Impairment of the retinoic acid-inducible gene-I-IFN-β signaling pathway in chronic hepatitis B virus infection.

abstract：:D-mannoheptulose was recently proposed as a tool to label preferentially insulin-producing cells in the pancreatic gland in the perspective of the non-invasive imaging of the endocrine pancreas. In such a perspective, we have now synthesized 1-deoxy-1-[125I]iodo-D-mannoheptulose ([125I]MH) and examined its uptake by d...

journal_title：International journal of molecular medicine

authors： Sener A,Bessieres B,Courtois P,Ladriere L,Louchami K,Jijakli H,Malaisse WJ

更新日期：2001-05-01 00:00:00

abstract：:After cessation of lactation, the mammary gland undergoes involution, regressing to a state resembling that of a virgin animal. This phase of mammary gland development is characterized by epithelial cell death and tissue remodeling. To understand molecular mechanisms of mammary gland involution, we identified involuti...

journal_title：International journal of molecular medicine

authors： Baik MG,Lee MJ,Choi YJ

更新日期：1998-07-01 00:00:00

abstract：:In recent studies, we and others have demonstrated that bone morphogenetic protein-2 (BMP-2) promotes vascularization, inhibits hypoxic cell death of cancer cells and may be involved in tumor angiogenesis. The activation of circulating endothelial progenitor cells (EPCs) and mesenchymal stem cells (MSCs) represents a ...

journal_title：International journal of molecular medicine

authors： Raida M,Heymann AC,Günther C,Niederwieser D

更新日期：2006-10-01 00:00:00

abstract：:Magnetic beads coated with an anionic polymer, poly(methyl vinyl ether-maleic anhydrate) [poly(MVE-MA)], were used in a method to capture human immunodeficiency virus type-1 (HIV-1). The beads were incubated with either HIV-1-infected cell culture medium or plasma from HIV-1 infecte...

journal_title：International journal of molecular medicine

authors： Sakudo A,Ikuta K

更新日期：2012-08-01 00:00:00

abstract：:Overconsumption of fats and sugars is a major cause of development of non‑alcoholic fatty liver disease (NAFLD). The main objectives of the present study were to explore the pathways sustaining the interfering metabolic effects of excess fructose and fatty acids in hepatocytes, and to clarify the mechanisms through wh...

journal_title：International journal of molecular medicine

authors： Grasselli E,Baldini F,Vecchione G,Oliveira PJ,Sardão VA,Voci A,Portincasa P,Vergani L

更新日期：2019-08-01 00:00:00

abstract：:β‑catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules (E‑cadherin/CDH1, N‑cadherin/CDH2, VE‑cadherin/CDH5 and α‑catenins), transmembrane‑type mucins (MUC1/CD227 and MUC16/CA125), signaling regulators (APC, AXIN1, AXIN2 and NHERF1/EBP50) and epigenetic or transcriptional regulator...

journal_title：International journal of molecular medicine

authors： Katoh M

更新日期：2018-08-01 00:00:00

abstract：:Arachidin-1 [trans-4-(3-methyl-1-butenyl)-3,5,3',4'-tetrahydroxystilbene] is a polyphenol produced by peanut kernels during germination. The aim of the present study was to investigate the mechanism underlying the anti-inflammatory effect of arachidin-1 in endothelial cells (ECs). The results of cell adhesion and west...

journal_title：International journal of molecular medicine

authors： Chen LG,Zhang YQ,Wu ZZ,Hsieh CW,Chu CS,Wung BS

更新日期：2018-01-01 00:00:00

abstract：:Glucosamine, a naturally occurring amino monosaccharide, is widely used to treat osteoarthritis in humans. Furthermore, glucosamine exhibits an anti-inflammatory action by inhibiting the activation of neutrophils, chondrocytes and synoviocytes. Recently, we revealed that glucosamine suppresses cytokine-induced activat...

journal_title：International journal of molecular medicine

authors： Yomogida S,Kojima Y,Tsutsumi-Ishii Y,Hua J,Sakamoto K,Nagaoka I

更新日期：2008-09-01 00:00:00

abstract：:Cell numbers are regulated by a balance between proliferation and apoptosis (programmed cell death). Recent evidence suggests that proteins regulating cell proliferation also mediate apoptosis. Therefore, cellular fate might be determined by cross talk between regulators of cell cycle progression and apoptosis. Previo...

journal_title：International journal of molecular medicine

authors： An B,Johnson DE,Jin JR,Antoku K,Dou QP

更新日期：1998-01-01 00:00:00

abstract：:The pathogenesis of inflammatory bowel disease (IBD) remains unknown. It has been suggested that luminal factors such as the microflora, short chain fatty acids (SCFAs), food antigens and so on play important roles in the disease progression. Many reports have revealed alterations in the SCFA and organic acid concentr...

journal_title：International journal of molecular medicine

authors： Araki Y,Andoh A,Fujiyama Y,Itoh A,Bamba T

更新日期：2002-06-01 00:00:00

abstract：:Differential diagnosis between adrenal cortical and adrenal medullary lesions may be difficult in many cases. Different immunohistochemical, histochemical tools as well as ultrastructural diagnostic techniques have been employed to aid in differentiating between these lesions. Recently, both inhibin-A and BCL-2 have b...

journal_title：International journal of molecular medicine

authors： Fogt F,Zimmerman RL,Mulligan N,Vortmeyer AO,Poremba C,Harris CA,Alsaigh N,Tomaszewski JE,Nikulasson ST

更新日期：1999-03-01 00:00:00

abstract：:Human CD46 was identified as a complement regulator and was later shown to be a measles virus receptor. The ubiquitous distribution profile of CD46 accounted for systemic measles infection and general protection of host tissue/organs from autologous complement. A similar ubiquitous distribution was observed for swine ...

journal_title：International journal of molecular medicine

authors： Seya T,Nomura M,Murakami Y,Begum NA,Matsumoto M,Nagasawa S

更新日期：1998-05-01 00:00:00

abstract：:One of the most aggressive human malignancies, anaplastic thyroid carcinoma (ATC), has an extremely poor prognosis that may be explained by its genomic instability. We hypothesized that the very rapid cell turnover observed in ATC might accelerate telomere shortening and chromosomal instability associated with tumor c...

journal_title：International journal of molecular medicine

authors： Kammori M,Onoda N,Nakamura K,Izumiyama N,Ogisawa K,Kurabayashi R,Ogawa T,Kaminishi M,Poon SS,Takubo K

更新日期：2006-07-01 00:00:00

abstract：:Molecular analysis are useful for diagnosis, prognosis and follow-up of the patients, as well as for addressing therapeutic choices. Most of the molecular methods are based on the analysis of nucleic acids. The DNA and RNA methodologies of routine applicability include Southern and Northern hybridizations and polymera...

journal_title：International journal of molecular medicine

authors： Scarpa A,Tognon M

更新日期：1998-06-01 00:00:00

abstract：:The commercial use of epidermal growth factor (EGF) is extensive and has been shown to be effective for skin wound healing in clinical practice. There is evidence to indicate that the topical administration of EGF significantly accelerates re-epithelialization by promoting keratinocyte mitogenesis and migration follow...

journal_title：International journal of molecular medicine

authors： Shen C,Sun L,Zhu N,Qi F

更新日期：2017-04-01 00:00:00

abstract：:Motility is a requirement for a number of biological processes, including embryonic development, neuronal development, immune responses, cancer progression and wound healing. Specific to wound healing is the migration of endothelial cells, fibroblasts and other key cellular players into the wound space. Aberrations in...

journal_title：International journal of molecular medicine

authors： Bosanquet DC,Ye L,Harding KG,Jiang WG

更新日期：2014-07-01 00:00:00

abstract：:Rats exposed from 7 weeks after birth and for the ensuing 3 to 7 months to a diet depleted in long-chain polyunsaturated omega3 fatty acids were recently proposed as a new animal model for the metabolic syndrome. The present study aimed mainly at investigating whether, in this new model, the perturbation of the fatty ...

journal_title：International journal of molecular medicine

authors： Portois L,Hacquebard M,Malaisse WJ,Carpentier YA

更新日期：2009-08-01 00:00:00

abstract：:The present study aimed to investigate the roles of miR‑132 in myocardial ischaemia/reperfusion (I/R) injury and the underlying mechanisms. The myocardial I/R model was established using C57BL/J6 mice. Haematoxylin and eosin staining was performed to observe the injury of myocardial tissues. Commercial kits were used ...

journal_title：International journal of molecular medicine

authors： Zhou Y,Li KS,Liu L,Li SL

更新日期：2020-06-01 00:00:00

abstract：:Neovascularization occurring in atherosclerotic plaque leads to acceleration of plaque growth through increased leukocyte infiltration and reactive oxygen species (ROS) production. Sema4D (CD100), a class IV semaphorin, not only plays a crucial role in axon guidance but also functions in the neovascularization process...

journal_title：International journal of molecular medicine

authors： Yukawa K,Tanaka T,Kishino M,Yoshida K,Takeuchi N,Ito T,Takamatsu H,Kikutani H,Kumanogoh A

更新日期：2010-07-01 00:00:00

abstract：:Rac1, an intracellular signal transducer, regulates a variety of cell functions, including the organization of the cytoskeleton, cell migration, and invasion. Overexpression of Rac1 has been reported in several human cancers. However, the underlying mechanisms are not well understood. In the present study, we evaluate...

journal_title：International journal of molecular medicine

authors： Chen QY,Xu LQ,Jiao DM,Yao QH,Wang YY,Hu HZ,Wu YQ,Song J,Yan J,Wu LJ

更新日期：2011-11-01 00:00:00

abstract：:Adult mesenchymal progenitor cells (MPCs) are adherent stromal cells of non-haematopoietic origin derived from bone marrow and other tissues. Upon limited in vitro expansion, they retain their self-renewal capacity as well as their potential to differentiate into tissues of mesenchymal lineage, such as bone, cartilage...

journal_title：International journal of molecular medicine

authors： Grässel S,Ahmed N,Göttl C,Grifka J

更新日期：2009-06-01 00:00:00

abstract：:The heat shock proteins (hsps) are induced by a variety of stressful stimuli and their overexpression has been shown to protect cells both in vitro and in vivo against such stimuli, as well as against stimuli-inducing apoptosis. The potential therapeutic benefit of elevating hsp levels in individuals with, for example...

journal_title：International journal of molecular medicine

authors： Latchman DS

更新日期：1998-10-01 00:00:00

abstract：:Needle biopsy is widely used to obtain specimens for physiological, anatomical and biochemical studies of skeletal muscle (SM). We optimized a procedure which we termed tiny percutaneous needle biopsy (TPNB), to efficiently gather good numbers of human satellite cells and single dissociated fibers for the functional s...

journal_title：International journal of molecular medicine

authors： Pietrangelo T,D'Amelio L,Doria C,Mancinelli R,Fulle S,Fanò G

更新日期：2011-03-01 00:00:00

abstract：:Small cell lung cancer (SCLC) is a highly aggressive lung neoplasm. To study the pathogenesis of SCLC, we investigated roles of ABCE1, a member of the ATP-binding cassette (ABC) superfamily, in the development of small cell lung cancer. RNA interference was used to knock down ABCE1 expression in human small cell lung ...

journal_title：International journal of molecular medicine

authors： Huang B,Gao Y,Tian D,Zheng M

更新日期：2010-05-01 00:00:00

abstract：:Apoptosis may limit the utility of cell-based therapies for articular cartilage disorders. We tested the hypothesis that chondrocyte apoptosis can be reduced by optimizing the conditions employed to expand chondrocyte numbers in culture. Chondrocyte apoptosis was examined in monolayer and suspension culture, in the pr...

journal_title：International journal of molecular medicine

authors： Takahashi T,Yamamoto H,Ogawa Y,Yoshida S,Kataoka S,Majumdar M,Morris E,Tripple SB

更新日期：2003-03-01 00:00:00

abstract：:Myocyte injury due to myocardial reperfusion injury plays a crucial role in the pathogenesis of acute myocardial infarction even after successful coronary revascularization. Identification of compounds that reduce reperfusion-associated myocyte death is important. Therefore, we developed an in vitro model of myocardia...

journal_title：International journal of molecular medicine

authors： Gerö D,Módis K,Nagy N,Szoleczky P,Tóth ZD,Dormán G,Szabó C

更新日期：2007-11-01 00:00:00

abstract：:p57 (Kip2) belongs to the Cip/Kip family and is one of the universal negative regulators of the cell cycle. In this study, we investigated the p57 expression of various types of thyroid neoplasm. p57 overexpression was observed in only 4.2% of normal thyroid tissues. In follicular adenoma and minimally invasive follic...

journal_title：International journal of molecular medicine

authors： Ito Y,Yoshida H,Nakano K,Kobayashi K,Yokozawa T,Hirai K,Matsuzuka F,Matsuura N,Kuma K,Miyauchi A

更新日期：2002-04-01 00:00:00

abstract：:The airway epithelium (AE) is the main protective barrier between the host and external environmental factors causing asthma. Allergens or pathogens induce AE dysfunction, including epithelial permeability alteration, trans‑epithelial electrical resistance (TEER) reduction, upregulation of inflammatory mediators and d...

journal_title：International journal of molecular medicine

authors： Yang R,Tan M,Xu J,Zhao X

更新日期：2019-08-01 00:00:00

abstract：:Safe, affordable and efficacious agents are urgently required for cancer prevention. Sesamin, a lipid‑soluble lignan from sesame (Sesamum indicum) displays anticancer activities through an unknown mechanism. In the present study, the anticancer activity of sesamin via cyclooxygenase 2 (COX2) was investigated in lung c...

journal_title：International journal of molecular medicine

authors： Fang Q,Zhu Y,Wang Q,Song M,Gao G,Zhou Z

更新日期：2019-01-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology with considerable morbidity and mortality. Seeking informative diagnostic markers with greater clinical significance is essential for the early diagnosis of IPF. microRNAs (miRNAs or miRs) have emerged as novel serum diagnostic biomarkers for various...

journal_title：International journal of molecular medicine

authors： Li P,Li J,Chen T,Wang H,Chu H,Chang J,Zang W,Wang Y,Ma Y,Du Y,Zhao G,Zhang G

更新日期：2014-06-01 00:00:00