Vibrio extracellular protease with prothrombin activation and fibrinolytic activities.

abstract：:Mammalian cardiomyocytes may permanently lose their ability to proliferate after birth. Therefore, studying the proliferation and growth arrest of cardiomyocytes during the postnatal period may enhance the current understanding regarding this molecular mechanism. The present study identified the differentially express...

journal_title：International journal of molecular medicine

authors： Wang R,Su C,Wang X,Fu Q,Gao X,Zhang C,Yang J,Yang X,Wei M

更新日期：2018-01-01 00:00:00

abstract：:Aberrant methylation of promoter CpG islands is known to be responsible for the alteration and silencing of genes in cancer. The data presented here describes that the CpG methylations of ERalpha and ERbeta are found in breast cancer tissues, and methylation exerts a considerable effect on gene silencing, investigated...

journal_title：International journal of molecular medicine

authors： Kim SJ,Kim TW,Lee SY,Park SJ,Kim HS,Chung KW,Lee ES,Kang HS

更新日期：2004-08-01 00:00:00

abstract：:To estimate the genetic and dietary factors influencing bone mineral density (BMD) in young adults, a total of 53 healthy volunteers (HV) (age 20.89+/-1.34), from whom informed consent was obtained, answered a questionnaire on dietary factors and had DNA from peripheral blood mononuclear cells analyzed for single nucl...

journal_title：International journal of molecular medicine

authors： Otsuki T,Sakaguchi H,Hatta E,Hatayama T,Hatada S,Miura Y,Takata-Tomokuni A,Hyodoh F,Tomomitsu T,Fukunaga M,Katsuyama H

更新日期：2004-10-01 00:00:00

abstract：:DNA vaccines raise immune responses by expressing proteins in vaccinated hosts. Responses are raised by nanogram levels of protein expression. Popular methods of DNA delivery include intramuscular (i. m.) injections of DNA in saline and gene gun delivery of DNA-coated gold beads to the epidermis. Professional antigen-...

journal_title：International journal of molecular medicine

authors： Robinson HL

更新日期：1999-11-01 00:00:00

abstract：:The ZNF268 gene was originally isolated from an early human embryo cDNA library. Several different transcripts have been isolated for the ZNF268 gene and developmental expression studies suggest that ZNF268 plays a role in the development of human fetal liver and the differentiation of blood cells. In our effort to st...

journal_title：International journal of molecular medicine

authors： Shao H,Zhu C,Zhao Z,Guo M,Qiu H,Liu H,Wang D,Xue L,Gao L,Sun C,Li W

更新日期：2006-09-01 00:00:00

abstract：:Although recent reports indicate an increasing incidence of patients with reflux esophagitis, its pathomechanism remains unclear. Cytokines and neutrophils, the latter of which produce reactive oxygen species (ROS), have been implicated in the formation of gastrointestinal diseases. This study investigated the roles o...

journal_title：International journal of molecular medicine

authors： Yamaguchi T,Yoshida N,Tomatsuri N,Takayama R,Katada K,Takagi T,Ichikawa H,Naito Y,Okanoue T,Yoshikawa T

更新日期：2005-07-01 00:00:00

abstract：:Antitumor vaccination therapy approaches using naked plasmid DNA or recombinant viruses encoding tumor-associated antigens are currently in development. In the present study, we examined the therapeutic efficacy of vaccination using the mouse alpha-fetoprotein (AFP) gene in mouse hepatocellular carcinoma (HCC) cells. ...

journal_title：International journal of molecular medicine

authors： Saeki A,Nakao K,Nagayama Y,Yanagi K,Matsumoto K,Hayashi T,Ishikawa H,Hamasaki K,Ishii N,Eguchi K

更新日期：2004-01-01 00:00:00

abstract：:The tree shrew (Tupaia belangeri) diverges from the primate order (Primates) and is classified as a separate taxonomic group of mammals - Scandentia. It has been suggested that the tree shrew can be used as an animal model for studying human diseases; however, the genomic sequence of the tree shrew is largely unidenti...

journal_title：International journal of molecular medicine

authors： Zheng Y,Yun C,Wang Q,Smith WW,Leng J

更新日期：2015-02-01 00:00:00

abstract：:In the present study, high-resolution magic-angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy was applied to live Pseudomonas aeruginosa (PA) bacterial cells to determine the metabolome of this opportunistic Gram-negative human pathogen, and in particular, its response to the volatile aromatic low m...

journal_title：International journal of molecular medicine

authors： Righi V,Constantinou C,Kesarwani M,Rahme LG,Tzika AA

更新日期：2018-10-01 00:00:00

abstract：:Apoptosis induced by docetaxel that interferes with microtubule polymerization dynamics and is used clinically to treat advanced cancers, has not been fully defined in squamous cell carcinoma. In this study, apoptotic events involved in docetaxel treatment were investigated. When the human oral squamous cell carcinoma...

journal_title：International journal of molecular medicine

authors： Taniguchi T,Takahashi M,Shinohara F,Sato T,Echigo S,Rikiishi H

更新日期：2005-04-01 00:00:00

abstract：:To assess effects of Celecoxib, selective cyclo-oxygenase (COX)-2 inhibitor, on matrix synthesis by chondrocytes under mechanical stress in vitro. Chondrocytes from 7-day-old rat articular cartilage were cultured. Cyclic mechanical stress (0.5 Hz, 7% elongation) was loaded using a Flexercell strain unit in the presenc...

journal_title：International journal of molecular medicine

authors： Iimoto S,Watanabe S,Takahashi T,Shimizu A,Yamamoto H

更新日期：2005-12-01 00:00:00

abstract：:Apelin, the endogenous ligand of APJ which is a member of G protein-coupled receptors, has been shown to be expressed in a variety of tissues in vivo and to exert significant biological effects. Studies have indicated that the apelin/APJ system is involved in the regulation of a variety of physiological functions and ...

journal_title：International journal of molecular medicine

authors： Zhou Q,Cao J,Chen L

更新日期：2016-05-01 00:00:00

abstract：:Curcumin is an orange-yellow colored, lipophilic polyphenol substance derived from the rhizome of Curcuma longa that is widely used in many countries. Curcumin has many reported functions, including antioxidant and anti‑inflammatory effects. Autophagy removes damaged organelles and protein aggregates in the cell. Howe...

journal_title：International journal of molecular medicine

authors： Wang JL,Wang JJ,Cai ZN,Xu CJ

更新日期：2018-11-01 00:00:00

abstract：:Molecular analysis are useful for diagnosis, prognosis and follow-up of the patients, as well as for addressing therapeutic choices. Most of the molecular methods are based on the analysis of nucleic acids. The DNA and RNA methodologies of routine applicability include Southern and Northern hybridizations and polymera...

journal_title：International journal of molecular medicine

authors： Scarpa A,Tognon M

更新日期：1998-06-01 00:00:00

abstract：:Proteasome inhibitors, like MG132, can exert cell growth inhibitory and apoptotic effects in different tumor types. The apoptotic mechanism of these compounds involves the activation of the effector caspases. beta-catenin, also an oncogene, represents one of the substrates of these proteases, but the consequences of i...

journal_title：International journal of molecular medicine

authors： Cervello M,Giannitrapani L,La Rosa M,Notarbartolo M,Labbozzetta M,Poma P,Montalto G,D'Alessandro N

更新日期：2004-05-01 00:00:00

abstract：:Hepatocellular carcinoma is a common type of cancer that is usually associated with poor prognosis. In this study, we examined the in vitro and in vivo mechanisms of the traditional Vietnamese herb Zanthoxylum avicennae on the inhibition of HA22T human hepatocellular carcinoma cell ...

journal_title：International journal of molecular medicine

authors： Dung TD,Chang HC,Binh TV,Lee MR,Tsai CH,Tsai FJ,Kuo WW,Chen LM,Huang CY

更新日期：2012-06-01 00:00:00

abstract：:The present study aimed to develop a tumor necrosis factor‑α (TNF‑α) B‑cell epitope/IL‑1β helper T lymphocyte epitope complex MAP vaccine for the alleviation of ulcerative colitis (UC) in mice. The B cell epitopes of murine TNF‑α (mTNF‑α) were predicted in silico and coupled with the universal interleukin 1β (IL‑1β) h...

journal_title：International journal of molecular medicine

authors： Sun Y,Pan W,Zhang J,Cui Y,Wang H,Ru G,Chen L

更新日期：2019-09-01 00:00:00

abstract：:The enhanced migratory ability of endometrial stromal cells (ESCs) is a key factor in the formation of functional endometrium‑like tissues outside the uterine cavity during endometriosis (EMS). Although accumulating evidence has suggested the importance of microRNAs (miRNAs) in the pathogenesis of EMS, the role of par...

journal_title：International journal of molecular medicine

authors： Zhang D,Wang L,Guo HL,Zhang ZW,Wang C,Chian RC,Zhang ZF

更新日期：2020-12-01 00:00:00

abstract：:betaA25-35, a neurotoxic fragment of the Alzheimer beta-amyloid peptide (betaA), acts as a strong inducer of pro-inflammatory cytokines, such as interleukin (IL)-1 and IL-6, in glial cells. Since IL-1 is known to induce expression of both IL-1 and IL-6, we have investigated to what extent the induction of IL-1alpha an...

journal_title：International journal of molecular medicine

authors： Eriksson G,Zetterström M,Cortes Toro V,Bartfai T,Iverfeldt K

更新日期：1998-01-01 00:00:00

abstract：:Small cell lung cancer (SCLC) is a highly aggressive lung neoplasm. To study the pathogenesis of SCLC, we investigated roles of ABCE1, a member of the ATP-binding cassette (ABC) superfamily, in the development of small cell lung cancer. RNA interference was used to knock down ABCE1 expression in human small cell lung ...

journal_title：International journal of molecular medicine

authors： Huang B,Gao Y,Tian D,Zheng M

更新日期：2010-05-01 00:00:00

abstract：:Tree shrews, one of the closest relatives of primates, have attracted increasing attention as a model of human diseases, particularly for viral infections. As the first line of defense against microbial pathogens, the innate immune system is crucial in tree shrews. Interleukin-6 (IL-6) is important in the pathophysiol...

journal_title：International journal of molecular medicine

authors： Han Y,Sun X,Kuang D,Tong P,Lu C,Wang W,Li N,Chen Y,Wang X,Dai J,Zhang H

更新日期：2017-12-01 00:00:00

abstract：:Midkine (MK), a retinoic acid responsible protein, is regulated during development and may play an important role in tumorigenesis. A search for genetic variations of the MK gene, located on chromosome 11q11.2 in humans, has not yet been conducted in cancers. To examine the entire coding region, as well as 4 regions o...

journal_title：International journal of molecular medicine

authors： Ahmed KM,Shitara Y,Kuwano H,Takenoshita S,Uchimuro K,Shinozawa T

更新日期：2000-09-01 00:00:00

abstract：:Cell numbers are regulated by a balance between proliferation and apoptosis (programmed cell death). Recent evidence suggests that proteins regulating cell proliferation also mediate apoptosis. Therefore, cellular fate might be determined by cross talk between regulators of cell cycle progression and apoptosis. Previo...

journal_title：International journal of molecular medicine

authors： An B,Johnson DE,Jin JR,Antoku K,Dou QP

更新日期：1998-01-01 00:00:00

abstract：:17β-estradiol (17β-E2) is a steroid hormone that is known to exert effects on blood glucose homeostasis. The G protein‑coupled estrogen receptor (GPER) has been identified as a non-genomic estrogenic receptor, and is involved in numerous physiological processes, including cell survival, energy provision and metabolism...

journal_title：International journal of molecular medicine

authors： Zhang L,Zhao Y,Guo L

更新日期：2018-05-01 00:00:00

abstract：:Arachidin-1 [trans-4-(3-methyl-1-butenyl)-3,5,3',4'-tetrahydroxystilbene] is a polyphenol produced by peanut kernels during germination. The aim of the present study was to investigate the mechanism underlying the anti-inflammatory effect of arachidin-1 in endothelial cells (ECs). The results of cell adhesion and west...

journal_title：International journal of molecular medicine

authors： Chen LG,Zhang YQ,Wu ZZ,Hsieh CW,Chu CS,Wung BS

更新日期：2018-01-01 00:00:00

abstract：:Mostotrin (MT), a novel compound, at least five orders of magnitude more soluble in water than its mother substance, was designed and synthesised from tryptanthrin (TR). Its structure was established by nuclear magnetic resonance and mass spectrometry data and confirmed by X‑ray analysis, revealing that MT is a pentac...

journal_title：International journal of molecular medicine

authors： Popov A,Klimovich A,Styshova O,Moskovkina T,Shchekotikhin A,Grammatikova N,Dezhenkova L,Kaluzhny D,Deriabin P,Gerasimenko A,Udovenko A,Stonik V

更新日期：2020-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) have important effects on cancer occurrence and development by adjusting gene expression. The aim of the present study was to examine the role of miR‑214 in papillary thyroid carcinoma cell proliferation and metastasis, and its molecular mechanisms. miR‑214 was demonstrated to be markedly downregula...

journal_title：International journal of molecular medicine

authors： Liu F,Lou K,Zhao X,Zhang J,Chen W,Qian Y,Zhao Y,Zhu Y,Zhang Y

更新日期：2018-12-01 00:00:00

abstract：:Bel1, a transactivator of the prototype foamy virus (PFV), plays pivotal roles in the replication of PFV. Previous studies have demonstrated that Bel1 bears a nuclear localization signal (NLS); however, its amino acid sequence remains unclear and the corresponding adaptor importins have not yet been identified. In thi...

journal_title：International journal of molecular medicine

authors： Duan J,Tang Z,Mu H,Zhang G

更新日期：2016-08-01 00:00:00

abstract：:The aim of the present study was to determine whether osteoprotegerin (OPG) influences the bone resorption activity of osteoclasts. RAW264.7 cells were induced by macrophage colony-stimulating factor (M-CSF) + receptor activator of nuclear factor-κB ligand (RANKL) and 0, 10, 20, 50 and 100 ng/ml OPG were added into va...

journal_title：International journal of molecular medicine

authors： Fu YX,Gu JH,Zhang YR,Tong XS,Zhao HY,Yuan Y,Liu XZ,Bian JC,Liu ZP

更新日期：2013-06-01 00:00:00

abstract：:Recently we have shown the antiproliferative activity of Gleditsia sinensis fruit extract (GSE) on various solid tumour and leukaemia cell lines as well as primary cultured bone marrow cells isolated from patients with acute and chronic myelogenous leukaemia. We further studied whether the growth inhibitory effect of ...

journal_title：International journal of molecular medicine

authors： Chui CH,Tang JC,Lau FY,Teo IT,Yau MY,Wong RS,Cheng GY,Ho SK,Leung TW,Hui KS,Wong MM,Fatima S,Cheng CH,Cheung F,Tan WQ,Chow LM,Guo D,Chan AS

更新日期：2004-01-01 00:00:00