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FERM family proteins and their importance in cellular movements and wound healing (review).

Abstract：

:Motility is a requirement for a number of biological processes, including embryonic development, neuronal development, immune responses, cancer progression and wound healing. Specific to wound healing is the migration of endothelial cells, fibroblasts and other key cellular players into the wound space. Aberrations in wound healing can result in either chronic wounds or abnormally healed wounds. The protein 4.1R, ezrin, radixin, moesin (FERM) superfamily consists of over 40 proteins all containing a three lobed N-terminal FERM domain which binds a variety of cell-membrane associated proteins and lipids. The C-terminal ends of these proteins typically contain an actin-binding domain (ABD). These proteins therefore mediate the linkage between the cell membrane and the actin cytoskeleton, and are involved in cellular movements and migration. Certain FERM proteins have been shown to promote cancer metastasis via this very mechanism. Herein we review the effects of a number of FERM proteins on wound healing and cancer. We show how these proteins typically aid wound healing through their effects on increasing cellular migration and movements, but also typically promote metastasis in cancer. We conclude that FERM proteins play important roles in cellular migration, with markedly different outcomes in the context of cancer and wound healing.

journal_name

Int J Mol Med

journal_title

International journal of molecular medicine

authors

Bosanquet DC,Ye L,Harding KG,Jiang WG

doi

10.3892/ijmm.2014.1775

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

3-12

issue

1

eissn

1107-3756

issn

1791-244X

journal_volume

34

pub_type

杂志文章,评审

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