MAPK/p38 regulation of cytoskeleton rearrangement accelerates induction of macrophage activation by TLR4, but not TLR3.

abstract：:Autologous chondrocyte implantation (ACI) relies on the use of cultured cells. However, the biosynthetic profile of cultured chondrocytes is shown to be altered during in vitro expansion. The purpose of this study therefore, was to examine the cellular phenotype of chondrocytes cultured for ACI and to determine the ap...

journal_title：International journal of molecular medicine

authors： Zheng MH,King E,Kirilak Y,Huang L,Papadimitriou JM,Wood DJ,Xu J

更新日期：2004-05-01 00:00:00

abstract：:Clinical evidence suggests that healing is faster and almost scarless at an early neonatal age in comparison with that in adults. In this study, the phenotypes of neonatal and adult dermal fibroblasts and keratinocytes (nestin, smooth muscle actin, keratin types 8, 14 and 19, and fibronectin) were compared. Furthermor...

journal_title：International journal of molecular medicine

authors： Mateu R,Živicová V,Krejčí ED,Grim M,Strnad H,Vlček Č,Kolář M,Lacina L,Gál P,Borský J,Smetana K Jr,Dvořánková B

更新日期：2016-10-01 00:00:00

abstract：:Ischemia/reperfusion (I/R)‑induced inflammatory reaction is one of the most important elements in myocardial I/R injury. In addition, autophagy serves an important role in normal cardiac homeostasis, and obstructions to the autophagy process lead to severe consequences for the heart. Hydrogen exerts an effective thera...

journal_title：International journal of molecular medicine

authors： Yao L,Chen H,Wu Q,Xie K

更新日期：2019-09-01 00:00:00

abstract：:Midkine (MK), a retinoic acid responsible protein, is regulated during development and may play an important role in tumorigenesis. A search for genetic variations of the MK gene, located on chromosome 11q11.2 in humans, has not yet been conducted in cancers. To examine the entire coding region, as well as 4 regions o...

journal_title：International journal of molecular medicine

authors： Ahmed KM,Shitara Y,Kuwano H,Takenoshita S,Uchimuro K,Shinozawa T

更新日期：2000-09-01 00:00:00

abstract：:Drug-induced toxic epidermal necrolysis (TEN) is a rare bullous disease characterized by severe epidermal necrosis and sloughing. Soluble TNF-alpha(sTNF-alpha), soluble IL-6 (sIL-6) and their reactive soluble receptors (sTNF-Rp55 or-R1, sTNF-Rp75 or-R2, sIL-6R) were quantified in blister fluid and serum of 6 TEN patie...

journal_title：International journal of molecular medicine

authors： Paquet P,Piérard GE

更新日期：1998-02-01 00:00:00

abstract：:Several recent studies have reported an association between neurodegeneration and histone modifications, such as acetylation, deacetylation and methylation. In addition, questions have been raised regarding a potential functional role for the histone acetylation enzymes in β-amyloid (Aβ)-mediated neurotoxicity, partic...

journal_title：International journal of molecular medicine

authors： Park SY,Kim MJ,Kim YJ,Lee YH,Bae D,Kim S,Na Y,Yoon HG

更新日期：2015-04-01 00:00:00

abstract：:Oxygen-related free radicals have been suggested as a cause of aging and various diseases, for example, various cancers and rheumatoid arthritis. Because of this a radical scavenger as an antioxidant has been sought in many foods. 'Nikogori' gelatin gel from cooked fish is a traditional food in Japan. Recently, 'Nikog...

journal_title：International journal of molecular medicine

authors： Nagatsuka N,Harada K,Ando M,Nagao K

更新日期：2005-09-01 00:00:00

abstract：:An early insulin regimen ameliorates glucotoxicity but also lipotoxicity in type 2 diabetes; however, the underlying mechanism remains elusive. In the present study, we investigated the role of mitochondria in lipid regulation following early insulin administration in insulin-resistant skeletal muscle cells. Male C57B...

journal_title：International journal of molecular medicine

authors： Tang W,Tang S,Wang H,Ge Z,Zhu D,Bi Y

更新日期：2017-12-01 00:00:00

abstract：:Adiponectin (APN) exerts anti‑inflammatory effects in various cells. Uric acid (UA) induces inflammation in proximal renal tubular epithelial cells (PTECs). It remains unknown whether APN protects against UA‑induced inflammation. In the present study, human PTECs were incubated with 100 µg/ml soluble (S) UA in the pre...

journal_title：International journal of molecular medicine

authors： Yang Q,Fu C,Zhang X,Zhang Z,Zou J,Xiao J,Ye Z

更新日期：2019-03-01 00:00:00

abstract：:Type 2 cytokine‑associated immunity may be involved in the pathogenesis of allergic asthma. Although interleukin 27 (IL‑27) has been reported as an initiator and suppressor of T‑helper 1 (Th1) and T‑helper 2 (Th2) responses, respectively, its effects on the development of asthma remain unclear. In the present study, m...

journal_title：International journal of molecular medicine

authors： Lu D,Lu J,Ji X,Ji Y,Zhang Z,Peng H,Sun F,Zhang C

更新日期：2020-08-01 00:00:00

abstract：:Periplaneta americana extracts (PAEs) play a crucial role in skin wound healing. However, their molecular effects and signaling pathways in regenerating tissues and cells are not clear. In this study, we refined the PAE from Periplaneta americana to investigate the mechanisms underlying skin wound healing. The human k...

journal_title：International journal of molecular medicine

authors： Song Q,Xie Y,Gou Q,Guo X,Yao Q,Gou X

更新日期：2017-08-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC), a tumor arising from the epithelial cells of the nasopharynx, is endemic in Southeast Asia and Taiwan. The prognosis of NPC patients with local recurrence and metastasis is poor. Resistance to anoikis is a primary characteristic of tumor cells that metastasize. However, the mechanism th...

journal_title：International journal of molecular medicine

authors： Lin CH,Chiang MC,Chen YJ

更新日期：2017-11-01 00:00:00

abstract：:It is not clear whether pseudoallergic reactions are caused by similar mechanisms as type I allergic reactions. 3‑Caffeoylquinic acid (chlorogenic acid) is an active ingredient in traditional Chinese medicines used for antibacterial, anti-inflammatory and cholagogic purposes. It is assumed to be the reason for the hig...

journal_title：International journal of molecular medicine

authors： Li Q,Zhao Y,Zheng X,Chen Q,Zhang X

更新日期：2013-12-01 00:00:00

abstract：:ACSL3 is a member of the long chain acyl-CoA synthetase (ACSL) family that consists of 5 isozymes responsible for cellular fatty acid metabolism in various tissues in an isozyme-specific manner. Our previous studies have demonstrated that expression of ACSL3 mRNA and protein in liver was specifically increased after f...

journal_title：International journal of molecular medicine

authors： Wu M,Cao A,Dong B,Liu J

更新日期：2011-05-01 00:00:00

abstract：:The polyacetate esters of certain non-nutrient monosaccharides, such as L-glucose and 2-deoxy-D-glucose, were recently reported to display positive insulinotropic action and, hence, proposed as possible tools for stimulation of insulin release in non-insulin-dependent diabetes. In the present study, the secretory resp...

journal_title：International journal of molecular medicine

authors： Malaisse WJ,Kadiata MM

更新日期：1998-07-01 00:00:00

abstract：:Androgen-independent growth of prostate cancer is correlated with expression of bcl-2. The impact of bcl-2 expression on the growth of prostate cancer cells following androgen ablation, was examined in the androgen-sensitive prostatic carcinoma cell line, LNCaP. Vector control and bcl-2 expressing LNCaP cells were gro...

journal_title：International journal of molecular medicine

authors： Beham AW,Sarkiss M,Brisbay S,Tu SM,von Eschenbach AC,McDonnell TJ

更新日期：1998-06-01 00:00:00

abstract：:Mutations in the known predisposing breast cancer genes BRCA1 and BRCA2 account for only a small proportion (<10%) of breast cancer families in the Stockholm region of Sweden. This study aims to identify novel predisposing genes in non-BRCA1/BRCA2 breast cancer families. We have employed comparative genomic hybridizat...

journal_title：International journal of molecular medicine

authors： Maguire P,Holmberg K,Kost-Alimova M,Imreh S,Skoog L,Lindblom A

更新日期：2005-07-01 00:00:00

abstract：:Biochemical modification of extracellular matrix (ECM) proteins can alter the function in overlying cells. We tested the hypothesis that metal-catalyzed oxidation of native ECM and individual matrix proteins modulates the activity of inducible nitric oxide synthase (iNOS) in cultured rat mesangial cells (RMC). Oxidize...

journal_title：International journal of molecular medicine

authors： Trachtman H,Futterweit S,Koss E,Bogart M,Mermelstein A

更新日期：1999-03-01 00:00:00

abstract：:In the wide horizon of ophthalmologically rare diseases among retinitis pigmentosa forms, Stargardt disease has gradually assumed a significant role due to its heterogeneity. In the present study, we aimed to support one of two opposite hypotheses concerning the causative or protective role of heterozygous c.1268A>G m...

journal_title：International journal of molecular medicine

authors： D'Angelo R,Donato L,Venza I,Scimone C,Aragona P,Sidoti A

更新日期：2017-04-01 00:00:00

abstract：:Synthetic biomaterials combined with cells and osteogenic factors represent a promising approach for the treatment of a number of orthopedic diseases, such as bone trauma and congenital malformations. To guarantee optimal biological properties, bone substitutes are prepared with a 3D structure and porosity grade funct...

journal_title：International journal of molecular medicine

authors： Di Liddo R,Paganin P,Lora S,Dalzoppo D,Giraudo C,Miotto D,Tasso A,Barbon S,Artico M,Bianchi E,Parnigotto PP,Conconi MT,Grandi C

更新日期：2014-12-01 00:00:00

abstract：:Thioredoxin domain‑containing 5 (TXNDC5) is reportedly overexpressed in colorectal cancer (CRC) and is therefore considered an oncogene. However, the role of TXNDC5 in CRC tumorigenesis remains unclear. The present study aimed to explore the role of TXNDC5 in CRC tumorigenesis in vitro and in vivo under hypoxic and no...

journal_title：International journal of molecular medicine

authors： Tan F,Zhu H,He X,Yu N,Zhang X,Xu H,Pei H

更新日期：2018-08-01 00:00:00

abstract：:Excessive expansion of the transit-amplifying (TA) cell compartment is a distinct morphological characteristic of psoriatic epidermal hyperplasia. In order to examine the activation of basal stem cells and how they replenish such an enlarged compartment of TA cells in psoriatic epidermis, we utilized a BrdU labeling m...

journal_title：International journal of molecular medicine

authors： Jia HY,Shi Y,Luo LF,Jiang G,Zhou Q,Xu SZ,Lei TC

更新日期：2016-02-01 00:00:00

abstract：:Osteosarcoma (OS), a malignant bone neoplasia in childhood, has poor prognosis if metastases appear in the lung. A novel therapeutic approach could consist in a gene therapeutic treatment of OS metastases. However, if promiscuous viral vectors are applied for the delivery of potentially toxic transgenes, their misdeli...

journal_title：International journal of molecular medicine

authors： Pollmann A,Kabisch H,Block A,Müller J,Hellwinkel OJ

更新日期：2004-10-01 00:00:00

abstract：:A female patient (64 years of age; body mass index, 26) had a markedly and relatively low low-density lipoprotein-cholesterol (LDL-C) level (97 mg/dl) despite high serum total cholesterol (TC) (331 mg/dl) and triacylglyceride levels (307 mg/dl). Since the expected LDL-C was 222 mg/dl, there was a significant differenc...

journal_title：International journal of molecular medicine

authors： Lee JH,Park JH,Lee SH,Kim JR,Cho KH

更新日期：2010-06-01 00:00:00

abstract：:Bel1, a transactivator of the prototype foamy virus (PFV), plays pivotal roles in the replication of PFV. Previous studies have demonstrated that Bel1 bears a nuclear localization signal (NLS); however, its amino acid sequence remains unclear and the corresponding adaptor importins have not yet been identified. In thi...

journal_title：International journal of molecular medicine

authors： Duan J,Tang Z,Mu H,Zhang G

更新日期：2016-08-01 00:00:00

abstract：:Subsequently to the publication of this article, the authors have realized that the address affiliation for the corresponding author, Chengheng Hu, and the authors Longyun Peng and Xinxue Liao appeared incorrectly. These authors' affiliation information should have appeared as follows (the corrected address affiliatio...

journal_title：International journal of molecular medicine

authors： Ke X,Chen J,Peng L,Zhang W,Yang Y,Liao X,Mo L,Guo R,Feng J,Hu C,Nie R

更新日期：2018-09-01 00:00:00

abstract：:The aim of the present study was to investigate the expression of bone morphogenetic protein 7 (BMP7) in cervical cancer tissues, the effect of BMP7 on the proliferation, migration and epithelial‑mesenchymal transition (EMT) of cervical cancer HeLa cells and the possible mechanism involved. Immunohistochemistry was us...

journal_title：International journal of molecular medicine

authors： Sun R,Guan H,Liu W,Liang J,Wang F,Li C

更新日期：2020-05-01 00:00:00

abstract：:Microglial activation-mediated inflammatory damage to oligodendrocytes is a key step in the etiology of ischemic white matter lesions. The adenosine A1 receptor (A1R) and adenosine A2a receptor (A2aR) have been reported to regulate the activation of microglia, however, the underlying mechanisms remain elusive. Thus, t...

journal_title：International journal of molecular medicine

authors： Huang W,Bai S,Zuo X,Tang W,Chen P,Chen X,Wang G,Wang H,Xie P

更新日期：2018-06-01 00:00:00

abstract：:Cell sheet technology is a novel tissue engineering technology that has been rapidly developed in recent years. As a novel technology, cell sheet technology is expected to become one of the preferred methods for cell transplantation. The present study investigated the biological effects of rutin on the formation of pe...

journal_title：International journal of molecular medicine

authors： Zhao B,Zhang Y,Xiong Y,Xu X

更新日期：2019-12-01 00:00:00

abstract：:We analyzed a series of ovarian carcinomas from patients treated with cisplatin-based chemotherapy for loss of heterozygosity (LOH) to determine the relationship between microsatellite alteration and prognosis. Patients with tumors that had lost alleles at loci 3p14-21, 12qter, or 17p13.3 showed significantly reduced ...

journal_title：International journal of molecular medicine

authors： Nakayama S,Nakayama K,Takebayashi Y,Hata K,Fujiwaki R,Fukumoto M,Miyazaki K

更新日期：2003-05-01 00:00:00