Identification and characterization of ARHGAP27 gene in silico.

abstract：:Kelch‑like ECH‑associated protein 1 (Keap1)/nuclear factor erythroid 2‑related factor 2 (Nrf2) signaling has a protective effect on normal cells. A number of previous studies demonstrated that Keap1/Nrf2 signaling is associated with drug resistance in numerous tumors. The aim of the present study was to investigate th...

journal_title：International journal of molecular medicine

authors： Huang H,Wu Y,Fu W,Wang X,Zhou L,Xu X,Huang F,Wu Y

更新日期：2019-05-01 00:00:00

abstract：:The miR-200 family was recently identified as a suppressor of epithelial-mesenchymal transition (EMT). The loss or gain of miR-200 family members is associated with cancer invasion. The epidermal growth factor receptor (EGFR) is overexpressed in the majority of anaplastic thyroid cancers (ATCs). The activation of EGFR...

journal_title：International journal of molecular medicine

authors： Zhang Z,Liu ZB,Ren WM,Ye XG,Zhang YY

更新日期：2012-10-01 00:00:00

abstract：:Inflammatory response has been shown to play a critical role in brain damage after cerebral ischemia-reperfusion (I/R) injury, which is tightly regulated by the Toll-like receptor (TLR)4/nuclear factor (NF)-κB pathway; therefore, suppression of TLR4/NF-κB signaling has become a prom...

journal_title：International journal of molecular medicine

authors： Lan L,Tao J,Chen A,Xie G,Huang J,Lin J,Peng J,Chen L

更新日期：2013-01-01 00:00:00

abstract：:The aim of this study was to evaluate in detail the histopathological characteristics of endarterectomized carotid atherosclerotic lesions in symptomatic versus asymptomatic patients. Twenty carotid lesions, 10 from asymptomatic and 10 from symptomatic patients who underwent carotid endarterectomy were classified acco...

journal_title：International journal of molecular medicine

authors： Hakimi M,Hyhlik-Dürr A,von Au A,Betz M,Demirel S,Dihlmann S,Böckler D,Gross-Weissmann ML

更新日期：2013-08-01 00:00:00

abstract：:Mechanosensitive (MS) neurons in the periodontal ligament (PDL) pass information to the trigeminal ganglion when excited by mechanical stimulation of the tooth. During occlusal tooth trauma of PDL tissues, MS neurons are injured, resulting in atrophic neurites and eventual degeneration of MS neurons. Nerve growth fact...

journal_title：International journal of molecular medicine

authors： Ohta M,Chosa N,Kyakumoto S,Yokota S,Okubo N,Nemoto A,Kamo M,Joh S,Satoh K,Ishisaki A

更新日期：2018-09-01 00:00:00

abstract：:In the above paper, the authors realize that an error inadvertently appeared in the funding section on p. 895. Where "This study was supported by the National Natural Science Foundation of China Science Fund Project (grant no. 30960389 and 8176010097)" was written, the application number 8176010097 was featured incorr...

journal_title：International journal of molecular medicine

authors： Li G,Zhou R,Zhao X,Liu R,Ye C

更新日期：2018-08-27 00:00:00

abstract：:MicroRNAs (miRNAs or miRs) play an important role in the tumorigenesis and progression of breast cancer. However, the function of miR‑28‑5p in breast cancer migration has yet to be determined. In the present study, Human MicroRNA Expression Database (HMED) analysis revealed that the expression level of miR‑28‑5p was s...

journal_title：International journal of molecular medicine

authors： Ma L,Zhang Y,Hu F

更新日期：2020-10-01 00:00:00

abstract：:Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, has been frequently used in targeted therapy for lung cancer. However, the widespread use of gefitinib in targeted therapy for patients with lung cancer is hampered by its common skin toxicities. The present study aimed to investigate the mechan...

journal_title：International journal of molecular medicine

authors： Fang H,Wang Y,Xu L,Zhou S,Bai J,Wu Y,Qiao J,Jiang X,Zhu D,Ding Y

更新日期：2019-03-01 00:00:00

abstract：:Down syndrome (DS) patients, after the fourth decade of life, display some neurophatological features of the Alzheimer's disease (AD). Several hypotheses suggested that apoE4 protein, an AD risk factor, might promote amyloid formation by stabilizing an aggregated conformation of the beta amyloid protein (Abeta). This ...

journal_title：International journal of molecular medicine

authors： Folin M,Baiguera S,Conconi MT,Pati T,Grandi C,Parnigotto PP,Nussdorfer GG

更新日期：2003-02-01 00:00:00

abstract：:Although endogenous digitalis‑like factor (EDLF) is associated with the development of various physical disorders, the role in preeclampsia remains unclear. This study investigated the effects of EDLF on vascular endothelial cell damage in patients with preeclampsia and the potential mechanisms. From July 2014 to July...

journal_title：International journal of molecular medicine

authors： Peng M,Yang M,Ding Y,Yu L,Deng Y,Lai W,Hu Y

更新日期：2018-02-01 00:00:00

abstract：:The tumor suppressor genes p15INK4B and p16INK4A, located in the chromosomal region 9p21, are frequently inactivated by homo- or hemizygous deletions, point mutation or promotor methylation in various types of cancer. No commercial probe is yet available that allows the detection of such deletions by FISH. Long distan...

journal_title：International journal of molecular medicine

authors： Bleichert A,Fiedler W,Claussen U,Ernst G,Loncarevic IF,Heller A,Liehr T,Kunert C,von Eggeling F

更新日期：2001-06-01 00:00:00

abstract：:Ghrelin is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R), which was originally isolated from rat stomach. Ghrelin and GHS-R are also expressed in several peripheral tissues, including adrenal glands, and this prompted us to study ghrelin expression and ghrelin-binding site localization in th...

journal_title：International journal of molecular medicine

authors： Tortorella C,Macchi C,Spinazzi R,Malendowicz LK,Trejter M,Nussdorfer GG

更新日期：2003-08-01 00:00:00

abstract：:It has been reported that the degeneration of cochlear hair cells is the typical cause of presbycusis (or age-related hearing loss). However, the molecular mechanisms that mediate cochlear hair cell apoptosis are not yet fully understood and there is no effective treatment for this disorder. MicroRNAs (miRNAs or miRs)...

journal_title：International journal of molecular medicine

authors： Xue T,Wei L,Zha DJ,Qiu JH,Chen FQ,Qiao L,Qiu Y

更新日期：2016-11-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) are a cell population mobilized from bone marrow into the peripheral circulation and recruited into sites of vessel injury to participate in blood vessel formation in both physiological and pathological conditions. Due to the lack of unique surfac...

journal_title：International journal of molecular medicine

authors： Li DW,Liu ZQ,Wei J,Liu Y,Hu LS

更新日期：2012-11-01 00:00:00

abstract：:Trypsinogen/trypsin is one of the major serine proteases and is produced by pancreatic acinar cells. Tumor-associated trypsinogen (TAT) has been reported to be produced by several cancer cell lines. The biological roles and activation mechanisms of both TAT and pancreatic acinar trypsinogen (PAT) have not been elucida...

journal_title：International journal of molecular medicine

authors： Uchima Y,Sawada T,Nishihara T,Umekawa T,Ohira M,Ishikawa T,Nishino H,Hirakawa K

更新日期：2003-12-01 00:00:00

abstract：:Soy sauce (Shoyu) is a traditional Japanese fermented seasoning and is available worldwide. We investigated the effect of Shoyu polysaccharides (SPS) prepared from soy sauce on the intestinal immune system of mice. SPS enhanced the production of immunoglobulin A (IgA) from Peyer's patch cells in vitro, and its oral ad...

journal_title：International journal of molecular medicine

authors： Matsushita H,Kobayashi M,Tsukiyama R,Fujimoto M,Suzuki M,Tsuji K,Yamamoto K

更新日期：2008-08-01 00:00:00

abstract：:Pulmonary hypertension (PH) is a life‑threatening lung disease, characterized by an increase in pulmonary arterial pressure caused by vasoconstriction and vascular remodeling. The pathogenesis of PH is not fully understood, and there is a lack of potential biomarkers for the diagnosis and treatment of patients with PH...

journal_title：International journal of molecular medicine

authors： Wang J,Zhu MC,Kalionis B,Wu JZ,Wang LL,Ge HY,Chen CC,Tang XD,Song YL,He H,Xia SJ

更新日期：2018-09-01 00:00:00

abstract：:Heparanase is an enzyme that degrades extracellular glycoprotein to release heparan sulfate molecules. CD44 variant exon 3 (CD44v3), a receptor for heparan sulfate, generates intracellular signals for cell migration. Production of CD44v3 and expression of heparanase were detected by immunohistochemistry and in situ hy...

journal_title：International journal of molecular medicine

authors： Kuniyasu H,Chihara Y,Kubozoe T,Takahashi T

更新日期：2002-09-01 00:00:00

abstract：:MicroRNAs (miRNAs or miRs) have emerged as key regulators of gene expression in essential cellular processes, such as cell growth, differentiation and development. Recent findings have established that the levels of miRNAs are modulated by cell signaling mechanisms, including the bone morphogenetic protein (BMP) signa...

journal_title：International journal of molecular medicine

authors： Hata A,Kang H

更新日期：2015-03-01 00:00:00

abstract：:Free radicals derived from the reaction of iron and oxygen are thought to be one of the causes of tissue injury. In order to identify whether oxygen concentrations are an important factor in iron-mediated damage to cells, cytotoxic effects of Fe(3+)-NTA on human fibroblasts (KMST-6 line) were studied under the conditi...

journal_title：International journal of molecular medicine

authors： Pu H,Sakaguchi M,Kondo T,Kondo A,Kawabata T,Namba M

更新日期：2001-03-01 00:00:00

abstract：:The number of patients suffering from diabetes mellitus is constantly rising worldwide, and diabetic retinopathy (DR) has become the most frequent cause of postnatal blindness. Vascular endothelial growth factor (VEGF) is known to play a central role during DR development. Thus, inhibiting the effects of VEGF may hamp...

journal_title：International journal of molecular medicine

authors： Ideno J,Mizukami H,Kakehashi A,Saito Y,Okada T,Urabe M,Kume A,Kuroki M,Kawakami M,Ishibashi S,Ozawa K

更新日期：2007-01-01 00:00:00

abstract：:Apelin, the endogenous ligand of APJ which is a member of G protein-coupled receptors, has been shown to be expressed in a variety of tissues in vivo and to exert significant biological effects. Studies have indicated that the apelin/APJ system is involved in the regulation of a variety of physiological functions and ...

journal_title：International journal of molecular medicine

authors： Zhou Q,Cao J,Chen L

更新日期：2016-05-01 00:00:00

abstract：:The development of diabetes mellitus (DM) is accompanied by hyperglycemia-induced oxidative stress. Hyperoside is a major bioactive component in Zanthoxylum bungeanum leaves (HZL) and is a natural antioxidant. However, the effects of HZL on DM and its mechanisms of action remain undefined. The present study evaluated ...

journal_title：International journal of molecular medicine

authors： Zhang Y,Wang M,Dong H,Yu X,Zhang J

更新日期：2018-01-01 00:00:00

abstract：:Clinical trials have started to implement tumor-associated antigens in the form of antigenic peptides in order to augment CD8(+) T-cell responses directed against autologous cancer cells. One of the surrogate markers for successful immunization is the characterization of T-lymphocytes reacting to the immunizing peptid...

journal_title：International journal of molecular medicine

authors： Höhn H,Reichert T,Neukirch C,Pilch H,Maeurer MJ

更新日期：1999-02-01 00:00:00

abstract：:Polysialic acid (PSA) is highly expressed during embryonic development, but barely expressed during postnatal development, and may be 're-expressed' in cancer tissues. In this study, motility and migration assays were performed to compare the changes in cell behavior between non-malignant and maligant cells. Next, the...

journal_title：International journal of molecular medicine

authors： Wang X,Li X,Zeng YN,He F,Yang XM,Guan F

更新日期：2016-01-01 00:00:00

abstract：:Chondrocyte senescence is associated with the aging and degeneration of cartilage, and eventually leads to joint destruction. The aim of this study was to elucidate the mechanisms responsible for the cytoprotective effects of heme oxygenase‑1 (HO‑1) on chondrocytes in cartilage. Chondrocyte senescence was induced usin...

journal_title：International journal of molecular medicine

authors： Kim KM,Park SE,Lee MS,Kim K,Park YC

更新日期：2014-11-01 00:00:00

abstract：:Osteosarcoma is the most common primary malignancy of bone in teenagers and approximately 30% of patients develop lung metastasis, which is the leading cause of mortality. Recent studies suggest that the Ezrin protein is correlated with the metastatic potential of several malignant ...

journal_title：International journal of molecular medicine

authors： Zhao H,Guo M,Zhao G,Ma Q,Ma B,Qiu X,Fan Q

更新日期：2012-11-01 00:00:00

abstract：:The prevalence of psoriasis is increasing, and poses a serious risk to human health and quality of life. Psoriasis, a chronic immune‑mediated skin disease with epidermal hyperkeratosis and parakeratosis, is associated with numerous complications, including metabolic syndromes that are regulated by sirtuins (SIRTs) via...

journal_title：International journal of molecular medicine

authors： Fan X,Yan K,Meng Q,Sun R,Yang X,Yuan D,Li F,Deng H

更新日期：2019-07-01 00:00:00

abstract：:Autologous chondrocyte implantation (ACI) relies on the use of cultured cells. However, the biosynthetic profile of cultured chondrocytes is shown to be altered during in vitro expansion. The purpose of this study therefore, was to examine the cellular phenotype of chondrocytes cultured for ACI and to determine the ap...

journal_title：International journal of molecular medicine

authors： Zheng MH,King E,Kirilak Y,Huang L,Papadimitriou JM,Wood DJ,Xu J

更新日期：2004-05-01 00:00:00

abstract：:We had shown previously that the novel, marine, anticancer compound dehydrothyrsiferol (DHT) does not modulate P-glycoprotein (P-gp) dependent drug efflux. Many chemotherapeutics with clinical impact are substrates for the structurally distant related membrane transport protein MRP1 (multidrug resistance-associated pr...

journal_title：International journal of molecular medicine

authors： Pec MK,Aguirre A,Fernández JJ,Souto ML,Dorta JF,Villar J

更新日期：2002-11-01 00:00:00