Chlorogenic acid alters the biological characteristics of basophil granulocytes by affecting the fluidity of the cell membrane and triggering pseudoallergic reactions.

abstract：:Prostate-specific antigen (PSA) has been used clinically as a marker for the diagnosis and staging of prostate cancer due to its specific expression in prostate epithelial cells. In addition to its medical importance, its complex hormonal and tissue-specific regulation makes it an attractive model to study gene regula...

journal_title：International journal of molecular medicine

authors： Willis RA,Wei C,Turner MJ,Callahan BP,Pugh AE,Barth RK,Lord EM,Frelinger JG

更新日期：1998-02-01 00:00:00

abstract：:Cysteine (Cys) is known to exert various effects, such as antioxidant, antipancreatitic and antidiabetic effects. However, the effects of Cys on longitudinal bone growth have not been elucidate to date. Thus, the aim of the present study was to evaluate the effects of Cys on bone growth. Growth-plate thickness and bon...

journal_title：International journal of molecular medicine

authors： Moon PD,Kim MH,Oh HA,Nam SY,Han NR,Jeong HJ,Kim HM

更新日期：2015-08-01 00:00:00

abstract：:Oral cancer is a serious disease caused by environmental factors and/or susceptible genes. In the present study, in order to identify useful genetic biomarkers for cancer prediction and prevention, and for personalized treatment, we detected somatic mutations in 5 pairs of oral cancer tissues and blood samples using w...

journal_title：International journal of molecular medicine

authors： Yi Y,Tian Z,Ju H,Ren G,Hu J

更新日期：2017-06-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a common, fatal and frequently recurrent disease. Changes in the activity of different coagulation factors serve as a pathophysiological basis for the recurrent risk of VTE. Systems biology approaches provide a better understanding of the pathological mechanisms responsible for recurren...

journal_title：International journal of molecular medicine

authors： Xie R,Li L,Chen L,Li W,Chen B,Jiang J,Huang H,Li Y,He Y,Lv J,He W

更新日期：2017-02-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a critical step and key factor during renal fibrosis. Preventing renal tubular EMT is important for delaying the progression of chronic kidney disease (CKD). P311, a highly conserved 8-kDa intracellular protein, has been indicated as an important factor in myofibroblast trans...

journal_title：International journal of molecular medicine

authors： Qi FH,Cai PP,Liu X,Si GM

更新日期：2018-05-01 00:00:00

abstract：:Cell numbers are regulated by a balance between proliferation and apoptosis (programmed cell death). Recent evidence suggests that proteins regulating cell proliferation also mediate apoptosis. Therefore, cellular fate might be determined by cross talk between regulators of cell cycle progression and apoptosis. Previo...

journal_title：International journal of molecular medicine

authors： An B,Johnson DE,Jin JR,Antoku K,Dou QP

更新日期：1998-01-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology with considerable morbidity and mortality. Seeking informative diagnostic markers with greater clinical significance is essential for the early diagnosis of IPF. microRNAs (miRNAs or miRs) have emerged as novel serum diagnostic biomarkers for various...

journal_title：International journal of molecular medicine

authors： Li P,Li J,Chen T,Wang H,Chu H,Chang J,Zang W,Wang Y,Ma Y,Du Y,Zhao G,Zhang G

更新日期：2014-06-01 00:00:00

abstract：:White blood cell (WBC) count is considered a prognostic risk factor in acute myeloid leukemia. As density of leukemic cells increases, the cytotoxic activity of certain anticancer drugs, such as vincristine and doxorubicin, progressively decreases. In this study, we investigated the cell density-dependent induction of...

journal_title：International journal of molecular medicine

authors： Navrátilová J,Jungová P,Vanhara P,Preisler J,Kanicky V,Smarda J

更新日期：2009-11-01 00:00:00

abstract：:Rac1, an intracellular signal transducer, regulates a variety of cell functions, including the organization of the cytoskeleton, cell migration, and invasion. Overexpression of Rac1 has been reported in several human cancers. However, the underlying mechanisms are not well understood. In the present study, we evaluate...

journal_title：International journal of molecular medicine

authors： Chen QY,Xu LQ,Jiao DM,Yao QH,Wang YY,Hu HZ,Wu YQ,Song J,Yan J,Wu LJ

更新日期：2011-11-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation and migration has been proven to be a critical event in the development of varicosity. Variations in estrogen levels, a pathological event related to age and pregnancy, play a role in the pathogenesis of varicosity. Previous studies have reported a different response of...

journal_title：International journal of molecular medicine

authors： Huang X,Jin Y,Zhou D,Xu G,Huang J,Shen L

更新日期：2015-05-01 00:00:00

abstract：:We had shown previously that the novel, marine, anticancer compound dehydrothyrsiferol (DHT) does not modulate P-glycoprotein (P-gp) dependent drug efflux. Many chemotherapeutics with clinical impact are substrates for the structurally distant related membrane transport protein MRP1 (multidrug resistance-associated pr...

journal_title：International journal of molecular medicine

authors： Pec MK,Aguirre A,Fernández JJ,Souto ML,Dorta JF,Villar J

更新日期：2002-11-01 00:00:00

abstract：:Cutaneous melanoma is very aggressive and results in high mortality rates for cancer patients. Determining molecular targets is important for developing novel therapies for cutaneous melanoma. Cell division cycle associated 8 (CDCA8) is a putative oncogene that is upregulated in multiple types of cancer. The present s...

journal_title：International journal of molecular medicine

authors： Ci C,Tang B,Lyu D,Liu W,Qiang D,Ji X,Qiu X,Chen L,Ding W

更新日期：2019-01-01 00:00:00

abstract：:Insulinoma-associated protein 2 (IA-2) is the major autoantigen that contributes to the pathogenesis of type 1 diabetes (T1D). IA-2-deficient (IA-2-/-) mice showed impaired insulin secretion after intraperitoneal injection of glucose as well as elevated glucose level in a glucose tolerance test. Despite the fact that ...

journal_title：International journal of molecular medicine

authors： Nakajima K,Wu G,Takeyama N,Sakudo A,Sugiura K,Yukawa M,Onodera T

更新日期：2009-07-01 00:00:00

abstract：:The basic helix loop helix (bHLH) transcription factor DEC2 is associated with the regulation of apoptosis, circadian rhythm and the response to hypoxia. However, the significance of DEC2 in pancreatic cancer remains unknown. Here, we showed for the first time that DEC2 inhibits the...

journal_title：International journal of molecular medicine

authors： Sato F,Kawamura H,Wu Y,Sato H,Jin D,Bhawal UK,Kawamoto T,Fujimoto K,Noshiro M,Seino H,Morohashi S,Kato Y,Kijima H

更新日期：2012-09-01 00:00:00

abstract：:Elevated anxiety symptoms have been reported to be present in many patients with diabetes mellitus. The underlying mechanisms by which diabetes mellitus influences behavior remain to be determined. We assessed feeding and anxiety behaviors in spontaneously diabetic Ins2Akita mice. We measured blood glucose, body weigh...

journal_title：International journal of molecular medicine

authors： Asakawa A,Toyoshima M,Inoue K,Koizumi A

更新日期：2007-04-01 00:00:00

abstract：:To characterize the changes in global gene expression in the livers of H1/siRNAinsulin-CMV/hIDE transgenic (Tg) mice in response to the reduced bioavailability of insulin, total RNA extracted from the livers of 20-week-old Tg and non-Tg mice was converted to cDNA, labeled with biotin and hybridized to oligonucleotide ...

journal_title：International journal of molecular medicine

authors： Jee S,Hwang D,Seo S,Kim Y,Kim C,Kim B,Shim S,Lee S,Sin J,Bae C,Lee B,Jang M,Kim M,Yim S,Jang I,Cho J,Chae K

更新日期：2007-12-01 00:00:00

abstract：:Synthetic biomaterials combined with cells and osteogenic factors represent a promising approach for the treatment of a number of orthopedic diseases, such as bone trauma and congenital malformations. To guarantee optimal biological properties, bone substitutes are prepared with a 3D structure and porosity grade funct...

journal_title：International journal of molecular medicine

authors： Di Liddo R,Paganin P,Lora S,Dalzoppo D,Giraudo C,Miotto D,Tasso A,Barbon S,Artico M,Bianchi E,Parnigotto PP,Conconi MT,Grandi C

更新日期：2014-12-01 00:00:00

abstract：:In the present study, high-resolution magic-angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy was applied to live Pseudomonas aeruginosa (PA) bacterial cells to determine the metabolome of this opportunistic Gram-negative human pathogen, and in particular, its response to the volatile aromatic low m...

journal_title：International journal of molecular medicine

authors： Righi V,Constantinou C,Kesarwani M,Rahme LG,Tzika AA

更新日期：2018-10-01 00:00:00

abstract：:Clinical situations with release of proteinases from blood cells or tissues into the circulation may result in a marked decrease of blood proteinase inhibitor content which in turn may result in a capillary leak syndrome, shock and even in exitus letalis. Replenishment of blood proteinase inhibitors is of benefit in s...

journal_title：International journal of molecular medicine

authors： Langner J,Thiem M,Bohning V

更新日期：1999-12-01 00:00:00

abstract：:The skin, the conjunctivae, the airways and the digestive tract compose a huge vulnerable biological surface, which is exposed to the external environment. An allergen can often trigger an allergic reaction at a number of sites or result in an atopic march. However, the mechanism of atopic march remains unclear. Less ...

journal_title：International journal of molecular medicine

authors： Luo J,Li Y,Gong R

更新日期：2010-12-01 00:00:00

abstract：:The phospholipase A (PLA)2 family is the most complex gene family of phospholipases and plays a crucial role in a number of physiological activities. However, the phylogenetic background of the PLA2 gene family and the amino acid residues of the PLA2G7 gene following positive selection gene remain undetermined. In thi...

journal_title：International journal of molecular medicine

authors： Huang Q,Wu Y,Qin C,He W,Wei X

更新日期：2015-03-01 00:00:00

abstract：:Reperfusion injury (RI) remains an important limitation of myocardial revascularization. The aim of the present study was to evaluate the influence of the intracoronary injection of adiponectin on RI and cardiomyocyte death in a porcine myocardial infarction model. Acute infarction in 14 Polish domestic pigs was induc...

journal_title：International journal of molecular medicine

authors： Dębiński M,Buszman PP,Milewski K,Wojakowski W,Jackiewicz W,Pająk J,Szurlej D,Fryc-Stanek J,Wiernek S,Jelonek M,Spurlock ME,Martin J,Bochenek A,Buszman PE

更新日期：2011-06-01 00:00:00

abstract：:Cancer stem cells (CSCs) have recently been linked to new treatment strategies for gastric cancer due to the critical role which they play as the 'heartbeat' of cancer. In the present study, we explored the effects of quercetin, an anti-inflammatory and antiviral compound, on gastric CSCs (GCSCs). We noted that quercet...

journal_title：International journal of molecular medicine

authors： Shen X,Si Y,Wang Z,Wang J,Guo Y,Zhang X

更新日期：2016-08-01 00:00:00

abstract：:Annexin A9 (ANXA9), a member of annexin family, has been reported be associated with colorectal cancer (CRC) carcinogenesis. However, the clinical significance of ANXA9 in CRC, particularly its correlation to invasion and metastasis remains ambiguous. The aim of the present study was to investigate the significance of...

journal_title：International journal of molecular medicine

authors： Yu S,Bian H,Gao X,Gui L

更新日期：2018-04-01 00:00:00

abstract：:The treatment of locoregional recurrence (LRR) of head and neck squamous cell carcinoma (HNSCC) often requires a combination of surgery, radiation therapy and/or chemotherapy. Survival outcomes are poor and the treatment outcomes are morbid. Cold atmospheric plasma (CAP) is an ionized gas produced at room temperature ...

journal_title：International journal of molecular medicine

authors： Guerrero-Preston R,Ogawa T,Uemura M,Shumulinsky G,Valle BL,Pirini F,Ravi R,Sidransky D,Keidar M,Trink B

更新日期：2014-10-01 00:00:00

abstract：:The tumor microenvironment is thought to affect malignant transformation and tumor progression. The histone methyltransferase, enhancer of zeste homologue 2 (EZH2), has recently been suggested to play a critical role in the tumorigenesis of several types of human cancer. The aim of this study was to investigate the ef...

journal_title：International journal of molecular medicine

authors： Xu L,Deng Q,Pan Y,Peng M,Wang X,Song L,Xiao M,Wang Z

更新日期：2014-01-01 00:00:00

abstract：:After cessation of lactation, the mammary gland undergoes involution, regressing to a state resembling that of a virgin animal. This phase of mammary gland development is characterized by epithelial cell death and tissue remodeling. To understand molecular mechanisms of mammary gland involution, we identified involuti...

journal_title：International journal of molecular medicine

authors： Baik MG,Lee MJ,Choi YJ

更新日期：1998-07-01 00:00:00

abstract：:Sindbis vectors have shown remarkable antitumor efficacy and tumor-targeting capacity in animal models and hold promise for cancer therapy. Different packaging systems are used to produce propagation-incompetent Sindbis vectors. However, the vectors produced using either DH-BB single helper RNA or split helper RNA can...

journal_title：International journal of molecular medicine

authors： Hyvärinen A,Yongabi F,Mäkinen K,Wahlfors J,Pellinen R

更新日期：2013-08-01 00:00:00

abstract：:ABCA3 is a surfactant lipid transporter in the limiting membrane of lamellar bodies in alveolar type II cells. Mutations in the ATP-binding cassette, sub-family A (ABC1), member 3 (ABCA3) gene cause respiratory distress syndrome in newborns, and chronic interstitial lung disease in children and adults. ABCA3 belongs t...

journal_title：International journal of molecular medicine

authors： Frixel S,Lotz-Havla AS,Kern S,Kaltenborn E,Wittmann T,Gersting SW,Muntau AC,Zarbock R,Griese M

更新日期：2016-08-01 00:00:00

abstract：:Neural stem cell transplantation is a promising new treatment of ischemic or traumatic brain injury. We have now investigated the involvement of the peroxynitrite - poly(ADP-ribose) polymerase (ONOO- - PARP) activation cascade in brain trauma and neural stem cell transplantation. The forelimb motor cortex of adult mal...

journal_title：International journal of molecular medicine

authors： Lacza Z,Horváth EM,Komjáti K,Hortobágyi T,Szabó C,Busija DW

更新日期：2003-08-01 00:00:00