infection. Here, we investigated the influence of SARS-CoV infection on CXCL8 (interleukin 8) and CXCL10 (interferon-gamma-inducible protein 10) in human intestin...

journal_title：International journal of molecular medicine

authors： Cinatl J Jr,Michaelis M,Morgenstern B,Doerr HW

更新日期：2005-02-01 00:00:00

abstract：:Many lines of evidence have shown that preproglucagon-derived peptides affect steroid secretion from dispersed adrenocortical cells, and that streptozotocin (STZ)-induced experimental diabetes alters adrenocortical-cell function. Hence, we compared the effects of glucagon, glucagon-like peptide (GLP)-1 and GLP-2 on ba...

journal_title：International journal of molecular medicine

authors： Malendowicz LK,Spinazzi R,Nussdorfer GG,Trejter M

更新日期：2003-07-01 00:00:00

abstract：:After the publication of the above paper, the authors noted that the names of a couple of the authors listed on the paper were associated with the wrong affliation: Specifically, the eighth and ninth listed authors, Francesca Antonaros and Allison Piovesan, are located at DIMES at the University of Florence (fourth af...

journal_title：International journal of molecular medicine

authors： Salvi A,Vezzoli M,Busatto S,Paolini L,Faranda T,Abeni E,Caracausi M,Antonaros F,Piovesan A,Locatelli C,Cocchi G,Alvisi G,De Petro G,Ricotta D,Bergese P,Radeghieri A

更新日期：2019-08-01 00:00:00

abstract：:Tree shrews, one of the closest relatives of primates, have attracted increasing attention as a model of human diseases, particularly for viral infections. As the first line of defense against microbial pathogens, the innate immune system is crucial in tree shrews. Interleukin-6 (IL-6) is important in the pathophysiol...

journal_title：International journal of molecular medicine

authors： Han Y,Sun X,Kuang D,Tong P,Lu C,Wang W,Li N,Chen Y,Wang X,Dai J,Zhang H

更新日期：2017-12-01 00:00:00

abstract：:An effective therapeutic strategy for suppressing liver fibrosis development should improve the overall prognosis of patients with chronic liver diseases. Despite efforts to develop anti-fibrotic agents, no drugs have yet been approved as anti-fibrotic treatments for humans. An alternative strategy may be to employ a ...

journal_title：International journal of molecular medicine

authors： Yoshiji H,Noguchi R,Ikenaka Y,Kaji K,Aihara Y,Shirai Y,Yoshii J,Yanase K,Fukui H

更新日期：2011-07-01 00:00:00

abstract：:Adrenomedullin (ADM) is a hypotensive peptide, that derives from the proteolytic cleavage of pro(p)ADM and acts through two subtypes of receptors, called L1-receptor (L1-R) and calcitonin receptor-like receptor (CRLR). CRLR may function as a calcitonin gene-related peptide or a selective ADM receptor depending on the ...

journal_title：International journal of molecular medicine

authors： Rebuffat P,Forneris ML,Aragona F,Ziolkowska A,Malendowicz LK,Nussdorfer GG

更新日期：2002-02-01 00:00:00

abstract：:The inhibition of the Smad2/3 pathway is a key step involved in the downregulation of type I collagen synthesis, thus preventing keloid formation in tissue. In this study, we investigated the effect of silibinin on the proliferation of human skin fibroblasts (HSFs), as well as its effect on the expression of type I co...

journal_title：International journal of molecular medicine

authors： Cho JW,Il KJ,Lee KS

更新日期：2013-05-01 00:00:00

abstract：:Dyslipidemia is an important risk factor for myocardial infarction (MI). We previously showed that gene polymorphisms associated with MI differed among individuals with different lipid profiles. We further examined whether genetic variants that confer susceptibility to MI might differ among individuals with low or hig...

journal_title：International journal of molecular medicine

authors： Yoshida T,Kato K,Yokoi K,Oguri M,Watanabe S,Metoki N,Yoshida H,Satoh K,Aoyagi Y,Nozawa Y,Yamada Y

更新日期：2010-04-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation and migration has been proven to be a critical event in the development of varicosity. Variations in estrogen levels, a pathological event related to age and pregnancy, play a role in the pathogenesis of varicosity. Previous studies have reported a different response of...

journal_title：International journal of molecular medicine

authors： Huang X,Jin Y,Zhou D,Xu G,Huang J,Shen L

更新日期：2015-05-01 00:00:00

abstract：:Congenital bicuspid aortic valve (BAV) represents the most common type of cardiac birth defect affecting 0.4‑2% of the general population, and accounts for a markedly increased incidence of life‑threatening complications, including valvulopathy and aortopathy. Accumulating evidence has demonstrated the genetic basis o...

journal_title：International journal of molecular medicine

authors： Wang J,Abhinav P,Xu YJ,Li RG,Zhang M,Qiu XB,Di RM,Qiao Q,Li XM,Huang RT,Xue S,Yang YQ

更新日期：2019-04-01 00:00:00

abstract：:Angiogenesis is an important process in several physiological situations and it is also implicated in the development of some diseases such as diabetes and cancer. This study investigated the antiangiogenic potential of Chrysobalanus icaco methanol extract in the chicken embrionary tissue. Clinical trials for cancer t...

journal_title：International journal of molecular medicine

authors： Alves De Paulo S,Teruszkin Balassiano I,Henriques Silva N,Oliveira Castilho R,Coelho Kaplan MA,Currie Cabral M,da Costa Carvalho MG

更新日期：2000-06-01 00:00:00

abstract：:Astragaloside IV is a monomer isolated from Astragalus membranaceus (Fisch.) Bunge, which is one of the most widely used plant-derived drugs in traditional Chinese medicine for diabetes therapy. In the present study, we aimed to examine the effects of astragaloside IV on glucose in C2C12 myotubes and the underlying mo...

journal_title：International journal of molecular medicine

authors： Zhu R,Zheng J,Chen L,Gu B,Huang S

更新日期：2016-06-01 00:00:00

abstract：:Bloom syndrome (BS) is a rare genetic disorder characterized by small body size, photosensitivity, immunodeficiency and a high predisposition to various types of cancer. BLM was identified as the causative gene for BS. The BLM protein is homologous to DNA helicase and has two basic amino acid clusters in its C-termina...

journal_title：International journal of molecular medicine

authors： Hayakawa S,Kaneko H,Fukao T,Kasahara K,Matsumoto T,Furuichi Y,Kondo N

更新日期：2000-05-01 00:00:00

abstract：:Although endogenous digitalis‑like factor (EDLF) is associated with the development of various physical disorders, the role in preeclampsia remains unclear. This study investigated the effects of EDLF on vascular endothelial cell damage in patients with preeclampsia and the potential mechanisms. From July 2014 to July...

journal_title：International journal of molecular medicine

authors： Peng M,Yang M,Ding Y,Yu L,Deng Y,Lai W,Hu Y

更新日期：2018-02-01 00:00:00

abstract：:betaA25-35, a neurotoxic fragment of the Alzheimer beta-amyloid peptide (betaA), acts as a strong inducer of pro-inflammatory cytokines, such as interleukin (IL)-1 and IL-6, in glial cells. Since IL-1 is known to induce expression of both IL-1 and IL-6, we have investigated to what extent the induction of IL-1alpha an...

journal_title：International journal of molecular medicine

authors： Eriksson G,Zetterström M,Cortes Toro V,Bartfai T,Iverfeldt K

更新日期：1998-01-01 00:00:00

abstract：:Synthetic biomaterials combined with cells and osteogenic factors represent a promising approach for the treatment of a number of orthopedic diseases, such as bone trauma and congenital malformations. To guarantee optimal biological properties, bone substitutes are prepared with a 3D structure and porosity grade funct...

journal_title：International journal of molecular medicine

authors： Di Liddo R,Paganin P,Lora S,Dalzoppo D,Giraudo C,Miotto D,Tasso A,Barbon S,Artico M,Bianchi E,Parnigotto PP,Conconi MT,Grandi C

更新日期：2014-12-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC), a tumor arising from the epithelial cells of the nasopharynx, is endemic in Southeast Asia and Taiwan. The prognosis of NPC patients with local recurrence and metastasis is poor. Resistance to anoikis is a primary characteristic of tumor cells that metastasize. However, the mechanism th...

journal_title：International journal of molecular medicine

authors： Lin CH,Chiang MC,Chen YJ

更新日期：2017-11-01 00:00:00

abstract：:The relationship between cell proliferation, protein tyrosine phosphorylation, phosphotyrosine kinase activity and bradykinin receptor activation in rat mesangial cells was investigated. We demonstrated that bradykinin (BK), through the B2 receptor, induced a dose-dependent inhibition of mesangial cell proliferation s...

journal_title：International journal of molecular medicine

authors： Alric C,Pecher C,Schanstra JP,Bascands JL,Girolami JP

更新日期：2000-01-01 00:00:00

abstract：:We examined whether generation of H2O2 is a critical event for the apoptotic pathway upstream of mitochondrial involvement and caspase-3 protease activation. Perylquinone photosensitizers such as Hypocrellin A (HA), Hypocrellin B (HB) and Hypericin (HY) induced activation of caspase-3 and apoptosis upon photoactivatio...

journal_title：International journal of molecular medicine

authors： Ali SM,Chee SK,Yuen GY,Olivo M

更新日期：2002-05-01 00:00:00

abstract：:CDC25A is a cell cycle-activating phosphatase that promotes transition from the G1 to S phase. We previously reported that overexpression of CDC25A in human hepatocellular carcinoma (HCC) tissue samples was associated with poor prognosis. In this study, we attempted suppression of CDC25A in HCC cells to elucidate the ...

journal_title：International journal of molecular medicine

authors： Xu X,Yamamoto H,Liu G,Ito Y,Ngan CY,Kondo M,Nagano H,Dono K,Sekimoto M,Monden M

更新日期：2008-02-01 00:00:00

abstract：:The elevation of natural killer cell activity (NKCA) by laughter was not confirmed due to incomplete methodology of previous studies although positive emotion is believed to be favorable for health. To verify NKCA elevation by laughter in a crossover design, we measured NKCA before and after watching films, presenting...

journal_title：International journal of molecular medicine

authors： Takahashi K,Iwase M,Yamashita K,Tatsumoto Y,Ue H,Kuratsune H,Shimizu A,Takeda M

更新日期：2001-12-01 00:00:00

abstract：:Celastrol, a natural biologically active compound isolated from Tripterygium wilfordii Hook F root extracts, has been shown to possess antitumor properties and therefore, is an interesting candidate for the development of novel chemotherapeutic cancer agents. In this study, we have demonstrated that Celastrol is a pot...

journal_title：International journal of molecular medicine

authors： Huang L,Zhang Z,Zhang S,Ren J,Zhang R,Zeng H,Li Q,Wu G

更新日期：2011-03-01 00:00:00

abstract：:The human prostate-specific antigen (PSA) and glandular kallikrein-1 (hGK-1, also known as hK2) genes are tandemly located on chromosome 19, separated by a 12-kb intergenic region. The coordinate regulation of these two genes suggests the presence of common regulatory elements responsible for tissue specificity and/or...

journal_title：International journal of molecular medicine

authors： Wei C,Callahan BP,Turner MJ,Willis RA,Lord EM,Barth RK,Frelinger JG

更新日期：1998-10-01 00:00:00

abstract：:In our previous study, the proliferation rate of esophageal squamous cell carcinoma cell lines, which poorly expressed p21Waf1, was found to be regulated by p21Waf1 gene transfection using adenovirus vector. In the present study, in order to examine the effect of p21Waf1 gene therapy in esophageal cancer, we used gene...

journal_title：International journal of molecular medicine

authors： Tanaka Y,Fujii T,Yamana H,Kato S,Morimatsu M,Shirouzu K

更新日期：2004-10-01 00:00:00

abstract：:Zinc has been shown to have an inhibitory effect on osteoclastic bone resorption in vitro. This study was undertaken to determine whether the inhibitory action of zinc on osteoclastogenesis is related to receptor activator of NF-kappaB ligand (RANKL), which plays a pivotal role in differentiation from pre-osteoclasts ...

journal_title：International journal of molecular medicine

authors： Yamaguchi M,Uchiyama S

更新日期：2004-07-01 00:00:00

abstract：:The efficacy of the most commonly used form of suicide gene therapy, the HSV-TK/GCV method, utilizing herpes simplex virus thymidine kinase (HSV-TK) and antiviral drug ganciclovir (GCV) has been demonstrated in clinical trials. However, safer delivery of the therapeutic gene and more controlled regulation of the trans...

journal_title：International journal of molecular medicine

authors： Määttä AM,Korja S,Venhoranta H,Hakkarainen T,Pirinen E,Heikkinen S,Pellinen R,Mäkinen K,Wahlfors J

更新日期：2006-11-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease with unknown etiology and undefined treatment modality. Fibroblasts are regarded as the major cell type that mediates the onset and progression of lung fibrosis by secreting large amounts of extracellular matrix (ECM) proteins, ...

journal_title：International journal of molecular medicine

authors： Zhang L,Li Y,Liang C,Yang W

更新日期：2014-02-01 00:00:00