A novel component of the ubiquitin pathway, ubiquitin carboxyl extension protein 1 is overexpressed in prostate cancer.

abstract：:Atopic dermatitis (AD) shows an increased susceptibility to Staphylococcus aureus infection partly due to decreased expression of human beta-defensin-2 (HBD-2). Interestingly, it was reported that the nasal carrier S. aureus down-regulates the expression of HBD-2 and -3, thereby the carrier strains of S. aureus retain...

journal_title：International journal of molecular medicine

authors： Cho JW,Cho SY,Lee KS

更新日期：2009-03-01 00:00:00

abstract：:Curcumin is an orange-yellow colored, lipophilic polyphenol substance derived from the rhizome of Curcuma longa that is widely used in many countries. Curcumin has many reported functions, including antioxidant and anti‑inflammatory effects. Autophagy removes damaged organelles and protein aggregates in the cell. Howe...

journal_title：International journal of molecular medicine

authors： Wang JL,Wang JJ,Cai ZN,Xu CJ

更新日期：2018-11-01 00:00:00

abstract：:Tree shrews, one of the closest relatives of primates, have attracted increasing attention as a model of human diseases, particularly for viral infections. As the first line of defense against microbial pathogens, the innate immune system is crucial in tree shrews. Interleukin-6 (IL-6) is important in the pathophysiol...

journal_title：International journal of molecular medicine

authors： Han Y,Sun X,Kuang D,Tong P,Lu C,Wang W,Li N,Chen Y,Wang X,Dai J,Zhang H

更新日期：2017-12-01 00:00:00

abstract：:Rac1, an intracellular signal transducer, regulates a variety of cell functions, including the organization of the cytoskeleton, cell migration, and invasion. Overexpression of Rac1 has been reported in several human cancers. However, the underlying mechanisms are not well understood. In the present study, we evaluate...

journal_title：International journal of molecular medicine

authors： Chen QY,Xu LQ,Jiao DM,Yao QH,Wang YY,Hu HZ,Wu YQ,Song J,Yan J,Wu LJ

更新日期：2011-11-01 00:00:00

abstract：:Recently, naringin (NAR; 4',5,7-trihydroxyflavanone-7-rhamnoglucoside) has been shown to have cardioprotective properties. However, the specific mechanisms underlying its cardioprotective effects remain unclear. In this study, we aimed to investigate the cardioprotective effects of NAR and the possible underlying mole...

journal_title：International journal of molecular medicine

authors： Huang H,Wu K,You Q,Huang R,Li S,Wu K

更新日期：2013-08-01 00:00:00

abstract：:The purpose of the present study was to investigate whether bone marrow mesenchymal stem cells (BMMSCs) modified by CXC‑chemokine receptor type 3 (CXCR3) and heme oxygenase‑1 (HO‑1) genes can repair damaged intestinal epithelial cells in vitro, and the role of the p38 mitogen‑activated protein kinase (p38‑MAPK) pathwa...

journal_title：International journal of molecular medicine

authors： Yin M,Shen Z,Yang L,Zheng W,Song H

更新日期：2019-05-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) are a cell population mobilized from bone marrow into the peripheral circulation and recruited into sites of vessel injury to participate in blood vessel formation in both physiological and pathological conditions. Due to the lack of unique surfac...

journal_title：International journal of molecular medicine

authors： Li DW,Liu ZQ,Wei J,Liu Y,Hu LS

更新日期：2012-11-01 00:00:00

abstract：:Substantial evidence has indicated that osteoblastic differentiation may be regulated by mechanical loads or bone morphogenetic protein-2 (BMP-2). BMP-2-induced in vivo osteogenesis can be significantly enhanced in the presence of mechanical stimuli, revealing the therapeutic potential of the combined application of B...

journal_title：International journal of molecular medicine

authors： Zeng Z,Yin X,Zhang X,Jing D,Feng X

更新日期：2015-11-01 00:00:00

abstract：:We have previously reported that the EVn-50 mixture of vitexins (lignan compounds) containing the purified vitexin (neolignan) compound, 6-hydroxy-4(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl‑7-methoxy-3,4-dihydro-2-naphthaldehyde, termed VB1, exhibits potent anticancer activity through the induction of apoptosis in s...

journal_title：International journal of molecular medicine

authors： Liu LH,Zhou YJ,Ding L,Zhang SZ,Sun J,Cao JG

更新日期：2014-02-01 00:00:00

abstract：:The development of diabetes mellitus (DM) is accompanied by hyperglycemia-induced oxidative stress. Hyperoside is a major bioactive component in Zanthoxylum bungeanum leaves (HZL) and is a natural antioxidant. However, the effects of HZL on DM and its mechanisms of action remain undefined. The present study evaluated ...

journal_title：International journal of molecular medicine

authors： Zhang Y,Wang M,Dong H,Yu X,Zhang J

更新日期：2018-01-01 00:00:00

abstract：:We previously identified a six-transmembrane epithelial antigen of the prostate (STEAP) 4 as a novel plasma membrane protein that is downregulated in obese patients and may play a significant role in the development of human obesity. This study was designed to identify the biological characteristics of the STEAP4 gene...

journal_title：International journal of molecular medicine

authors： Chen X,Zhu C,Ji C,Zhao Y,Zhang C,Chen F,Gao C,Zhu J,Qian L,Guo X

更新日期：2010-03-01 00:00:00

abstract：:Acute myocardial infarction is the leading cause of cardiovascular‑related mortality and chronic heart failure worldwide. As regards treatment, the reperfusion of ischemic tissue generates irreversible damage to the myocardium, which is termed 'cardiac ischemia‑reperfusion (IR) injury'. Due to the large number of mito...

journal_title：International journal of molecular medicine

authors： Marin W,Marin D,Ao X,Liu Y

更新日期：2021-02-01 00:00:00

abstract：:Astrocyte activation has been described as a multi‑stage defensive response, which is characterized by the morphological alteration of astrocytes and the overexpression of intermediate filament proteins. However, the functional mechanism of the secretion system in activated astroglia remains unclear. It has previously...

journal_title：International journal of molecular medicine

authors： Zhan X,Li F,Chu Q,Pang H

更新日期：2018-12-01 00:00:00

abstract：:Human serum amyloid P (hSAP), a member of the pentraxin family, inhibits the activation of fibrocytes in culture and inhibits experimental renal, lung, skin and cardiac fibrosis. As hepatic inflammation is one of the causes of liver fibrosis, in the present study, we investigated the hepatoprotective effects of hSAP a...

journal_title：International journal of molecular medicine

authors： Cong M,Zhao W,Liu T,Wang P,Fan X,Zhai Q,Bao X,Zhang D,You H,Kisseleva T,Brenner DA,Jia J,Zhuang H

更新日期：2017-08-01 00:00:00

abstract：:The commercial use of epidermal growth factor (EGF) is extensive and has been shown to be effective for skin wound healing in clinical practice. There is evidence to indicate that the topical administration of EGF significantly accelerates re-epithelialization by promoting keratinocyte mitogenesis and migration follow...

journal_title：International journal of molecular medicine

authors： Shen C,Sun L,Zhu N,Qi F

更新日期：2017-04-01 00:00:00

abstract：:Cardiovascular diseases (CVDs), such as atherosclerosis, hypertension, myocardial infarction and diabetic heart disease, are associated with high morbidity and mortality rates worldwide, and may also induce multiple organ failure in their later stages, greatly reducing the long‑term survival of the patients. There are...

journal_title：International journal of molecular medicine

authors： Zhu Y,Shui X,Liang Z,Huang Z,Qi Y,He Y,Chen C,Luo H,Lei W

更新日期：2020-09-01 00:00:00

abstract：:High-fidelity maintenance of genomic integrity in eukaryotes is ensured by cell cycle checkpoints and DNA repair. The checkpoint kinase, Chk2, has been implicated in both of these responses. In response to DNA damage, Chk2 is initially phosphorylated at Thr-68, which leads to its full activation. The fully activated C...

journal_title：International journal of molecular medicine

authors： Liang X,Reed E,Yu JJ

更新日期：2006-05-01 00:00:00

abstract：:Circular RNAs (circRNAs) have been studied in a number of diseases. However, the roles of circRNAs in hypoxic‑ischemic brain damage (HIBD) remains unknown. In the present study, high throughput sequencing was used to profile altered circRNAs in HIBD rats. A total of 66 circRNAs were identified to be differentially exp...

journal_title：International journal of molecular medicine

authors： Jiang L,Li H,Fan Z,Zhao R,Xia Z

更新日期：2019-04-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is mainly associated with myosin, heavy chain 7 (MYH7) and myosin binding protein C, cardiac (MYBPC3) mutations. In order to better explain the clinical and genetic heterogeneity in HCM patients, in this study, we implemented a target-next generation sequencing (NGS) assay. An Ion Amp...

journal_title：International journal of molecular medicine

authors： Cecconi M,Parodi MI,Formisano F,Spirito P,Autore C,Musumeci MB,Favale S,Forleo C,Rapezzi C,Biagini E,Davì S,Canepa E,Pennese L,Castagnetta M,Degiorgio D,Coviello DA

更新日期：2016-10-01 00:00:00

abstract：:Tumor necrosis factor-α (TNF-α) has been suggested to be a putative tumor promoter gene, and autocrine of TNF-α expression has been found in colon cancer and ovarian cancer. As the role of autocrine TNF-α in human gallbladder cancer has not yet been elucidated, the present study examined the expression of TNF-α in gal...

journal_title：International journal of molecular medicine

authors： Zhu G,Du Q,Wang X,Tang N,She F,Chen Y

更新日期：2014-06-01 00:00:00

abstract：:It has been reported that the degeneration of cochlear hair cells is the typical cause of presbycusis (or age-related hearing loss). However, the molecular mechanisms that mediate cochlear hair cell apoptosis are not yet fully understood and there is no effective treatment for this disorder. MicroRNAs (miRNAs or miRs)...

journal_title：International journal of molecular medicine

authors： Xue T,Wei L,Zha DJ,Qiu JH,Chen FQ,Qiao L,Qiu Y

更新日期：2016-11-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is recognized as a main regulator of energy homeostasis. Osteocalcin (OC), which is produced specifically by mature osteoblasts, is stored in bone matrix, strongly binds to hydroxyapatite and is released into the circulation, has been recognized as a marker of bone metabolism. It ha...

journal_title：International journal of molecular medicine

authors： Kondo A,Otsuka T,Kato K,Matsushima-Nishiwaki R,Kuroyanagi G,Mizutani J,Tokuda H,Kozawa O

更新日期：2013-06-01 00:00:00

abstract：:O6-methylguanin-DNA methyltransferase (MGMT) is a DNA repair enzyme that transfers methyl groups from O6-methylguanine to itself. Alkylation of DNA at the O6 position of guanine is the first step by alkylating agents in inducing DNA mutations in an organism. When MGMT and the mismatch repair (MMR) system are impaired,...

journal_title：International journal of molecular medicine

authors： Kohya N,Kitajima Y,Kitahara K,Miyazaki K

更新日期：2003-01-01 00:00:00

abstract：:Tumor suppressor gene mutations in TSG101, FHIT, and PTEN/MMAC1 were found in many types of cancer and the defects in these genes are responsible for the tumor development. Since aberrant transcripts of these genes were also identified in normal tissues, the significance of these mutations in carcinogenesis has become...

journal_title：International journal of molecular medicine

authors： Wang NM,Chang JG

更新日期：1999-05-01 00:00:00

abstract：:Metabolic syndrome (MetS), a clustering of components, is closely associated with the development and prognosis of cardiovascular disease and diabetes. Sphingosine 1-phosphate (S1P) is a lysophospholipid with paracrine and autocrine effects, which is associated with obesity, insulin resistance, hyperglycemia, dyslipid...

journal_title：International journal of molecular medicine

authors： Chen W,Lu H,Yang J,Xiang H,Peng H

更新日期：2016-10-01 00:00:00

abstract：:There is much interest in precise functions of amino acids on mammalian growth and development. Some of amino acids play important roles in the control of gene expression by controlling the initiation phase of mRNA translation. The signal induced by leucine or arginine may stimulate cell growth. On the other hand, the...

journal_title：International journal of molecular medicine

authors： Naomoto Y,Yamatsuji T,Shigemitsu K,Ban H,Nakajo T,Shirakawa Y,Motok T,Kobayashi M,Gunduz M,Tanaka N

更新日期：2005-08-01 00:00:00

abstract：:Oral cancer is a serious disease caused by environmental factors and/or susceptible genes. In the present study, in order to identify useful genetic biomarkers for cancer prediction and prevention, and for personalized treatment, we detected somatic mutations in 5 pairs of oral cancer tissues and blood samples using w...

journal_title：International journal of molecular medicine

authors： Yi Y,Tian Z,Ju H,Ren G,Hu J

更新日期：2017-06-01 00:00:00

abstract：:Type I interferon (IFN) receptor consists of two chains (Hu-IFN-alphaR1 and Hu-IFN-alphaR2), and Hu-IFN-alphaR2 takes a soluble, short, or long form (Hu-IFN-alphaR2a, Hu-IFN-alphaR2b, or Hu-IFN-alphaR2c, respectively). We examined Hu-IFN-alphaR2 expression in hepatocellular carcinoma (HCC) tissues and their correspond...

journal_title：International journal of molecular medicine

authors： Takayama A,Yano H,Ogasawara S,Higaki K,Kojiro M

更新日期：2000-12-01 00:00:00

abstract：:Three human pleural malignant mesothelioma cell cultures (MM) of epithelioid (E1), fibrous (F1) and byphasic (B1) histotype were studied in their synthesis of the extracellular matrix (ECM) components laminin (LM), fibronectin (FN), type IV collagen (cIV), and in their chemotactic and haptotactic migration towards the...

journal_title：International journal of molecular medicine

authors： Scarpa S,Giuffrida A,Fazi M,Coletti A,Palumbo C,Pass HI,Procopio A,Modesti A

更新日期：1999-07-01 00:00:00

abstract：:In the present study, we examined whether Acer okamotoanum (A. okamotoanum) sap decreased the serum alcohol and acetaldehyde levels after acute ethanol treatment in a rat model. Male rats were orally administered 25, 50 or 100% A. okamotoanum sap 30 min prior to oral challenge with 3 ml of ethanol (15 ml/kg of a 20% e...

journal_title：International journal of molecular medicine

authors： Yoo YM,Jung EM,Kang HY,Choi IG,Choi KC,Jeung EB

更新日期：2011-10-01 00:00:00