Effects of different cellulose membranes regenerated from Styela clava tunics on wound healing.

abstract：:Epithelial-mesenchymal transition (EMT) is a critical step and key factor during renal fibrosis. Preventing renal tubular EMT is important for delaying the progression of chronic kidney disease (CKD). P311, a highly conserved 8-kDa intracellular protein, has been indicated as an important factor in myofibroblast trans...

journal_title：International journal of molecular medicine

authors： Qi FH,Cai PP,Liu X,Si GM

更新日期：2018-05-01 00:00:00

abstract：:Hepatocellular carcinoma is a common type of cancer that is usually associated with poor prognosis. In this study, we examined the in vitro and in vivo mechanisms of the traditional Vietnamese herb Zanthoxylum avicennae on the inhibition of HA22T human hepatocellular carcinoma cell ...

journal_title：International journal of molecular medicine

authors： Dung TD,Chang HC,Binh TV,Lee MR,Tsai CH,Tsai FJ,Kuo WW,Chen LM,Huang CY

更新日期：2012-06-01 00:00:00

abstract：:Akt1/protein kinase Bα (Akt1/PKBα) is a downstream mediator of the insulin signaling system. In this study we explored mechanism(s) for its role in burn injury. Akt1/PKBα in liver extracts from mice with burn injury fed with (2H7)-L-Leu was immunoprecipitated and isolated with SDS-PAGE. Two tryptic peptides, one in th...

journal_title：International journal of molecular medicine

authors： Lu XM,Tompkins RG,Fischman AJ

更新日期：2012-03-01 00:00:00

abstract：:Resveratrol is a representative polyphenol of diet‑derived putative cancer chemopreventive agents, which have attracted increasing interest in the cancer chemoprevention community. The inhibition of the action of human papillomavirus (HPV) E6 and E7 has been considered a key approach for cervical cancer therapy. Resve...

journal_title：International journal of molecular medicine

authors： Sun X,Fu P,Xie L,Chai S,Xu Q,Zeng L,Wang X,Jiang N,Sang M

更新日期：2021-01-01 00:00:00

abstract：:We have recently established a clonal mesenchymal stem cell line (rBM25/S3) from adult rat bone marrow. The cells have practically unlimited proliferation capacity (over 300 PDL), maintaining multipotency for differentiation. In the present study, we examined the potential for rBM25/S3 cells to differentiate into insu...

journal_title：International journal of molecular medicine

authors： Masaka T,Miyazaki M,Du G,Hardjo M,Sakaguchi M,Takaishi M,Kataoka K,Yamamoto K,Huh NH

更新日期：2008-10-01 00:00:00

abstract：:Thioredoxin (TRX), which is a stress-inducible protein with redox-active disulfide structures, has various biological activities by regulating DNA binding of transcription factors in cells. In Graves' disease that is among the common diseases of the thyroid, endogenous stresses that are induced by excess thyroid hormo...

journal_title：International journal of molecular medicine

authors： Kihara M,Kontani K,Yamauchi A,Miyauchi A,Nakamura H,Yodoi J,Yokomise H

更新日期：2005-05-01 00:00:00

abstract：:In the above paper, the authors realize that an error inadvertently appeared in the funding section on p. 895. Where "This study was supported by the National Natural Science Foundation of China Science Fund Project (grant no. 30960389 and 8176010097)" was written, the application number 8176010097 was featured incorr...

journal_title：International journal of molecular medicine

authors： Li G,Zhou R,Zhao X,Liu R,Ye C

更新日期：2018-08-27 00:00:00

abstract：:Motility is a requirement for a number of biological processes, including embryonic development, neuronal development, immune responses, cancer progression and wound healing. Specific to wound healing is the migration of endothelial cells, fibroblasts and other key cellular players into the wound space. Aberrations in...

journal_title：International journal of molecular medicine

authors： Bosanquet DC,Ye L,Harding KG,Jiang WG

更新日期：2014-07-01 00:00:00

abstract：:We are interested in the possibility of a new prostate cancer therapy that would control tumor malignancy via induction of terminal cell differentiation. We previously reported that 12-O-tetra-decanoylphorbol-13-acetate (TPA) induces differentiation into cells with characteristics of microglia and decreases the malign...

journal_title：International journal of molecular medicine

authors： Suzuki T,Shimizu T,Satoh K,Sugibayashi R,Takeda K

更新日期：2002-12-01 00:00:00

abstract：:The tumor suppressor genes p15INK4B and p16INK4A, located in the chromosomal region 9p21, are frequently inactivated by homo- or hemizygous deletions, point mutation or promotor methylation in various types of cancer. No commercial probe is yet available that allows the detection of such deletions by FISH. Long distan...

journal_title：International journal of molecular medicine

authors： Bleichert A,Fiedler W,Claussen U,Ernst G,Loncarevic IF,Heller A,Liehr T,Kunert C,von Eggeling F

更新日期：2001-06-01 00:00:00

abstract：:p63, a recently identified member of the p53 gene family, plays an important role in human tissue functions. We examined the pattern of p63 expression in human esophageal squamous cell carcinomas including early-stage cancers, and its clinicopathological significance. Immunoreactivity for p63 was detected in 96.9% (63...

journal_title：International journal of molecular medicine

authors： Hara T,Kijima H,Yamamoto S,Kenmochi T,Kise Y,Tanaka H,Chino O,Shimada H,Takazawa K,Tanaka M,Inokuchi S,Makuuchi H

更新日期：2004-08-01 00:00:00

abstract：:Molecular analysis are useful for diagnosis, prognosis and follow-up of the patients, as well as for addressing therapeutic choices. Most of the molecular methods are based on the analysis of nucleic acids. The DNA and RNA methodologies of routine applicability include Southern and Northern hybridizations and polymera...

journal_title：International journal of molecular medicine

authors： Scarpa A,Tognon M

更新日期：1998-06-01 00:00:00

abstract：:Trastuzumab has efficacy to improve the effect of cytotoxic drugs, such as paclitaxel and anthracyclin, against HER2-overexpressing breast cancer cells. Sodium butyrate (NaB), a histone deacetylase inhibitor, is known to have antitumoral properties. However, whether and how trastuzumab possesses the potential to syner...

journal_title：International journal of molecular medicine

authors： Chen W,Wei F,Xu J,Wang Y,Chen L,Wang J,Guan X

更新日期：2011-12-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase and a key element in the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. Moreover, it is a negative regulator of autophagy and acts as a central regulator in cell growth. For the treatment of cancer, mTOR is a nove...

journal_title：International journal of molecular medicine

authors： Cai Y,Xia Q,Su Q,Luo R,Sun Y,Shi Y,Jiang W

更新日期：2013-04-01 00:00:00

abstract：:Apoptosis induced by docetaxel that interferes with microtubule polymerization dynamics and is used clinically to treat advanced cancers, has not been fully defined in squamous cell carcinoma. In this study, apoptotic events involved in docetaxel treatment were investigated. When the human oral squamous cell carcinoma...

journal_title：International journal of molecular medicine

authors： Taniguchi T,Takahashi M,Shinohara F,Sato T,Echigo S,Rikiishi H

更新日期：2005-04-01 00:00:00

abstract：:Previously, a specific angiogenesis inhibitor, angiostatin, discovered in urine and serum of tumor-bearing mice, was reported to potently block tumor growth and metastasis in animal models. Detection of angiostatin and its precursor proteins in urine from cancer patients has not been reported. Now, we report the devel...

journal_title：International journal of molecular medicine

authors： Cao Y,Veitonmaki N,Keough K,Cheng H,Lee LS,Zurakowski D

更新日期：2000-05-01 00:00:00

abstract：:The present study reports the identification of human sex hormone binding globulin (SHBG)-interacting proteins in the brain using a phage display-based screening technology. Phage display is a system in which a foreign protein is displayed on the surface of a bacteriophage as a fusion protein with one of the coat prot...

journal_title：International journal of molecular medicine

authors： Gnanasekar M,Suleman FG,Ramaswamy K,Caldwell JD

更新日期：2009-10-01 00:00:00

abstract：:Synovial membrane consists of fibroblasts and macrophages forming the synovial lining supported by vascularized subsynovium. Each of these components may specifically react to a particular stimulus. Thus, reactions of isolated synovial cells may not correspond to that of intact tissue. We characterized the production ...

journal_title：International journal of molecular medicine

authors： Hyc A,Osiecka-Iwan A,Niderla-Bielinska J,Jankowska-Steifer E,Moskalewski S

更新日期：2009-10-01 00:00:00

abstract：:To estimate the genetic and dietary factors influencing bone mineral density (BMD) in young adults, a total of 53 healthy volunteers (HV) (age 20.89+/-1.34), from whom informed consent was obtained, answered a questionnaire on dietary factors and had DNA from peripheral blood mononuclear cells analyzed for single nucl...

journal_title：International journal of molecular medicine

authors： Otsuki T,Sakaguchi H,Hatta E,Hatayama T,Hatada S,Miura Y,Takata-Tomokuni A,Hyodoh F,Tomomitsu T,Fukunaga M,Katsuyama H

更新日期：2004-10-01 00:00:00

abstract：:Adult mesenchymal progenitor cells (MPCs) are adherent stromal cells of non-haematopoietic origin derived from bone marrow and other tissues. Upon limited in vitro expansion, they retain their self-renewal capacity as well as their potential to differentiate into tissues of mesenchymal lineage, such as bone, cartilage...

journal_title：International journal of molecular medicine

authors： Grässel S,Ahmed N,Göttl C,Grifka J

更新日期：2009-06-01 00:00:00

abstract：:A role of GLP-1 (glucagon-like peptide-1) in the recovery of the metabolic conditions of morbidly obese patients after bariatric surgery has been proposed. Exendin 4 (Ex-4) and exendin 9 (Ex-9) both have GLP-1-like effects upon glucose metabolism in human myocytes. We investigated in normal human adipocytes the effect...

journal_title：International journal of molecular medicine

authors： Sancho V,Nuche B,Arnés L,Cancelas J,González N,Díaz-Miguel M,Martín-Duce A,Valverde I,Villanueva-Peñacarrillo ML

更新日期：2007-06-01 00:00:00

abstract：:Circular RNAs (circRNAs) have been studied in a number of diseases. However, the roles of circRNAs in hypoxic‑ischemic brain damage (HIBD) remains unknown. In the present study, high throughput sequencing was used to profile altered circRNAs in HIBD rats. A total of 66 circRNAs were identified to be differentially exp...

journal_title：International journal of molecular medicine

authors： Jiang L,Li H,Fan Z,Zhao R,Xia Z

更新日期：2019-04-01 00:00:00

abstract：:A wide range of therapeutic options exists for the treatment of keloids, all of which have their own strengths; however, a high risk of side‑effects and frequent recurrence remains. Therefore, the present study aimed to identify improved therapeutic approaches or drugs for the treatment of keloids. Ginsenoside Rg3 (Rg...

journal_title：International journal of molecular medicine

authors： Tang M,Bian W,Cheng L,Zhang L,Jin R,Wang W,Zhang Y

更新日期：2018-03-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of metformin on endothelial progenitor cell (EPC) migration and to explore the possible mechanisms. EPCs were treated with metformin, and the migration of EPCs was evaluated by wound healing and Matrigel invasion assays. We also examined the expression levels ...

journal_title：International journal of molecular medicine

authors： Li WD,Li NP,Song DD,Rong JJ,Qian AM,Li XQ

更新日期：2017-05-01 00:00:00

abstract：:Hypertension impairs the morphological and functional integrity of circulation. Previous research has shown that the loss of endothelial cells (ECs) is a common event in many cardiovascular diseases. p120 catenin (p120ctn) plays an important role in the regulation of inflammatory responses in ECs. However, the functio...

journal_title：International journal of molecular medicine

authors： Zhang Y,Zou C,Yang S,Fu J

更新日期：2016-03-01 00:00:00

abstract：:Hyposalivation is an intractable side‑effect of radiotherapy for head and neck cancer. It is caused by the irreversible loss of acinar cells and decreased saliva secretion. However, this situation severely compromises the quality of life of affected patients. Currently, there is no effective treatment for this conditi...

journal_title：International journal of molecular medicine

authors： Xiong X,Shi X,Chen F

更新日期：2014-09-01 00:00:00

abstract：:Toll-like receptor 3 (TLR3) and TLR4 utilize adaptor proteins to activate mitogen‑activated protein kinase (MAPK), resulting in the acute but transient inflammatory response aimed at the clearance of pathogens. In the present study, it was demonstrated that macrophage activation by lipopolysaccharide (LPS) or poly(I:C...

journal_title：International journal of molecular medicine

authors： Bian H,Li F,Wang W,Zhao Q,Gao S,Ma J,Li X,Ren W,Qin C,Qi J

更新日期：2017-11-01 00:00:00

abstract：:The purpose of the present study was to investigate whether bone marrow mesenchymal stem cells (BMMSCs) modified by CXC‑chemokine receptor type 3 (CXCR3) and heme oxygenase‑1 (HO‑1) genes can repair damaged intestinal epithelial cells in vitro, and the role of the p38 mitogen‑activated protein kinase (p38‑MAPK) pathwa...

journal_title：International journal of molecular medicine

authors： Yin M,Shen Z,Yang L,Zheng W,Song H

更新日期：2019-05-01 00:00:00

abstract：:The enhancement and promotion of health is necessary to maintain the quality of life (QOL) of the aged population in developed nations such as Japan where the number of elderly has been increasing rapidly. For this purpose, low-resistance training using exercise machines ('Power Rehabilitation') has been established a...

journal_title：International journal of molecular medicine

authors： Murakami S,Otsuki T,Maeda M,Miura Y,Morii S,Kiyokane K,Hayakawa S,Maeda A,Imakawa T,Harada S,Handa T,Nishimura Y,Murakami S,Kumagai N,Hayashi H,Chen Y,Suemori S,Fukushima Y,Nishida S,Fukushima K

更新日期：2009-01-01 00:00:00

abstract：:To investigate whether in vivo gene transfer causes leptin-antagonistic effects on food intake, animal body weight and fat tissue weight, the R128Q mutated-leptin gene, an R to Q substitution at position 128 of mouse leptin, was transferred into mouse liver and leg muscle by electroporation and hydrodynamics-based gen...

journal_title：International journal of molecular medicine

authors： Xiang L,Murai A,Muramatsu T

更新日期：2005-12-01 00:00:00