Cellular Na+ handling mechanisms involved in airway smooth muscle contraction (Review).

abstract：:Granulomatous lobular mastitis (GLM) is a type of chronic mammary inflammation with unclear etiology. Currently systematic corticosteroids and methitrexate are considered as the main drugs for GLM treatment, but a high toxicity and risk of recurrence greatly limit their application. It is therefore an urgent requireme...

journal_title：International journal of molecular medicine

authors： Wang Z,Wang N,Liu X,Wang Q,Xu B,Liu P,Zhu H,Chen J,Situ H,Lin Y

更新日期：2018-01-01 00:00:00

abstract：:The response of living cells to change in cell environment depends on the action of second messenger molecules. The two second messenger molecules cAMP and Ca2+ regulate a large number of eukaryotic cellular events. Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1) is one of the key enzymes involved in ...

journal_title：International journal of molecular medicine

authors： Sharma RK,Das SB,Lakshmikuttyamma A,Selvakumar P,Shrivastav A

更新日期：2006-07-01 00:00:00

abstract：:Influenza is the most common infectious disease and is caused by influenza A virus (IAV) infection. Hemagglutinin (HA) is an important viral protein of influenza A and is a major component of current IAV vaccines. The side effects associated with IAV vaccination are well studied; however, the HA‑induced immunopatholog...

journal_title：International journal of molecular medicine

authors： Li Y,Hu H,Qi Z,Sun J,Li Y,Feng Q,Guo C,Wang H,Zhao P,Liu Y,Zhao X,Wang G,Zhang H,Liu L,Hu J

更新日期：2018-03-01 00:00:00

abstract：:Current therapy for glioma is suboptimal. The transfer of apoptosis genes to tumors constitutes one of the most promising strategies for cancer gene therapy. We have previously shown that massive apoptosis occurs when wild-type p53 or E2F-1 expression is induced in glioma. However, the mechanism of action and the effi...

journal_title：International journal of molecular medicine

authors： Gomez-Manzano C,Fueyo J,Alameda F,Kyritsis AP,Yung WK

更新日期：1999-01-01 00:00:00

abstract：:O6-methylguanin-DNA methyltransferase (MGMT) is a DNA repair enzyme that transfers methyl groups from O6-methylguanine to itself. Alkylation of DNA at the O6 position of guanine is the first step by alkylating agents in inducing DNA mutations in an organism. When MGMT and the mismatch repair (MMR) system are impaired,...

journal_title：International journal of molecular medicine

authors： Kohya N,Kitajima Y,Kitahara K,Miyazaki K

更新日期：2003-01-01 00:00:00

abstract：:Altered D-glucose metabolism prevails in the soleus muscle of rats depleted in long-chain polyunsaturated omega3 fatty acids (omega3). In these animals, the prior intravenous injection of an omega3-rich medium-chain triglyceride:fish oil emulsion (omega3-FO rats), as compared to that of an omega3-poor medium-chain tri...

journal_title：International journal of molecular medicine

authors： Malaisse WJ,Portois L,Sener A,Carpentier YA

更新日期：2007-12-01 00:00:00

abstract：:Imatinib is the therapeutic standard for newly diagnosed patients with chronic myeloid leukemia (CML). In these patients, imatinib has been shown to induce an apoptotic response specifically in cells expressing the oncogenic fusion protein BCR-ABL. Previous studies in our lab revealed that imatinib-induced apoptosis i...

journal_title：International journal of molecular medicine

authors： Liu J,Xiao Y,Xiong HM,Li J,Huang B,Zhang HB,Feng DQ,Chen XM,Wang XZ

更新日期：2012-04-01 00:00:00

abstract：:The present study aimed to explore possible prognostic marker genes in glioblastoma (GBM). Differentially expressed genes (DEGs) were screened by comparing microarray data of tumor and normal tissue samples from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) dataset GSE22866. Subsequently, the pr...

journal_title：International journal of molecular medicine

authors： Zhang Y,Xu J,Zhu X

更新日期：2018-04-01 00:00:00

abstract：:Maspin, identified as a 42 kDa unique tumor suppressive serine protease inhibitor (serpin), has multifaceted biological functions by interacting with various target molecules under physiological and pathological conditions including oxidative stress. However, the type of post-translational modification that confers th...

journal_title：International journal of molecular medicine

authors： Nawata S,Shi HY,Sugino N,Zhang M

更新日期：2011-02-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) epidemic in Brazil is spreading to small municipalities as well as the innermost parts of the country and scarce information has been reported on the frequency of HIV-1 resistance-associated mutations in these areas. To determine the frequency and diversity of the HIV-1 ...

journal_title：International journal of molecular medicine

authors： Figueiredo Saad F,Kaminami Morimoto H,Wiechmann SL,Bonametti AM,Ueda LT,Matsuo T,Reiche EM

更新日期：2010-10-01 00:00:00

abstract：:Mutations in the known predisposing breast cancer genes BRCA1 and BRCA2 account for only a small proportion (<10%) of breast cancer families in the Stockholm region of Sweden. This study aims to identify novel predisposing genes in non-BRCA1/BRCA2 breast cancer families. We have employed comparative genomic hybridizat...

journal_title：International journal of molecular medicine

authors： Maguire P,Holmberg K,Kost-Alimova M,Imreh S,Skoog L,Lindblom A

更新日期：2005-07-01 00:00:00

abstract：:Human gastric cancer SNU 484 cells express mutant p16, which migrates slower than the wild-type p16. We constructed an expression vector containing human p16 cDNA to evaluate the cytotoxic effects of exogenous p16 expression on SNU 484 cell proliferation and to explore the potential use of p16 in cancer gene therapy. ...

journal_title：International journal of molecular medicine

authors： Jeong YW,Kim KS,Oh JY,Park JC,Baek WK,Suh SI,Suh MH,Lee JC,Cho JW

更新日期：2003-07-01 00:00:00

abstract：:Aberrant DNA methylation on CpG islands is one of the most consistent epigenetic changes in human cancers, and the methylation process is catalyzed by DNA methyltransferase (DNMT). We evaluated i) the mRNA levels of three DNMTs; DNMT1, DNMT3a and DNMT3b, in 25 hepatocellular carcinomas (HCCs), in their corresponding n...

journal_title：International journal of molecular medicine

authors： Oh BK,Kim H,Park HJ,Shim YH,Choi J,Park C,Park YN

更新日期：2007-07-01 00:00:00

abstract：:The active fraction of the extract of Asiasari radix, the 60% methanol chromatographic fraction from the ethyl acetate layer (PPAR), was used to investigate the melanogenesis signal pathway in B16F10 melanoma cells. PPAR led to significantly decreased melanin synthesis and tyrosinase activity in a dose-dependent manne...

journal_title：International journal of molecular medicine

authors： Jang JY,Lee JH,Shin HK,Choi YH,Lee JD,Choi BT

更新日期：2010-02-01 00:00:00

abstract：:Aberrant glycosylation is a universal feature of cancer cells. There are quantitative and qualitative changes in expression of gangliosides observed in tumors of a neuroectodermal origin such as neuroblastoma, melanoma and astrocytoma. The presence of large amounts of GD2 ganglioside on neuroblastoma cells, as compare...

journal_title：International journal of molecular medicine

authors： Horwacik I,Czaplicki D,Talarek K,Kowalczyk A,Bolesta E,Kozbor D,Rokita H

更新日期：2007-05-01 00:00:00

abstract：:Trichostatin A (TSA), a histone deacetylase inhibitor, is widely used as an anticancer drug. Recently, TSA has been shown to exert a protective effect on ischemia/reperfusion (I/R) injury; however, the underlying mechanisms remain unclear. Forkhead box O3a (FoxO3a), a unique FoxO family member, has been shown to atten...

journal_title：International journal of molecular medicine

authors： Guo Y,Li Z,Shi C,Li J,Yao M,Chen X

更新日期：2017-10-01 00:00:00

abstract：:Although endogenous digitalis‑like factor (EDLF) is associated with the development of various physical disorders, the role in preeclampsia remains unclear. This study investigated the effects of EDLF on vascular endothelial cell damage in patients with preeclampsia and the potential mechanisms. From July 2014 to July...

journal_title：International journal of molecular medicine

authors： Peng M,Yang M,Ding Y,Yu L,Deng Y,Lai W,Hu Y

更新日期：2018-02-01 00:00:00

abstract：:Type I interferon (IFN) receptor consists of two chains (Hu-IFN-alphaR1 and Hu-IFN-alphaR2), and Hu-IFN-alphaR2 takes a soluble, short, or long form (Hu-IFN-alphaR2a, Hu-IFN-alphaR2b, or Hu-IFN-alphaR2c, respectively). We examined Hu-IFN-alphaR2 expression in hepatocellular carcinoma (HCC) tissues and their correspond...

journal_title：International journal of molecular medicine

authors： Takayama A,Yano H,Ogasawara S,Higaki K,Kojiro M

更新日期：2000-12-01 00:00:00

abstract：:GATA binding protein 3 (GATA3) is a key molecule regulating the balance in the ratio of type 1 helper T (Th1) cells to type 2 helper T (Th2) cells, which is thought to be indicative of the pathogenesis of allergic diseases such as asthma and atopic dermatitis. The aim of this study was to investigate the role of GATA3...

journal_title：International journal of molecular medicine

authors： Bae CJ,Lee JW,Shim SB,Jee SW,Lee SH,Woo JM,Lee CK,Hwang DY

更新日期：2011-08-01 00:00:00

abstract：:S100A4, one of the tandemly arranged S100 genes at chromosome 1q21, has been suggested to play a functional role in cell motility and invasiveness of tumor cell growth. We investigated the expression of S100A4 and the in vitro invasiveness of 4 human bile duct adenocarcinoma cell lines by the Matrigel assay. S100A4 wa...

journal_title：International journal of molecular medicine

authors： Katayama N,Murao S,Ajiki T,Kitazawa S,Onoyama H,Kuroda Y,Maeda S

更新日期：2000-11-01 00:00:00

abstract：:Colorectal cancer is the second leading cause of malignant death, and better preventive strategies are needed. The treatment of colonic cancer remains difficult because of the lack of effective chemotherapeutic agents; therefore it is important to continue to search for cellular functions that can be disrupted by chem...

journal_title：International journal of molecular medicine

authors： Selvakumar P,Pasha MK,Ashakumary L,Dimmock JR,Sharma RK

更新日期：2002-10-01 00:00:00

abstract：:CDC25A is a cell cycle-activating phosphatase that promotes transition from the G1 to S phase. We previously reported that overexpression of CDC25A in human hepatocellular carcinoma (HCC) tissue samples was associated with poor prognosis. In this study, we attempted suppression of CDC25A in HCC cells to elucidate the ...

journal_title：International journal of molecular medicine

authors： Xu X,Yamamoto H,Liu G,Ito Y,Ngan CY,Kondo M,Nagano H,Dono K,Sekimoto M,Monden M

更新日期：2008-02-01 00:00:00

abstract：:In the above paper, the authors realize that an error inadvertently appeared in the funding section on p. 895. Where "This study was supported by the National Natural Science Foundation of China Science Fund Project (grant no. 30960389 and 8176010097)" was written, the application number 8176010097 was featured incorr...

journal_title：International journal of molecular medicine

authors： Li G,Zhou R,Zhao X,Liu R,Ye C

更新日期：2018-08-27 00:00:00

abstract：:To gain a better understanding of the mechanisms that underpin aortic calcification, rodent models have been previously utilised. Regions of calcium and phosphate deposition are commonly visualised using labor-intensive two-dimensional histomorphometric techniques. In this study, we developed a novel micro-computed to...

journal_title：International journal of molecular medicine

authors： Huesa C,Millán JL,van 't Hof RJ,MacRae VE

更新日期：2013-11-01 00:00:00

abstract：:Selenium deficiency is a causative factor in heart failure and microRNAs (known as miRNAs or miRs) play an important role in numerous cardiovascular diseases. However, the changes of miRNA expression during selenium deficiency and whether selenium deficiency is involved in cardiac dysfunction remain unclear. In the pr...

journal_title：International journal of molecular medicine

authors： Xing Y,Liu Z,Yang G,Gao D,Niu X

更新日期：2015-01-01 00:00:00

abstract：:The effect of interferon-alpha (IFN) for chronic myeloid leukemia (CML) in the chronic phase (CP) was retrospectively evaluated in comparison with that of busulfan (BU) or hydroxyurea (HU) given alone. Among 107 patients diagnosed with CML between 1982 and 1997, 72 CP cases evaluable for long-term follow-up included 1...

journal_title：International journal of molecular medicine

authors： Itoh T,Tamura S,Takemoto Y,Kakishita E

更新日期：1999-12-01 00:00:00

abstract：:Telomerase activity and hTERT mRNA expression are upregulated in colorectal cancer. Whether they are inherent in colorectal adenomas, premalignant lesions to cancer, however, remains to be elucidated. We examined telomerase activity by the fluorescence-based telomeric repeat amplification protocol method and analyzed ...

journal_title：International journal of molecular medicine

authors： Kanamaru T,Tanaka K,Kotani J,Ueno K,Yamamoto M,Idei Y,Hisatomi H,Takeyama Y

更新日期：2002-08-01 00:00:00

abstract：:Autologous chondrocyte implantation (ACI) relies on the use of cultured cells. However, the biosynthetic profile of cultured chondrocytes is shown to be altered during in vitro expansion. The purpose of this study therefore, was to examine the cellular phenotype of chondrocytes cultured for ACI and to determine the ap...

journal_title：International journal of molecular medicine

authors： Zheng MH,King E,Kirilak Y,Huang L,Papadimitriou JM,Wood DJ,Xu J

更新日期：2004-05-01 00:00:00

abstract：:15-Deoxy-∆(12,14)-prostaglandin J(2) (15d-PGJ(2)), a peroxisome proliferator-activated receptor γ ligand, has been reported to have antiproliferative activity in certain types of cancer. The purpose of this study was to elucidate the effect of 15d-PGJ(2) on endometrial cancer cells, as well as the mechanism of action....

journal_title：International journal of molecular medicine

authors： Li H,Narahara H

更新日期：2013-04-01 00:00:00

abstract：:betaA25-35, a neurotoxic fragment of the Alzheimer beta-amyloid peptide (betaA), acts as a strong inducer of pro-inflammatory cytokines, such as interleukin (IL)-1 and IL-6, in glial cells. Since IL-1 is known to induce expression of both IL-1 and IL-6, we have investigated to what extent the induction of IL-1alpha an...

journal_title：International journal of molecular medicine

authors： Eriksson G,Zetterström M,Cortes Toro V,Bartfai T,Iverfeldt K

更新日期：1998-01-01 00:00:00