Tiny percutaneous needle biopsy: An efficient method for studying cellular and molecular aspects of skeletal muscle in humans.

abstract：:We previously identified a six-transmembrane epithelial antigen of the prostate (STEAP) 4 as a novel plasma membrane protein that is downregulated in obese patients and may play a significant role in the development of human obesity. This study was designed to identify the biological characteristics of the STEAP4 gene...

journal_title：International journal of molecular medicine

authors： Chen X,Zhu C,Ji C,Zhao Y,Zhang C,Chen F,Gao C,Zhu J,Qian L,Guo X

更新日期：2010-03-01 00:00:00

abstract：:Mycobacterium tuberculosis (MTB), one of the major bacterial pathogens for lethal infectious diseases, is capable of surviving within the phagosomes of host alveolar macrophages; therefore, host genetic variations may alter the susceptibility to MTB. In this study, to identify host genes exploited by MTB during infect...

journal_title：International journal of molecular medicine

authors： Bao Z,Chen R,Zhang P,Lu S,Chen X,Yao Y,Jin X,Sun Y,Zhou J

更新日期：2016-09-01 00:00:00

abstract：:Physical exercise has a neuroprotective effect and is an important treatment after ischemic stroke. Promoting neurogenesis and myelin repair in the penumbra is an important method for the treatment of ischemic stroke. However, the role and potential mechanism of exercise in neurogenesis and myelin repair still needs t...

journal_title：International journal of molecular medicine

authors： Cheng J,Shen W,Jin L,Pan J,Zhou Y,Pan G,Xie Q,Hu Q,Wu S,Zhang H,Chen X

更新日期：2020-05-01 00:00:00

abstract：:The spindle checkpoint proteins (SCPs), which sense the existence of misaligned sister chromatids during mitosis and meiosis, are essential for cell proliferation and differentiation. Therefore, the role of SCPs in carcinogenesis is gaining increased attention. In this study, we ana...

journal_title：International journal of molecular medicine

authors： Liao S,Deng D,Hu X,Wang W,Li L,Li W,Zhou J,Xu G,Meng L,Wang S,Ma D

更新日期：2013-01-01 00:00:00

abstract：:The positive correlation between the number of M2 phenotype TAMs (M2‑TAMs) and tumour development suggests a supportive role of M2‑TAMs in glioma progression. In the present study, the molecular link between glioma cells and M2‑TAMs was investigated and it was demonstrated that transforming growth factor‑β1 (TGF‑β1) s...

journal_title：International journal of molecular medicine

authors： Liu Z,Kuang W,Zhou Q,Zhang Y

更新日期：2018-12-01 00:00:00

abstract：:The kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) signaling axis plays an important role in regulating oxidative stress in ischemic cardiomyocytes. Targeting Keap1 in order to promote Nrf2 activation is considered a potential method for protecting cardiomyocytes against...

journal_title：International journal of molecular medicine

authors： Sun X,Zuo H,Liu C,Yang Y

更新日期：2016-10-01 00:00:00

abstract：:Retinoic acid (RA) analogs have been used in the treatment of a variety of cancers; however, their application is limited due to serious therapy-related sequelae. In the present study, the effects of a novel RA analog, 4-amino-2-trifluoromethyl-phenyl retinate (ATPR), on the growth of gastric cancer cells were evaluat...

journal_title：International journal of molecular medicine

authors： Hu KW,Pan XH,Chen FH,Qin R,Wu LM,Zhu HG,Wu FR,Ge JF,Han WX,Yin CL,Li HJ

更新日期：2014-02-01 00:00:00

abstract：:The volatile anesthetic, sevoflurane, is widely used in surgery. Over the years, there has been a growing interest in the biological effects of sevoflurane on tissue and organ systems and the molecular mechanisms involved. MicroRNAs (miRNAs or miRs) acting as pivotal post‑transcriptional regulators for fine-tuning gen...

journal_title：International journal of molecular medicine

authors： Takeuchi J,Sakamoto A,Takizawa T

更新日期：2014-07-01 00:00:00

abstract：:Down syndrome (DS) is caused by the presence of part or all of a third copy of chromosome 21. DS is associated with several phenotypes, including intellectual disability, congenital heart disease, childhood leukemia and immune defects. Specific microRNAs (miRNAs/miR) have been described to be associated with DS, altho...

journal_title：International journal of molecular medicine

authors： Salvi A,Vezzoli M,Busatto S,Paolini L,Faranda T,Abeni E,Caracausi M,Antonaros F,Piovesan A,Locatelli C,Cocchi G,Alvisi G,De Petro G,Ricotta D,Bergese P,Radeghieri A

更新日期：2019-06-01 00:00:00

abstract：:Oxygen-related free radicals have been suggested as a cause of aging and various diseases, for example, various cancers and rheumatoid arthritis. Because of this a radical scavenger as an antioxidant has been sought in many foods. 'Nikogori' gelatin gel from cooked fish is a traditional food in Japan. Recently, 'Nikog...

journal_title：International journal of molecular medicine

authors： Nagatsuka N,Harada K,Ando M,Nagao K

更新日期：2005-09-01 00:00:00

abstract：:Dextromethorphan is a widely used anti-tussive drug with non-competitive antagonistic effects on excitatory amino acid receptors of the N-methyl-D-aspartate (NMDA) type. This study examined the effect of daily dextromethorphan administration on gene expression in rat brain hippocampus and cortex regions using Rat 5K c...

journal_title：International journal of molecular medicine

authors： Lee KH,Ahn JI,Yu DH,Koh HC,Kim SH,Yang BH,Lee YS,Lee YS

更新日期：2003-05-01 00:00:00

abstract：:ARHGAP1, ARHGAP2, ARHGAP3, ARHGAP4, ARHGAP5, ARHGAP6, ARHGAP7 (DLC1), ARHGAP8, ARHGAP9, ARHGAP10, ARHGAP12, ARHGAP13 (SRGAP1), ARHGAP14 (SRGAP2), ARHGAP15, ARHGAP17 (RICH1), ARHGAP18, ARHGAP19, ARHGAP20, ARHGAP21, ARHGAP22, ARHGAP23, ARHGAP24, ARHGAP25, ARHGAP26, STARD13 (DLC2), HA-1, GMIP, PARG1, RACGAP1, PIK3R1, PIK...

journal_title：International journal of molecular medicine

authors： Katoh Y,Katoh M

更新日期：2004-11-01 00:00:00

abstract：:Vitiligo is an acquired and progressive disorder manifested by the selective destruction of melanocytes in the skin. An extremely high level of hydrogen peroxide (H2O2) in plasma as well as in lesional skin has been reported in vitiligo patients. High H2O2 level has been suggested to be responsible for the disappearan...

journal_title：International journal of molecular medicine

authors： Song X,Xu A,Pan W,Wallin B,Kivlin R,Lu S,Cao C,Bi Z,Wan Y

更新日期：2008-07-01 00:00:00

abstract：:Exposure of the skin to ultraviolet (UV) radiation causes extracellular matrix (ECM) collapse in the dermis, owing to an increase in matrix metalloproteinase (MMP) production in both the epidermis and dermis, and a decrease in type I collagen expression in the dermis. Recently, black rice (Oryza sativa L.) was reporte...

journal_title：International journal of molecular medicine

authors： Han M,Bae JS,Ban JJ,Shin HS,Lee DH,Chung JH

更新日期：2018-05-01 00:00:00

abstract：:Phellinus linteus is a well-known Oriental medicinal fungus that has various biological activities, including immunomodulatory and anti-tumor activities, the mechanisms of which are poorly understood. In the present study, we investigated the effects of mycelium extracts of P. linteus (MEPL) on the growth of human neu...

journal_title：International journal of molecular medicine

authors： Choi YH,Huh MK,Ryu CH,Choi BT,Jeong YK

更新日期：2004-08-01 00:00:00

abstract：:Atherosclerosis is now considered a chronic inflammatory disease, and glucosamine has the potential to exhibit an anti-inflammatory action. Thus, we investigated the effect of glucosamine on tumor necrosis factor alpha (TNF-alpha)-induced endothelial cell activation. Human umbilical vein endothelial cells (HUVECs) wer...

journal_title：International journal of molecular medicine

authors： Ju Y,Hua J,Sakamoto K,Ogawa H,Nagaoka I

更新日期：2008-12-01 00:00:00

abstract：:It is not clear whether pseudoallergic reactions are caused by similar mechanisms as type I allergic reactions. 3‑Caffeoylquinic acid (chlorogenic acid) is an active ingredient in traditional Chinese medicines used for antibacterial, anti-inflammatory and cholagogic purposes. It is assumed to be the reason for the hig...

journal_title：International journal of molecular medicine

authors： Li Q,Zhao Y,Zheng X,Chen Q,Zhang X

更新日期：2013-12-01 00:00:00

abstract：:Connective tissue growth factor (CTGF) plays an important role in the pathogenesis of atherosclerosis by promoting vascular smooth muscle cell (VSMC) growth, migration, apoptosis, adhesion and the secretion of matrix components. The osteogenic differentiation of VSMCs is essential in the development of vascular calcif...

journal_title：International journal of molecular medicine

authors： Huang J,Huang H,Wu M,Li J,Xie H,Zhou H,Liao E,Peng Y

更新日期：2013-08-01 00:00:00

abstract：:Prostate-specific antigen (PSA) has been used clinically as a marker for the diagnosis and staging of prostate cancer due to its specific expression in prostate epithelial cells. In addition to its medical importance, its complex hormonal and tissue-specific regulation makes it an attractive model to study gene regula...

journal_title：International journal of molecular medicine

authors： Willis RA,Wei C,Turner MJ,Callahan BP,Pugh AE,Barth RK,Lord EM,Frelinger JG

更新日期：1998-02-01 00:00:00

abstract：:The ectromelia virus (ECTV) is a mouse specific Orthopoxvirus that causes lethal infection in some mouse strains. ECTV infection of these mouse strains has been used as a valuable model for understanding the interplay between Orthopoxvirus species and their hosts, including variola virus in humans. Although poxviruses...

journal_title：International journal of molecular medicine

authors： Cheng W,Jia H,Wang X,He X,Jin Q,Cao J,Jing Z

更新日期：2018-08-01 00:00:00

abstract：:The aim of the present study was to investigate the biological role and underlying mechanisms of action of miR-518a-3p in the progression and invasion of colorectal cancer (CRC). Reverse transcription-quantitative PCR (RT-qPCR) was used to examine the mRNA expression levels of miR-518a-3p in 5 CRC cell lines (SW480, S...

journal_title：International journal of molecular medicine

authors： Qu LL,He L,Zhao X,Xu W

更新日期：2015-05-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is a lethal disease due to its high aggressiveness. The aim of the present study was to investigate the role of xeroderma pigmentosum complementation group D (XPD) in the growth and invasion of ESCC and to elucidate the potential underlying molecular mechanisms. Western blot a...

journal_title：International journal of molecular medicine

authors： Jian J,Li S,Liu LZ,Zhen L,Yao L,Gan LH,Huang YQ,Fang N

更新日期：2020-07-01 00:00:00

abstract：:We examined whether generation of H2O2 is a critical event for the apoptotic pathway upstream of mitochondrial involvement and caspase-3 protease activation. Perylquinone photosensitizers such as Hypocrellin A (HA), Hypocrellin B (HB) and Hypericin (HY) induced activation of caspase-3 and apoptosis upon photoactivatio...

journal_title：International journal of molecular medicine

authors： Ali SM,Chee SK,Yuen GY,Olivo M

更新日期：2002-05-01 00:00:00

abstract：:The aim of this study was to examine the anti-obesity effects of boiled tuna extract in C57BL/6N mice with obesity induced by a high-fat diet (HFD). We determined the anti-obesity effects of boiled tuna extract (100, 200, or 400 mg/kg) on the progression of HFD-induced obesity for 10 weeks. The mice were divided into ...

journal_title：International journal of molecular medicine

authors： Kim Y,Kwon MJ,Choi JW,Lee MK,Kim C,Jung J,Aprianita H,Nam H,Nam TJ

更新日期：2016-10-01 00:00:00

abstract：:Inflammation and remodeling play a role in the pathogenesis of pulmonary arterial hypertension (PAH). Nuclear factor-κB (NF-κB) and nuclear factor of activated T cells-1 (NFAT-1) participate in inflammation and remodeling in a number of diseases. As a tryptophan hydroxylase inhibitor, 4-chloro-DL-phenylalanine (PCPA) ...

journal_title：International journal of molecular medicine

authors： Bai Y,Li ZX,Wang HL,Lian GC,Wang Y

更新日期：2017-07-01 00:00:00

abstract：:Bcl-2 family member proteins are differentially expressed in skin and in non-melanoma skin cancer (NMSC). To elucidate the contribution of bcl-2 and bax proteins to epidermal differentiation and skin carcinogenesis, we investigated keratinocyte proliferation, differentiation and tumourigenesis in bcl-2(-/-) and bax(-/...

journal_title：International journal of molecular medicine

authors： Cho SH,Delehedde M,Rodriguez-Villanueva J,Brisbay S,McDonnell TJ

更新日期：2001-03-01 00:00:00

abstract：:Dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp., is known to exhibit significant selective cytotoxicity against several human tumor cell lines. In the present study, we investigated the possible mechanisms by which dideoxypetrosynol A exerts its anti-proliferative action in cultured human SK-MEL-2 sk...

journal_title：International journal of molecular medicine

authors： Choi HJ,Bae SJ,Kim ND,Jung JH,Choi YH

更新日期：2004-12-01 00:00:00

abstract：:The aim of the present study was to elucidate whether extracts of Vigna angularis (EVA) inhibit allergic inflammatory reactions and to elucidate the possible mechanisms of action. For the assessment of allergic inflammatory response, histamine release and the expression of pro-inflammatory cytokines from human mast ce...

journal_title：International journal of molecular medicine

authors： Kim HH,Kim SW,Kim DS,Oh HM,Rho MC,Kim SH

更新日期：2013-09-01 00:00:00

abstract：:Chamomile has long been used in traditional medicine for the treatment of inflammation-related disorders. In this study we investigated the inhibitory effects of chamomile on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression, and explored its potential anti-inflammatory mechanisms usin...

journal_title：International journal of molecular medicine

authors： Bhaskaran N,Shukla S,Srivastava JK,Gupta S

更新日期：2010-12-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by progressive lung scarring and excessive extracellular matrix depositon. When stimulated, alveolar epithelial cells (AECs) are aberrantly activated, the expression of profibrotic molecules is enhanced, and lung fibro...

journal_title：International journal of molecular medicine

authors： Li B,Huang X,Xu X,Ning W,Dai H,Wang C

更新日期：2019-07-01 00:00:00