miR‑28‑5p inhibits the migration of breast cancer by regulating WSB2.

abstract：:Platelet-rich plasma (PRP) is used in the clinic as an autologous blood product to stimulate bone regeneration and chondrogenesis. Numerous studies have demonstrated that PRP affects bone remodeling by accelerating osteoblast formation. With the research perspective focusing on osteoclasts, the present study establish...

journal_title：International journal of molecular medicine

authors： Wang D,Weng Y,Guo S,Zhang Y,Zhou T,Zhang M,Wang L,Ma J

更新日期：2018-02-01 00:00:00

abstract：:The molecular cloning and sequencing of the cDNA coding for a novel regucalcin gene promoter region-related protein (RGPR) was investigated using rat, mouse and human liver cDNA library with a yeast one-hybrid system and a rapid amplification of cDNA ends (RACE) method. The clone coding an unknown protein was isolated...

journal_title：International journal of molecular medicine

authors： Misawa H,Yamaguchi M

更新日期：2001-11-01 00:00:00

abstract：:The emergence of colorectal cancer in developed nations can be attributed to dietary habits, smoking, a sedentary lifestyle and obesity. Several treatment regimens are available for primary and metastatic colorectal cancer; however, these treatment options have had limited impact on cure and disease‑free survival, and...

journal_title：International journal of molecular medicine

authors： Ahmad R,Vaali-Mohammed MA,Elwatidy M,Al-Obeed O,Al-Khayal K,Eldehna WM,Abdel-Aziz HA,Alafeefy A,Abdulla M

更新日期：2019-10-01 00:00:00

abstract：:Oral cancer is a serious disease caused by environmental factors and/or susceptible genes. In the present study, in order to identify useful genetic biomarkers for cancer prediction and prevention, and for personalized treatment, we detected somatic mutations in 5 pairs of oral cancer tissues and blood samples using w...

journal_title：International journal of molecular medicine

authors： Yi Y,Tian Z,Ju H,Ren G,Hu J

更新日期：2017-06-01 00:00:00

abstract：:Survivin is a novel apoptosis inhibitor. Its gene is related to the baculovirus gene, which is believed to play a crucial role in fetal development and in cancer. We attempted to determine the expression of survivin in both thyroid goiter and carcinoma tissues, and to evaluate its prognostic value in human thyroid dis...

journal_title：International journal of molecular medicine

authors： Chen Z,Liu N,Zhu G,Dralle H,Hoang-Vu C

更新日期：2012-09-01 00:00:00

abstract：:Metabolic syndrome (MetS), a clustering of components, is closely associated with the development and prognosis of cardiovascular disease and diabetes. Sphingosine 1-phosphate (S1P) is a lysophospholipid with paracrine and autocrine effects, which is associated with obesity, insulin resistance, hyperglycemia, dyslipid...

journal_title：International journal of molecular medicine

authors： Chen W,Lu H,Yang J,Xiang H,Peng H

更新日期：2016-10-01 00:00:00

abstract：:The fusion gene of herpes simplex virus thymidine kinase and green fluorescent protein (TK-GFP) was shown to be a versatile tool for examining the features of thymidine kinase/ganciclovir gene therapy in vitro. In this study, we used viral vectors carrying the fusion gene to characterize the aspects of this gene thera...

journal_title：International journal of molecular medicine

authors： Pasanen T,Hakkarainen T,Timonen P,Parkkinen J,Tenhunen A,Loimas S,Wahlfors J

更新日期：2003-10-01 00:00:00

abstract：:PU.1 is a key transcription factor for hematopoiesis and the reduction of this protein expression plays important roles in various hematological malignancies. To identify PU.1 downstream target genes, we recently reported dual microarray analyses, using PU.1 knockdown K562 (K562PU.1...

journal_title：International journal of molecular medicine

authors： Iseki Y,Nakahara M,Kubo M,Obata F,Harigae H,Takahashi S

更新日期：2012-02-01 00:00:00

abstract：:Skeletal metastasis is the major problem in the management of prostate cancer (PCa). Even though the regulatory role of microRNAs (miRNAs) in the control of tumor metastases has been well described in numerous types of cancer, the importance in bone metastasis of PCa remains largely unknown. In the present study, the ...

journal_title：International journal of molecular medicine

authors： Fu Q,Liu X,Liu Y,Yang J,Lv G,Dong S

更新日期：2015-11-01 00:00:00

abstract：:Metformin, a widely prescribed antidiabetic drug, has previously been shown to lower the risk of certain types of cancer, including that of breast cancer, and to improve prognosis. Its anticancer effects, which are mediated by the activation of AMP-activated protein kinase (AMPK), have become notable. The Sonic hedgeh...

journal_title：International journal of molecular medicine

authors： Fan C,Wang Y,Liu Z,Sun Y,Wang X,Wei G,Wei J

更新日期：2015-07-01 00:00:00

abstract：:The activation of the protease-activated receptor 1 (PAR-1) by thrombin has been shown to induce an activation of the MAP kinase cascade and to stimulate cell proliferation. To examine the mechanisms of signal transduction by PAR-1, we constructed several PAR-1 mutants which were stably expressed in CHO cells. When co...

journal_title：International journal of molecular medicine

authors： Chen X,Berrou J,Vigneau C,Rondeau E

更新日期：2001-09-01 00:00:00

abstract：:Tubular atrophy and dysfunction is a critical process underlying diabetic nephropathy (DN). Understanding the mechanisms underlying renal tubular epithelial cell survival is important for the prevention of kidney failure associated with glucotoxicity. Autophagy is a cellular pathway involved in protein and organelle d...

journal_title：International journal of molecular medicine

authors： Zhao X,Liu G,Shen H,Gao B,Li X,Fu J,Zhou J,Ji Q

更新日期：2015-03-01 00:00:00

abstract：:Cell numbers are regulated by a balance between proliferation and apoptosis (programmed cell death). Recent evidence suggests that proteins regulating cell proliferation also mediate apoptosis. Therefore, cellular fate might be determined by cross talk between regulators of cell cycle progression and apoptosis. Previo...

journal_title：International journal of molecular medicine

authors： An B,Johnson DE,Jin JR,Antoku K,Dou QP

更新日期：1998-01-01 00:00:00

abstract：:Baicalin, extracted and purified from the Chinese medicinal plant, Scutellaria baicalensis Georgi (Huang qin in Chinese), exhibits potent anti-inflammatory activity against asthma. However, it remains unknown whether baicalin inhibits the activity of CC chemokine receptor 7 (CCR7) and its ligands, which are crucial fo...

journal_title：International journal of molecular medicine

authors： Liu J,Wei Y,Luo Q,Xu F,Zhao Z,Zhang H,Lu L,Sun J,Liu F,Du X,Li M,Wei K,Dong J

更新日期：2016-11-01 00:00:00

abstract：:Adiponectin (APN) exerts anti‑inflammatory effects in various cells. Uric acid (UA) induces inflammation in proximal renal tubular epithelial cells (PTECs). It remains unknown whether APN protects against UA‑induced inflammation. In the present study, human PTECs were incubated with 100 µg/ml soluble (S) UA in the pre...

journal_title：International journal of molecular medicine

authors： Yang Q,Fu C,Zhang X,Zhang Z,Zou J,Xiao J,Ye Z

更新日期：2019-03-01 00:00:00

abstract：:After the publication of the above paper, the authors noted that the names of a couple of the authors listed on the paper were associated with the wrong affliation: Specifically, the eighth and ninth listed authors, Francesca Antonaros and Allison Piovesan, are located at DIMES at the University of Florence (fourth af...

journal_title：International journal of molecular medicine

authors： Salvi A,Vezzoli M,Busatto S,Paolini L,Faranda T,Abeni E,Caracausi M,Antonaros F,Piovesan A,Locatelli C,Cocchi G,Alvisi G,De Petro G,Ricotta D,Bergese P,Radeghieri A

更新日期：2019-08-01 00:00:00

abstract：:Midkine (MK), a retinoic acid responsible protein, is regulated during development and may play an important role in tumorigenesis. A search for genetic variations of the MK gene, located on chromosome 11q11.2 in humans, has not yet been conducted in cancers. To examine the entire coding region, as well as 4 regions o...

journal_title：International journal of molecular medicine

authors： Ahmed KM,Shitara Y,Kuwano H,Takenoshita S,Uchimuro K,Shinozawa T

更新日期：2000-09-01 00:00:00

abstract：:Microsporum canis (M. canis) is a common pathogen that causes tinea capitis and is present worldwide. The incidence of M. canis infection, particularly tinea capitis, has been increasing in China. In our previous studies, family of serine hydrolases 1 (FSH1) was identified as a potential virulence factor in tinea capi...

journal_title：International journal of molecular medicine

authors： Zhang F,Tan C,Xu Y,Yang G

更新日期：2019-12-01 00:00:00

abstract：:Malocclusion caused by abnormal jaw development or muscle overuse during mastication results in abnormal mechanical stress to the tissues surrounding the temporomandibular joint (TMJ). Excessive mechanical stress against soft and hard tissues around the TMJ is involved in the pathogenesis of inflammatory diseases, inc...

journal_title：International journal of molecular medicine

authors： Yokota S,Chosa N,Kyakumoto S,Kimura H,Ibi M,Kamo M,Satoh K,Ishisaki A

更新日期：2017-04-01 00:00:00

abstract：:Angiogenesis is an important process in several physiological situations and it is also implicated in the development of some diseases such as diabetes and cancer. This study investigated the antiangiogenic potential of Chrysobalanus icaco methanol extract in the chicken embrionary tissue. Clinical trials for cancer t...

journal_title：International journal of molecular medicine

authors： Alves De Paulo S,Teruszkin Balassiano I,Henriques Silva N,Oliveira Castilho R,Coelho Kaplan MA,Currie Cabral M,da Costa Carvalho MG

更新日期：2000-06-01 00:00:00

abstract：:Rosiglitazone has been found to have anti-atherogenic effects and to increase serum high-density lipoprotein (HDL) cholesterol (HDL-C) levels. However, in vivo studies investigating the regulation of adenosine triphosphate-binding cassette transporter A1 (ABCA1) and scavenger receptor class B type I (SR-BI) by rosigli...

journal_title：International journal of molecular medicine

authors： Li C,Tu Y,Liu TR,Guo ZG,Xie D,Zhong JK,Fan YZ,Lai WY

更新日期：2015-03-01 00:00:00

abstract：:The aim of this study was to investigate the role of microRNAs (miRNAs or miRs) in vascular smooth muscle cell (VSMC) proliferation and to elucidate the underlying molecular mechanisms. In a previous study, using microarray analysis, differentially expressed miRNAs were identified in primary VSMCs isolated from the me...

journal_title：International journal of molecular medicine

authors： Liu K,Ying Z,Qi X,Shi Y,Tang Q

更新日期：2015-09-01 00:00:00

abstract：:Rats exposed from 7 weeks after birth and for the ensuing 3 to 7 months to a diet depleted in long-chain polyunsaturated omega3 fatty acids were recently proposed as a new animal model for the metabolic syndrome. The present study aimed mainly at investigating whether, in this new model, the perturbation of the fatty ...

journal_title：International journal of molecular medicine

authors： Portois L,Hacquebard M,Malaisse WJ,Carpentier YA

更新日期：2009-08-01 00:00:00

abstract：:The aim of this study was to evaluate in detail the histopathological characteristics of endarterectomized carotid atherosclerotic lesions in symptomatic versus asymptomatic patients. Twenty carotid lesions, 10 from asymptomatic and 10 from symptomatic patients who underwent carotid endarterectomy were classified acco...

journal_title：International journal of molecular medicine

authors： Hakimi M,Hyhlik-Dürr A,von Au A,Betz M,Demirel S,Dihlmann S,Böckler D,Gross-Weissmann ML

更新日期：2013-08-01 00:00:00

abstract：:Catamenial epilepsy is a common phenomenon in female epileptic patients that is, in part, influenced by the 17-β-estradiol level during the menstrual cycle, which modulates the strength of the epileptic seizures. However, the underlying mechanism(s) for catamenial epilepsy remains unknown. In the present study, the ef...

journal_title：International journal of molecular medicine

authors： Zhang Y,Huang Y,Liu X,Wang G,Wang X,Wang Y

更新日期：2015-09-01 00:00:00

abstract：:Neuropathic pain is a condition characterized by unpleasant sensory and emotional experiences associated with a number of diseases or injuries affecting the sensory system through various mechanisms. In this study, we focused on the impact of chronic neuropathic pain on the microglial state and hippocampal neurogenesi...

journal_title：International journal of molecular medicine

authors： Tyrtyshnaia A,Manzhulo I,Kipryushina Y,Ermolenko E

更新日期：2019-05-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is recognized as a main regulator of energy homeostasis. Osteocalcin (OC), which is produced specifically by mature osteoblasts, is stored in bone matrix, strongly binds to hydroxyapatite and is released into the circulation, has been recognized as a marker of bone metabolism. It ha...

journal_title：International journal of molecular medicine

authors： Kondo A,Otsuka T,Kato K,Matsushima-Nishiwaki R,Kuroyanagi G,Mizutani J,Tokuda H,Kozawa O

更新日期：2013-06-01 00:00:00

abstract：:Human vitiligo is an acquired depigmenting skin disorder characterized by milk-white skin macules resulting from a chronic and progressive loss of melanocytes. It has been suggested that autoimmune mechanisms are involved in this disorder. We undertook this project to obtain an MCHR1-C linear peptide containing four m...

journal_title：International journal of molecular medicine

authors： Zhou M,Guan C,Lin F,Xu W,Fu L,Hong W,Wan Y,Xu A

更新日期：2011-05-01 00:00:00

abstract：:β‑catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules (E‑cadherin/CDH1, N‑cadherin/CDH2, VE‑cadherin/CDH5 and α‑catenins), transmembrane‑type mucins (MUC1/CD227 and MUC16/CA125), signaling regulators (APC, AXIN1, AXIN2 and NHERF1/EBP50) and epigenetic or transcriptional regulator...

journal_title：International journal of molecular medicine

authors： Katoh M

更新日期：2018-08-01 00:00:00

abstract：:The prognosis of patients suffering from glioblastoma [also referred to as glioblastoma multiforme (GBM)] is dismal despite multimodal therapy. Chemotherapy with temozolomide may suppress tumor growth for a certain period of time (a few months); however, invariable tumor recurrence suggests that glioblastoma initiatin...

journal_title：International journal of molecular medicine

authors： Cheng ZX,Yin WB,Wang ZY

更新日期：2017-11-01 00:00:00