Hypocrellins and Hypericin induced apoptosis in human tumor cells: a possible role of hydrogen peroxide.

abstract：:Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus. It can cause adult T cell leukemia (ATL) and other diseases. The HTLV-1 basic leucine zipper (bZIP) factor (HBZ), which is encoded by the minus-strand of the provirus, is expressed in all cases of ATL and involved in T cell proliferation. However,...

journal_title：International journal of molecular medicine

authors： Ma Y,Zhang B,Wang D,Qian L,Song X,Wang X,Yang C,Zhao G

更新日期：2017-03-01 00:00:00

abstract：:Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by aberrant tau protein hyperphosphorylation, which eventually leads to the formation of neurofibrillary tangles. Hyperphosphorylated tau protein is considered as a vital factor in the development of AD and is highly associated with cognitiv...

journal_title：International journal of molecular medicine

authors： Shen XY,Luo T,Li S,Ting OY,He F,Xu J,Wang HQ

更新日期：2018-02-01 00:00:00

abstract：:Hypertension impairs the morphological and functional integrity of circulation. Previous research has shown that the loss of endothelial cells (ECs) is a common event in many cardiovascular diseases. p120 catenin (p120ctn) plays an important role in the regulation of inflammatory responses in ECs. However, the functio...

journal_title：International journal of molecular medicine

authors： Zhang Y,Zou C,Yang S,Fu J

更新日期：2016-03-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) alpha, delta and gamma are nuclear transcription factors that control key genes involved in fatty acid metabolism and energy homeostasis. Little is known about PPAR activation in vivo and the existence of overlapping functions between PPARalpha, -delta and -gamma. As...

journal_title：International journal of molecular medicine

authors： Kannisto K,Chibalin A,Glinghammar B,Zierath JR,Hamsten A,Ehrenborg E

更新日期：2006-01-01 00:00:00

abstract：:Propofol is a commonly used drug for the induction and maintenance of anesthesia. Previous studies have reported that propofol is involved in the progression of numerous human cancer types, including hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms in HCC are yet to be elucidated. The prese...

journal_title：International journal of molecular medicine

authors： Song F,Liu J,Feng Y,Jin Y

更新日期：2020-09-01 00:00:00

abstract：:We have recently established a clonal mesenchymal stem cell line (rBM25/S3) from adult rat bone marrow. The cells have practically unlimited proliferation capacity (over 300 PDL), maintaining multipotency for differentiation. In the present study, we examined the potential for rBM25/S3 cells to differentiate into insu...

journal_title：International journal of molecular medicine

authors： Masaka T,Miyazaki M,Du G,Hardjo M,Sakaguchi M,Takaishi M,Kataoka K,Yamamoto K,Huh NH

更新日期：2008-10-01 00:00:00

abstract：:The aetiological agent of chronic hepatitis C is the hepatitis C virus. The hepatitis C virus is spread by parenteral transmission of body fluids, primarily blood or blood products. In 1989, after more than a decade of research, HCV was isolated and characterised. The hepatitis C viral genome is a positive-sense, sing...

journal_title：International journal of molecular medicine

authors： Fanning LJ

更新日期：2002-02-01 00:00:00

abstract：:The miR-200 family was recently identified as a suppressor of epithelial-mesenchymal transition (EMT). The loss or gain of miR-200 family members is associated with cancer invasion. The epidermal growth factor receptor (EGFR) is overexpressed in the majority of anaplastic thyroid cancers (ATCs). The activation of EGFR...

journal_title：International journal of molecular medicine

authors： Zhang Z,Liu ZB,Ren WM,Ye XG,Zhang YY

更新日期：2012-10-01 00:00:00

abstract：:To estimate the genetic and dietary factors influencing bone mineral density (BMD) in young adults, a total of 53 healthy volunteers (HV) (age 20.89+/-1.34), from whom informed consent was obtained, answered a questionnaire on dietary factors and had DNA from peripheral blood mononuclear cells analyzed for single nucl...

journal_title：International journal of molecular medicine

authors： Otsuki T,Sakaguchi H,Hatta E,Hatayama T,Hatada S,Miura Y,Takata-Tomokuni A,Hyodoh F,Tomomitsu T,Fukunaga M,Katsuyama H

更新日期：2004-10-01 00:00:00

abstract：:Although diabetes mellitus has been recognized as a risk factor for chronic kidney disease (CKD), genetic factors for predisposition to CKD in individuals with diabetes mellitus remain elucidated. The purpose of the present study was to identify genetic variants that confer susceptibility to CKD among individuals with...

journal_title：International journal of molecular medicine

authors： Yoshida T,Kato K,Yokoi K,Watanabe S,Metoki N,Yoshida H,Satoh K,Aoyagi Y,Nishigaki Y,Suzuki T,Nozawa Y,Yamada Y

更新日期：2009-04-01 00:00:00

abstract：:Needle biopsy is widely used to obtain specimens for physiological, anatomical and biochemical studies of skeletal muscle (SM). We optimized a procedure which we termed tiny percutaneous needle biopsy (TPNB), to efficiently gather good numbers of human satellite cells and single dissociated fibers for the functional s...

journal_title：International journal of molecular medicine

authors： Pietrangelo T,D'Amelio L,Doria C,Mancinelli R,Fulle S,Fanò G

更新日期：2011-03-01 00:00:00

abstract：:Synovial membrane consists of fibroblasts and macrophages forming the synovial lining supported by vascularized subsynovium. Each of these components may specifically react to a particular stimulus. Thus, reactions of isolated synovial cells may not correspond to that of intact tissue. We characterized the production ...

journal_title：International journal of molecular medicine

authors： Hyc A,Osiecka-Iwan A,Niderla-Bielinska J,Jankowska-Steifer E,Moskalewski S

更新日期：2009-10-01 00:00:00

abstract：:Trichostatin A (TSA), a histone deacetylase inhibitor, is widely used as an anticancer drug. Recently, TSA has been shown to exert a protective effect on ischemia/reperfusion (I/R) injury; however, the underlying mechanisms remain unclear. Forkhead box O3a (FoxO3a), a unique FoxO family member, has been shown to atten...

journal_title：International journal of molecular medicine

authors： Guo Y,Li Z,Shi C,Li J,Yao M,Chen X

更新日期：2017-10-01 00:00:00

abstract：:Osteoarthritis (OA) is a chronic disease that results in chronic arthralgia and functional disability of the affected joint. To date, there is no effective treatment available for this disease. Circular RNAs (circRNAs) are a type of intracellular stable RNA that can regulate the development and progression of OA. Howe...

journal_title：International journal of molecular medicine

authors： Xiao J,Wang R,Zhou W,Cai X,Ye Z

更新日期：2021-01-01 00:00:00

abstract：:Temozolomide (TMZ) is an alkylating agent commonly used as a first‑line treatment for high‑grade glioblastoma. However, TMZ has short half‑life and frequently induces tumor resistance, which can limit its therapeutic efficiency. In the present study, it was hypothesized that combined treatment with TMZ and acteoside h...

journal_title：International journal of molecular medicine

authors： Hwang TW,Kim DH,Kim DB,Jang TW,Kim GH,Moon M,Yoon KA,Choi DE,Park JH,Kim JJ

更新日期：2019-03-01 00:00:00

abstract：:DNA microarrays, which are among the most popular genomic tools, are widely applied in biology and medicine. Boutique arrays, which are small, spotted, dedicated microarrays, constitute an inexpensive alternative to whole-genome screening methods. The data extracted from each microarray-based experiment must be transf...

journal_title：International journal of molecular medicine

authors： Uszczyńska B,Zyprych-Walczak J,Handschuh L,Szabelska A,Kaźmierczak M,Woronowicz W,Kozłowski P,Sikorski MM,Komarnicki M,Siatkowski I,Figlerowicz M

更新日期：2013-09-01 00:00:00

abstract：:Administration of a single acute intravenous injection of interleukin-15 (IL-15) (100 microg/kg bw) to rats resulted in a significant decrease (22%) in triacylglycerol absorption, as measured by using [14C]-triolein load. The cytokine, however, did not influence the oxidation of the exogenously administered lipid or t...

journal_title：International journal of molecular medicine

authors： Almendro V,Carbó N,Busquets S,López-Soriano J,Figueras M,Ametller E,Argilés JM,López-Soriano FJ

更新日期：2005-06-01 00:00:00

abstract：:A variety of microRNAs (miRNAs) have been reported to be significantly be involved in the regulation of vascular smooth muscle cell (VSMC) proliferation, which is an essential process for the formation of atherosclerotic plaque. The objective of the present study was to explore the role of microRNA-155 (miR-155) in th...

journal_title：International journal of molecular medicine

authors： Zhang J,Zhao F,Yu X,Lu X,Zheng G

更新日期：2015-06-01 00:00:00

abstract：:We examined the P16 expression by immunohistochemical stain and detected the methylation by methylation specific polymerase chain reaction (MSP) in 48 primary oral squamous cell carcinoma (SCC) tissues. The results showed that 20/48 (41.7%) of cancerous tissues had CpG methylation around the promoter region, but 8/48 ...

journal_title：International journal of molecular medicine

authors： Huang MJ,Yeh KT,Shih HC,Wang YF,Lin TH,Chang JY,Shih MC,Chang JG

更新日期：2002-11-01 00:00:00

abstract：:Although the upregulation of enhancer of zeste homolog 2 (EZH2) expression and downregulation of long non-coding RNA (lncRNA) LET expression are known to be associated with cell apoptosis and proliferation, little is known about the interaction of EZH2 with lncRNA LET. The present study aimed to investigate the intera...

journal_title：International journal of molecular medicine

authors： Zheng W,Yu A

更新日期：2018-04-01 00:00:00

abstract：:The active fraction of the extract of Asiasari radix, the 60% methanol chromatographic fraction from the ethyl acetate layer (PPAR), was used to investigate the melanogenesis signal pathway in B16F10 melanoma cells. PPAR led to significantly decreased melanin synthesis and tyrosinase activity in a dose-dependent manne...

journal_title：International journal of molecular medicine

authors： Jang JY,Lee JH,Shin HK,Choi YH,Lee JD,Choi BT

更新日期：2010-02-01 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease characterized by areas of inflammation, demyelination and axonal damage. The etiology of MS is multifactorial with an interaction between genetic, environmental and geographical factors. The objective of this study was to review the physiopathology and the genetic polym...

journal_title：International journal of molecular medicine

authors： Kallaur AP,Kaimen-Maciel DR,Morimoto HK,Watanabe MA,Georgeto SM,Reiche EM

更新日期：2011-10-01 00:00:00

abstract：:Glucosamine, a naturally occurring amino monosaccharide, is widely used to treat osteoarthritis in humans. Furthermore, glucosamine exhibits an anti-inflammatory action by inhibiting the activation of neutrophils, chondrocytes and synoviocytes. Recently, we revealed that glucosamine suppresses cytokine-induced activat...

journal_title：International journal of molecular medicine

authors： Yomogida S,Kojima Y,Tsutsumi-Ishii Y,Hua J,Sakamoto K,Nagaoka I

更新日期：2008-09-01 00:00:00

abstract：:The relationship between cell proliferation, protein tyrosine phosphorylation, phosphotyrosine kinase activity and bradykinin receptor activation in rat mesangial cells was investigated. We demonstrated that bradykinin (BK), through the B2 receptor, induced a dose-dependent inhibition of mesangial cell proliferation s...

journal_title：International journal of molecular medicine

authors： Alric C,Pecher C,Schanstra JP,Bascands JL,Girolami JP

更新日期：2000-01-01 00:00:00

abstract：:Acidic pH is frequently used to inactivate viruses. We have previously shown that arginine synergizes with low pH in enhancing virus inactivation. Considering a potential application of the acid inactivation of viruses for the prevention and treatment of superficial virus infection at body surfaces and fixtures, herei...

journal_title：International journal of molecular medicine

authors： Nishide M,Tsujimoto K,Uozaki M,Ikeda K,Yamasaki H,Koyama AH,Arakawa T

更新日期：2011-06-01 00:00:00

abstract：:The family of chromosomal high mobility group I/Y consists of proteins involved in gene regulation and chromatin organization. A common feature of these proteins is the presence of multiple copies of DNA binding domains (DBD), the so-called AT-hooks. Bi- or tridendate interaction of two or three DBDs with appropriatel...

journal_title：International journal of molecular medicine

authors： Wisniewski JR,Schwanbeck R

更新日期：2000-10-01 00:00:00

abstract：:Atherosclerotic plaque growth requires angiogenesis, and acute coronary syndrome (ACS) is usually triggered by the rupture of unstable atherosclerotic plaques. Previous studies have identified typically circulating microRNA (miRNA/miR) profiles in patients with ACS. miRNAs serve important roles in the pathophysiology ...

journal_title：International journal of molecular medicine

authors： Li S,Geng Q,Chen H,Zhang J,Cao C,Zhang F,Song J,Liu C,Liang W

更新日期：2018-02-01 00:00:00

abstract：:Tubular atrophy and dysfunction is a critical process underlying diabetic nephropathy (DN). Understanding the mechanisms underlying renal tubular epithelial cell survival is important for the prevention of kidney failure associated with glucotoxicity. Autophagy is a cellular pathway involved in protein and organelle d...

journal_title：International journal of molecular medicine

authors： Zhao X,Liu G,Shen H,Gao B,Li X,Fu J,Zhou J,Ji Q

更新日期：2015-03-01 00:00:00

abstract：:We are interested in the possibility of a new prostate cancer therapy that would control tumor malignancy via induction of terminal cell differentiation. We previously reported that 12-O-tetra-decanoylphorbol-13-acetate (TPA) induces differentiation into cells with characteristics of microglia and decreases the malign...

journal_title：International journal of molecular medicine

authors： Suzuki T,Shimizu T,Satoh K,Sugibayashi R,Takeda K

更新日期：2002-12-01 00:00:00

abstract：:Transporters such as P-glycoprotein (MDR1), multidrug resistance protein 1 (MRP1), lung resistance-related protein (LRP) and breast cancer resistance protein (BCRP) are associated with multidrug resistance in various carcinoma cell lines. The expression of these molecules has been also characterized in human normal ti...

journal_title：International journal of molecular medicine

authors： Takebayashi Y,Nakayama K,Fujioka T,Kanzaki A,Mutho M,Uchida T,Miyazaki K,Ito M,Fukumoto M

更新日期：2001-04-01 00:00:00