当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE期刊下所有文献 > MicroRNA-132 induces temozolomide resistance and promotes the formation of cancer stem cell phenotypes by targeting tumor suppressor candidate 3 in glioblastoma.

MicroRNA-132 induces temozolomide resistance and promotes the formation of cancer stem cell phenotypes by targeting tumor suppressor candidate 3 in glioblastoma.

Abstract：

:The prognosis of patients suffering from glioblastoma [also referred to as glioblastoma multiforme (GBM)] is dismal despite multimodal therapy. Chemotherapy with temozolomide may suppress tumor growth for a certain period of time (a few months); however, invariable tumor recurrence suggests that glioblastoma initiating cells (GICs) render these tumors persistant. Thus, the understanding of the molecular mechanisms of action of GICs as regards their role in the progression of GBM is important as such knowledge will be helpful in the discovery of novel drug targets, as well as in the design of novel therapeutic strategies for more effective treatment of the disease. In this study, we found that tumor suppressor candidate 3 (TUSC3) was downregulated in temozolomide-resistant U87MG cells (U87MG-res cells) and its restoration sensitized U87MG-res cells to temozolomide. TUSC3 was able to inhibit the formation of GIC phenotypes in the U87MG-res cells. The overexpression of microRNA (miR)‑132 inhibited TUSC3 protein expression in the U87MG cells. However, its overexpression did not degrade TUSC3 mRNA expression in the cells. miR‑132 was upregulated in the U87MG-res cells and its overexpression induced temozolomide resistance and the formation of cancer stem cell phenotypes in the U87MG cells. Thus, our data indicate that miR-132 induces temozolomide resistance and promotes the formation of cancer stem cell phenotypes by targeting TUSC3 in glioblastoma.

journal_name

Int J Mol Med

journal_title

International journal of molecular medicine

authors

Cheng ZX,Yin WB,Wang ZY

doi

10.3892/ijmm.2017.3124

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

1307-1314

issue

5

eissn

1107-3756

issn

1791-244X

journal_volume

40

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE文献大全
  • Overexpression of the small GTPase Arl4D suppresses adipogenesis.

    abstract：:Arl4D is a developmentally-regulated member of the ADP-ribosylation factor/ARF-like protein (ARF/Arl) family of Ras-related GTPases. Although Arl4 protein is reported to be expressed in adipose tissue, the function of Arl4D is unknown. To investigate the potential role of Arl4D in adipogenesis, we examined Arl4D expre...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2011.751

    authors： Yu J,Ka SO,Kwon KB,Lee SM,Park JW,Park BH

    更新日期：2011-11-01 00:00:00

  • Black rice (Oryza sativa L.) extract modulates ultraviolet-induced expression of matrix metalloproteinases and procollagen in a skin cell model.

    abstract：:Exposure of the skin to ultraviolet (UV) radiation causes extracellular matrix (ECM) collapse in the dermis, owing to an increase in matrix metalloproteinase (MMP) production in both the epidermis and dermis, and a decrease in type I collagen expression in the dermis. Recently, black rice (Oryza sativa L.) was reporte...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2018.3508

    authors： Han M,Bae JS,Ban JJ,Shin HS,Lee DH,Chung JH

    更新日期：2018-05-01 00:00:00

  • Induction of apoptosis by S-allylmercapto-L-cysteine, a biotransformed garlic derivative, on a human gastric cancer cell line.

    abstract：:Epidemiological and experimental carcinogenesis studies provide evidence that certain components of garlic have anti-cancer activity. Although the biotransformed garlic derivative S-allylmercapto-L-cysteine (SAMC) has been reported to show an inhibitory effect on tumorigenesis, the mechanisms are poorly understood. Th...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Lee Y

    更新日期：2008-06-01 00:00:00

  • Astragaloside IV facilitates glucose transport in C2C12 myotubes through the IRS1/AKT pathway and suppresses the palmitate-induced activation of the IKK/IκBα pathway.

    abstract：:Astragaloside IV is a monomer isolated from Astragalus membranaceus (Fisch.) Bunge, which is one of the most widely used plant-derived drugs in traditional Chinese medicine for diabetes therapy. In the present study, we aimed to examine the effects of astragaloside IV on glucose in C2C12 myotubes and the underlying mo...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2016.2555

    authors： Zhu R,Zheng J,Chen L,Gu B,Huang S

    更新日期：2016-06-01 00:00:00

  • Mechanism of HMGB1 release inhibition from RAW264.7 cells by oleanolic acid in Prunus mume Sieb. et Zucc.

    abstract：:High mobility group box-1 protein (HMGB1), primarily from the nucleus, is released into the extracellular milieu either passively from necrotic cells or actively through secretion by monocytes/macrophages. Extracellular HMGB1 acts as a potent inflammatory agent by promoting the release of cytokines such as tumor necro...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm_00000172

    authors： Kawahara K,Hashiguchi T,Masuda K,Saniabadi AR,Kikuchi K,Tancharoen S,Ito T,Miura N,Morimoto Y,Biswas KK,Nawa Y,Meng X,Oyama Y,Takenouchi K,Shrestha B,Sameshima H,Shimizu T,Adachi T,Adachi M,Maruyama I

    更新日期：2009-05-01 00:00:00

  • The profibrotic effect of downregulated Na,K‑ATPase β1 subunit in alveolar epithelial cells during lung fibrosis.

    abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by progressive lung scarring and excessive extracellular matrix depositon. When stimulated, alveolar epithelial cells (AECs) are aberrantly activated, the expression of profibrotic molecules is enhanced, and lung fibro...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2019.4201

    authors： Li B,Huang X,Xu X,Ning W,Dai H,Wang C

    更新日期：2019-07-01 00:00:00

  • Metformin exerts anticancer effects through the inhibition of the Sonic hedgehog signaling pathway in breast cancer.

    abstract：:Metformin, a widely prescribed antidiabetic drug, has previously been shown to lower the risk of certain types of cancer, including that of breast cancer, and to improve prognosis. Its anticancer effects, which are mediated by the activation of AMP-activated protein kinase (AMPK), have become notable. The Sonic hedgeh...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2015.2217

    authors： Fan C,Wang Y,Liu Z,Sun Y,Wang X,Wei G,Wei J

    更新日期：2015-07-01 00:00:00

  • Telomerase activity as a novel marker of lung cancer and immune-associated lung diseases.

    abstract：:Telomerase maintains telomere length and is considered to be necessary for the indefinite proliferation of human cells. Telomerase activity is detected not only in germline and immortal cancer cells, but also in stem/progenitor cells of renewal tissues and activated lymphocytes. While it is generally agreed that telom...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Hiyama K,Ishioka S,Shay JW,Taooka Y,Maeda A,Isobe T,Hiyama E,Maeda H,Yamakido M

    更新日期：1998-03-01 00:00:00

  • Gain of Xq detected by comparative genomic hybridization in elastofibroma.

    abstract：:Elastofibroma is a rare, benign, slow-growing degenerative pseudotumor that typically occurs in the subscapular region and has been considered a peculiar fibroblastic proliferation with accumulation of abnormal elastic fibers. Very little is known about the cytogenetic and molecular genetic changes in elastofibroma. I...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Nishio JN,Iwasaki H,Ohjimi Y,Ishiguro M,Koga T,Isayama T,Naito M,Kikuchi M

    更新日期：2002-09-01 00:00:00

  • MicroRNA‑16 inhibits endometrial stromal cell migration and invasion through suppression of the inhibitor of nuclear factor‑κB kinase subunit β/nuclear factor‑κB pathway.

    abstract：:Accumulating evidence has demonstrated that endometrial stromal cells (ESCs) are responsible for the pathogenesis of endometriosis (Ems), which is characterized by the presence of functional endometrial‑like tissues outside the uterine cavity. Abnormal expression of microRNAs (miRNAs) in ESCs may be implicated in the ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2020.4620

    authors： Wang X,Ren R,Shao M,Lan J

    更新日期：2020-08-01 00:00:00

  • Transcriptome and methylome profiling in a rat model of irritable bowel syndrome induced by stress.

    abstract：:Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that is associated with psychological stress. However, the full landscape of IBS‑related epigenetic factors remains unveiled and needs to be elucidated. The water‑avoidance stress (WAS) method was used to induce a rat IBS model. Each rat was monitore...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2018.3823

    authors： Zhu S,Min L,Guo Q,Li H,Yu Y,Zong Y,Wang L,Li P,Gu J,Zhang S

    更新日期：2018-11-01 00:00:00

  • Alterations in CD44 isoforms and HAS expression in human articular chondrocytes during the de- and re-differentiation processes.

    abstract：:The purpose of this study was to investigate the expression of different CD44 and hyaluronan synthase isoforms in cartilage, their alterations during the chondrocyte dedifferentiation process in monolayer culture and during the redifferentiation process on 3D scaffolds. Chondrocytes isolated from human articular carti...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Albrecht C,Schlegel W,Eckl P,Jagersberger T,Sadeghi K,Berger A,Vécsei V,Marlovits S

    更新日期：2009-02-01 00:00:00

  • Cysteine induces longitudinal bone growth in mice by upregulating IGF-I.

    abstract：:Cysteine (Cys) is known to exert various effects, such as antioxidant, antipancreatitic and antidiabetic effects. However, the effects of Cys on longitudinal bone growth have not been elucidate to date. Thus, the aim of the present study was to evaluate the effects of Cys on bone growth. Growth-plate thickness and bon...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2015.2257

    authors： Moon PD,Kim MH,Oh HA,Nam SY,Han NR,Jeong HJ,Kim HM

    更新日期：2015-08-01 00:00:00

  • Effects of oxygen concentrations on human fibroblasts treated with Fe(3+)-NTA.

    abstract：:Free radicals derived from the reaction of iron and oxygen are thought to be one of the causes of tissue injury. In order to identify whether oxygen concentrations are an important factor in iron-mediated damage to cells, cytotoxic effects of Fe(3+)-NTA on human fibroblasts (KMST-6 line) were studied under the conditi...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Pu H,Sakaguchi M,Kondo T,Kondo A,Kawabata T,Namba M

    更新日期：2001-03-01 00:00:00

  • Thrombospondin-1 induces apoptosis in primary leukemia and cell lines mediated by CD36 and Caspase-3.

    abstract：:Thrombospondin-1 (TSP-1) is a naturally occurring anti-angiogenic compound that induces apoptosis of endothelial and cancer cells via its receptor CD36. The objectives of our study were to investigate the in vitro effects of TSP-1 on the apoptosis of primary human leukemia cells as well as leukemia cell lines and the ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Li K,Yang M,Yuen PM,Chik KW,Li CK,Shing MM,Lam HK,Fok TF

    更新日期：2003-12-01 00:00:00

  • Gender dimorphism in neutrophil priming and activation following trauma-hemorrhagic shock.

    abstract：:Although gender influences T-cell, macrophage and organ functions following trauma-hemorrhage and resuscitation (T-H), it remains unknown whether it also influences polymorphonuclear cell (PMN) activity under such conditions. To study this, proestrus female and male Sprague-Dawley rats underwent trauma-hemorrhage foll...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Toth B,Schwacha MG,Kuebler JF,Bland KI,Wang P,Chaudrya IH

    更新日期：2003-03-01 00:00:00

  • Association of genetic variants with myocardial infarction in Japanese individuals with different lipid profiles.

    abstract：:Dyslipidemia is an important risk factor for myocardial infarction (MI). We previously showed that gene polymorphisms associated with MI differed among individuals with different lipid profiles. We further examined whether genetic variants that confer susceptibility to MI might differ among individuals with low or hig...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm_00000383

    authors： Yoshida T,Kato K,Yokoi K,Oguri M,Watanabe S,Metoki N,Yoshida H,Satoh K,Aoyagi Y,Nozawa Y,Yamada Y

    更新日期：2010-04-01 00:00:00

  • Protective effect of geranylgeranylacetone on trinitrobenzene sulfonic acid-induced colitis in mice.

    abstract：:Geranylgeranylacetone (GGA) has recently been reported to have a protective effect against ischemic, injurious and apoptotic stress in several tissues. The aim of this study was to determine the effect of GGA on colitis induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) in mice. Colitis was induced by intrarectal i...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Ohkawara T,Nishihira J,Takeda H,Katsurada T,Kato K,Yoshiki T,Sugiyama T,Asaka M

    更新日期：2006-02-01 00:00:00

  • Transcriptome analysis of Klf15‑mediated inhibitory functions in a mouse deep venous thrombosis model.

    abstract：:Krüppel‑like family (KLF) members are important regulators of proinflammatory activation in the vasculature. A transcriptome study involving RNA sequencing (RNA‑seq) and quantitative PCR (qPCR) was performed to investigate Klf15 and Klf15‑regulated gene levels in C57BL/6 mice with inferior vena cava thrombi and in con...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2020.4538

    authors： Zhou J,Zhao X,Xie S,Zhou R

    更新日期：2020-06-01 00:00:00

  • Growth inhibition and apoptosis-inducing effect on human cancer cells by RCE-4, a spirostanol saponin derivative from natural medicines.

    abstract：:Reineckia carnea has been used to treat several diseases in folk remedies. RCE-4 has been isolated from several plants of the family Liliaceae, but its biological activity has not yet been reported. In the present study, we found that RCE-4 exhibited potent cytotoxicity to the teste...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2012.1178

    authors： Wang G,Huang W,He H,Fu X,Wang J,Zou K,Chen J

    更新日期：2013-01-01 00:00:00

  • Bone morphogenetic protein 2 alleviated intervertebral disc degeneration through mediating the degradation of ECM and apoptosis of nucleus pulposus cells via the PI3K/Akt pathway.

    abstract：:The present study aimed to explore the underlying mechanisms of bone morphogenetic protein 2 (BMP2) in alleviating intervertebral disc degeneration (IDD). A rat puncture IDD model was constructed, and the rats were randomly divided into six groups: Control; IDD (model); IDD+PBS [containing 1010 adeno‑associated virus ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2018.3972

    authors： Tan Y,Yao X,Dai Z,Wang Y,Lv G

    更新日期：2019-01-01 00:00:00

  • Luteolin attenuates sepsis‑induced myocardial injury by enhancing autophagy in mice.

    abstract：:Sepsis‑induced cardiomyopathy (SIC) is a complication of severe sepsis and septic shock characterized by an invertible myocardial depression. This study sought to explore the potential effects and mechanism of luteolin, a flavonoid polyphenolic compound, in lipopolysaccharide (LPS)‑induced myocardial injury. Experimen...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2020.4536

    authors： Wu B,Song H,Fan M,You F,Zhang L,Luo J,Li J,Wang L,Li C,Yuan M

    更新日期：2020-05-01 00:00:00

  • The mechanism of atopic march may be the 'social' event of cells and molecules (Review).

    abstract：:The skin, the conjunctivae, the airways and the digestive tract compose a huge vulnerable biological surface, which is exposed to the external environment. An allergen can often trigger an allergic reaction at a number of sites or result in an atopic march. However, the mechanism of atopic march remains unclear. Less ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章,评审

    doi：10.3892/ijmm_00000525

    authors： Luo J,Li Y,Gong R

    更新日期：2010-12-01 00:00:00

  • Rational role of amino acids in intestinal epithelial cells (Review).

    abstract：:There is much interest in precise functions of amino acids on mammalian growth and development. Some of amino acids play important roles in the control of gene expression by controlling the initiation phase of mRNA translation. The signal induced by leucine or arginine may stimulate cell growth. On the other hand, the...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章,评审

    doi：

    authors： Naomoto Y,Yamatsuji T,Shigemitsu K,Ban H,Nakajo T,Shirakawa Y,Motok T,Kobayashi M,Gunduz M,Tanaka N

    更新日期：2005-08-01 00:00:00

  • Evaluation of proteasome-inhibitory and apoptosis-inducing potencies of novel (-)-EGCG analogs and their prodrugs.

    abstract：:The anti-cancer and cancer-preventive effects of green tea and its main constituent (-)-epigallocatechin gallate [(-)-EGCG] are well documented by a variety of studies, including epidemiological, cell culture, animal, and clinical studies. While (-)-EGCG remains the most potent polyphenol in green tea, it is very unst...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Landis-Piwowar KR,Kuhn DJ,Wan SB,Chen D,Chan TH,Dou QP

    更新日期：2005-04-01 00:00:00

  • Sulforaphane suppresses the viability and metastasis, and promotes the apoptosis of bladder cancer cells by inhibiting the expression of FAT‑1.

    abstract：:FAT atypical cadherin 1 (FAT1) regulates complex mechanisms for the promotion of oncogenesis or the suppression of malignancies. Sulforaphane (SFN) has antioxidant and anti‑tumor activities. The present study investigated the roles of SFN and FAT1 in bladder cancer (BC). The expression of FAT1 in BC cell lines and tis...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2020.4665

    authors： Wang F,Liu P,An H,Zhang Y

    更新日期：2020-09-01 00:00:00

  • Development of finasteride polymer microspheres for systemic application in androgenic alopecia.

    abstract：:The use of finasteride for alleviating hair loss has been investigated, and it has been applied as an oral dose medication. However, due to the inconvenience of daily drug administration over long period of time, novel controllable finasteride delivery has been actively investigated. As a novel method of finasteride d...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2019.4149

    authors： Kim JH,Na J,Bak DH,Lee BC,Lee E,Choi MJ,Ryu CH,Lee S,Mun SK,Park BC,Kim BJ,Lee HS

    更新日期：2019-06-01 00:00:00

  • Orexin A upregulates the protein expression of OX1R and enhances the proliferation of SGC-7901 gastric cancer cells through the ERK signaling pathway.

    abstract：:Orexins are hypothalamic peptides that regulate food intake, wakefulness, the reward system and energy metabolism. Recent studies have demonstrated the ability of orexins to promote a robust apoptosis and subsequent inhibition of cell growth in various types of cancer cells. The present study was conducted to investig...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2014.2038

    authors： Liu Y,Zhao Y,Ju S,Guo L

    更新日期：2015-02-01 00:00:00

  • MicroRNA‑202 inhibits endometrial stromal cell migration and invasion by suppressing the K‑Ras/Raf1/MEK/ERK signaling pathway.

    abstract：:The enhanced migratory ability of endometrial stromal cells (ESCs) is a key factor in the formation of functional endometrium‑like tissues outside the uterine cavity during endometriosis (EMS). Although accumulating evidence has suggested the importance of microRNAs (miRNAs) in the pathogenesis of EMS, the role of par...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2020.4749

    authors： Zhang D,Wang L,Guo HL,Zhang ZW,Wang C,Chian RC,Zhang ZF

    更新日期：2020-12-01 00:00:00

  • Remodeling of the human endometrial epithelium is regulated by laminin and type IV collagen.

    abstract：:We investigated the expression and function of laminin and type IV collagen (COL-4) in the human endometrial epithelium throughout the menstrual cycle. Their expression was demonstrated by immunohistochemistry, while cytological analysis of the human endometrial epithelial cell line HHUA cultured on laminin- or COL-4-...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Tanaka T,Wang C,Umesaki N

    更新日期：2009-02-01 00:00:00