Glucosamine, a naturally occurring amino monosaccharide, suppresses dextran sulfate sodium-induced colitis in rats.

abstract：:p63, a recently identified member of the p53 gene family, plays an important role in human tissue functions. We examined the pattern of p63 expression in human esophageal squamous cell carcinomas including early-stage cancers, and its clinicopathological significance. Immunoreactivity for p63 was detected in 96.9% (63...

journal_title：International journal of molecular medicine

authors： Hara T,Kijima H,Yamamoto S,Kenmochi T,Kise Y,Tanaka H,Chino O,Shimada H,Takazawa K,Tanaka M,Inokuchi S,Makuuchi H

更新日期：2004-08-01 00:00:00

abstract：:The activation of the classical angiotensin (Ang)-converting enzyme (ACE)/Ang II/Ang II type 1 receptor (AT1R) axis of the renin-angiotensin system (RAS) has been associated with islet dysfunction and insulin resistance. Hyperglycaemia, hypertension and obesity, major components of metabolic syndrome, are all associat...

journal_title：International journal of molecular medicine

authors： Härdtner C,Mörke C,Walther R,Wolke C,Lendeckel U

更新日期：2013-10-01 00:00:00

abstract：:The skin, the conjunctivae, the airways and the digestive tract compose a huge vulnerable biological surface, which is exposed to the external environment. An allergen can often trigger an allergic reaction at a number of sites or result in an atopic march. However, the mechanism of atopic march remains unclear. Less ...

journal_title：International journal of molecular medicine

authors： Luo J,Li Y,Gong R

更新日期：2010-12-01 00:00:00

abstract：:The uptake of D-[3H]mannoheptulose by isolated pancreatic islets was recently proposed as a tool to assess the relative contribution of insulin-producing cells to the total mass of the islets. In the present study, the uptake of the tritiated heptose over 60 min incubation at 37 degrees C was about 21% lower in islets...

journal_title：International journal of molecular medicine

authors： Sener A,Ladriere L,Malaisse WJ

更新日期：2001-08-01 00:00:00

abstract：:The aim of the present study was to determine whether osteoprotegerin (OPG) influences the bone resorption activity of osteoclasts. RAW264.7 cells were induced by macrophage colony-stimulating factor (M-CSF) + receptor activator of nuclear factor-κB ligand (RANKL) and 0, 10, 20, 50 and 100 ng/ml OPG were added into va...

journal_title：International journal of molecular medicine

authors： Fu YX,Gu JH,Zhang YR,Tong XS,Zhao HY,Yuan Y,Liu XZ,Bian JC,Liu ZP

更新日期：2013-06-01 00:00:00

abstract：:Numerous studies have demonstrated the antioxidant effects of grape seed proanthocyanidin extract (GSPE). The generation of free radicals and the ensuing apoptosis may contribute to the pathogenesis of epilepsy; therefore, in the present study, we examined the effects of GSPE on cognitive impairment and neuronal damag...

journal_title：International journal of molecular medicine

authors： Zhen J,Qu Z,Fang H,Fu L,Wu Y,Wang H,Zang H,Wang W

更新日期：2014-08-01 00:00:00

abstract：:DJ-1 plays roles in transcriptional regulation and anti-oxidative stress, and loss of its function is thought to result in the onset of Parkinson's disease. DJ-1 has a protease-like structure and transthyretin (TTR), a protein causing familial amyloidotic polyneuropathy (FAP), was identified as a substrate for DJ-1 pr...

journal_title：International journal of molecular medicine

authors： Koide-Yoshida S,Niki T,Ueda M,Himeno S,Taira T,Iguchi-Ariga SM,Ando Y,Ariga H

更新日期：2007-06-01 00:00:00

abstract：:Prostate cancer is among the most common tumors in industrialized nations. However, little is known about the molecular events underlying its development. In the present study we used suppressive subtraction hybridization (SSH) in combination with laser-assisted microdissection in order to compare gene expression betw...

journal_title：International journal of molecular medicine

authors： Ko Y,Hahn T,Lu H,Ma ZL,Chen J,Rothe M,Florin A,Fronhoffs S,Albers P,Sachinidis A,Vetter H,Kaminski A,Behrens P,Wellmann A,Wernert N

更新日期：2005-02-01 00:00:00

abstract：:Fibrosarcoma is an aggressive and highly metastatic cancer of the connective tissue, for which effective therapeutic methods are limited. Recently, there has been a renewed interest in small molecular compounds from natural products in the treatment of cancer. In the present study, we investigated the compound, scutel...

journal_title：International journal of molecular medicine

authors： Shi X,Chen G,Liu X,Qiu Y,Yang S,Zhang Y,Fang X,Zhang C,Liu X

更新日期：2015-01-01 00:00:00

abstract：:Rosiglitazone has been found to have anti-atherogenic effects and to increase serum high-density lipoprotein (HDL) cholesterol (HDL-C) levels. However, in vivo studies investigating the regulation of adenosine triphosphate-binding cassette transporter A1 (ABCA1) and scavenger receptor class B type I (SR-BI) by rosigli...

journal_title：International journal of molecular medicine

authors： Li C,Tu Y,Liu TR,Guo ZG,Xie D,Zhong JK,Fan YZ,Lai WY

更新日期：2015-03-01 00:00:00

abstract：:Overconsumption of fats and sugars is a major cause of development of non‑alcoholic fatty liver disease (NAFLD). The main objectives of the present study were to explore the pathways sustaining the interfering metabolic effects of excess fructose and fatty acids in hepatocytes, and to clarify the mechanisms through wh...

journal_title：International journal of molecular medicine

authors： Grasselli E,Baldini F,Vecchione G,Oliveira PJ,Sardão VA,Voci A,Portincasa P,Vergani L

更新日期：2019-08-01 00:00:00

abstract：:A preceding hypoxic insult can sensitize the cells or the organism to a subsequent, second insult. The aim of the present study was to investigate the molecular mechanism of this phenomenon (often termed 'two-hit' injury paradigm), in an in vitro model of hypoxia/oxidative stress injury in A549 epithelial cells, with ...

journal_title：International journal of molecular medicine

authors： Erdélyi K,Pacher P,Virág L,Szabó C

更新日期：2013-08-01 00:00:00

abstract：:The kallikrein-kinin system (KKS) is a complex multi-enzyme system which is composed of circulating and tissue kallikrein and kinin. It is well established that tissue kallikrein and kinin play crucial and diverse roles in cardiovascular and renal homeostasis. Recent data indicate t...

journal_title：International journal of molecular medicine

authors： Xu X,Tu L,Jiang W,Feng W,Zhao CX,Wang DW

更新日期：2012-05-01 00:00:00

abstract：:Icariin (ICA) and icaritin (ICT), with a similar structure to genistein, are the important bioactive components of the genus Epimedium, and regulate many cellular processes. In the present study, using the estrogen receptor (ER)-negative breast cancer cell line, SKBr3, as a model, we examined the hypothesis that ICA a...

journal_title：International journal of molecular medicine

authors： Ma HR,Wang J,Chen YF,Chen H,Wang WS,Aisa HA

更新日期：2014-06-01 00:00:00

abstract：:Fas antigen, also termed APO-1 or CD95, is a transmembrane protein and a member of the tumor necrosis factor receptor/nerve growth factor receptor superfamily which mediates apoptosis upon oligomerization. The Fas/Fas ligand system is considered to be a key regulator of apoptosis. Recently, we have demonstrated that F...

journal_title：International journal of molecular medicine

authors： Ogawa Y,Nishioka A,Kubonishi I,Inomata T,Yoshida S,Kataoka S

更新日期：1998-10-01 00:00:00

abstract：:Melatonin is known to reduce the growth of endocrine-responsive breast cancers by interacting with estrogen signaling pathways. Estrogens play an important role in breast cancer, but also in various types of tissues, including vascular tissue. Estrogen sulfatase (STS) converts inactive estrogen sulfates into active es...

journal_title：International journal of molecular medicine

authors： González A,Martínez-Campa C,Alonso-González C,Cos S

更新日期：2015-12-01 00:00:00

abstract：:Platinum compounds induce their cytotoxic effect by binding to a DNA molecule in the form of a platinum-DNA-adduct. Many previous studies have shown that the level of platinum-DNA-adduct correlats with response to platinum-based chemotherapy. Although the mechanism of platinum resistance in vivo is not clearly underst...

journal_title：International journal of molecular medicine

authors： Altaha R,Liang X,Yu JJ,Reed E

更新日期：2004-12-01 00:00:00

abstract：:Bisphosphonates consist of a family of pyrophosphate analogues that are currently being used to treat metastatic bone diseases as well as systemic bone diseases such as osteoporosis. There is accumulating evidence suggesting that patients treated with these bisphosphonates can develop, particularly with invasive denta...

journal_title：International journal of molecular medicine

authors： Rao MV,Berk J,Almojaly SA,Goodloe Iii S,Margarone Iii J,Sullivan M,Dziak R

更新日期：2009-03-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation and migration has been proven to be a critical event in the development of varicosity. Variations in estrogen levels, a pathological event related to age and pregnancy, play a role in the pathogenesis of varicosity. Previous studies have reported a different response of...

journal_title：International journal of molecular medicine

authors： Huang X,Jin Y,Zhou D,Xu G,Huang J,Shen L

更新日期：2015-05-01 00:00:00

abstract：:Autologous chondrocyte implantation (ACI) relies on the use of cultured cells. However, the biosynthetic profile of cultured chondrocytes is shown to be altered during in vitro expansion. The purpose of this study therefore, was to examine the cellular phenotype of chondrocytes cultured for ACI and to determine the ap...

journal_title：International journal of molecular medicine

authors： Zheng MH,King E,Kirilak Y,Huang L,Papadimitriou JM,Wood DJ,Xu J

更新日期：2004-05-01 00:00:00

abstract：:Osteoarthritis (OA) is a chronic disease that results in chronic arthralgia and functional disability of the affected joint. To date, there is no effective treatment available for this disease. Circular RNAs (circRNAs) are a type of intracellular stable RNA that can regulate the development and progression of OA. Howe...

journal_title：International journal of molecular medicine

authors： Xiao J,Wang R,Zhou W,Cai X,Ye Z

更新日期：2021-01-01 00:00:00

abstract：:Reperfusion injury (RI) remains an important limitation of myocardial revascularization. The aim of the present study was to evaluate the influence of the intracoronary injection of adiponectin on RI and cardiomyocyte death in a porcine myocardial infarction model. Acute infarction in 14 Polish domestic pigs was induc...

journal_title：International journal of molecular medicine

authors： Dębiński M,Buszman PP,Milewski K,Wojakowski W,Jackiewicz W,Pająk J,Szurlej D,Fryc-Stanek J,Wiernek S,Jelonek M,Spurlock ME,Martin J,Bochenek A,Buszman PE

更新日期：2011-06-01 00:00:00

abstract：:Non‑alcoholic fatty liver disease (NAFLD) is the consequence of insulin resistance, fatty acid accumulation, oxidative stress and lipotoxicity. The present study aimed to elucidate the effect of Quaking 5 (QKI 5) as mediated by Sirtuin 1 (SIRT1) on triglyceride (TG) synthesis in the liver of an NAFLD mouse model. A hi...

journal_title：International journal of molecular medicine

authors： Zhang W,Sun Y,Liu W,Dong J,Chen J

更新日期：2019-03-01 00:00:00

abstract：:Mitogen‑activated protein kinase‑activated protein kinase 2 (MK2) and its mediated inflammation are involved in various diseases, including spinal cord injury (SCI). Ultrashortwave (USW) radiation has previously been reported to exert a protective effect on SCI. In the present study, through a series of reverse transc...

journal_title：International journal of molecular medicine

authors： Wang N,Feng Z,Zhao W,Zhang Z,Zhang L

更新日期：2018-10-01 00:00:00

abstract：:Bladder cancer (BC) is one of the most common malignant tumors in males globally. Its progression imposes a heavy burden on patients; however, the expression profile of circular (circ)RNAs in BC progression remains unclear. This study explored changes in circRNA expression during BC progression by sequencing different...

journal_title：International journal of molecular medicine

authors： Li W,Li Y,Sun Z,Zhou J,Cao Y,Ma W,Xie K,Yan X

更新日期：2019-11-01 00:00:00

abstract：:Retinoic acid (RA) analogs have been used in the treatment of a variety of cancers; however, their application is limited due to serious therapy-related sequelae. In the present study, the effects of a novel RA analog, 4-amino-2-trifluoromethyl-phenyl retinate (ATPR), on the growth of gastric cancer cells were evaluat...

journal_title：International journal of molecular medicine

authors： Hu KW,Pan XH,Chen FH,Qin R,Wu LM,Zhu HG,Wu FR,Ge JF,Han WX,Yin CL,Li HJ

更新日期：2014-02-01 00:00:00

abstract：:The present study investigated the mechanism underlying the effects of glucosamine (GlcN) on the proliferation of chondrocytes isolated from the knee cartilage of Sprague‑Dawley rats. Chondrocytes were treated with various concentrations of GlcN or without GlcN. The effects of GlcN on chondrocyte proliferation were de...

journal_title：International journal of molecular medicine

authors： Ma Y,Zheng W,Chen H,Shao X,Lin P,Liu X,Li X,Ye H

更新日期：2018-07-01 00:00:00

abstract：:White blood cell (WBC) count is considered a prognostic risk factor in acute myeloid leukemia. As density of leukemic cells increases, the cytotoxic activity of certain anticancer drugs, such as vincristine and doxorubicin, progressively decreases. In this study, we investigated the cell density-dependent induction of...

journal_title：International journal of molecular medicine

authors： Navrátilová J,Jungová P,Vanhara P,Preisler J,Kanicky V,Smarda J

更新日期：2009-11-01 00:00:00

abstract：:A female patient (64 years of age; body mass index, 26) had a markedly and relatively low low-density lipoprotein-cholesterol (LDL-C) level (97 mg/dl) despite high serum total cholesterol (TC) (331 mg/dl) and triacylglyceride levels (307 mg/dl). Since the expected LDL-C was 222 mg/dl, there was a significant differenc...

journal_title：International journal of molecular medicine

authors： Lee JH,Park JH,Lee SH,Kim JR,Cho KH

更新日期：2010-06-01 00:00:00

abstract：:The molecular mechanisms mediating mercury‑induced neurotoxicity are not yet completely understood. Thus, the aim of this study was to investigate whether the severity of MeHg‑ and HgCl2‑mediated cytotoxicity to SH‑SY5Y human dopaminergic neurons can be attenuated by regulating glutamate‑mediated signal‑transmission t...

journal_title：International journal of molecular medicine

authors： Engin AB,Engin ED,Golokhvast K,Spandidos DA,Tsatsakis AM

更新日期：2017-05-01 00:00:00