当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE期刊下所有文献 > Broadleaf Mahonia attenuates granulomatous lobular mastitis‑associated inflammation by inhibiting CCL‑5 expression in macrophages.

Broadleaf Mahonia attenuates granulomatous lobular mastitis‑associated inflammation by inhibiting CCL‑5 expression in macrophages.

Abstract：

:Granulomatous lobular mastitis (GLM) is a type of chronic mammary inflammation with unclear etiology. Currently systematic corticosteroids and methitrexate are considered as the main drugs for GLM treatment, but a high toxicity and risk of recurrence greatly limit their application. It is therefore an urgent requirement that safe and efficient natural drugs are found to improve the GLM prognosis. Broadleaf Mahonia (BM) is a traditional Chinese herb that is believed to have anti‑inflammatory properties according to ancient records of traditional Chinese medicine. The present study investigated this belief and demonstrated that BM significantly inhibited the expression of interleukin‑1β (IL‑1β), IL‑6, cyclooxygenase‑2 and inducible nitric oxide synthase in RAW264.7 cells, but had little influence on the cell viability, cell cycle and apoptosis. Meanwhile, the lipopolysaccharide‑induced elevation of reactive oxygen species and nitric oxide was also blocked following BM treatment, accompanied with decreased activity of nuclear factor‑κB and MAPK signaling. A cytokine array further validated that BM exhibited significant inhibitory effects on several chemoattractants, including chemokine (C‑C motif) ligand (CCL)‑2, CCL‑3, CCL‑5 and secreted tumor necrosis factor receptor 1, among which CCL‑5 exhibited the highest inhibition ratio in cell and clinical GLM specimens. Collectively, the results show that BM is a novel effective anti‑inflammatory herb in vitro and ex vivo, and that CCL‑5 may be closely associated with GLM pathogenesis.

journal_name

Int J Mol Med

journal_title

International journal of molecular medicine

authors

Wang Z,Wang N,Liu X,Wang Q,Xu B,Liu P,Zhu H,Chen J,Situ H,Lin Y

doi

10.3892/ijmm.2017.3246

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

340-352

issue

1

eissn

1107-3756

issn

1791-244X

journal_volume

41

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE文献大全
  • Proinflammatory circulating molecules in peripheral arterial disease.

    abstract：:Peripheral arterial disease (PAD) affects about 5% of the elderly population in the western world. It has been reported that PAD is associated with elevated plasma levels of the inflammatory markers. The goal of this review is to describe which proinflammatory molecules may play a role in PAD development, C-reactive p...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章,评审

    doi：

    authors： Signorelli SS,Mazzarino MC,Spandidos DA,Malaponte G

    更新日期：2007-09-01 00:00:00

  • Growth of rat mesangial cells on oxidized extracellular matrix increases inducible nitric oxide synthase activity.

    abstract：:Biochemical modification of extracellular matrix (ECM) proteins can alter the function in overlying cells. We tested the hypothesis that metal-catalyzed oxidation of native ECM and individual matrix proteins modulates the activity of inducible nitric oxide synthase (iNOS) in cultured rat mesangial cells (RMC). Oxidize...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.3.3.323

    authors： Trachtman H,Futterweit S,Koss E,Bogart M,Mermelstein A

    更新日期：1999-03-01 00:00:00

  • Cannabinoid receptor type 1 mediates high-fat diet-induced insulin resistance by increasing forkhead box O1 activity in a mouse model of obesity.

    abstract：:Hepatic glucose production is promoted by forkhead box O1 (FoxO1) under conditions of insulin resistance. The overactivity of cannabinoid receptor type 1 (CB1R) partly causes increased liver fat deposits and metabolic dysfunction in obese rodents by decreasing mitochondrial function. The aim of the present study was t...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2016.2475

    authors： Chen CC,Lee TY,Kwok CF,Hsu YP,Shih KC,Lin YJ,Ho LT

    更新日期：2016-03-01 00:00:00

  • Cytokine-induced neutrophil accumulation in the pathogenesis of acute reflux esophagitis in rats.

    abstract：:Although recent reports indicate an increasing incidence of patients with reflux esophagitis, its pathomechanism remains unclear. Cytokines and neutrophils, the latter of which produce reactive oxygen species (ROS), have been implicated in the formation of gastrointestinal diseases. This study investigated the roles o...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Yamaguchi T,Yoshida N,Tomatsuri N,Takayama R,Katada K,Takagi T,Ichikawa H,Naito Y,Okanoue T,Yoshikawa T

    更新日期：2005-07-01 00:00:00

  • Gain of Xq detected by comparative genomic hybridization in elastofibroma.

    abstract：:Elastofibroma is a rare, benign, slow-growing degenerative pseudotumor that typically occurs in the subscapular region and has been considered a peculiar fibroblastic proliferation with accumulation of abnormal elastic fibers. Very little is known about the cytogenetic and molecular genetic changes in elastofibroma. I...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Nishio JN,Iwasaki H,Ohjimi Y,Ishiguro M,Koga T,Isayama T,Naito M,Kikuchi M

    更新日期：2002-09-01 00:00:00

  • Transcriptome analysis of Klf15‑mediated inhibitory functions in a mouse deep venous thrombosis model.

    abstract：:Krüppel‑like family (KLF) members are important regulators of proinflammatory activation in the vasculature. A transcriptome study involving RNA sequencing (RNA‑seq) and quantitative PCR (qPCR) was performed to investigate Klf15 and Klf15‑regulated gene levels in C57BL/6 mice with inferior vena cava thrombi and in con...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2020.4538

    authors： Zhou J,Zhao X,Xie S,Zhou R

    更新日期：2020-06-01 00:00:00

  • Platelet-rich plasma inhibits RANKL-induced osteoclast differentiation through activation of Wnt pathway during bone remodeling.

    abstract：:Platelet-rich plasma (PRP) is used in the clinic as an autologous blood product to stimulate bone regeneration and chondrogenesis. Numerous studies have demonstrated that PRP affects bone remodeling by accelerating osteoblast formation. With the research perspective focusing on osteoclasts, the present study establish...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2017.3258

    authors： Wang D,Weng Y,Guo S,Zhang Y,Zhou T,Zhang M,Wang L,Ma J

    更新日期：2018-02-01 00:00:00

  • The inhibitory effect and the molecular mechanism of glabridin on RANKL-induced osteoclastogenesis in RAW264.7 cells.

    abstract：:Osteoblastic bone formation and osteoclastic bone resorption are in balance to maintain a constant, homeostatically controlled amount of bone. Excessive bone resorption by osteoclasts is involved in the pathogenesis of bone-related disorders. In the present study, we evaluated the i...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2011.822

    authors： Kim HS,Suh KS,Sul D,Kim BJ,Lee SK,Jung WW

    更新日期：2012-02-01 00:00:00

  • Inducible HSP70 antagonizes cisplatin‑induced cell apoptosis through inhibition of the MAPK signaling pathway in HGC‑27 cells.

    abstract：:Inducible heat shock protein 70 (HSP70; also known as HSPA1 or HSP72) is implicated in cancer. As a stress‑inducible heat shock protein, HSP70 is highly expressed in a variety of cancers and correlates with metastasis, chemotherapy resistance and tumor prognosis. The present study demonstrated that suppression of HSP7...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2018.3789

    authors： Sheng L,Tang T,Liu Y,Ma Y,Wang Z,Tao H,Zhang Y,Qi Z

    更新日期：2018-10-01 00:00:00

  • Adipose‑derived stem cells overexpressing SK4 calcium‑activated potassium channel generate biological pacemakers.

    abstract：:Recent studies have suggested that calcium‑activated potassium channel (KCa) agonists increase the proportion of mouse embryonic stem cell‑derived cardiomyocytes and promote the differentiation of pacemaker cells. In the present study, it was hypothesized that adipose‑derived stem cells (ADSCs) can differentiate into ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2019.4374

    authors： Yang M,Zhao Q,Zhao H,Yang A,Wang F,Wang X,Tang Y,Huang C

    更新日期：2019-12-01 00:00:00

  • Genetic differences in osteogenic differentiation potency in the thoracic ossification of the ligamentum flavum under cyclic mechanical stress.

    abstract：:Mechanical stress and genetic factors play important roles in the occurrence of thoracic ossification of ligament flavum (TOLF), which can occur at one, two, or multiple levels of the spine. It is unclear whether single- and multiple-level TOLF differ in terms of osteogenic differentiation potency and osteogenesis-rel...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2016.2803

    authors： Ning S,Chen Z,Fan D,Sun C,Zhang C,Zeng Y,Li W,Hou X,Qu X,Ma Y,Yu H

    更新日期：2017-01-01 00:00:00

  • Effects of electrolytes on virus inactivation by acidic solutions.

    abstract：:Acidic pH is frequently used to inactivate viruses. We have previously shown that arginine synergizes with low pH in enhancing virus inactivation. Considering a potential application of the acid inactivation of viruses for the prevention and treatment of superficial virus infection at body surfaces and fixtures, herei...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2011.668

    authors： Nishide M,Tsujimoto K,Uozaki M,Ikeda K,Yamasaki H,Koyama AH,Arakawa T

    更新日期：2011-06-01 00:00:00

  • Role of TXNDC5 in tumorigenesis of colorectal cancer cells: In vivo and in vitro evidence.

    abstract：:Thioredoxin domain‑containing 5 (TXNDC5) is reportedly overexpressed in colorectal cancer (CRC) and is therefore considered an oncogene. However, the role of TXNDC5 in CRC tumorigenesis remains unclear. The present study aimed to explore the role of TXNDC5 in CRC tumorigenesis in vitro and in vivo under hypoxic and no...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2018.3664

    authors： Tan F,Zhu H,He X,Yu N,Zhang X,Xu H,Pei H

    更新日期：2018-08-01 00:00:00

  • Molecular correlates of bcl-2-enhanced growth following androgen-ablation in prostate carcinoma cells in vivo.

    abstract：:Androgen-independent growth of prostate cancer is correlated with expression of bcl-2. The impact of bcl-2 expression on the growth of prostate cancer cells following androgen ablation, was examined in the androgen-sensitive prostatic carcinoma cell line, LNCaP. Vector control and bcl-2 expressing LNCaP cells were gro...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.1.6.953

    authors： Beham AW,Sarkiss M,Brisbay S,Tu SM,von Eschenbach AC,McDonnell TJ

    更新日期：1998-06-01 00:00:00

  • Sevoflurane inhibits the proliferation and invasion of hepatocellular carcinoma cells through regulating the PTEN/Akt/GSK‑3β/β‑catenin signaling pathway by downregulating miR‑25‑3p.

    abstract：:Sevoflurane (Sevo) is one of the most frequently used volatile anesthetic agents in surgical oncology and has various effects on tumors, including inhibiting tumor growth, recurrence, and metastases; however, the molecular mechanisms are unknown. This study tried to investigate the influence of Sevo on hepatocellular ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2020.4577

    authors： Cao Y,Lv W,Ding W,Li J

    更新日期：2020-07-01 00:00:00

  • Involvement of vascular endothelial growth factor signaling in CLR/RAMP1 and CLR/RAMP2-mediated pro-angiogenic effect of intermedin on human vascular endothelial cells.

    abstract：:Intermedin (IMD) is a recently discovered peptide closely related to adrenomedullin. Its principal physiological activity is its role in the regulation of the cardiovascular system, where it exerts a potent hypotensive effect. In addition, data were recently provided showing that this peptide is able to exert a clearc...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm_00000464

    authors： Albertin G,Sorato E,Oselladore B,Mascarin A,Tortorella C,Guidolin D

    更新日期：2010-08-01 00:00:00

  • DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy.

    abstract：:DJ-1 plays roles in transcriptional regulation and anti-oxidative stress, and loss of its function is thought to result in the onset of Parkinson's disease. DJ-1 has a protease-like structure and transthyretin (TTR), a protein causing familial amyloidotic polyneuropathy (FAP), was identified as a substrate for DJ-1 pr...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Koide-Yoshida S,Niki T,Ueda M,Himeno S,Taira T,Iguchi-Ariga SM,Ando Y,Ariga H

    更新日期：2007-06-01 00:00:00

  • Alteration of T helper cell subsets in the optic nerve of experimental autoimmune encephalomyelitis.

    abstract：:The objective of this study was to detect interleukin-17 (IL-17), interferon-gamma (IFN-gamma), interleukin-4 (IL-4) and forkhead/winged helix transcription factor p3 (Foxp3) protein and gene expression of the optic nerve and to further explore the role of T helper cell subsets such as Th1, Th2, Th17 and Treg in the p...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm_00000416

    authors： Tian AY,Zhang RW,Shi XG,Yu HM

    更新日期：2010-06-01 00:00:00

  • Adenosine and inosine exert cytoprotective effects in an in vitro model of liver ischemia-reperfusion injury.

    abstract：:Liver ischemia represents a common clinical problem. In the present study, using an in vitro model of hepatic ischemia-reperfusion injury, we evaluated the potential cytoprotective effect of the purine metabolites, such as adenosine and inosine, and studied the mode of their pharmacological actions. The human hepatoce...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2012.1203

    authors： Módis K,Gerő D,Stangl R,Rosero O,Szijártó A,Lotz G,Mohácsik P,Szoleczky P,Coletta C,Szabó C

    更新日期：2013-02-01 00:00:00

  • p38 mitogen-activated protein kinase gene silencing rescues rat hippocampal neurons from ketamine-induced apoptosis: An in vitro study.

    abstract：:Ketamine (KTM) is an anesthetic drug with several advantages, including the elevation of cardiac output and blood pressure. However, KTM may also induce the apoptosis of hippocampal neurons. Notably, p38 mitogen‑activated protein kinase (p38MAPK) has previously been studied for its role in neuronal injury. Therefore, ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2018.3750

    authors： Guo XQ,Cao YL,Zhao L,Zhang X,Yan ZR,Chen WM

    更新日期：2018-09-01 00:00:00

  • Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.

    abstract：:The prevalence of psoriasis is increasing, and poses a serious risk to human health and quality of life. Psoriasis, a chronic immune‑mediated skin disease with epidermal hyperkeratosis and parakeratosis, is associated with numerous complications, including metabolic syndromes that are regulated by sirtuins (SIRTs) via...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2019.4173

    authors： Fan X,Yan K,Meng Q,Sun R,Yang X,Yuan D,Li F,Deng H

    更新日期：2019-07-01 00:00:00

  • The action of GLP-1 and exendins upon glucose transport in normal human adipocytes, and on kinase activity as compared to morbidly obese patients.

    abstract：:A role of GLP-1 (glucagon-like peptide-1) in the recovery of the metabolic conditions of morbidly obese patients after bariatric surgery has been proposed. Exendin 4 (Ex-4) and exendin 9 (Ex-9) both have GLP-1-like effects upon glucose metabolism in human myocytes. We investigated in normal human adipocytes the effect...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Sancho V,Nuche B,Arnés L,Cancelas J,González N,Díaz-Miguel M,Martín-Duce A,Valverde I,Villanueva-Peñacarrillo ML

    更新日期：2007-06-01 00:00:00

  • Growth promoting in vitro effect of synthetic cyclic RGD-peptides on human osteoblast-like cells attached to cancellous bone.

    abstract：:In tissue engineering, the application of biofunctional compounds on biomaterials such as integrin binding RGD-peptides has gained growing interest. Anchorage-dependent cells like osteoblasts bind to these peptides thus ameliorating the integration of a synthetic implant. In case sterilized bone grafts are used as sub...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Magdolen U,Auernheimer J,Dahmen C,Schauwecker J,Gollwitzer H,Tübel J,Gradinger R,Kessler H,Schmitt M,Diehl P

    更新日期：2006-06-01 00:00:00

  • The effect of zipper-interacting protein kinase on high glucose-stimulated human aortic smooth muscle cells.

    abstract：:Biologic abnormalities in vascular smooth muscle cells (VSMC) may perform a crucial role in the pathogenesis of diabetic vascular disease. The principal aim of this study was to determine the effects of zipper-interacting protein kinase (ZIPK) on human aortic smooth muscle cells (HASMCs) stimulated by high glucose (HG...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2014.1697

    authors： Ye Z,Wu W,He M,Leong M,Hu R,Li Y,Zhang S

    更新日期：2014-05-01 00:00:00

  • Induction of tumor cell apoptosis by taurine Schiff base copper complex is associated with the inhibition of proteasomal activity.

    abstract：:Schiff bases have been intensively investigated due to their antibacterial and antitumor properties. Copper is a cofactor essential for the tumor angiogenesis processes, whereas other transition metals are not. Consistently, high serum or tissue levels of copper were found in many types of human cancer including breas...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Zhang X,Bi C,Fan Y,Cui Q,Chen D,Xiao Y,Dou QP

    更新日期：2008-11-01 00:00:00

  • Vibrio extracellular protease with prothrombin activation and fibrinolytic activities.

    abstract：:A 36 kDa extracellular metalloprotease (designated to as vEP-MO6) was purified and characterized from Vibrio vulnificus sp. strain MO6 24/0. vEP-MO6 cleaved azocasein and a few other proteins such as prothrombin, plasminogen, fibrinogen and Factor Xa, which are associated with the blood coagulation pathway. The enzyme...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Kwon JY,Chang AK,Park JE,Shin SY,Yoon SM,Lee JS

    更新日期：2007-01-01 00:00:00

  • Increased expression of human histocompatibility leukocyte antigen-G in colorectal cancer cells.

    abstract：:Human histocompatibility leukocyte antigen (HLA)-G is a nonclassical major histocompatibility complex class I molecule. HLA-G is known to provide tolerance from recognition by natural killer cells. We studied HLA-G expression in 39 human colorectal cancers and 23 extra-neoplastic colon tissue samples by RT-PCR. The ex...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2.3.349

    authors： Fukushima Y,Oshika Y,Nakamura M,Tokunaga T,Hatanaka H,Abe Y,Yamazaki H,Kijima H,Ueyama Y,Tamaoki N

    更新日期：1998-09-01 00:00:00

  • Role of LOX-1 in Ang II-induced oxidative functional damage in renal tubular epithelial cells.

    abstract：:The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), plays an important role in angiotension II (Ang II)-induced hypertensive renal injury associated with pro-inflammatory responses, tubular functional damage and cellular apoptosis. In this study, we report on the role of LOX-1 in Ang II-induced oxidat...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm_00000514

    authors： Xu Y,Ruan S,Xie H,Lin J

    更新日期：2010-11-01 00:00:00

  • Epigenetic silencing of HDAC1 by miR-449a upregulates Runx2 and promotes osteoblast differentiation.

    abstract：:Human-induced pluripotent (iPS) cells can be induced to differentiate into osteoblasts, but the process is inefficient and time-consuming. Previous studies indicated a close association between the expression of Runx2 and osteoblast differentiation, and established that the transcriptional activation of the Runx2 gene...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2014.2004

    authors： Liu T,Hou L,Zhao Y,Huang Y

    更新日期：2015-01-01 00:00:00

  • Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion.

    abstract：:Epidemiological studies suggest that the intake of natural/nutrient products is inversely related to cancer risk. While oxidative stress, generating reactive oxygen species, has been linked to cancer initiation and progression, dietary antioxidants have reduced the risk of certain cancers. Experimental studies have de...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Thyagarajan A,Jiang J,Hopf A,Adamec J,Sliva D

    更新日期：2006-10-01 00:00:00