Abstract:
:Three human pleural malignant mesothelioma cell cultures (MM) of epithelioid (E1), fibrous (F1) and byphasic (B1) histotype were studied in their synthesis of the extracellular matrix (ECM) components laminin (LM), fibronectin (FN), type IV collagen (cIV), and in their chemotactic and haptotactic migration towards the ECM produced proteins. MM-B1 showed the highest FN synthesis and release; MM-E1 produced the highest quantity of basement membrane constituents LM and cIV; MM-F1 weakly produced and released FN, LM and cIV. MM-B1 had the highest chemotactic and haptotactic motility, MM-F1 migrated toward the lowest concentration of LM while had reduced chemotactic activity toward FN and cIV; MM-E1 had the lowest migratory activity toward each ECM substrate. We demonstrated that three MM of different histotype are characterized by different ECM production and that these differences determine a variable ability of each MM to spread and migrate towards ECM substrates.
journal_name
Int J Mol Medjournal_title
International journal of molecular medicineauthors
Scarpa S,Giuffrida A,Fazi M,Coletti A,Palumbo C,Pass HI,Procopio A,Modesti Adoi
10.3892/ijmm.4.1.67subject
Has Abstractpub_date
1999-07-01 00:00:00pages
67-71issue
1eissn
1107-3756issn
1791-244Xjournal_volume
4pub_type
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