miR-214 regulates papillary thyroid carcinoma cell proliferation and metastasis by targeting PSMD10.

abstract：:The differentiation of atrial fibroblasts into myofibroblasts is a critical event in atrial fibrosis. One of the most important factors in atrial fibroblast differentiation is transforming growth factor-β1 (TGF-β1). Accumulating evidence indicates that sodium tanshinone IIA sulfonate (STS) possesses antifibrotic prope...

journal_title：International journal of molecular medicine

authors： Yang L,Hu J,Hao HZ,Yin Z,Liu G,Zou XJ

更新日期：2015-04-01 00:00:00

abstract：:Osteoporosis is a bone disease that poses a tremendous burden to health care. The receptor activator of nuclear factor-κB (RANK) and its ligand (RANKL) have been a major focus of this research field. RANKL signaling not only activates a variety of downstream signaling pathways required for osteoclast development, but ...

journal_title：International journal of molecular medicine

authors： Minami A,Ogino M,Nakano N,Ichimura M,Nakanishi A,Murai T,Kitagishi Y,Matsuda S

更新日期：2017-02-01 00:00:00

abstract：:The circulating concentrations of triglycerides, high density lipoprotein (HDL)‑cholesterol, and low density lipoprotein (LDL)‑cholesterol have a substantial genetic component, and the heritability of early‑onset dyslipidemia might be expected to be higher compared with late‑onset forms. In the present study, exome‑wi...

journal_title：International journal of molecular medicine

authors： Yamada Y,Kato K,Oguri M,Horibe H,Fujimaki T,Yasukochi Y,Takeuchi I,Sakuma J

更新日期：2019-01-01 00:00:00

abstract：:The isolation of rare cells, such as fetal nucleated red blood cells and trophoblasts, from maternal blood for non-invasive prenatal diagnosis is a new field of research exhibiting several difficulties since this strategy requires unresolved basic technological protocols for a successful outcome. However, several achi...

journal_title：International journal of molecular medicine

authors： Borgatti M,Bianchi N,Mancini I,Feriotto G,Gambari R

更新日期：2008-01-01 00:00:00

abstract：:In the absence of antibodies specific for lymphatic vessels, analysis of lymphatic vessels within different tissues has been widely performed with light microscopic and, most importantly, electron microscopic techniques. In regard to lymphatic vessels in the ocular globe and the periocular structures, controversy rema...

journal_title：International journal of molecular medicine

authors： Fogt F,Zimmerman RL,Daly T,Gausas RE

更新日期：2004-05-01 00:00:00

abstract：:In the present study, we examined whether Acer okamotoanum (A. okamotoanum) sap decreased the serum alcohol and acetaldehyde levels after acute ethanol treatment in a rat model. Male rats were orally administered 25, 50 or 100% A. okamotoanum sap 30 min prior to oral challenge with 3 ml of ethanol (15 ml/kg of a 20% e...

journal_title：International journal of molecular medicine

authors： Yoo YM,Jung EM,Kang HY,Choi IG,Choi KC,Jeung EB

更新日期：2011-10-01 00:00:00

abstract：:Adrenomedullin (AM) is a hypotensive peptide, which originates from the proteolytic cleavage of pro(p)AM and acts via AM22-52-sensitive receptors. Reverse transcription polymerase chain reaction allowed the detection of the specific mRNAs of pAM in the mononuclear hematopoietic cells of the cord blood and immunocytoch...

journal_title：International journal of molecular medicine

authors： Del Pup L,Belloni AS,Carraro G,De Angeli S,Parnigotto PP,Nussdorfer GG

更新日期：2003-02-01 00:00:00

abstract：:The molecular pathogenesis of osteosarcoma is very complicated and associated with chaotic abnormalities on many chromosomal arms. We analyzed 12 cases of osteosarcomas with comparative genomic hybridization (CGH) to identify chromosomal imbalances, and detected highly frequent chromosomal alterations in chromosome 6q...

journal_title：International journal of molecular medicine

authors： Ohata N,Ito S,Yoshida A,Kunisada T,Numoto K,Jitsumori Y,Kanzaki H,Ozaki T,Shimizu K,Ouchida M

更新日期：2006-12-01 00:00:00

abstract：:A 36 kDa extracellular metalloprotease (designated to as vEP-MO6) was purified and characterized from Vibrio vulnificus sp. strain MO6 24/0. vEP-MO6 cleaved azocasein and a few other proteins such as prothrombin, plasminogen, fibrinogen and Factor Xa, which are associated with the blood coagulation pathway. The enzyme...

journal_title：International journal of molecular medicine

authors： Kwon JY,Chang AK,Park JE,Shin SY,Yoon SM,Lee JS

更新日期：2007-01-01 00:00:00

abstract：:We have previously reported that the calcium-sensing receptor (CaSR) plays an important role in modulating lipid metabolism under low calcium conditions. The aim of this study was to identify possible regulators of CaSR and the mechanisms of action of CaSR in obese individuals. Subcutaneous fat samples were obtained f...

journal_title：International journal of molecular medicine

authors： He Y,Perry B,Bi M,Sun H,Zhao T,Li Y,Sun C

更新日期：2013-08-01 00:00:00

abstract：:The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), plays an important role in angiotension II (Ang II)-induced hypertensive renal injury associated with pro-inflammatory responses, tubular functional damage and cellular apoptosis. In this study, we report on the role of LOX-1 in Ang II-induced oxidat...

journal_title：International journal of molecular medicine

authors： Xu Y,Ruan S,Xie H,Lin J

更新日期：2010-11-01 00:00:00

abstract：:The purpose of this study was to detect the differentially expressed genes between ossified herniated discs and herniated discs without ossification. In addition, we sought to identify a few candidate genes and pathways by using bioinformatics analysis. We analyzed 6 samples each of ossified herniated discs (experimen...

journal_title：International journal of molecular medicine

authors： Shao J,Yu M,Jiang L,Wu F,Liu X

更新日期：2017-01-01 00:00:00

abstract：:The thymus is the primary site for T-cell lympho-poiesis. Its function includes the maturation and selection of antigen specific T cells and selective release of these cells to the periphery. These highly complex processes require precise parenchymal organization and compartmentation where a plethora of signalling pat...

journal_title：International journal of molecular medicine

authors： Mignini F,Sabbatini M,Mattioli L,Cosenza M,Artico M,Cavallotti C

更新日期：2014-06-01 00:00:00

abstract：:Guettarda speciosa Linn. (G. speciosa, Rubiaceae) has been used as a traditional medicinal plant in Asia for the treatment of various inflammatory conditions, including cough, fever and maternal postpartum infection. However, the mechanisms underlying the anti‑inflammatory action of G. speciosa extracts have remained ...

journal_title：International journal of molecular medicine

authors： Le HTT,Cho YC,Cho S

更新日期：2018-03-01 00:00:00

abstract：:Recently we have shown the antiproliferative activity of Gleditsia sinensis fruit extract (GSE) on various solid tumour and leukaemia cell lines as well as primary cultured bone marrow cells isolated from patients with acute and chronic myelogenous leukaemia. We further studied whether the growth inhibitory effect of ...

journal_title：International journal of molecular medicine

authors： Chui CH,Tang JC,Lau FY,Teo IT,Yau MY,Wong RS,Cheng GY,Ho SK,Leung TW,Hui KS,Wong MM,Fatima S,Cheng CH,Cheung F,Tan WQ,Chow LM,Guo D,Chan AS

更新日期：2004-01-01 00:00:00

abstract：:Neuropathic pain is a condition characterized by unpleasant sensory and emotional experiences associated with a number of diseases or injuries affecting the sensory system through various mechanisms. In this study, we focused on the impact of chronic neuropathic pain on the microglial state and hippocampal neurogenesi...

journal_title：International journal of molecular medicine

authors： Tyrtyshnaia A,Manzhulo I,Kipryushina Y,Ermolenko E

更新日期：2019-05-01 00:00:00

abstract：:GINS2 has been found to be closely related to cell proliferation, survival and maintenance of genomic integrity in addition to the induction of polyploidy. However, the molecular mechanisms of GINS2-mediated tumor regression have not been fully elucidated. Our study showed that GINS2 interacted with PML-C (a structura...

journal_title：International journal of molecular medicine

authors： Gao Y,Wang S,Liu B,Zhong L

更新日期：2013-06-01 00:00:00

abstract：:Human vitiligo is an acquired depigmenting skin disorder characterized by milk-white skin macules resulting from a chronic and progressive loss of melanocytes. It has been suggested that autoimmune mechanisms are involved in this disorder. We undertook this project to obtain an MCHR1-C linear peptide containing four m...

journal_title：International journal of molecular medicine

authors： Zhou M,Guan C,Lin F,Xu W,Fu L,Hong W,Wan Y,Xu A

更新日期：2011-05-01 00:00:00

abstract：:In hypercholesterolemia increased lipid and lipoprotein peroxidation occurs. The renin-angiotensin system plays an important role in atherogenesis. Angiotensin II induces smooth muscle cells proliferation and stimulates oxidation of LDL particles and foam cell accumulation. Inhibition of ang II production leads to dec...

journal_title：International journal of molecular medicine

authors： Wojakowski W,Gminski J,Siemianowicz K,Goss M,Machalski M

更新日期：2000-11-01 00:00:00

abstract：:Needle biopsy is widely used to obtain specimens for physiological, anatomical and biochemical studies of skeletal muscle (SM). We optimized a procedure which we termed tiny percutaneous needle biopsy (TPNB), to efficiently gather good numbers of human satellite cells and single dissociated fibers for the functional s...

journal_title：International journal of molecular medicine

authors： Pietrangelo T,D'Amelio L,Doria C,Mancinelli R,Fulle S,Fanò G

更新日期：2011-03-01 00:00:00

abstract：:MicroRNAs (miRNAs or miRs) play an important role in the tumorigenesis and progression of breast cancer. However, the function of miR‑28‑5p in breast cancer migration has yet to be determined. In the present study, Human MicroRNA Expression Database (HMED) analysis revealed that the expression level of miR‑28‑5p was s...

journal_title：International journal of molecular medicine

authors： Ma L,Zhang Y,Hu F

更新日期：2020-10-01 00:00:00

abstract：:Angioplasty is a principal treatment for occlusive vascular disease but 30-50% of patients show a restenosis of the vessel. There is no clinical effective therapy for this disease. It has been demonstrated, in animal models, that various drugs such as NO-donor, plasminogen inhibitor tranexamic acid and MMP (matrix met...

journal_title：International journal of molecular medicine

authors： Indolfi C,Stabile E,Perrino C,Chiariello M

更新日期：1998-08-01 00:00:00

abstract：:miR-30a is situated on chromosome 6q.13 and is produced by an intronic transcriptional unit. However, its role in regulating the apoptosis, invasion and metastasis of breast cancer cells is not yet fully understood. The aim of this study was to research the biological function of miR‑30a and its direct target gene in ...

journal_title：International journal of molecular medicine

authors： Zhang HD,Jiang LH,Sun DW,Li J,Tang JH

更新日期：2017-10-01 00:00:00

abstract：:Human interleukin-15 (hIL15) exerts anticancer effects through the activities of lymphokine-activated killer (LAK) cells. However, its short half-life hinders its clinical application. Recombinant adeno-associated virus serotype 2 (rAAV2) is used for hIL15 gene transfer vectors, bec...

journal_title：International journal of molecular medicine

authors： Yiang GT,Chou PL,Tsai HF,Chen LA,Chang WJ,Yu YL,Wei CW

更新日期：2012-05-01 00:00:00

abstract：:Calcium channel blocker is useful for a variety of purposes and is effective for preventing hepatitis elicited by different inducers, suggesting its possible clinical application for treating hepatitis. The alpha1-subunit of the dihydropyridine-sensitive L-type calcium channel is a target of calcium channel blocker. F...

journal_title：International journal of molecular medicine

authors： Okamoto T,Jeong SY,Takahashi Y,Baughman KW,Ogata K,Goto J,Kanazawa I

更新日期：2001-10-01 00:00:00

abstract：:The objective of this study was to detect interleukin-17 (IL-17), interferon-gamma (IFN-gamma), interleukin-4 (IL-4) and forkhead/winged helix transcription factor p3 (Foxp3) protein and gene expression of the optic nerve and to further explore the role of T helper cell subsets such as Th1, Th2, Th17 and Treg in the p...

journal_title：International journal of molecular medicine

authors： Tian AY,Zhang RW,Shi XG,Yu HM

更新日期：2010-06-01 00:00:00

abstract：:We studied whether feeding pregnant female mice with different fats affects lipid exchange and activity of the splenic lymphoid system in offspring exposed to low doses of carcinogen. Female mice were fed diets with either 7% or 15% corn oil or olive oil. The 4-week-old offspring of these mice were transferred to a ch...

journal_title：International journal of molecular medicine

authors： Zusman I,Ben-Hur H,Budovsky A,Geva D,Gurevich P,Tendler Y,Lavee S,Stark A,Madar Z

更新日期：2000-09-01 00:00:00

abstract：:To characterize the changes in global gene expression in the livers of H1/siRNAinsulin-CMV/hIDE transgenic (Tg) mice in response to the reduced bioavailability of insulin, total RNA extracted from the livers of 20-week-old Tg and non-Tg mice was converted to cDNA, labeled with biotin and hybridized to oligonucleotide ...

journal_title：International journal of molecular medicine

authors： Jee S,Hwang D,Seo S,Kim Y,Kim C,Kim B,Shim S,Lee S,Sin J,Bae C,Lee B,Jang M,Kim M,Yim S,Jang I,Cho J,Chae K

更新日期：2007-12-01 00:00:00

abstract：:Inflammatory response has been shown to play a critical role in brain damage after cerebral ischemia-reperfusion (I/R) injury, which is tightly regulated by the Toll-like receptor (TLR)4/nuclear factor (NF)-κB pathway; therefore, suppression of TLR4/NF-κB signaling has become a prom...

journal_title：International journal of molecular medicine

authors： Lan L,Tao J,Chen A,Xie G,Huang J,Lin J,Peng J,Chen L

更新日期：2013-01-01 00:00:00

abstract：:Idiopathic cardiomyopathy is reviewed from molecular standpoint. About a half of all patients with hypertrophic cardiomyopathy show intra-familial occurrence. In familial hypertrophic cardiomyopathy, nine gene abnormalities have been discovered in the sarcomere, i.e. the genes of beta cardiac myosin heavy chain, cardi...

journal_title：International journal of molecular medicine

authors： Takeda N

更新日期：2003-01-01 00:00:00