[Corrigendum] Correlation between the expression of IL‑18 and deep venous thrombosis.

abstract：:Aberrant glycosylation is a universal feature of cancer cells. There are quantitative and qualitative changes in expression of gangliosides observed in tumors of a neuroectodermal origin such as neuroblastoma, melanoma and astrocytoma. The presence of large amounts of GD2 ganglioside on neuroblastoma cells, as compare...

journal_title：International journal of molecular medicine

authors： Horwacik I,Czaplicki D,Talarek K,Kowalczyk A,Bolesta E,Kozbor D,Rokita H

更新日期：2007-05-01 00:00:00

abstract：:Apoptosis induced by docetaxel that interferes with microtubule polymerization dynamics and is used clinically to treat advanced cancers, has not been fully defined in squamous cell carcinoma. In this study, apoptotic events involved in docetaxel treatment were investigated. When the human oral squamous cell carcinoma...

journal_title：International journal of molecular medicine

authors： Taniguchi T,Takahashi M,Shinohara F,Sato T,Echigo S,Rikiishi H

更新日期：2005-04-01 00:00:00

abstract：:Physical exercise has a neuroprotective effect and is an important treatment after ischemic stroke. Promoting neurogenesis and myelin repair in the penumbra is an important method for the treatment of ischemic stroke. However, the role and potential mechanism of exercise in neurogenesis and myelin repair still needs t...

journal_title：International journal of molecular medicine

authors： Cheng J,Shen W,Jin L,Pan J,Zhou Y,Pan G,Xie Q,Hu Q,Wu S,Zhang H,Chen X

更新日期：2020-05-01 00:00:00

abstract：:miR-30a is situated on chromosome 6q.13 and is produced by an intronic transcriptional unit. However, its role in regulating the apoptosis, invasion and metastasis of breast cancer cells is not yet fully understood. The aim of this study was to research the biological function of miR‑30a and its direct target gene in ...

journal_title：International journal of molecular medicine

authors： Zhang HD,Jiang LH,Sun DW,Li J,Tang JH

更新日期：2017-10-01 00:00:00

abstract：:Small cell lung cancer (SCLC) is a highly aggressive lung neoplasm. To study the pathogenesis of SCLC, we investigated roles of ABCE1, a member of the ATP-binding cassette (ABC) superfamily, in the development of small cell lung cancer. RNA interference was used to knock down ABCE1 expression in human small cell lung ...

journal_title：International journal of molecular medicine

authors： Huang B,Gao Y,Tian D,Zheng M

更新日期：2010-05-01 00:00:00

abstract：:Peroxisome proliferator activated receptors (PPARs) are nuclear receptors regulating the expression of genes involved in lipid and glucose metabolism. Three different PPARs; alpha (PPARA), gamma (PPARG) and delta (PPARD) have been characterized and they are distinguished from each other by tissue distribution and cell...

journal_title：International journal of molecular medicine

authors： Skogsberg J,Kannisto K,Roshani L,Gagne E,Hamsten A,Larsson C,Ehrenborg E

更新日期：2000-07-01 00:00:00

abstract：:Glioblastoma is one of the most radioresistant tumors. Exposure of cells to ionizing radiation leads to formation of reactive oxygen species (ROS) that are associated with radiation-induced cytotoxicity. ROS scavengers, therefore, are one of the important factors in protecting cells against ROS injury during ionizing ...

journal_title：International journal of molecular medicine

authors： Lee HC,Kim DW,Jung KY,Park IC,Park MJ,Kim MS,Woo SH,Rhee CH,Yoo H,Lee SH,Hong SI

更新日期：2004-06-01 00:00:00

abstract：:Rac1, an intracellular signal transducer, regulates a variety of cell functions, including the organization of the cytoskeleton, cell migration, and invasion. Overexpression of Rac1 has been reported in several human cancers. However, the underlying mechanisms are not well understood. In the present study, we evaluate...

journal_title：International journal of molecular medicine

authors： Chen QY,Xu LQ,Jiao DM,Yao QH,Wang YY,Hu HZ,Wu YQ,Song J,Yan J,Wu LJ

更新日期：2011-11-01 00:00:00

abstract：:Hydrogen sulfide (H2S) has antifibrotic activity in the kidneys, heart, lungs, and other organs. The present study investigated the protective activity of exogenous H2S against myocardial fibrosis in a rat model of diabetes. Animals were assigned to normal control, diabetes mellitus (DM), DM + sodium hydrosulfide (NaH...

journal_title：International journal of molecular medicine

authors： Yang R,Jia Q,Ma SF,Wang Y,Mehmood S,Chen Y

更新日期：2019-08-01 00:00:00

abstract：:We have previously reported that the EVn-50 mixture of vitexins (lignan compounds) containing the purified vitexin (neolignan) compound, 6-hydroxy-4(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl‑7-methoxy-3,4-dihydro-2-naphthaldehyde, termed VB1, exhibits potent anticancer activity through the induction of apoptosis in s...

journal_title：International journal of molecular medicine

authors： Liu LH,Zhou YJ,Ding L,Zhang SZ,Sun J,Cao JG

更新日期：2014-02-01 00:00:00

abstract：:An effective therapeutic strategy for suppressing liver fibrosis development should improve the overall prognosis of patients with chronic liver diseases. Despite efforts to develop anti-fibrotic agents, no drugs have yet been approved as anti-fibrotic treatments for humans. An alternative strategy may be to employ a ...

journal_title：International journal of molecular medicine

authors： Yoshiji H,Noguchi R,Ikenaka Y,Kaji K,Aihara Y,Shirai Y,Yoshii J,Yanase K,Fukui H

更新日期：2011-07-01 00:00:00

abstract：:Cardiovascular diseases (CVDs), such as atherosclerosis, hypertension, myocardial infarction and diabetic heart disease, are associated with high morbidity and mortality rates worldwide, and may also induce multiple organ failure in their later stages, greatly reducing the long‑term survival of the patients. There are...

journal_title：International journal of molecular medicine

authors： Zhu Y,Shui X,Liang Z,Huang Z,Qi Y,He Y,Chen C,Luo H,Lei W

更新日期：2020-09-01 00:00:00

abstract：:The present study aimed to analyze the responses to autophagy in osteoarthritis (OA) and aging chondrocytes in order to elucidate the role of autophagy in the pathogenesis of OA. We used multiple assays to confirm that autophagic activity was downregulated in chondrocytes of aged articular cartilage. Surprisingly, we ...

journal_title：International journal of molecular medicine

authors： Chang J,Wang W,Zhang H,Hu Y,Wang M,Yin Z

更新日期：2013-12-01 00:00:00

abstract：:The aim of the present study was to investigate the expression of bone morphogenetic protein 7 (BMP7) in cervical cancer tissues, the effect of BMP7 on the proliferation, migration and epithelial‑mesenchymal transition (EMT) of cervical cancer HeLa cells and the possible mechanism involved. Immunohistochemistry was us...

journal_title：International journal of molecular medicine

authors： Sun R,Guan H,Liu W,Liang J,Wang F,Li C

更新日期：2020-05-01 00:00:00

abstract：:The circulating concentrations of triglycerides, high density lipoprotein (HDL)‑cholesterol, and low density lipoprotein (LDL)‑cholesterol have a substantial genetic component, and the heritability of early‑onset dyslipidemia might be expected to be higher compared with late‑onset forms. In the present study, exome‑wi...

journal_title：International journal of molecular medicine

authors： Yamada Y,Kato K,Oguri M,Horibe H,Fujimaki T,Yasukochi Y,Takeuchi I,Sakuma J

更新日期：2019-01-01 00:00:00

abstract：:Melanin-concentrating hormone (MCH) is known to be an important regulator for feeding and energy balance. MCH was recently reported to stimulate water intake independent of food intake. The purpose of the present study is to examine the dipsogenic response of MCH with special emphasis on sweetened beverages, the prefe...

journal_title：International journal of molecular medicine

authors： Sakamaki R,Uemoto M,Inui A,Asakawa A,Ueno N,Ishibashi C,Hirono S,Yukioka H,Kato A,Shinfuku N,Kasuga M,Katsuura G

更新日期：2005-06-01 00:00:00

abstract：:Aromatic turmerone (ar-turmerone) has been reported to have a cytotoxic effect on L-1210 and HL-60 cells. In the present study, we investigated the anticancer responses and immune activities in implanted tumor cells. Our study found that ar-turmerone inhibited the increase in the nu...

journal_title：International journal of molecular medicine

authors： Kim D,Suh Y,Lee H,Lee Y

更新日期：2013-02-01 00:00:00

abstract：:Paeonol (2'-hydroxy-4'-methoxyacetophenone) is an active component isolated from the root of Paeonia Suffruticosa Andrews. We previously found that paeonol inhibited vascular cell adhesion molecule-1 (VCAM‑1) expression, and thus may be useful for the prevention and treatment of rabbit atherosclerosis (AS); however, t...

journal_title：International journal of molecular medicine

authors： Yuan X,Chen J,Dai M

更新日期：2016-12-01 00:00:00

abstract：:MicroRNAs (miRNAs or miRs) play an important role in the tumorigenesis and progression of breast cancer. However, the function of miR‑28‑5p in breast cancer migration has yet to be determined. In the present study, Human MicroRNA Expression Database (HMED) analysis revealed that the expression level of miR‑28‑5p was s...

journal_title：International journal of molecular medicine

authors： Ma L,Zhang Y,Hu F

更新日期：2020-10-01 00:00:00

abstract：:Microsporum canis (M. canis) is a common pathogen that causes tinea capitis and is present worldwide. The incidence of M. canis infection, particularly tinea capitis, has been increasing in China. In our previous studies, family of serine hydrolases 1 (FSH1) was identified as a potential virulence factor in tinea capi...

journal_title：International journal of molecular medicine

authors： Zhang F,Tan C,Xu Y,Yang G

更新日期：2019-12-01 00:00:00

abstract：:It has been reported that the degeneration of cochlear hair cells is the typical cause of presbycusis (or age-related hearing loss). However, the molecular mechanisms that mediate cochlear hair cell apoptosis are not yet fully understood and there is no effective treatment for this disorder. MicroRNAs (miRNAs or miRs)...

journal_title：International journal of molecular medicine

authors： Xue T,Wei L,Zha DJ,Qiu JH,Chen FQ,Qiao L,Qiu Y

更新日期：2016-11-01 00:00:00

abstract：:Fatty liver is one of the local morphological manifestations of metabolic syndrome and is frequently associated with insulin resistance. Insulin resistance is also common in patients with chronic hepatitis C. Hyperinsulinemia is an independent risk factor for hypertension and cardiovascular mortality. The aim of this ...

journal_title：International journal of molecular medicine

authors： Enjoji M,Kotoh K,Kato M,Higuchi N,Kohjima M,Nakashima M,Nakamuta M

更新日期：2008-10-01 00:00:00

abstract：:Aquaporins (AQPs) have been found to be associated with a number of diseases. However, the role of AQP‑1 in the pathogenesis of osteoarthritis remains unclear. We previously found that AQP‑1 expression was upregulated in osteoarthritic cartilage and strongly correlated with caspase‑3 expression and activity. The aim o...

journal_title：International journal of molecular medicine

authors： Gao H,Gui J,Wang L,Xu Y,Jiang Y,Xiong M,Cui Y

更新日期：2016-12-01 00:00:00

abstract：:Biochemical modification of extracellular matrix (ECM) proteins can alter the function in overlying cells. We tested the hypothesis that metal-catalyzed oxidation of native ECM and individual matrix proteins modulates the activity of inducible nitric oxide synthase (iNOS) in cultured rat mesangial cells (RMC). Oxidize...

journal_title：International journal of molecular medicine

authors： Trachtman H,Futterweit S,Koss E,Bogart M,Mermelstein A

更新日期：1999-03-01 00:00:00

abstract：:Resistin is thought to cause insulin resistance and link obesity to type 2 diabetes mellitus. However, little is known about the effects of neuropeptide Y (NPY) on resistin gene expression in white adipose tissue (WAT). Resistin gene expression was determined by northern blot analysis in food-deprived mice after NPY a...

journal_title：International journal of molecular medicine

authors： Yuzuriha H,Inui A,Goto K,Asakawa A,Fujimiya M,Kasuga M

更新日期：2003-05-01 00:00:00

abstract：:The current study aimed to clarify the role of nucleolin in the phenotypic transformation of vascular smooth muscle cells (VSMCs) and to preliminarily explore its underlying mechanism. The spatial and temporal expression patterns of nucleolin, and the effects of angiotensin II (Ang II) on the expression of VSMC phenot...

journal_title：International journal of molecular medicine

authors： Fang L,Zhang PF,Wang KK,Xiao ZL,Yang M,Yu ZX

更新日期：2019-04-01 00:00:00

abstract：:O6-methylguanin-DNA methyltransferase (MGMT) is a DNA repair enzyme that transfers methyl groups from O6-methylguanine to itself. Alkylation of DNA at the O6 position of guanine is the first step by alkylating agents in inducing DNA mutations in an organism. When MGMT and the mismatch repair (MMR) system are impaired,...

journal_title：International journal of molecular medicine

authors： Kohya N,Kitajima Y,Kitahara K,Miyazaki K

更新日期：2003-01-01 00:00:00

abstract：:Parathyroid hormone (PTH) is the primary regulator of serum calcium homeostasis and bone metabolism. PTH acts primarily by binding to its receptor, PTH1R, in the bone and kidney. In addition to PTH, PTH1R also recognizes PTH-related peptide (PTHrP), a paracrine/autocrine factor originally described as the hormone resp...

journal_title：International journal of molecular medicine

authors： Müller M,Gagiannis S,Nawroth PP,Brune M,Schilling T

更新日期：2009-09-01 00:00:00

abstract：:We describe a novel spontaneous autosomal recessive mutation, cervelet-4 (crv4), which arose in a BALB/c strain. Mice homozygous for the mutation exhibit principally a reduced body size, a congenital neurological phenotype characterized by ataxic gait and intention tremor, with no gross anomalies observed in brain or ...

journal_title：International journal of molecular medicine

authors： Conti V,Aghaie A,Cilli M,Martin N,Caridi G,Musante L,Candiano G,Castagna M,Fairen A,Ravazzolo R,Guenet JL,Puliti A

更新日期：2006-10-01 00:00:00

abstract：:Plasminogen activator inhibitor-1 (PAI-1), a member of the serpin super-family, forms a covalent complex with its target proteinases, such as tissue and urokinase plasminogen activators. Thus, PAI-1 controls the physiological and pathological proteolysis. An abnormal expression of PAI-1 has been observed in different ...

journal_title：International journal of molecular medicine

authors： Jankun J,Specht Z,Szkudlarek M,Greenfield R,Gaikwad B,Trifonov L,Vaugeois J,Aleem AM,Basrur V,Selman SH,Zavodszky MI,Skrzypczak-Jankun E

更新日期：2006-03-01 00:00:00