Abstract:
:The present study aimed to analyze the responses to autophagy in osteoarthritis (OA) and aging chondrocytes in order to elucidate the role of autophagy in the pathogenesis of OA. We used multiple assays to confirm that autophagic activity was downregulated in chondrocytes of aged articular cartilage. Surprisingly, we found that the expression of autophagy-related proteins was not decreased in the tissues of patients with OA. We also observed that rapamycin-induced autophagy prevented the accumulation of subdiploid cells in young chondrocytes, while it induced cell death by autophagy in OA chondrocytes. Our results demonstrate that autophagic activity decreases with aging, and may be responsible for the cytoprotective effects in young cartilage. However, we found that autophagic activity in patients with OA was higher than in the aging group, and reported autophagic cell death in OA chondrocytes. These results suggest that autophagy plays both a cytoprotective and death-promoting role in the pathogenesis of OA.
journal_name
Int J Mol Medjournal_title
International journal of molecular medicineauthors
Chang J,Wang W,Zhang H,Hu Y,Wang M,Yin Zdoi
10.3892/ijmm.2013.1520subject
Has Abstractpub_date
2013-12-01 00:00:00pages
1311-8issue
6eissn
1107-3756issn
1791-244Xjournal_volume
32pub_type
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