Monoclonal TCR mRNA transcripts are preferentially detected in the TCR variable alpha chain in CD8(+) T-lymphocytes: implications for immunomonitoring.

abstract：:Xuebijing injection (XBJ) has long been used to treat infectious diseases in China. The therapeutic effect of XBJ is probably associated with anti-inflammatory effects. However, the precise mechanisms responsible for the effects of XBJ remain unknown. The present study was conducted in order to evaluate the protective...

journal_title：International journal of molecular medicine

authors： Liu MW,Liu R,Wu HY,Zhang W,Xia J,Dong MN,Yu W,Wang Q,Xie FM,Wang R,Huang YQ,Qian CY

更新日期：2016-11-01 00:00:00

abstract：:Recently we have shown the antiproliferative activity of Gleditsia sinensis fruit extract (GSE) on various solid tumour and leukaemia cell lines as well as primary cultured bone marrow cells isolated from patients with acute and chronic myelogenous leukaemia. We further studied whether the growth inhibitory effect of ...

journal_title：International journal of molecular medicine

authors： Chui CH,Tang JC,Lau FY,Teo IT,Yau MY,Wong RS,Cheng GY,Ho SK,Leung TW,Hui KS,Wong MM,Fatima S,Cheng CH,Cheung F,Tan WQ,Chow LM,Guo D,Chan AS

更新日期：2004-01-01 00:00:00

abstract：:Type 2 cytokine‑associated immunity may be involved in the pathogenesis of allergic asthma. Although interleukin 27 (IL‑27) has been reported as an initiator and suppressor of T‑helper 1 (Th1) and T‑helper 2 (Th2) responses, respectively, its effects on the development of asthma remain unclear. In the present study, m...

journal_title：International journal of molecular medicine

authors： Lu D,Lu J,Ji X,Ji Y,Zhang Z,Peng H,Sun F,Zhang C

更新日期：2020-08-01 00:00:00

abstract：:In the present study, a highly efficient method, referred to as optimized ultrafiltration (OUF), was developed. This method is effective for exosome purification and also facilitates clinical work involving substantial urinary exosome isolation. In the OUF method, 0.22‑µm filters along with a dialysis membrane with a ...

journal_title：International journal of molecular medicine

authors： He L,Zhu D,Wang J,Wu X

更新日期：2019-01-01 00:00:00

abstract：:Bisphosphonates consist of a family of pyrophosphate analogues that are currently being used to treat metastatic bone diseases as well as systemic bone diseases such as osteoporosis. There is accumulating evidence suggesting that patients treated with these bisphosphonates can develop, particularly with invasive denta...

journal_title：International journal of molecular medicine

authors： Rao MV,Berk J,Almojaly SA,Goodloe Iii S,Margarone Iii J,Sullivan M,Dziak R

更新日期：2009-03-01 00:00:00

abstract：:Noise-induced hearing loss (NIHL) is one of the most frequent disabilities in industrialized countries. It has been demonstrated that hair cell loss in the auditory end organ may account for the majority of ear pathological conditions. Previous studies have indicated that histone deacetylases (HDACs) play an important...

journal_title：International journal of molecular medicine

authors： Wen LT,Wang J,Wang Y,Chen FQ

更新日期：2015-08-01 00:00:00

abstract：:Living donor liver transplantation (LDLT) requires ischemia/reperfusion (I/R), which can cause early graft injury. However, the detailed mechanism of I/R injury remains unknown. Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in heme catabolism and results in the production of iro...

journal_title：International journal of molecular medicine

authors： Matsumi J,Morimatsu H,Matsusaki T,Kaku R,Shimizu H,Takahashi T,Yagi T,Matsumi M,Morita K

更新日期：2012-02-01 00:00:00

abstract：:The polyacetate esters of certain non-nutrient monosaccharides, such as L-glucose and 2-deoxy-D-glucose, were recently reported to display positive insulinotropic action and, hence, proposed as possible tools for stimulation of insulin release in non-insulin-dependent diabetes. In the present study, the secretory resp...

journal_title：International journal of molecular medicine

authors： Malaisse WJ,Kadiata MM

更新日期：1998-07-01 00:00:00

abstract：:Anabolic agents are doping substances which are commonly used in sports. Stanozolol, a 17α‑alkylated derivative of testosterone, has a widespread use among athletes and bodybuilders. Several medical and behavioral adverse effects are associated with anabolic androgenic steroids (AAS) abuse, while the liver remains the...

journal_title：International journal of molecular medicine

authors： Ozcagli E,Kara M,Kotil T,Fragkiadaki P,Tzatzarakis MN,Tsitsimpikou C,Stivaktakis PD,Tsoukalas D,Spandidos DA,Tsatsakis AM,Alpertunga B

更新日期：2018-07-01 00:00:00

abstract：:The differentiation of atrial fibroblasts into myofibroblasts is a critical event in atrial fibrosis. One of the most important factors in atrial fibroblast differentiation is transforming growth factor-β1 (TGF-β1). Accumulating evidence indicates that sodium tanshinone IIA sulfonate (STS) possesses antifibrotic prope...

journal_title：International journal of molecular medicine

authors： Yang L,Hu J,Hao HZ,Yin Z,Liu G,Zou XJ

更新日期：2015-04-01 00:00:00

abstract：:The treatment of locoregional recurrence (LRR) of head and neck squamous cell carcinoma (HNSCC) often requires a combination of surgery, radiation therapy and/or chemotherapy. Survival outcomes are poor and the treatment outcomes are morbid. Cold atmospheric plasma (CAP) is an ionized gas produced at room temperature ...

journal_title：International journal of molecular medicine

authors： Guerrero-Preston R,Ogawa T,Uemura M,Shumulinsky G,Valle BL,Pirini F,Ravi R,Sidransky D,Keidar M,Trink B

更新日期：2014-10-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide and there is an urgent need to identify effective pharmacological strategies to treat NAFLD. For this purpose, in the present study, we examined the the possible molecular mechanisms responsible for the effects of MgIG and the...

journal_title：International journal of molecular medicine

authors： Xu Q,Wang J,Chen F,Lin K,Zhu M,Chen L,Zhou X,Li C,Zhu H

更新日期：2016-07-01 00:00:00

abstract：:The positive effect of low-magnitude, high‑frequency (LMHF) vibration on implant osseointegration has been demonstrated; however, the underlying cellular and molecular mechanisms remain unknown. The aim of this study was to explore the effect of LMHF vibration on the adhesion and the osteogenic differentiation of bone...

journal_title：International journal of molecular medicine

authors： Chen B,Lin T,Yang X,Li Y,Xie D,Zheng W,Cui H,Deng W,Tan X

更新日期：2016-11-01 00:00:00

abstract：:Gap junctions are intercellular channels made of connexin proteins, mediating both electrical and biochemical signals between cells. The ability of gap junction proteins to regulate immune responses, cell proliferation, migration, apoptosis and carcinogenesis makes them attractive therapeutic targets for treating infl...

journal_title：International journal of molecular medicine

authors： Wong P,Laxton V,Srivastava S,Chan YW,Tse G

更新日期：2017-03-01 00:00:00

abstract：:Mostotrin (MT), a novel compound, at least five orders of magnitude more soluble in water than its mother substance, was designed and synthesised from tryptanthrin (TR). Its structure was established by nuclear magnetic resonance and mass spectrometry data and confirmed by X‑ray analysis, revealing that MT is a pentac...

journal_title：International journal of molecular medicine

authors： Popov A,Klimovich A,Styshova O,Moskovkina T,Shchekotikhin A,Grammatikova N,Dezhenkova L,Kaluzhny D,Deriabin P,Gerasimenko A,Udovenko A,Stonik V

更新日期：2020-10-01 00:00:00

abstract：:The colonic crypt contains highly proliferative cells in its base and differentiated cells on its luminal surface. Carcinogenesis significantly affects this orderly cellular distribution. The aims of this study were: i) to examine the expression of apoptosis-related proteins along the crypt-lumen axis during 1, 2-dime...

journal_title：International journal of molecular medicine

authors： Avivi-Green C,Madar Z,Schwartz B

更新日期：2000-12-01 00:00:00

abstract：:Ovarian cancer is the main cause of gynecological cancer‑associated mortality around the world. Despite initial responses to chemotherapy, frequent relapse occurs. Daidzein is an important flavonoid and has been shown to exhibit a diversity of pharmacological properties, including antimicrobial and anticancer activiti...

journal_title：International journal of molecular medicine

authors： Hua F,Li CH,Chen XG,Liu XP

更新日期：2018-06-01 00:00:00

abstract：:Bel1, a transactivator of the prototype foamy virus (PFV), plays pivotal roles in the replication of PFV. Previous studies have demonstrated that Bel1 bears a nuclear localization signal (NLS); however, its amino acid sequence remains unclear and the corresponding adaptor importins have not yet been identified. In thi...

journal_title：International journal of molecular medicine

authors： Duan J,Tang Z,Mu H,Zhang G

更新日期：2016-08-01 00:00:00

abstract：:Colonic paracellular permeability is regulated by various factors, including dynamics of the cytoskeleton. Recently, ACF7 has been found to play a critical role in cytoskeletal dynamics as an essential integrator. To elucidate the physiological importance of ACF7 and paracellular permeability, we conditionally knocked...

journal_title：International journal of molecular medicine

authors： Liang Y,Shi C,Yang J,Chen H,Xia Y,Zhang P,Wang F,Han H,Qin H

更新日期：2013-04-01 00:00:00

abstract：:CREB binding protein (CBP) plays a central role in cell differentiation and proliferation, interacting with a large number of nuclear factors. To find novel nuclear factors associating with CBP, we have carried out yeast two-hybrid screening of human chondrocyte cDNA library using the C/H3 region of CBP as a bait and ...

journal_title：International journal of molecular medicine

authors： Hirose T,Fujii R,Nakamura H,Aratani S,Fujita H,Nakazawa M,Nakamura K,Nishioka K,Nakajima T

更新日期：2003-06-01 00:00:00

abstract：:Atherosclerosis is now considered a chronic inflammatory disease, and glucosamine has the potential to exhibit an anti-inflammatory action. Thus, we investigated the effect of glucosamine on tumor necrosis factor alpha (TNF-alpha)-induced endothelial cell activation. Human umbilical vein endothelial cells (HUVECs) wer...

journal_title：International journal of molecular medicine

authors： Ju Y,Hua J,Sakamoto K,Ogawa H,Nagaoka I

更新日期：2008-12-01 00:00:00

abstract：:Exposure of the skin to ultraviolet (UV) radiation causes extracellular matrix (ECM) collapse in the dermis, owing to an increase in matrix metalloproteinase (MMP) production in both the epidermis and dermis, and a decrease in type I collagen expression in the dermis. Recently, black rice (Oryza sativa L.) was reporte...

journal_title：International journal of molecular medicine

authors： Han M,Bae JS,Ban JJ,Shin HS,Lee DH,Chung JH

更新日期：2018-05-01 00:00:00

abstract：:The most common tumors in children are infantile hemangiomas which could cause morbidity and severe complications. The development of novel alternative drugs to treat infantile hemangiomas is necessary, since Hemangeol is the only US Food and Drug Administration-approved drug for infantile hemangiomas. However, Hemang...

journal_title：International journal of molecular medicine

authors： Li H,Teng Y,Xu X,Liu J

更新日期：2018-06-01 00:00:00

abstract：:Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids (EETs) have multiple biological functions in cardiovascular homeostasis. The antiinflammatory, anti-migratory and pro-proliferative effects of EETs suggest a possible beneficial role for EETs in the apoptosis, proliferation and migration of pulmonary vascular...

journal_title：International journal of molecular medicine

authors： Feng W,Xu X,Zhao G,Li G,Liu T,Zhao J,Dong R,Wang DW,Tu L

更新日期：2013-09-01 00:00:00

abstract：:A substantial increase in NADH production, arising from accelerated glycolysis, occurs in cardiac hypertrophy and this raises the question of how the NADH is oxidised. We have addressed this problem by reconstructing appropriate mitochondrial shuttles in vitro, using mitochondria from the left ventricles of both normo...

journal_title：International journal of molecular medicine

authors： Atlante A,Seccia TM,De Bari L,Marra E,Passarella S

更新日期：2006-07-01 00:00:00

abstract：:The active fraction of the extract of Asiasari radix, the 60% methanol chromatographic fraction from the ethyl acetate layer (PPAR), was used to investigate the melanogenesis signal pathway in B16F10 melanoma cells. PPAR led to significantly decreased melanin synthesis and tyrosinase activity in a dose-dependent manne...

journal_title：International journal of molecular medicine

authors： Jang JY,Lee JH,Shin HK,Choi YH,Lee JD,Choi BT

更新日期：2010-02-01 00:00:00

abstract：:Van der Woude syndrome (VWS) is the most common autosomal dominant disorder with characteristic lip pits and clefts of the lip and/or palate (CL/P). The interferon regulatory factor 6 gene (IRF6) has been recently identified as the gene mutated in patients with VWS. Here, we report two novel mutations of IRF6 in two u...

journal_title：International journal of molecular medicine

authors： Kim Y,Park JY,Lee TJ,Yoo HW

更新日期：2003-10-01 00:00:00

abstract：:Radiotherapy and adjuvant cisplatin (DDP) chemotherapy are standard approaches used in the treatment of nasopharyngeal carcinoma (NPC). However, resistance to chemotherapy has recently become more common, resulting in the failure of this combination therapy for NPC. The aim of the present study was to assess the cellu...

journal_title：International journal of molecular medicine

authors： Zhang P,Liu H,Xia F,Zhang QW,Zhang YY,Zhao Q,Chao ZH,Jiang ZW,Jiang CC

更新日期：2014-01-01 00:00:00

abstract：:S100A4, one of the tandemly arranged S100 genes at chromosome 1q21, has been suggested to play a functional role in cell motility and invasiveness of tumor cell growth. We investigated the expression of S100A4 and the in vitro invasiveness of 4 human bile duct adenocarcinoma cell lines by the Matrigel assay. S100A4 wa...

journal_title：International journal of molecular medicine

authors： Katayama N,Murao S,Ajiki T,Kitazawa S,Onoyama H,Kuroda Y,Maeda S

更新日期：2000-11-01 00:00:00

abstract：:Evodiamine is a botanical alkaloid compound extracted from Tetradium plants. Previous studies have reported that evodiamine (Evo) treatment can reduce food uptake and improve insulin resistance in animals . The skeletal muscle comprises about 40% of the body mass of adults and has a vital role in regulating whole body...

journal_title：International journal of molecular medicine

authors： Yao X,Yu T,Zhao C,Li Y,Peng Y,Xi F,Yang G

更新日期：2018-03-01 00:00:00