Abstract：
:We investigated the expression and function of laminin and type IV collagen (COL-4) in the human endometrial epithelium throughout the menstrual cycle. Their expression was demonstrated by immunohistochemistry, while cytological analysis of the human endometrial epithelial cell line HHUA cultured on laminin- or COL-4-coated plates provided information on their roles in cell proliferation, structure and apoptosis. Laminin and COL-4 were detected in subepithelial basement membrane-like structures and their expression levels varied throughout the menstrual cycle. Laminin expression was significantly decreased in secretory phase endometrial surface epithelium, while COL-4 expression was significantly decreased in late proliferative phase endometrial epithelium and in vascular endothelium. The morphology of proliferating HHUA cells varied depending on the extracellular matrix component coated on the culture plates. COL-4 strongly inhibited cell proliferation of HHUA cells and enhanced Fas antigen (CD95)-mediated apoptosis, while laminin inhibited Fas-mediated apoptosis. These results indicate that the cyclic expression of laminin and COL-4 in basement membrane-like structures of endometrial epithelium may regulate the endometrial epithelial remodeling and embryo implantation during the menstrual cycle.
journal_name
Int J Mol Medjournal_title
International journal of molecular medicineauthors
Tanaka T,Wang C,Umesaki Nsubject
Has Abstractpub_date
2009-02-01 00:00:00pages
173-80issue
2eissn
1107-3756issn
1791-244Xjournal_volume
23pub_type
杂志文章abstract：:Our previous study demonstrated that intranasal administration of histone deacetylase inhibitor sodium butyrate (NaB) exhibits therapeutic effects on a mouse model of allergic rhinitis (AR). However, whether NaB is effective on AR when administered orally and prophylactically, as well as its potential effects on gene ...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2020.4489
更新日期：2020-04-01 00:00:00
abstract：:Reperfusion injury (RI) remains an important limitation of myocardial revascularization. The aim of the present study was to evaluate the influence of the intracoronary injection of adiponectin on RI and cardiomyocyte death in a porcine myocardial infarction model. Acute infarction in 14 Polish domestic pigs was induc...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2011.643
更新日期：2011-06-01 00:00:00
abstract：:Osteoarthritis (OA) is a chronic disease that results in chronic arthralgia and functional disability of the affected joint. To date, there is no effective treatment available for this disease. Circular RNAs (circRNAs) are a type of intracellular stable RNA that can regulate the development and progression of OA. Howe...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2020.4772
更新日期：2021-01-01 00:00:00
abstract：:The aim of this study was to identify key genes associated with coronary artery disease (CAD) and to explore the related signaling pathways. Gene expression profiles of 110 CAD and 112 non-CAD, healthy patients [CAD index (CADi) >23 and =0, respectively] were downloaded from the Gene Expression Omnibus (GEO) database ...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2014.1817
更新日期：2014-09-01 00:00:00
abstract：:The aetiological agent of chronic hepatitis C is the hepatitis C virus. The hepatitis C virus is spread by parenteral transmission of body fluids, primarily blood or blood products. In 1989, after more than a decade of research, HCV was isolated and characterised. The hepatitis C viral genome is a positive-sense, sing...
journal_title：International journal of molecular medicine
pub_type： 杂志文章,评审
doi：
更新日期：2002-02-01 00:00:00
abstract：:Musk has been traditionally used in East Asia to alleviate the symptoms of angina pectoris. However, it remains unclear as to whether muscone, the main active ingredient of musk, has any beneficial effects on persistent myocardial ischemia in vivo. The aim of the present study was to investigate whether muscone can im...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2014.1766
更新日期：2014-07-01 00:00:00
abstract：:Tuberculous meningitis (TBM) is a serious complication of tuberculosis that affects the central nervous system. As TBM may result in permanent sequelae and death, rapid, accurate diagnostic tests using novel biomarkers are required for the early diagnosis and treatment of TBM. A quantitative proteomic study was theref...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2015.2131
更新日期：2015-05-01 00:00:00
abstract：:Osteosarcoma is the most common primary malignancy of bone in teenagers and approximately 30% of patients develop lung metastasis, which is the leading cause of mortality. Recent studies suggest that the Ezrin protein is correlated with the metastatic potential of several malignant ...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2012.1111
更新日期：2012-11-01 00:00:00
abstract：:The phospholipase A (PLA)2 family is the most complex gene family of phospholipases and plays a crucial role in a number of physiological activities. However, the phylogenetic background of the PLA2 gene family and the amino acid residues of the PLA2G7 gene following positive selection gene remain undetermined. In thi...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2014.2047
更新日期：2015-03-01 00:00:00
abstract：:Peroxisome proliferator activated receptors (PPARs) are nuclear receptors regulating the expression of genes involved in lipid and glucose metabolism. Three different PPARs; alpha (PPARA), gamma (PPARG) and delta (PPARD) have been characterized and they are distinguished from each other by tissue distribution and cell...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.6.1.73
更新日期：2000-07-01 00:00:00
abstract：:Clinical trials have started to implement tumor-associated antigens in the form of antigenic peptides in order to augment CD8(+) T-cell responses directed against autologous cancer cells. One of the surrogate markers for successful immunization is the characterization of T-lymphocytes reacting to the immunizing peptid...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.3.2.139
更新日期：1999-02-01 00:00:00
abstract：:Vitiligo is an acquired and progressive disorder manifested by the selective destruction of melanocytes in the skin. An extremely high level of hydrogen peroxide (H2O2) in plasma as well as in lesional skin has been reported in vitiligo patients. High H2O2 level has been suggested to be responsible for the disappearan...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：
更新日期：2008-07-01 00:00:00
abstract：:It is known that cancers develop by a multi-step process. Normal cells are first immortalized, and then transformed into tumorigenic cells. Normal human cells are very rarely immortalized, but once they are, they are relatively easily transformed into tumorigenic cells. This indicates that the immortalization step pla...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2.5.603
更新日期：1998-11-01 00:00:00
abstract：:Myocyte injury due to myocardial reperfusion injury plays a crucial role in the pathogenesis of acute myocardial infarction even after successful coronary revascularization. Identification of compounds that reduce reperfusion-associated myocyte death is important. Therefore, we developed an in vitro model of myocardia...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：
更新日期：2007-11-01 00:00:00
abstract：:Post-transcriptional control of mRNA trafficking and metabolism plays a critical role in the actualization and fine tuning of the genetic program of cells, both in development and in differentiated tissues. Cis-acting signals, responsible for post-transcriptional regulation, reside in the RNA message itself, usually i...
journal_title：International journal of molecular medicine
pub_type： 杂志文章,评审
doi：10.3892/ijmm.2014.1629
更新日期：2014-04-01 00:00:00
abstract：:Numerous studies have demonstrated the antioxidant effects of grape seed proanthocyanidin extract (GSPE). The generation of free radicals and the ensuing apoptosis may contribute to the pathogenesis of epilepsy; therefore, in the present study, we examined the effects of GSPE on cognitive impairment and neuronal damag...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2014.1796
更新日期：2014-08-01 00:00:00
abstract：:The clinical diagnosis of cutaneous melanoma always calls for histological confirmation. In addition to the recognition of the classic aspects of the neoplasm, immunohistochemistry is determinant, in particular in the assessment of the size of the replicative compartment. Generally, the proliferation rate is indicativ...
journal_title：International journal of molecular medicine
pub_type： 杂志文章,评审
doi：10.3892/ijmm_00000232
更新日期：2009-09-01 00:00:00
abstract：:Abnormal gap junction communication (GJC) has been associated with carcinogenesis. We investigated the role of endothelial cell GJC and connexin 43 (Cx43), the main gap junction protein in these cells, during tumour cell extravasation. GJC was determined by the ability of cells to transfer Lucifer yellow, to neighbour...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:The prognosis of patients suffering from glioblastoma [also referred to as glioblastoma multiforme (GBM)] is dismal despite multimodal therapy. Chemotherapy with temozolomide may suppress tumor growth for a certain period of time (a few months); however, invariable tumor recurrence suggests that glioblastoma initiatin...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2017.3124
更新日期：2017-11-01 00:00:00
abstract：:The present study aimed to investigate the influence of microRNA-4649-3p on nasopharyngeal carcinoma (NPC) cell proliferation and how it regulated SHP-1 expression. The online software TargetScan was used to predict the microRNAs targeting SHP-1 and identified that miR-4649-3p was one of the possible miRNAs targeting ...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2015.2245
更新日期：2015-08-01 00:00:00
abstract：:Living donor liver transplantation (LDLT) requires ischemia/reperfusion (I/R), which can cause early graft injury. However, the detailed mechanism of I/R injury remains unknown. Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in heme catabolism and results in the production of iro...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2011.821
更新日期：2012-02-01 00:00:00
abstract：:The immunosuppressive effect of triptolide has been associated with suppression of T-cell activation. However, the immunosuppressive effects of triptolide on innate immunity in the epithelial barrier remain to be elucidated. Human beta-defensin (HBD)-2 is an inducible antimicrobial peptide and plays an important role ...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
abstract：:Acute lung injury (ALI) is among the most common causes of mortality in intensive care units. Recent in vivo and in vitro studies have suggested that mesenchymal stem cells (MSCs) attenuate pulmonary edema and inflammatory factors, but the mechanisms of the effects of MSCs on pulmonary vascular function remain unknown...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2013.1328
更新日期：2013-06-01 00:00:00
abstract：:The thermo-enhancement effects of the sesquiterpene lactone parthenolide (PTL), which targets the transcription factor nuclear factor-kappaB (NF-kappaB), and hyperthermia at 40, 42 and 44 degrees C on the human lung adenocarcinoma A549 cell line were investigated in vitro. Thermotherapy using a combined treatment with...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：
更新日期：2008-05-01 00:00:00
abstract：:p38 has been shown to be involved in TGF-beta-induced gene expression, but the upstream of the signaling pathway leading to the activation of p38 is left undefined. We investigated the pathway in cultured human keratinocytes (HaCat cells). Western blot analysis revealed that TGF-beta induced the activation of p38 with...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
abstract：:The skin, the conjunctivae, the airways and the digestive tract compose a huge vulnerable biological surface, which is exposed to the external environment. An allergen can often trigger an allergic reaction at a number of sites or result in an atopic march. However, the mechanism of atopic march remains unclear. Less ...
journal_title：International journal of molecular medicine
pub_type： 杂志文章,评审
doi：10.3892/ijmm_00000525
更新日期：2010-12-01 00:00:00
abstract：:Dental pulp cells (DPCs), including dental pulp (DP) stem cells, play a role in dentine repair under certain conditions caused by bacterial infections associated with caries, tooth fracture and injury. Mesenchymal stem cells (MSCs) have also been shown to be involved in this process of repair. However, the mechanisms ...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2015.2247
更新日期：2015-08-01 00:00:00
abstract：:The aim of this study was to investigate the therapeutic effects of three different cellulose membranes (CMs) manufactured from Styela clava tunics (SCTs) on the healing of cutaneous wounds. We examined the physical properties and therapeutic effects of three CMs regenerated from SCTs (referred to as SCT‑ CMs), includ...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2017.2923
更新日期：2017-05-01 00:00:00
abstract：:New drugs are continuously being developed for the treatment of patients with estrogen receptor-positive breast cancer. Thymoquinone is one of the drugs that exhibits anticancer characteristics based on in vivo and in vitro models. This study further investigates the effects of thymoquinone on human gene expression us...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2013.1563
更新日期：2014-01-01 00:00:00
abstract：:Angioplasty is a principal treatment for occlusive vascular disease but 30-50% of patients show a restenosis of the vessel. There is no clinical effective therapy for this disease. It has been demonstrated, in animal models, that various drugs such as NO-donor, plasminogen inhibitor tranexamic acid and MMP (matrix met...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：
更新日期：1998-08-01 00:00:00
